Lineage-negative bone marrow cells travel bidirectionally in the olfactory migratory stream but maintain hematopoietic phenotype.

abstract：:Hypoxia promotes keratinocyte migration on wound bed connective tissues and is a profound biological signal that transforms a basal keratinocyte, destined to differentiate, into a motile cell that is essential for re-epithelialization. In this study, we examined the effect of hypoxia on keratinocyte-derived collagenas...

journal_title：Journal of cellular physiology

authors： O'Toole EA,van Koningsveld R,Chen M,Woodley DT

更新日期：2008-01-01 00:00:00

abstract：:Cystamine together with colchicine markedly enhanced the uptake of [3H]-thymidine into DNA of quiescent cultures of insulin-stimulated Swiss 3T3 mouse fibroblasts. Flow cytofluorometric analyses showed an increased rate of transition of cells from G0/G1----S + G2 in response to combinations of insulin, colchicine, and...

journal_title：Journal of cellular physiology

authors： Fong S,Friedkin M

更新日期：1984-09-01 00:00:00

abstract：:Phospholipase C-ε (PLCε) is frequently overexpressed in tumors and plays an important role in the regulation of tumorigenesis. Although great progress has been made in understanding biological roles of PLCε, the relevant molecular mechanisms underlying its pro-tumor activity remain largely unclear. Here, we demonstrat...

journal_title：Journal of cellular physiology

authors： Fan Y,Ou L,Fan J,Li L,Wang X,Niu L,Wu X,Luo C

更新日期：2020-11-01 00:00:00

abstract：:Mesenchymal stem cells (MSC) represent emerging cell-based therapies for diabetes and associated complications. Ongoing clinical trials are using exogenous MSC to treat type 1 and 2 diabetes, cardiovascular disease and non-healing wounds due to diabetes. The majority of these trials are aimed at exploiting the ability...

journal_title：Journal of cellular physiology

authors： Smith AN,Muffley LA,Bell AN,Numhom S,Hocking AM

更新日期：2012-09-01 00:00:00

abstract：:Cervical cancer is a deadly gynecological malignancy in need of innovative treatment strategies. Emerging preclinical data has suggested the benefits of nanocarriers over the traditional chemotherapy for cancer treatment. In particular, gold nanoparticles are gaining popularity due to gold's inert nature, limited side...

journal_title：Journal of cellular physiology

authors： Guan YH,Tian M,Liu XY,Wang YN

更新日期：2019-02-20 00:00:00

abstract：:At the end of December 2019, a novel acute respiratory syndrome coronavirus 2 (SARS-CoV2) appeared as the third unheard of outbreak of human coronavirus infection in the 21st century. First, in Wuhan, China, the novel SARS-CoV2 was named by the World Health Organization (WHO), as 2019-nCOV (COVID-19), and spread extre...

journal_title：Journal of cellular physiology

authors： Tahmasebi S,Khosh E,Esmaeilzadeh A

更新日期：2020-12-01 00:00:00

abstract：:The development of atherosclerotic plaque is associated with neovascularization in the thickened intima and media of vascular walls. Neovascularization may have a role in the progression of atherosclerotic plaque as well as in the development of intraplaque hemorrhage. However, the mechanism and stimulus for neovascul...

journal_title：Journal of cellular physiology

authors： Kuzuya M,Satake S,Esaki T,Yamada K,Hayashi T,Naito M,Asai K,Iguchi A

更新日期：1995-09-01 00:00:00

abstract：:While mesenchymal stem cells (MSCs) have been widely used to repair radiation-induced bone damage, the molecular mechanism underlying the effects of MSCs in the maintenance of bone homeostasis under radiation stress remains largely unknown. In this study, the role and mechanisms of R-spondin 1 (Rspo1)-leucine-rich rep...

journal_title：Journal of cellular physiology

authors： Chen X,Chen L,Tan J,Zhang L,Xia J,Cheng B,Zhang W

更新日期：2021-01-16 00:00:00

abstract：:Considerable evidence has accumulated for a role of a nonsteroidal mevalonate product in the regulation of DNA replication and cell division. We report here a similar requirement for mevalonate in a nonreplicative function, that of natural killer (NK) cell cytotoxicity. Treatment of NK cells with 10 microM compactin f...

journal_title：Journal of cellular physiology

authors： Cutts JL,Scallen TJ,Watson J,Bankhurst AD

更新日期：1989-06-01 00:00:00

abstract：:We evaluated the role of cytoskeletal elements in the degradation of endogenous proteins via autophagy using biochemical and morphological techniques. In the absence of exogenous amino acids, degradation of endogenous proteins was enhanced in cultured normal rat kidney cells. This enhanced degradative state was accomp...

