Emerging role of SIRT3 in endothelial metabolism, angiogenesis, and cardiovascular disease.


:Sirtuin 3 (SIRT3) a mitochondrial enzyme that plays an important role in energy homeostasis, cardiac remodeling, and heart failure (HF). The expression of SIRT3 declines with advanced age, cardiovascular, and metabolic diseases. Accumulating evidence suggests that SIRT3 plays a critical role in protecting the heart from cardiac hypertrophy, cardiac dysfunction associated with HF, and in the protection of cardiac cells from stress-mediated cell death. Clinical studies have demonstrated that HF with preserved ejection fraction (HFpEF) in patients present with abnormalities in coronary microcirculation related to endothelial dysfunction and coronary microvascular rarefaction. Although SIRT3-mediated regulation of mitochondrial homeostasis and heart function has been intensively investigated, the effect of SIRT3 on endothelial cell (EC) glycolytic metabolism and microvascular function has not been well studied. ECs utilize glycolysis for generating ATP rather than oxidative phosphorylation to maintain their normal functions and promote angiogenesis and EC-cardiomyocyte interactions. Emerging evidence indicates that SIRT3 is involved in the regulation of endothelial metabolism and angiogenesis and thus affects the development of cardiovascular diseases associated with aging. This review will discuss the current knowledge of SIRT3 and its functional role on endothelial metabolism, cardiac function, and cardiovascular diseases.


J Cell Physiol


He X,Zeng H,Chen JX




Has Abstract


2019-03-01 00:00:00












  • Small GTPase Arf6 regulates diabetes-induced cholesterol accumulation in podocytes.

    abstract::Podocyte injury is a critical factor for the initiation and progression of diabetic kidney disease (DKD). However, the underlying mechanisms of podocyte injury in DKD have not been completely elucidated. Studies suggested that intracellular cholesterol accumulation was correlated with podocyte injury, but the cause of...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章


    authors: Hu J,Yang Q,Chen Z,Liang W,Feng J,Ding G

    更新日期:2019-12-01 00:00:00

  • Modulation of TGF-beta type 1 receptor: flow cytometric detection with biotinylated TGF-beta.

    abstract::Transforming growth factor beta type 1 (TGF-beta 1) was reacted with NHS-biotin to yield a derivative of TGF-beta 1 which was biotinylated on lysine residues. The biotinylated form of TGF-beta 1 was separated from the unreacted material by reverse phase chromatography. In three separate bioassays, the derivatized pept...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章


    authors: Newman W,Beall LD,Bertolini DR,Cone JL

    更新日期:1989-10-01 00:00:00

  • Repurposing an old drug for new use: Niclosamide in psoriasis-like skin inflammation.

    abstract::Drug discovery is an onerous, extremely expensive, and time-consuming process. Instead, drug repurposing is an attractive strategy for exploiting novel indications for a drug beyond its original use. The untapped potential of drug repurposing compensates the barriers associated with the drug discovery pipeline. Psoria...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章


    authors: Thatikonda S,Pooladanda V,Godugu C

    更新日期:2020-06-01 00:00:00

  • MicroRNA-206 upregulation relieves circTCF25-induced osteosarcoma cell proliferation and migration.

    abstract::Circular RNA TCF25 (circTCF25) has been proven to be upregulated in human malignancy and correlated with tumor process. Our study aimed to unravel whether circTCF25 dictates cellular activities of osteosarcoma cells and address the possible mechanisms associated with microRNA (miR). circTCF25 and miR-206 in clinical s...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章


    authors: Wang Y,Shi S,Zhang Q,Dong H,Zhang J

    更新日期:2020-02-13 00:00:00

  • Inflammatory molecules produced by meniscus and synovium in early and end-stage osteoarthritis: a coculture study.

    abstract::The aim of this study was to identify the molecules and pathways involved in the cross-talk between meniscus and synovium that may play a critical role in osteoarthritis (OA) pathophysiology. Samples of synovium and meniscus were collected from patients with early and end-stage OA and cultured alone or cocultured. Cyt...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章


    authors: Favero M,Belluzzi E,Trisolino G,Goldring MB,Goldring SR,Cigolotti A,Pozzuoli A,Ruggieri P,Ramonda R,Grigolo B,Punzi L,Olivotto E

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  • Cytochrome P450 (CYP) 2J2 gene transfection attenuates MMP-9 via inhibition of NF-kappabeta in hyperhomocysteinemia.

