Involvement of protein phosphatase 2A in the maintenance of E-cadherin-mediated cell-cell adhesion through recruitment of IQGAP1.

abstract：:Osteoporosis is a class of metabolic bone disease caused by complexed ramifications. Overactivation of osteoclasts due to a sudden decreased estrogen level plays a pivotal role for postmenopausal women suffering from osteoporosis. Therefore, inhibiting osteoclast formation and function has become a major direction for...

journal_title：Journal of cellular physiology

authors： Li K,Xiao Y,Wang Z,Fu F,Shao S,Song F,Zhao J,Lin X,Liu Q,Xu J

更新日期：2019-02-27 00:00:00

abstract：:Radiotherapy remains a prime approach to adjuvant therapies in patients with early and advanced breast cancer. In spite of therapeutic success, metastatic progression in patients undergoing therapy, limits its application. However, effective therapeutic strategies to understand the cellular and molecular machinery in ...

journal_title：Journal of cellular physiology

authors： Rajput S,Kumar BN,Banik P,Parida S,Mandal M

更新日期：2015-03-01 00:00:00

abstract：:The ultimate destiny of a cell to undergo division, differentiation, survival, and death results from an intricate balance between multiple regulators including oncogenes, tumor suppressor genes, and cell cycle associated proteins. Deregulation of the cell cycle machinery switches the phenotype from a normal cell to a...

journal_title：Journal of cellular physiology

authors： Tonini T,Hillson C,Claudio PP

更新日期：2002-08-01 00:00:00

abstract：:The bone marrow landscape consists of specialized and stem/progenitor cells, which coordinate important tissue-related and systemic physiological features. Within the marrow cavity, stem/progenitor and differentiated hematopoietic and skeletal cells congregate into dynamic functional assemblies throughout specific ana...

journal_title：Journal of cellular physiology

authors： Agas D,Sabbieti MG

更新日期：2021-01-25 00:00:00

abstract：:Type IV collagenases are secreted as latent 92 and 72 kDa proenzymes which are then activated extracellularly. The mechanisms by which they are activated in vivo are not clear. We have studied the activation of porcine endothelial cell type IV collagenases by tissue and plasma kallikrein, and found that tissue kallikr...

journal_title：Journal of cellular physiology

authors： Desrivières S,Lu H,Peyri N,Soria C,Legrand Y,Ménashi S

更新日期：1993-12-01 00:00:00

abstract：:Differentiation of myofibroblast, as evidenced by alpha-smooth muscle actin (alpha-SMA) expression, is largely mediated by transforming growth factor-beta1 (TGF-beta1). This mechanism often follows inflammatory events such as endothelial damage due to oxidative stress, which can further leads to vascular thickening, s...

journal_title：Journal of cellular physiology

authors： Sen U,Moshal KS,Tyagi N,Kartha GK,Tyagi SC

更新日期：2006-12-01 00:00:00

abstract：:Tfcp2l1 is a transcription factor critical for mouse embryonic stem cell (mESC) maintenance. However, its role in human ESCs (hESCs) remains unclear. Here, we investigated the role of Tfcp2l1 in controlling hESC activity and showed that Tfcp2l1 is functionally important in the maintenance of hESC identity. Tfcp2l1 exp...

journal_title：Journal of cellular physiology

authors： Sun H,You Y,Guo M,Wang X,Zhang Y,Ye S

更新日期：2018-09-01 00:00:00

abstract：:Peroxisome proliferator activated receptors (PPARs, alpha, beta/delta, gamma) control lipid homeostasis and differentiation in various tissues and tumor cells. PPARbeta and PPARgamma increase oligodendrocyte maturation in glial mixed populations and spinal cord oligodendrocytes, respectively, and PPARbeta is known to ...

journal_title：Journal of cellular physiology

authors： Leisewitz AV,Urrutia CR,Martinez GR,Loyola G,Bronfman M

更新日期：2008-11-01 00:00:00

abstract：:P-glycoproteins (Pgp) are comprised of a small family of plasma membrane proteins whose abundance in cultured cells is often associated with the multidrug resistance phenotype. Overexpression of Pgp has been observed in many types of human cancers, but the molecular basis for this overexpression has not been establish...

journal_title：Journal of cellular physiology

authors： Lee CH,Bradley G,Ling V

更新日期：1998-10-01 00:00:00

abstract：:Parathyroid hormone (PTH) greatly increased the level of adenosine 3', 5' cyclic monophosphate (cAMP) in rabbit costal chondrocytes in culture 2 minutes after its addition. PTH, as well as N6 O2' dibutyryl adenosine 3', 5' cyclic monophosphate (DBcAMP) and 8 Bromo adenosine 3', 5' cyclic monophosphate (8 Br-cAMP) indu...

