Interplay between the retinoblastoma related pRb2/p130 and E2F-4 and -5 in relation to JCV-TAg.

abstract：:We have previously shown that retinoic acid (RA) has protective effects on high glucose (HG)-induced cardiomyocyte apoptosis. To further elucidate the molecular mechanisms of RA effects, we determined the interaction between nuclear factor (NF)-κB and RA signaling. HG induced a sustained phosphorylation of IKK/IκBα an...

journal_title：Journal of cellular physiology

authors： Nizamutdinova IT,Guleria RS,Singh AB,Kendall JA Jr,Baker KM,Pan J

更新日期：2013-02-01 00:00:00

abstract：:Nerve-evoked contractile activity in skeletal muscle regulates transcript and protein levels of many metabolic genes in a coordinate fashion, including the muscle isozyme of glycogen phosphorylase (MGP). Cellular signaling mechanisms mediating the activity-dependent modulation of MGP transcript levels were investigate...

journal_title：Journal of cellular physiology

authors： Vali S,Carlsen R,Pessah I,Gorin F

更新日期：2000-11-01 00:00:00

abstract：:Spinal cord injury (SCI) is a public health problem in the world. The SCI usually triggers an excessive inflammatory response that brings about a secondary tissue wreck leading to further cellular and organ dysfunction. Hence, there is great potential of reducing inflammation for therapeutic strategies of SCI. In this...

journal_title：Journal of cellular physiology

authors： Su Y,Zong S,Wei C,Song F,Feng H,Qin A,Lian Z,Fu F,Shao S,Fang F,Wu T,Xu J,Liu Q,Zhao J

更新日期：2019-08-01 00:00:00

abstract：:The carboxyl-terminal domain (CTD) of the largest subunit of mammalian RNA polymerase II (RNAP II) consists of 52 repeats of a consensus heptapeptide and is subject to phosphorylation and dephosphorylation events during each round of transcription. RNAP II activity is regulated during the cell cycle and cell cycle-dep...

journal_title：Journal of cellular physiology

authors： Oelgeschläger T

更新日期：2002-02-01 00:00:00

abstract：:Annexin A1 (ANXA1, lipocortin-1) is the first characterized member of the annexin superfamily of proteins, so called since their main property is to bind (i.e., to annex) to cellular membranes in a Ca(2+) -dependent manner. ANXA1 has been involved in a broad range of molecular and cellular processes, including anti-in...

journal_title：Journal of cellular physiology

authors： Bizzarro V,Petrella A,Parente L

更新日期：2012-08-01 00:00:00

abstract：:We previously demonstrated that 4-oxoretinol (4-oxo-ROL) activated retinoic acid receptors (RARs) in F9 stem cells. We showed that 4-oxo-ROL inhibited the proliferation of normal human mammary epithelial cells (HMECs). To understand the mechanisms by which 4-oxo-ROL regulates HMEC growth we examined gene expression pr...

journal_title：Journal of cellular physiology

authors： Liu L,Derguini F,Gudas LJ

更新日期：2009-09-01 00:00:00

abstract：:The level of adhesion molecules expressed at the endothelial cell surface is critical in the control of inflammation. Adenylate cyclase (AC) activity allowing cyclic adenosine monophosphate (cAMP) production can modulate the inflammatory process. We investigated the AC-dependent modulation of ICAM-1 surface expression...

journal_title：Journal of cellular physiology

authors： Bernot D,Peiretti F,Canault M,Juhan-Vague I,Nalbone G

更新日期：2005-02-01 00:00:00

abstract：:The biological roles of sphingosine 1-phosphate (S1P) and S1P receptors (S1PRs) have been broadly investigated. However, at present pathophysiological roles of S1P/S1PRs axis in liver fibrosis are not well defined. Here, we investigated the functions of S1P/S1PRs axis in human hepatic stellate cells (HSC) line, LX-2 c...

journal_title：Journal of cellular physiology

authors： Liu X,Yue S,Li C,Yang L,You H,Li L

更新日期：2011-09-01 00:00:00

abstract：:Macrophages are central mediators of the immune, contributing both to the initiation and the resolution of inflammation. The concept of macrophage activation and program has stimulated interest in its definition, and functional significance in homeostasis and diseases. It has been known that macrophages could be diffe...

journal_title：Journal of cellular physiology

authors： Liu G,Yang H

更新日期：2013-03-01 00:00:00

abstract：:Epigallocatechin-3-gallate (EGCG) plays a crucial role in hepatic lipid metabolism. However, the underlying regulatory mechanism of hepatic lipid metabolism by EGCG in canine is unclear. Primary canine hepatocytes were treated with EGCG (0.01, 0.1, or 1 μM) and BML-275 (an AMP-activated protein kinase [AMPK] inhibitor...