journal_title：Journal of cellular physiology

authors： Aplin A,Jasionowski T,Tuttle DL,Lenk SE,Dunn WA Jr

更新日期：1992-09-01 00:00:00

abstract：:Colon cancer remains one of the lethal malignancies in the world. Aberrant activation of canonical Wnt/β-catenin signaling pathway has been observed in colon cancer. In contrast, the non-canonical Wnt signaling functions remain obscure. Wnt5a is a representative non-canonical Wnt ligand which has gained extensive atte...

journal_title：Journal of cellular physiology

authors： Cheng R,Sun B,Liu Z,Zhao X,Qi L,Li Y,Gu Q

更新日期：2014-12-01 00:00:00

abstract：:Glutathione S-transferases (GSTs) are enzymes that are involved in the detoxification of harmful electrophilic endogenous and exogenous compounds by conjugating with glutathione (GSH). The liver fluke GSTs have multifunctional roles in the host-parasite interaction, such as general detoxification and bile acid sequest...

journal_title：Journal of cellular physiology

authors： Kalita J,Shukla R,Tripathi T

更新日期：2019-04-01 00:00:00

abstract：:Changes in the concentration of intracellular Ca(2+) ([Ca(2+) ]i) trigger and/or regulate principal sperm functions during fertilization, such as motility, capacitation, and the acrosome reaction (AR). Members of the large TRP channel family participate in a variety of Ca(2+) -dependent cell signaling processes. The e...

journal_title：Journal of cellular physiology

authors： Martínez-López P,Treviño CL,de la Vega-Beltrán JL,De Blas G,Monroy E,Beltrán C,Orta G,Gibbs GM,O'Bryan MK,Darszon A

更新日期：2011-06-01 00:00:00

abstract：:Baculoviral IAP repeat containing 5 (BIRC5) gene encodes the important protein as survivin, a multifunctional protein, which is involved in cellular and molecular networks, progression of cell cycle, homeostasis, developmental morphogenesis, and apoptosis. The proximal BIRC5 promoter possesses specific binding sites f...

journal_title：Journal of cellular physiology

authors： Pahlavan Y,Kahroba H,Samadi N,Karimi A,Ansarin K,Khabbazi A

更新日期：2019-11-01 00:00:00

abstract：:Although it is well established that epidermal growth factor receptors (EGFRs) are asymmetrically expressed at the basolateral plasma membrane in polarized epithelial cells, how this process is regulated is not known. The purpose of this study was to address the mechanism of directed EGFR basolateral sorting using the...

journal_title：Journal of cellular physiology

authors： Hobert M,Carlin C

更新日期：1995-03-01 00:00:00

abstract：:It has been reported that p21, p53, and p16 affect the cell cycle and cell senescence. However, their roles in keratinocyte senescence are not clear. We established primary keratinocyte strains from 15 donors and maintained them until replicative senescence; their population doublings ranged from 5.7-45.2. These strai...

journal_title：Journal of cellular physiology

authors： Sayama K,Shirakata Y,Midorikawa K,Hanakawa Y,Hashimoto K

更新日期：1999-04-01 00:00:00

abstract：:The development of resistance accounts for therapy failure in the majority of advanced cases of neuroblastoma in children. A new transplantable murine C-1300 neuroblastoma cell line was developed in vitro, by repeated exposure of a sensitive cell line to increasing, but sublethal, doses of Homoharringtonine (HHT). The...

journal_title：Journal of cellular physiology

authors： Tebbi CK,Chervinsky D,Baker RM

更新日期：1991-09-01 00:00:00

abstract：:Arsenicosis induced by chronic exposure to arsenic is recognized as one of the main damaging effects on public health. Exposure to arsenic can cause hepatic fibrosis, but the molecular mechanisms by which this occurs are complex and elusive. It is not known if miRNAs are involved in arsenic-induced liver fibrosis. We ...

journal_title：Journal of cellular physiology

authors： Xue J,Xiao T,Wei S,Sun J,Zou Z,Shi M,Sun Q,Dai X,Wu L,Li J,Xia H,Tang H,Zhang A,Liu Q

更新日期：2021-01-22 00:00:00

abstract：:Wg/Wnts are paracrine and autocrine ligands that activate distinct signaling pathways while being internalized through surface receptors. Converging and contrasting views are shaping our understanding of whether, where, and how endocytosis may modulate Wnt signaling. We gather considerable amount of evidences to elabo...

journal_title：Journal of cellular physiology

authors： Feng Q,Gao N

更新日期：2015-06-01 00:00:00

abstract：:Proprotein convertase subtilisin/kexin 4 (PCSK4) is implicated for sperm fertilizing ability, based on studies using Pcsk4-null mice. Herein we demonstrated proprotein convertase (PC) activity in intact sperm and acrosomal vesicles. To determine whether this activity was important for sperm fertilizing ability, a pept...

journal_title：Journal of cellular physiology

authors： Iamsaard S,Vanichviriyakit R,Hommalai G,Saewu A,Srakaew N,Withyachumnarnkul B,Basak A,Tanphaichitr N