journal_title：Journal of cellular physiology

authors： Takigawa M,Takano T,Suzuki F

更新日期：1981-02-01 00:00:00

abstract：:We studied the clinicopathological significance for Calreticulin (CRT) expression in pancreatic cancer (PC), and its functional relationship with other signaling genes (especially with p53) in regulating the biological behavior of PC cells. IHC, IF, IB, and real-time PCR were used to detect CRT expression in PC, while...

journal_title：Journal of cellular physiology

authors： Sheng W,Chen C,Dong M,Zhou J,Liu Q,Dong Q,Li F

更新日期：2014-07-01 00:00:00

abstract：:The transmural heterogeneity of the contractility in ventricular muscle has not been well-studied. Here, we investigated the calcium transient and sarcomere contraction/relaxation in the endocardial (Endo) and epicardial (Epi) myocytes. Endo and Epi myocytes were isolated from C57/BL6 mice by Langendorff perfusion. Ca...

journal_title：Journal of cellular physiology

authors： Pan W,Yang Z,Cheng J,Qian C,Wang Y

更新日期：2018-08-01 00:00:00

abstract：:p53-mediated apoptosis involves multiple mechanisms. A number of p53-regulated apoptosis-related genes have been identified. Some of these genes encode proteins that are important in controlling the integrity of mitochondria while the others code for membrane death receptors. p53 may also induce apoptosis by interferi...

journal_title：Journal of cellular physiology

authors： Sheikh MS,Fornace AJ Jr

更新日期：2000-02-01 00:00:00

abstract：:The F-40 cell line, a stable variant of LM fibroblasts selected for its resistance to polyethylene glycol (PEG)-induced fusion (Roos and Davidson: Somatic Cell and Molecular Genetics 6:381-391, 1980), has a decreased capacity to internalize fluid-phase markers and nonspecifically surface-bound macromolecules. It is no...

journal_title：Journal of cellular physiology

authors： Ryser HJ,Li W,Mandel R,Shen WC

更新日期：1988-12-01 00:00:00

abstract：:Ubiquitin-specific protease 14 (USP14) is a ubiquitin-specific protease that is associated with the proteasome and plays important roles in cellular functions, viral infection, inflammatory responses, neurodegenerative diseases, and tumorigenesis. USP14 appears to have a dual function in regulating intracellular prote...

journal_title：Journal of cellular physiology

authors： Wang D,Ma H,Zhao Y,Zhao J

更新日期：2020-11-01 00:00:00

abstract：:The biosynthesis and turnover of nicotinamide adenine dinucleotide (NAD) have been examined in mitotic cells of the human culture line, D98/AH2. No significant difference in the incorporation of nicotinic acid or nicotinamide could be detected between mitotic and interphase cells. The distribution of newly-incorporate...

journal_title：Journal of cellular physiology

authors： Elliott G,Rechsteiner M

更新日期：1975-12-01 00:00:00

abstract：:A sialoglycopeptide (SGP), isolated and purified from bovine cerebral cortex cells, was studied in regard to early signal transduction events associated with the cell cycle. Previously shown to be a potent antagonist to a variety of mitogens, the SGP abrogated the ability of 12-O-tetradecanoylphorbol-13 acetate (TPA) ...

journal_title：Journal of cellular physiology

authors： Toole-Simms WE,Loder DK,Fattaey HK,Johnson TC

更新日期：1991-05-01 00:00:00

abstract：:CCN1 is highly expressed in cancer cells and has been identified in the secretome of bone marrow-derived mesenchymal stem cells (BM-MSC). Although secreted CCN1 is known to promote angiogenesis, its underlying mechanism remains unclear. Here, we examined whether our recently-established tonsil-derived MSC (T-MSC) secr...

journal_title：Journal of cellular physiology

authors： Park YS,Hwang S,Jin YM,Yu Y,Jung SA,Jung SC,Ryu KH,Kim HS,Jo I

更新日期：2015-01-01 00:00:00

abstract：:Lithium has been used or explored to treat psychiatric and neurodegenerative diseases that are frequently associated with an abnormal immune status. It is likely that lithium may work through modulation of immune responses in these patients. Because dendritic cells (DC) play a central role in regulating immune respons...

journal_title：Journal of cellular physiology

authors： Liu KJ,Lee YL,Yang YY,Shih NY,Ho CC,Wu YC,Huang TS,Huang MC,Liu HC,Shen WW,Leu SJ

更新日期：2011-02-01 00:00:00

abstract：:Although it is well established that epidermal growth factor receptors (EGFRs) are asymmetrically expressed at the basolateral plasma membrane in polarized epithelial cells, how this process is regulated is not known. The purpose of this study was to address the mechanism of directed EGFR basolateral sorting using the...