    abstract::Hyperhomocysteinemia (HHcy) is associated with atherosclerotic events involving the modulation of arachidonic acid (AA) metabolism and the activation of matrix metalloproteinase-9 (MMP-9). Cytochrome P450 (CYP) epoxygenase-2J2 (CYP2J2) is abundant in the heart endothelium, and its AA metabolites epoxyeicosatrienoic ac...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章


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    更新日期:2008-06-01 00:00:00

  • Sulfated malto-oligosaccharides bind to basic FGF, inhibit endothelial cell proliferation, and disrupt endothelial cell tube formation.

    abstract::The interaction of basic FGF (bFGF) with heparin, heparan sulfate and related sugars can potentiate or antagonize bFGF activity, depending on the size of the saccharide used. Oligosaccharides based on heparin structures, as small as six sugar residues, have been demonstrated to bind to bFGF and block its activity, whi...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章


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    更新日期:1996-09-01 00:00:00

  • Reversible G1 arrest of a human lung epithelial cell line by staurosporine.

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    pub_type: 杂志文章


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    更新日期:1992-09-01 00:00:00

  • Leukemia stem cell immunophenotyping tool for diagnostic, prognosis, and therapeutics.

    abstract::The existence of cancer stem cells is debatable in numerous solid tumors, yet in leukemia, there is compelling evidence of this cell population. Leukemic stem cells (LSCs) are altered cells in which accumulating genetic and/or epigenetic alterations occur, resulting in the transition between the normal, preleukemic, a...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章,评审


    authors: Mastelaro de Rezende M,Ferreira AT,Paredes-Gamero EJ

    更新日期:2020-06-01 00:00:00

  • Control of melanin synthesis and secretion by B16/C3 melanoma cells.

    abstract::In culture, B16/C3 murine melanoma cells grown in the presence of serum undergo melanogenesis at a specific time after plating. At this time, melanin is synthesized intracellularly and then secreted into the extracellular culture fluid. We have found that melanin secretion is dependent on the presence of serum in the ...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章


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    更新日期:1982-12-01 00:00:00

  • Functional coupling of TRPC2 cation channels and the calcium-activated anion channels in rat thyroid cells: implications for iodide homeostasis.

    abstract::The initial step in a synthesis of thyroid hormones is the uptake of iodide from the circulation. Iodide (I(-)) is transported into thyroid cells via a Na(+)/I(-) symporter (NIS), which is electrogenic and thus sensitive to alterations in membrane potential (V(m)). I(-) is then released to the lumen of thyroid follicl...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章


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    更新日期:2013-04-01 00:00:00

  • Fibroblast growth factor-2 inhibits CD40-mediated periodontal inflammation.

    abstract::Fibroblast growth factor-2 (FGF-2) stimulates periodontal regeneration by a broad spectrum of effects on periodontal ligament (PDL) cells, such as proliferation, migration, and production of extracellular matrix. A critical factor in the success of periodontal regeneration is the rapid resolution of inflammatory respo...

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    pub_type: 杂志文章


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  • Dibutyryl cyclic adenosine monophosphate differentially regulates cell proliferation in low and high alkaline phosphatase SaOS-2 human osteosarcoma cells: evidence for mediation by the insulin-like growth factor-II system.

    abstract::In the present study, we have sought to determine whether a given signal transduction pathway can have diverse effects on subpopulations of cells of a lineage depending upon the stage of differentiation. To test this hypothesis, we selected the cyclic adenosine monophosphate (cAMP) signal transduction pathway because ...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章


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    更新日期:1993-09-01 00:00:00

  • Raloxifene induces cell death and inhibits proliferation through multiple signaling pathways in prostate cancer cells expressing different levels of estrogen receptor α and β.

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    journal_title:Journal of cellular physiology

    pub_type: 杂志文章


    authors: Rossi V,Bellastella G,De Rosa C,Abbondanza C,Visconti D,Maione L,Chieffi P,Della Ragione F,Prezioso D,De Bellis A,Bellastella A,Sinisi AA

    更新日期:2011-05-01 00:00:00

  • Extinction of the human insulin gene expression in insulinoma x fibroblast somatic cell hybrids involves cis-acting DNA elements.

    abstract::Insulin gene expression in rat insulinoma (RIN) cells is extinct in RIN x fibroblast hybrids and can reappear upon loss of DNA contributed by the fibroblast parent. (Besnard et al., Exp. Cell Res. 185:101-108, 1989). In the present study, we looked for the role of 5'-flanking sequences of the human insulin gene in the...