更新日期：2011-11-01 00:00:00

abstract：:We have examined the ability of epidermal growth factor (EGF) to regulate prostacyclin production by cultured A10 smooth muscle cells. EGF by itself had no effect on prostacyclin production, but it augmented the response to arg8-vasopressin. An AGF stimulation of prostacyclin production was also observed in the presen...

journal_title：Journal of cellular physiology

authors： Blay J,Hollenberg MD

更新日期：1989-06-01 00:00:00

abstract：:Cultured pig kidney cells designated LLC-PK1, previously shown to acquire Na+-dependent concentrative transport of hexoses as the cells become growth arrested, also show Na+-dependent concentrative uptake of the amino acid analogs alpha-aminoisobutyric acid (AIB) and (methyl) meAIB. This A system-like transport is mos...

journal_title：Journal of cellular physiology

authors： Amsler K,Shaffer C,Cook JS

更新日期：1983-02-01 00:00:00

abstract：:Glial fibrillary acidic protein (GFAP) is an intermediate filament that is expressed in specifically expressed auricular chondrocytes, which are good cell sources of cartilage regenerative medicine. Although our group uses GFAP as a biomarker of matrix production in the cultured auricular chondrocytes, the biological ...

journal_title：Journal of cellular physiology

authors： Kanazawa S,Nishizawa S,Takato T,Hoshi K

更新日期：2017-11-01 00:00:00

abstract：:Copper, an essential trace element, can be toxic to some cells when present in excess. But thorough investigations into the cytotoxicity of copper and subsequent molecular mechanisms are rare, although the cytotoxicity of copper has been applied to cancer chemotherapy. The present study demonstrates that Cu(2+) inhibi...

journal_title：Journal of cellular physiology

authors： Zhai Q,Ji H,Zheng Z,Yu X,Sun L,Liu X

更新日期：2000-08-01 00:00:00

abstract：:Nucleoside transporter proteins are specialized proteins that mediate the transport of nucleosides and nucleoside analog drugs across the plasma membrane. The human equilibrative nucleoside transporter 1 (hENT1) is a member of these proteins and mediates cellular entry of gemcitabine, cytarabine, and fludarabine. The ...

journal_title：Journal of cellular physiology

authors： Santini D,Vincenzi B,Fratto ME,Perrone G,Lai R,Catalano V,Cass C,Ruffini PA,Spoto C,Muretto P,Rizzo S,Muda AO,Mackey JR,Russo A,Tonini G,Graziano F

更新日期：2010-05-01 00:00:00

abstract：:An increasing body of evidence suggests that tumors might originate from a few transformed cells that share many properties with normal stem cells. However, it remains unclear how normal stem cells are transformed into cancer stem cells (CSCs). Here, we demonstrated that mutations causing the loss of tumor suppressor ...

journal_title：Journal of cellular physiology

authors： Zeng X,Singh SR,Hou D,Hou SX

更新日期：2010-09-01 00:00:00

abstract：:1,25-Dihydroxyvitamin D3 [1,25(OH)2D3] and all-trans retinoic acid (RA), the active metabolites of vitamins D and A respectively, regulate the proliferation and differentiation of keratinocytes. Both the vitamin D receptor (VDR) and the retinoic acid receptor family (RAR) bind to DNA response elements as heterodimers ...

journal_title：Journal of cellular physiology

authors： Gibson DF,Bikle DD,Harris J

更新日期：1998-01-01 00:00:00

abstract：:The purpose of this study was to delineate the traffic patterns of EGF and EGF receptors (EGFR) in primary cultured acinar epithelial cells from rabbit lacrimal glands. Uptake of [(125)I]-EGF exhibited saturable and non-saturable, temperature-dependent components, suggesting both receptor-mediated and fluid phase endo...

journal_title：Journal of cellular physiology

authors： Xie J,Qian L,Wang Y,Rose CM,Yang T,Nakamura T,Hamm-Alvarez SF,Mircheff AK

更新日期：2004-04-01 00:00:00

abstract：:We recently reported that peptidoglycan (PGN), a cell wall component of the Gram-positive bacterium, induces NF-κB activation and microglia activation. However, PGN-regulated AP-1 activation and cytokine expression in microglia remains unclear. This study investigated how PGN influences the signaling pathway involved ...

journal_title：Journal of cellular physiology

authors： Lin HY,Tang CH,Chen JH,Chuang JY,Huang SM,Tan TW,Lai CH,Lu DY

更新日期：2011-06-01 00:00:00

abstract：:Cell division, neurite formation and acetylcholinesterase activity were examined in a clone (NBA2) of mouse neuroblastoma cells maintained for up to 120 hours in medium with pH values between 6.6 and 8.0. Growth rate decreased as pH was reduced from 7.8 to 6.6. Generation time at pH 7.4 was 25 hours, while the rate of...

journal_title：Journal of cellular physiology

authors： Bear MP,Schneider FH

更新日期：1977-04-01 00:00:00