PPARα Antagonist AA452 Triggers Metabolic Reprogramming and Increases Sensitivity to Radiation Therapy in Human Glioblastoma Primary Cells.

abstract：:Early biochemical changes associated with adjuvant stimulation of macrophage protein synthesis were studied using two murine macrophage cell lines, PU5-1.8 and J774.1. An induction of ornithine decarboxylase (ODC) was detected 2 hours after exposure of PU5-1.8 and J774.1 cells to two crude immunoadjuvants, BCG cell wa...

journal_title：Journal of cellular physiology

authors： Prosser FH,Schmidt CJ,Nichols SV,Nichols WK

更新日期：1984-07-01 00:00:00

abstract：:Insulin-like growth factor-I receptor (IGF-IR) is often overexpressed in malignant tumors, and is involved in the establishment and maintenance of malignant phenotypes. Tyrosine kinase receptor endocytosis is commonly triggered by ligand binding and occurs via clathrin-coated vescicles that transfer the receptor to th...

journal_title：Journal of cellular physiology

authors： Carelli S,Di Giulio AM,Paratore S,Bosari S,Gorio A

更新日期：2006-08-01 00:00:00

abstract：:Dose-response curves for the inhibition of heterogeneous nuclear RNA (hnRNA) synthesis in HeLa cells by 5,6-dichloro-1-beta-D-ribofuranosylbenzimidazole (DRB; 5-100 microM; 30 min) are biphasic and indicate the existence of two subpopulations of hnRNA molecules, one highly sensitive and the other completely resistant,...

journal_title：Journal of cellular physiology

authors： Tamm I

更新日期：1983-07-01 00:00:00

abstract：:The beneficial effects of light-emitting diode (LED) irradiation have been reported in various pathologies, including cancer. However, its effect in pancreatic cancer cells remains unclear. Herein, we demonstrated that blue LED of 460 nm regulated pancreatic cancer cell proliferation and apoptosis by suppressing the e...

journal_title：Journal of cellular physiology

authors： Kim YM,Ko SH,Shin YI,Kim Y,Kim T,Jung J,Lee SY,Kim NG,Park KJ,Ryu JH

更新日期：2021-02-01 00:00:00

abstract：:Up-regulation of atrial natriuretic peptide (ANP) mRNA in the kidneys in several disorders has been demonstrated; however, evidence that ANP synthesized by the kidney exerts a local function has never been produced. Therefore, we investigated whether endogenous ANP could modulate high glucose-stimulated TGF-beta1, col...

journal_title：Journal of cellular physiology

authors： Lo CS,Chen CH,Hsieh TJ,Lin KD,Hsiao PJ,Shin SJ

更新日期：2009-06-01 00:00:00

abstract：:A growing number of studies have suggested that long noncoding RNAs (lncRNAs) play critical roles in human malignant cancers, including hepatocellular carcinoma (HCC). However, the functions of most lncRNAs have not been elucidated in HCC. In the present study, we explored the potential functions of a novel lncRNA LOC...

journal_title：Journal of cellular physiology

authors： E C,Li C,Li H,Yang J

更新日期：2019-08-01 00:00:00

abstract：:Nitric oxide (NO) has been shown to be both an intercellular and intracellular messenger. We propose here that exogenous NO induces chemotactic locomotion of human neutrophils. Indeed, when human neutrophils were placed in a gradient of a nitric oxide donor (S-nitroso-N-acetylpenicillamine; SNAP), a directed locomotio...

journal_title：Journal of cellular physiology

authors： Beauvais F,Michel L,Dubertret L

更新日期：1995-12-01 00:00:00

abstract：:Resistance to conventional chemotherapy remains a major cause of cancer relapse and cancer-related deaths. Therefore, there is an urgent need to overcome resistance barriers. To improve cancer treatment approaches, it is critical to elucidate the basic mechanisms underlying drug resistance. Increasingly, the mechanism...

journal_title：Journal of cellular physiology

authors： Naghizadeh S,Mohammadi A,Duijf PHG,Baradaran B,Safarzadeh E,Cho WC,Mansoori B

更新日期：2020-10-01 00:00:00

abstract：:Maintenance of intestinal epithelial barrier functions is crucial to prevent systemic contamination by microbes that penetrate from the gut lumen. GTPases of the Rho-family such as RhoA, Rac1, and Cdc42 are known to be critically involved in the regulation of intestinal epithelial barrier functions. However, it is sti...

journal_title：Journal of cellular physiology

authors： Schlegel N,Meir M,Spindler V,Germer CT,Waschke J

更新日期：2011-05-01 00:00:00

abstract：:Hedgehog (Hh) family members are involved in multiple cellular processes including proliferation, migration, differentiation, and cell fate determination. Recently, the novel Hh agonists Hh-Ag 1.3 and 1.7 were identified in a high-throughput screening of small molecule compounds that activate the expression of Gli1, a...