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    pub_type: 杂志文章


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    更新日期:1991-03-01 00:00:00

  • Differences of SiHa (human cancer of cervix) and BMG-1 (brain glioma) cell lines as 2D and 3D cultures.

    abstract::Cell cultures have seen much progress in the numbers available cell lines, their applications and culture techniques. Three dimensional cultures and co-cultures are examples of strategies that bring in vitro conditions closer to natural in vivo systems. We describe here, the formation of cell aggregates in three-dimen...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章


    authors: Ravi M,Sah S,Bhammar R

    更新日期:2014-02-01 00:00:00

  • Selective lethal effect of thymidine on human and mouse tumor cells.

    abstract::Human cell lines derived from a melanoma and a colon carcinoma, and cultures of human melanocytes and intestinal epithelial cells, as well as a mouse mesenchymal non-neoplastic cell line and a malignant subline of the same have been quantitatively studied in tissue culture for their sensitivity to thymidine. All three...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章


    authors: Lee SS,Giovanella BC,Stehlin JS Jr

    更新日期:1977-09-01 00:00:00

  • GP130/OSMR is the only LIF/IL-6 family receptor complex to promote osteoblast differentiation of calvaria progenitors.

    abstract::Leukemia inhibitory factor (LIF) and its receptor (LIFR) are "twins" of Oncostatin M (OSM) and OSMR, respectively, likely having arisen through gene duplications. We compared their effects in a bone nodule-forming model of in vitro osteogenesis, rat calvaria (RC) cell cultures. Using a dominant-negative LIF mutant (hL...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章


    authors: Malaval L,Liu F,Vernallis AB,Aubin JE

    更新日期:2005-08-01 00:00:00

  • ELP2 negatively regulates osteoblastic differentiation impaired by tumor necrosis factor α in MC3T3-E1 cells through STAT3 activation.

    abstract::Tumor necrosis factor-α (TNF-α) is a pluripotent signaling molecule. The biological effect of TNF-α includes slowing down osteogenic differentiation, which can lead to bone dysplasia in long-term inflammatory microenvironments. Signal transducer and activator of transcription 3 (STAT3)-interacting protein 1 (StIP1, al...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章


    authors: Xu CP,Sun HT,Yang YJ,Cui Z,Wang J,Yu B,Wang FZ,Yang QP,Qi Y

    更新日期:2019-08-01 00:00:00

  • FAK activation is required for TNF-alpha-induced IL-6 production in myoblasts.

    abstract::Tumor necrosis factor-alpha (TNF-alpha) is a pleiotropic cytokine produced by activated macrophages. IL-6 is a multifunctional cytokine that plays a central role in both innate and acquired immune responses. We investigated the signaling pathway involved in IL-6 production stimulated by TNF-alpha in cultured myoblasts...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章


    authors: Tseng WP,Su CM,Tang CH

    更新日期:2010-05-01 00:00:00

  • Enhancing developmental rate and quality of mouse single blastomeres into blastocysts using a microplatform.

    abstract::The present work reports the beneficial effects of using a microplatform on the development of mouse single blastomeres (SBs) to the blastocyst stage. Development of blastocysts from SBs separated from two- and four-cell stage embryos (two- and four-cell SBs) can provide a valuable supply both for couples who use fert...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章


    authors: Yekani F,Fazel-Tabar M,Kowsari-Esfahan R,Renaud P,Kavand H,Esfandiari F,Azarnia M,Montazeri L,Baharvand H

    更新日期:2018-12-01 00:00:00

  • CRM197 in Combination With shRNA Interference of VCAM-1 Displays Enhanced Inhibitory Effects on Human Glioblastoma Cells.

    abstract::CRM197 is a naturally nontoxic diphtheria toxin mutant that binds and inhibits heparin-binding epidermal growth factor-like growth factor. CRM197 serves as carrier protein for vaccine and other therapeutic agents. CRM197 also inhibits the growth, migration, invasion, and induces apoptosis in various tumors. Vascular c...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章


    authors: Hu Y,Lin X,Wang P,Xue YX,Li Z,Liu LB,Yu B,Feng TD,Liu YH

    更新日期:2015-08-01 00:00:00

  • L-ascorbic acid 2-phosphate stimulates collagen accumulation, cell proliferation, and formation of a three-dimensional tissuelike substance by skin fibroblasts.

