Abstract:
:Neuroblastoma (NB) is the leading pediatric cancer known for its heterogeneity and clinical aggressiveness leading to chemoresistance. Recent evidence in small RNA research has led to the discovery of PIWI-interacting RNAs (piRNAs) which work in an orchestrated fashion to modulate gene expression both in homeostatic conditions and abnormalities like cancer including NB. This study aims to decipher the possible role of a repeat-derived piRNA, piR-39980 (identified from our previous piRNA profiling study in human NB cell lines) in tumorigenesis of NB cells. piR-39980, overexpressed in NB cells act as an oncopiR and promotes tumor progression, while its inhibition resulted in reduced viability, invasion as well as the migration of IMR-32 cells. Interestingly, we observed that inhibition of piRNA induces senescence of NB cells without affecting the classical apoptosis pathway by modulating the expression of JAK3 through target binding. In addition, piR-39980 was found to desensitize the effect of doxorubicin and inhibit drug-induced apoptosis. Overall, we report piR-39980, as the first oncopiR which might serve as a novel therapeutic target for this malignancy.
journal_name
J Cell Physioljournal_title
Journal of cellular physiologyauthors
Roy J,Das B,Jain N,Mallick Bdoi
10.1002/jcp.29136subject
Has Abstractpub_date
2020-03-01 00:00:00pages
2286-2299issue
3eissn
0021-9541issn
1097-4652journal_volume
235pub_type
杂志文章abstract::The effects of adenosine and two analogs, L-phenylisopropyladenosine (L-PIA) and 5'-N-ethylcarboxamidoadenosine (NECA), on cAMP production and on platelet-derived growth factor (PDGF)-stimulated initiation of DNA synthesis in growth-arrested cultures of rat arterial smooth muscle cells (SMC) were studied. The intracel...
journal_title:Journal of cellular physiology
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pub_type: 杂志文章,评审
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journal_title:Journal of cellular physiology
pub_type: 杂志文章
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更新日期:1997-12-01 00:00:00
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pub_type: 杂志文章
doi:10.1002/jcp.30189
更新日期:2021-01-09 00:00:00
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journal_title:Journal of cellular physiology
pub_type: 杂志文章
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更新日期:2003-10-01 00:00:00
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journal_title:Journal of cellular physiology
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doi:10.1002/jcp.1041130318
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journal_title:Journal of cellular physiology
pub_type: 杂志文章
doi:10.1002/jcp.22865
更新日期:2012-04-01 00:00:00
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journal_title:Journal of cellular physiology
pub_type: 杂志文章,评审
doi:10.1002/jcp.26414
更新日期:2018-10-01 00:00:00
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journal_title:Journal of cellular physiology
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更新日期:2020-11-01 00:00:00
abstract::A sensitive serum-free culture system was used to demonstrate that cells derived from normal human skin release soluble mediators which can modulate keratinocyte, melanocyte, and fibroblast growth in vitro. In M199 supplemented with epidermal growth factor, hydrocortisone, insulin, transferrin, triidothyronine, bovine...
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doi:10.1002/jcp.1041170215
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journal_title:Journal of cellular physiology
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更新日期:2006-08-01 00:00:00
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journal_title:Journal of cellular physiology
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journal_title:Journal of cellular physiology
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abstract::The neuropeptide pituitary adenylate cyclase-activating polypeptide (PACAP), a member of the glucagon/vasoactive intestinal peptide (VIP) superfamily, stimulates cyclic AMP accumulation initiating a variety of biological processes such as: neurotropic actions, immune and pituitary function, learning and memory, catech...
journal_title:Journal of cellular physiology
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abstract::Adult bone marrow mesenchymal stromal cells (BMSCs) can easily be differentiated into a variety of cells. In vivo transplantation of BMSCs-differentiated cells has had limited success, suggesting that these cells may not be fully compatible with the cells they are intended to replace in vivo. We investigated the struc...
journal_title:Journal of cellular physiology
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更新日期:2016-04-01 00:00:00