journal_title：Journal of cellular physiology

authors： Ding H,Li Y,Li W,Tao H,Liu L,Zhang C,Kong T,Feng S,Li J,Wang X,Wu J

更新日期：2021-01-01 00:00:00

abstract：:Hepatocyte growth factor (HGF) plays a crucial role in the differentiation of skeletal muscle cells, where a process in which the retinoblastoma protein (pRb) has been implicated. We addressed the role of pRb in HGF-mediated effects on the proliferation and differentiation of adult skeletal muscle myoblasts. HGF shift...

journal_title：Journal of cellular physiology

authors： Leshem Y,Halevy O

更新日期：2002-05-01 00:00:00

abstract：:High temperature requirement A1 (HTRA1) is a serine protease playing a modulatory role in various cell processes, particularly in the regulation of transforming growth factor-β (TGF-β) signaling. A deleterious role in late-onset cerebral small vessel diseases (CSVDs) of heterozygous HTRA1 mutations, otherwise causativ...

journal_title：Journal of cellular physiology

authors： Fasano A,Formichi P,Taglia I,Bianchi S,Di Donato I,Battisti C,Federico A,Dotti MT

更新日期：2020-10-01 00:00:00

abstract：:Dental pulp stem cells (DPSCs) are clonogenic, self-renewing, and multi-potential DPSCs capable of differentiating into osteoblasts. In this study, primary cell cultures were obtained from human dental pulp tissue of developing third molars, and flow cytometry was used to sort the subpopulation of DPSCs with STRO-1 an...

journal_title：Journal of cellular physiology

authors： Huang CH,Tseng WY,Yao CC,Jeng JH,Young TH,Chen YJ

更新日期：2010-10-01 00:00:00

abstract：:Hepatocellular carcinoma (HCC) is one of the most common malignancies and is a serious threat to people's health worldwide. The prognosis of advanced HCC is dim if left untreated. In the clinic, the treatment options for advanced HCC include surgery, radiotherapy, transcatheter arterial chemoembolization, and so forth...

journal_title：Journal of cellular physiology

authors： Zhu J,Yin T,Xu Y,Lu XJ

更新日期：2019-08-01 00:00:00

abstract：:Tissue expansion, a technique to enlarge the skin surface area with an expandable balloon, has been widely used in reconstructive surgery. Although the effect of tissue expansion on in vivo skin physiology and histology has been well documented, it remains unclear whether keratinocytes or other cell types are responsi...

journal_title：Journal of cellular physiology

authors： Takei T,Rivas-Gotz C,Delling CA,Koo JT,Mills I,McCarthy TL,Centrella M,Sumpio BE

更新日期：1997-10-01 00:00:00

abstract：:Inhibition of the gap-filling, polymerizing step of excision repair by 1-beta-D-arabinofuranosylcytosine (ara-C) after irradiation with ultraviolet light in human diploid fibroblasts resulted in the formation of persistent DNA strand breaks in G1, G2, and plateau phase cells, but not in S phase cells. Addition of hydr...

journal_title：Journal of cellular physiology

authors： Cleaver JE

更新日期：1981-08-01 00:00:00

abstract：:Ischemia is a situation occurring in several diseases including myocardial infarction and organ transplantation in which oxygenated blood supply is impaired. Ischemia leads to many cellular and tissue modifications, the most important one being cell death. Several explanations have been proposed to account for these m...

journal_title：Journal of cellular physiology

authors： Arnould T,Michiels C,Alexandre I,Remacle J

更新日期：1992-07-01 00:00:00

abstract：:Total cellular calcium levels do not change when 3T3-4a cells stop proliferating due to serum depletion, or when serum-arrested quiescent cells are incubated for up to 44 hours in calcium-deficient medium (approximately 10 micrometer Ca++). Upon stimulation with dialyzed serum cells enter S and progress through at lea...

journal_title：Journal of cellular physiology

authors： Paul D,Ristow HJ

更新日期：1979-01-01 00:00:00

abstract：:Bone tissues reportedly contain considerable amounts of activin A and follistatin, an activin A-binding protein. In the present study, we found that follistatin strongly inhibited osteoclast formation in cocultures of mouse bone marrow cells and primary osteoblasts induced by 1alpha,25 dihydroxyvitamin D(3), prostagla...

journal_title：Journal of cellular physiology

authors： Murase Y,Okahashi N,Koseki T,Itoh K,Udagawa N,Hashimoto O,Sugino H,Noguchi T,Nishihara T

更新日期：2001-08-01 00:00:00

abstract：:We investigated the actions of human placental lactogen (HPL) and human growth hormone (HGH) on [3H]thymidine incorporation and the release of immunoassayable somatomedin-C (SM-C) by isolated myoblasts, dermal fibroblasts, and costal cartilage explants taken from human fetuses at 11-21 weeks of gestation. The incorpor...