journal_title：Journal of cellular physiology

authors： Hobert M,Carlin C

更新日期：1995-03-01 00:00:00

abstract：:Kinetic studies of binding and internalization of 125I-platelet-derived growth factor (PDGF) demonstrate that up to 15% of membrane-associated radioactivity is internalized within 2 minutes after warming to 37 degrees C in a variety of cell types. The T 1/2 for internalization is approximately 20 minutes. The T 1/2 fo...

journal_title：Journal of cellular physiology

authors： Rosenfeld ME,Bowen-Pope DF,Ross R

更新日期：1984-11-01 00:00:00

abstract：:Earlier studies in multiple epithelia have shown that cell-cell actin-based adherens junction (AJ) dynamics are regulated, at least in part, by the interplay of kinases and phosphatases that determines the intracellular phosphoprotein content. Yet it is virtually unknown regarding the role of protein kinases in Sertol...

journal_title：Journal of cellular physiology

authors： Lee NP,Cheng CY

更新日期：2005-02-01 00:00:00

abstract：:Visualizing protein dynamics is the key to a quantitative understanding of molecular mechanisms in biological systems. Recent developments in fluorescent microscopy techniques allow for novel experimental approaches to study stochastic localization, distribution, and movement of fluorescently labeled molecules in high...

journal_title：Journal of cellular physiology

authors： Rieckher M

更新日期：2017-01-01 00:00:00

abstract：:Fibroblastic and epithelioid clones have been isolated from the normal rat kidney line, NRK. These clones were studied for their ability to bind epidermal growth factor (EGF), susceptibility to transformation by mouse sarcoma virus (MSV), and alteration in EGF binding upon sarcoma virus transformation. The epithelioid...

journal_title：Journal of cellular physiology

authors： de Larco JE,Todaro GJ

更新日期：1978-03-01 00:00:00

abstract：:Baculoviral IAP repeat containing 5 (BIRC5) gene encodes the important protein as survivin, a multifunctional protein, which is involved in cellular and molecular networks, progression of cell cycle, homeostasis, developmental morphogenesis, and apoptosis. The proximal BIRC5 promoter possesses specific binding sites f...

journal_title：Journal of cellular physiology

authors： Pahlavan Y,Kahroba H,Samadi N,Karimi A,Ansarin K,Khabbazi A

更新日期：2019-11-01 00:00:00

abstract：:Selective spermatozoa movement from storage of the oviduct to fertilization site is suggested to be a result of chemotaxis. In the present study, Natriuretic peptide precursor A (NPPA) induced sperm chemotaxis in capillaries and enhanced intracellular Ca(2+) level, both of which could be blocked by the Natriuretic Pep...

journal_title：Journal of cellular physiology

authors： Bian F,Mao G,Guo M,Mao G,Wang J,Li J,Han Y,Chen X,Zhang M,Xia G

更新日期：2012-05-01 00:00:00

abstract：:We have investigated the role of the plasminogen activation cascade in skeletal muscle differentiation. Migrating, undifferentiated myoblasts express urokinase plasminogen activator (uPA) and its cell surface receptor (uPAR). Consequently, uPA is localized predominantly to the cell surface. Preventing uPA from associa...

journal_title：Journal of cellular physiology

authors： Wells JM,Strickland S

更新日期：1997-05-01 00:00:00

abstract：:Proteolytic cleavage of extracellular matrix (ECM) is a critical feature of tumor cell invasion, and affects cancer cell growth, differentiation, apoptosis, and migration. Malignant cells secrete most proteases as inactive proenzymes that undergo proteolytic cleavage for activation, and proteolytic activity is elevate...

journal_title：Journal of cellular physiology

authors： Kusick S,Bertram H,Oberleithner H,Ludwig T

更新日期：2005-09-01 00:00:00

abstract：:CRSBP-1 (mammalian LYVE-1) is a membrane glycoprotein highly expressed in lymphatic endothelial cells (LECs). It has multiple ligands, including hyaluronic acid (HA) and growth factors/cytokines (e.g., PDGF-BB and VEGF-A) containing CRS motifs (clusters of basic amino-acid residues). The ligand binding activities are ...

journal_title：Journal of cellular physiology

authors： Huang SS,Li YW,Wu JL,Johnson FE,Huang JS

更新日期：2018-04-01 00:00:00

abstract：:The phenotype of a ouabain-resistant Aedes albopictus cell line has been partially characterized. Treatment of ouabain-sensitive cells with 0.005-1.0 mM ouabain resulted in an 80% reduction in the uptake of 86rubidium (86Rb+), an ion with an affinity for the K+ pump binding site; ouabain-resistant cells showed only a ...

journal_title：Journal of cellular physiology

authors： Mento SJ,Malinoski F,Stollar V

更新日期：1979-12-01 00:00:00