Abstract:
:Polycystin-1 regulates a number of cellular processes through the formation of complexes with the polycystin-2 ion channel or with other signal transduction proteins. Polycystin-1 is expressed in many tissues but other members of this gene family are distributed in a more restricted fashion. PKDREJ expression has been detected only in the mammalian testis, where it is restricted to the spermatogenic lineage and retained in mature sperm. However, the functional characteristics of this protein and its role in sperm biology are not well understood. In this study it is shown that PKDREJ can modulate G protein signaling and associates with several members of the polycystin-2 family. These interactions, as well as polycystin-2 association with TRPC channels, are consistent with a role of this protein in the regulation of the acrosome reaction and in other aspects of sperm physiology.
journal_name
J Cell Physioljournal_title
Journal of cellular physiologyauthors
Sutton KA,Jungnickel MK,Ward CJ,Harris PC,Florman HMdoi
10.1002/jcp.20755subject
Has Abstractpub_date
2006-11-01 00:00:00pages
493-500issue
2eissn
0021-9541issn
1097-4652journal_volume
209pub_type
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