journal_title：Journal of cellular physiology

authors： Hill DJ,Crace CJ,Milner RD

更新日期：1985-11-01 00:00:00

abstract：:The export of rRNP particles from nuclei isolated from Tetrahymena was investigated after preincubating the nuclei at different temperatures under nonpermissive export-conditions. We observed a new phenomenon: Temperature elevation from the sublethal cells' growth temperature, 8 degrees C, to the optimal temperature, ...

journal_title：Journal of cellular physiology

authors： Wunderlich F,Giese G,Herlan G

更新日期：1984-08-01 00:00:00

abstract：:Human promyelocytic leukemia (HL-60) cells display a novel voltage-dependent outward current under voltage clamp. This current is present at low levels in the proliferative state and in granulocytes derived from HL-60 cells which were induced to differentiate with retinoic acid. It is elevated in macrophages derived f...

journal_title：Journal of cellular physiology

authors： Wieland SJ,Chou RH,Chen TA

更新日期：1987-08-01 00:00:00

abstract：:Raloxifene (RAL), a selective estrogen receptor (ER) modulator (SERM) seems to induce apoptosis in both androgen-dependent and -independent prostate cell (PC) lines via activation of ERβ and an antagonistic effect on ERα. In this study, we evaluated the effects of RAL on epithelial PC growth using the two following in...

journal_title：Journal of cellular physiology

authors： Rossi V,Bellastella G,De Rosa C,Abbondanza C,Visconti D,Maione L,Chieffi P,Della Ragione F,Prezioso D,De Bellis A,Bellastella A,Sinisi AA

更新日期：2011-05-01 00:00:00

abstract：:As a natural metabolite of limonoids from Dictamnus dasycarpus, fraxinellone has been reported to be neuroprotective and anti-inflammatory. However, its influence on cellular metabolism remains largely unknown. In the present study, we investigated the effect of fraxinellone on cellular senescence-induced by oxidative...

journal_title：Journal of cellular physiology

authors： Han X,Chen H,Zhou J,Tai H,Gong H,Wang X,Huang N,Qin J,Fang T,Wang F,Xiao H

更新日期：2018-05-01 00:00:00

abstract：:Several organic cations are actively transported by proximal renal tubules by mediated processes across both the apical and basolateral cell membranes. In order to evaluate this transport system in a cultured renal epithelium, uptake of 3H-tetraethylammonium (TEA) across the apical membrane was measured in LLCPK1 cell...

journal_title：Journal of cellular physiology

authors： McKinney TD,DeLeon C,Speeg KV Jr

更新日期：1988-12-01 00:00:00

abstract：:The effects of the glucose supply on growth and metabolism of an SP2/0 derived recombinant myeloma cell line were studied in chemostat culture during growth on IMDM medium at a fixed dilution rate of 0.032 h-1. Lowering of the feed medium glucose concentration from 25.0 to 1.4 mmol/L resulted in a decrease of steady-s...

journal_title：Journal of cellular physiology

authors： Meijer JJ,van Dijken JP

更新日期：1995-02-01 00:00:00

abstract：:Polycystin-1 regulates a number of cellular processes through the formation of complexes with the polycystin-2 ion channel or with other signal transduction proteins. Polycystin-1 is expressed in many tissues but other members of this gene family are distributed in a more restricted fashion. PKDREJ expression has been...

journal_title：Journal of cellular physiology

authors： Sutton KA,Jungnickel MK,Ward CJ,Harris PC,Florman HM

更新日期：2006-11-01 00:00:00

abstract：:Vero M3 cells, a line derived from the kidney of an African Green Monkey, display certain alterations in their protein synthetic apparatus as a function of time during a growth cycle. (Growth cycle here refers to exponential growth of unsynchronized cells in culture and their subsequent passage into the stationary pha...

journal_title：Journal of cellular physiology

authors： Engelhardt DL,Sarnoski J

更新日期：1975-08-01 00:00:00

abstract：:KCNQ1 encodes a potassium voltage-gated channel and represents a susceptibility locus for type 2 diabetes mellitus (T2DM). Here, we explored the association between KCNQ1 polymorphisms and hypertension risk in individuals with T2DM, as well as the role of KCNQ1 in vascular smooth muscle cell contraction in vitro. To i...

journal_title：Journal of cellular physiology

authors： Huang KC,Li TM,Liu X,Chen JH,Chien WK,Shiao YT,Tsang H,Lin TH,Liao CC,Huang SM,Li JP,Lin CW,Lin JC,Lin CC,Lai CH,Cheng CF,Liang WM,Hung CH,Chen CC,Lin YJ,Tsai FJ

更新日期：2017-12-01 00:00:00

abstract：:MicroRNAs play an important regulatory role in the proliferation and differentiation of skeletal muscle-derived satellite cells (MDSCs). In particular, miR-139 can inhibit tumor cell proliferation and invasion, and its expression is down-regulated during C2C12 myoblast differentiation. The aim of this study was thus t...

journal_title：Journal of cellular physiology

authors： Zhou S,Li S,Zhang W,Tong H,Li S,Yan Y

更新日期：2018-01-01 00:00:00