Cholera toxin and analogues of cyclic AMP stimulate the growth of cultured human mammary epithelial cells.

Abstract:

:The growth of human epithelial cells is stimulated by cholera toxin and analogues of cyclic AMP, while the growth of breast derived fibroblasts is inhibited. These compounds have little effect on DNA synthesis in the absence of other mitogens but show a synergistic effect with serum and/or EGF. The results suggest that high intracellular levels of cyclic AMP in human mammary epithelial cells increase the growth response of the cell to mitogens.

journal_name

J Cell Physiol

authors

Taylor-Papadimitriou J,Purkis P,Fentiman IS

doi

10.1002/jcp.1041020306

subject

Has Abstract

pub_date

1980-03-01 00:00:00

pages

317-21

issue

3

eissn

0021-9541

issn

1097-4652

journal_volume

102

pub_type

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