journal_title：Journal of cellular physiology

authors： Nakamura T,Naruse M,Chiba Y,Komori T,Sasaki K,Iwamoto M,Fukumoto S

更新日期：2015-04-01 00:00:00

abstract：:The ratio of mouse to rat albumin secreted by mouse hepatoma x rat hepatoma hybrid cells is constant (of the order of 5.0) irrespective of the total amounts produced. The present results establish for seven independent hybrid clones that the coordination in the ratio of mouse to rat product applies also at the level o...

journal_title：Journal of cellular physiology

authors： Sellem CH,Cassio D,Sala-Trepat JM,Weiss MC

更新日期：1983-05-01 00:00:00

abstract：:We have observed that some of the DNA damage or damage product caused by irradiation of interphase cells persisted throughout the cell cycle, and resulted in the expression of gamma-H2AX foci on the mitotic chromosomes. These mitotic expressions of damage after gamma-irradiation of G1 or G2 phase cells were compared i...

journal_title：Journal of cellular physiology

authors： Kato TA,Okayasu R,Bedford JS

更新日期：2009-06-01 00:00:00

abstract：:Pyroptosis is a form of necrotic and inflammatory programmed cell death, which could be characterized by cell swelling, pore formation on plasma membranes, and release of proinflammatory cytokines (IL-1β and IL-18). The process of pyroptosis presents as dual effects: protecting multicellular organisms from microbial i...

journal_title：Journal of cellular physiology

authors： Lu F,Lan Z,Xin Z,He C,Guo Z,Xia X,Hu T

更新日期：2020-04-01 00:00:00

abstract：:Methionine dependence is a metabolic defect found thus far only in transformed and malignant cells. The defect is manifested as the inability of cells to grow in media in which methionine (Met) is replaced by its immediate precursor homocysteine (Hcy). We have termed this Met- Hcy+ media. We demonstrate here that meth...

journal_title：Journal of cellular physiology

authors： Stern PH,Wallace CD,Hoffman RM

更新日期：1984-04-01 00:00:00

abstract：:Current osteoinductive protein therapy utilizes bolus administration of large doses of bone morphogenetic proteins (BMPs), which is costly, and may not replicate normal bone healing. The limited in vivo biologic activity of BMPs requires the investigation of growth factors that may enhance this activity. In this study...

journal_title：Journal of cellular physiology

authors： Arosarena OA,Del Carpio-Cano FE,Dela Cadena RA,Rico MC,Nwodim E,Safadi FF

更新日期：2011-11-01 00:00:00

abstract：:Wnt5a, a member of the noncanonical Wnt proteins, is known to play important roles in the development of various organs and in postnatal cell functions. However, little is known about the effects of Wnt5a on human periodontal ligament (PDL) cells. In this study, we examined the localization and potential function of W...

journal_title：Journal of cellular physiology

authors： Hasegawa D,Wada N,Maeda H,Yoshida S,Mitarai H,Tomokiyo A,Monnouchi S,Hamano S,Yuda A,Akamine A

更新日期：2015-11-01 00:00:00

abstract：:Histone deacetylases (HDACs) play a crucial role in the regulation of gene expression through remodeling of chromatin structures. However, the molecular mechanisms involved in this event remain unknown. In this study, we sought to examine whether HDAC inhibition-mediated protective effects involved HDAC4 sumoylation, ...

journal_title：Journal of cellular physiology

authors： Du J,Zhang L,Zhuang S,Qin GJ,Zhao TC

更新日期：2015-06-01 00:00:00

abstract：:Adhesion of calf lens epithelial cells to lens capsule, their natural basement membrane was found to be considerably more rapid than either to plastic or to type I or type IV collagen coated surfaces. No polarity of the basement membrane was observed as the cells were able to attach to either side of the anterior or p...

journal_title：Journal of cellular physiology

authors： Cammarata PR,Spiro RG

更新日期：1982-11-01 00:00:00

abstract：:The glycoprotein laminin appears to function in the attachment of various epithelial cells to basement membranes. We examined whether its putative cell-adhesive activity could be analyzed in a simple, one-component model system--the agglutination of erythrocytes. Laminin is a potent agglutinin of aldehyde-fixed sheep ...

journal_title：Journal of cellular physiology

authors： Kennedy DW,Rohrbach DH,Martin GR,Momoi T,Yamada KM

更新日期：1983-03-01 00:00:00

abstract：:The effects of src oncogene expression on epidermal growth factor (EGF) receptors have been investigated in mouse 3T3 and rat-1 fibroblasts. Transformation of both cell types with src resulted in marked reductions in cellular EGF receptor levels, as assayed by either 125I-EGF binding or immunoprecipitation of receptor...