    abstract::Proliferation of human skin fibroblasts was stimulated significantly by the presence of L-ascorbic acid 2-phosphate (Asc 2-P). The presence of Asc 2-P (0.1-1.0 mM) in the culture medium for 3 weeks enhanced the relative rate of collagen synthesis to total protein synthesis 2-fold as well as cell growth 4-fold. Coexist...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章


    authors: Hata R,Senoo H

    更新日期:1989-01-01 00:00:00

  • Hesperetin suppresses RANKL-induced osteoclastogenesis and ameliorates lipopolysaccharide-induced bone loss.

    abstract::Destructive bone diseases caused by osteolysis are increasing in incidence. They are characterized by an excessive imbalance of osteoclast formation and activation. During osteolysis, the activation of nuclear factor-κB (NF-κB) and mitogen-activated protein kinase (MAPK) signaling pathways are triggered by receptor ac...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章


    authors: Liu H,Dong Y,Gao Y,Zhao L,Cai C,Qi D,Zhu M,Zhao L,Liu C,Guo F,Xiao J,Huang H

    更新日期:2019-07-01 00:00:00

  • Sox18 preserves the pulmonary endothelial barrier under conditions of increased shear stress.

    abstract::Shear stress secondary to increased pulmonary blood flow (PBF) is elevated in some children born with congenital cardiac abnormalities. However, the majority of these patients do not develop pulmonary edema, despite high levels of permeability inducing factors. Previous studies have suggested that laminar fluid shear ...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章


    authors: Gross CM,Aggarwal S,Kumar S,Tian J,Kasa A,Bogatcheva N,Datar SA,Verin AD,Fineman JR,Black SM

    更新日期:2014-11-01 00:00:00

  • LINC00261 suppresses human colon cancer progression via sponging miR-324-3p and inactivating the Wnt/β-catenin pathway.

    abstract::Growing evidence indicates long noncoding RNAs (lncRNAs) are significant regulators in the progression of various malignant tumors including colon cancer. Dysregulation of lncRNA LINC00261 has been identified in many cancers. Investigations on LINC00261 function have revealed that LINC00261 could act as a crucial tumo...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章


    authors: Yan D,Liu W,Liu Y,Luo M

    更新日期:2019-12-01 00:00:00

  • Effect of tumor-associated mutant E-cadherin variants with defects in exons 8 or 9 on matrix metalloproteinase 3.

    abstract::Tumor progression is characterized by loss of cell adhesion and increase of invasion and metastasis. The cell adhesion molecule E-cadherin is frequently down-regulated or mutated in tumors. In addition to down-regulation of cell adhesion, degradation of the extracellular matrix by matrix metalloproteinases is necessar...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章


    authors: Fuchs M,Hermannstädter C,Specht K,Knyazev P,Ullrich A,Rosivatz E,Busch R,Hutzler P,Höfler H,Luber B

    更新日期:2005-03-01 00:00:00

  • Effects of retinoic acid on protein synthesis in cultured melanoma cells.

    abstract::Retinoic acid reduces the growth rate of mouse S91 melanoma cells in culture and increases the proportion of cells in the G1 phase of the cell cycle. Because of the integral role protein synthesis has been shown to play in growth control we studied the effect of retinoic acid on the protein synthesis machinery with a ...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章


    authors: Lotan R,Fischer I,Meromsky L,Moldave K

    更新日期:1982-10-01 00:00:00

  • Overexpression of calreticulin contributes to the development and progression of pancreatic cancer.

    abstract::We studied the clinicopathological significance for Calreticulin (CRT) expression in pancreatic cancer (PC), and its functional relationship with other signaling genes (especially with p53) in regulating the biological behavior of PC cells. IHC, IF, IB, and real-time PCR were used to detect CRT expression in PC, while...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章


    authors: Sheng W,Chen C,Dong M,Zhou J,Liu Q,Dong Q,Li F

    更新日期:2014-07-01 00:00:00

  • Effect of antioxidants on lipopolysaccharide-stimulated induction of mangano superoxide dismutase mRNA in bovine pulmonary artery endothelial cells.

    abstract::Generation of reactive oxygen species (ROS) is a common event in the pathogenesis of acute lung injury. Endothelial cells may be both a target and a source of the ROS. Exposure of bovine pulmonary endothelial cells (BPAEC) to lipopolysaccharide (LPS) has been shown to result in intracellular generation of both ROS and...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章


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    更新日期:1996-11-01 00:00:00