Elevation of a potassium current in differentiating human leukemic (HL-60) cells.

Abstract:

:Human promyelocytic leukemia (HL-60) cells display a novel voltage-dependent outward current under voltage clamp. This current is present at low levels in the proliferative state and in granulocytes derived from HL-60 cells which were induced to differentiate with retinoic acid. It is elevated in macrophages derived from HL-60 cells after exposure to phorbol-12-myristate-13-acetate (PMA). The current is carried primarily by K+, is blocked by Cs+ and by increased intracellular concentrations of Cl-. From a holding potential of -80 mV, significant activation required depolarization to +20 mV membrane potential. Activation was not influenced by intracellular Ca2+ (1-2 X 10(-6) M). These properties appear to differ significantly from the Ca2+-activated K+ channel and the delayed rectifier. The increase of this voltage-activated current in differentiation toward the macrophage, but not the granulocyte, suggests that this current is correlated specifically with macrophage differentiation.

journal_name

J Cell Physiol

authors

Wieland SJ,Chou RH,Chen TA

doi

10.1002/jcp.1041320227

subject

Has Abstract

pub_date

1987-08-01 00:00:00

pages

371-5

issue

2

eissn

0021-9541

issn

1097-4652

journal_volume

132

pub_type

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