journal_title：Journal of cellular physiology

authors： Wasilenko WJ,Shawver LK,Weber MJ

更新日期：1987-06-01 00:00:00

abstract：:The release of superoxide anion (O2-) by inflammatory macrophages, multinucleated giant cells, and epithelioid cells, obtained by the insertion of round glass coverslips into the subcutaneous tissue of mice, was investigated. O2- was shown to be spontaneously released by cells on the surface of glass coverslips implan...

journal_title：Journal of cellular physiology

authors： Camarero VC,Junqueira VB,Colepicolo P,Karnovsky ML,Mariano M

更新日期：1990-12-01 00:00:00

abstract：:Cardiac hypertrophy (CH), characterized by the enlargement of cardiomyocytes, fibrosis and apoptosis, is one of the leading causes of death worldwide. Despite the advances in cardiovascular research, there remains a need to further investigate the signaling pathways that mediate CH in order to identify novel therapeut...

journal_title：Journal of cellular physiology

authors： Riaz S,Zeidan A,Mraiche F

更新日期：2017-12-01 00:00:00

abstract：:We recently reported that peptidoglycan (PGN), a cell wall component of the Gram-positive bacterium, induces NF-κB activation and microglia activation. However, PGN-regulated AP-1 activation and cytokine expression in microglia remains unclear. This study investigated how PGN influences the signaling pathway involved ...

journal_title：Journal of cellular physiology

authors： Lin HY,Tang CH,Chen JH,Chuang JY,Huang SM,Tan TW,Lai CH,Lu DY

更新日期：2011-06-01 00:00:00

abstract：:Epidermal growth factor-like domain-containing protein 7 (EGFL7), a member of the epidermal growth factor (EGF)-like protein family, is a potent angiogenic factor expressed in many different cell types. EGFL7 plays a vital role in controlling vascular angiogenesis during embryogenesis, organogenesis, and maintaining s...

journal_title：Journal of cellular physiology

authors： Hong G,Kuek V,Shi J,Zhou L,Han X,He W,Tickner J,Qiu H,Wei Q,Xu J

更新日期：2018-11-01 00:00:00

abstract：:Retinoic acid (RA) reduced growth, fibronectin, and retinoic acid receptor (RAR alpha) in NIH 3T3 cells but not in cells transformed by the Ha-ras oncogene. RA lowered RAR alpha transcript and protein, increased RAR beta transcripts, and had no effect on RAR gamma. H-ras transformation downregulated RAR expression and...

journal_title：Journal of cellular physiology

authors： De Luca LM,Scita G,Takatsuka J

更新日期：1997-11-01 00:00:00

abstract：:Adenosine is an ubiquitous nucleoside present in all body cells. It is released from metabolically active or stressed cells and subsequently acts as a regulatory molecule through binding to specific A1, A2A, A2B and A3 cell surface receptors. The synthesis of agonists and antagonists to the adenosine receptors and the...

journal_title：Journal of cellular physiology

authors： Ohana G,Bar-Yehuda S,Barer F,Fishman P

更新日期：2001-01-01 00:00:00

abstract：:The main aim of this investigation was to determine whether a functional relationship existed between epidermal growth factor (EGF) and voltage-gated sodium channel (VGSC) upregulation, both associated with strongly metastatic prostate cancer cells. Incubation with EGF for 24 h more than doubled VGSC current density. ...

journal_title：Journal of cellular physiology

authors： Ding Y,Brackenbury WJ,Onganer PU,Montano X,Porter LM,Bates LF,Djamgoz MB

更新日期：2008-04-01 00:00:00

abstract：:Methylxantine derivative, caffeine, is known to prevent the p53-dependent apoptosis pathway via inhibition of ATM (ataxia telangiectasia mutated) kinase, which activates p53 by phosphorylation of the Ser-15 residue. In contrast, it has been reported that caffeine induces p53-mediated apoptosis through Bax protein in n...

journal_title：Journal of cellular physiology

authors： Ito K,Nakazato T,Miyakawa Y,Yamato K,Ikeda Y,Kizaki M

更新日期：2003-08-01 00:00:00

abstract：:Phenotypically different osteoclasts may be generated from different subsets of precursors. To what extent the formation of these osteoclasts is influenced or mediated by the inflammatory cytokine TNF-α, is unknown and was investigated in this study. The osteoclast precursors early blasts (CD31hi Ly-6C- ), myeloid bla...

journal_title：Journal of cellular physiology

authors： Cao Y,Jansen IDC,Sprangers S,de Vries TJ,Everts V

更新日期：2017-12-01 00:00:00

abstract：:The unique vascular supply of the retina, the ability to visualize the vasculature in vivo, and the ability to selectively express genes in the retina make the retina an ideal model system to study molecular mechanisms of angiogenesis. In addition, this area of investigation has great clinical significance, because re...

journal_title：Journal of cellular physiology

authors： Campochiaro PA

更新日期：2000-09-01 00:00:00