Kinin B1 Receptor Deletion Affects Bone Healing in Type 1 Diabetic Mice.

abstract：:Osteoblasts are terminally differentiated cells with mesenchymal origins, known to possess pivotal roles in sustaining bone microstructure and homeostasis. These cells are implicated in the pathophysiology of various bone disorders, especially osteoporosis. Over the last few decades, strategies to impede bone resorpti...

journal_title：Journal of cellular physiology

authors： Aslani S,Abhari A,Sakhinia E,Sanajou D,Rajabi H,Rahimzadeh S

更新日期：2019-06-01 00:00:00

abstract：:Indirect evidence for the presence of a growth inhibitor in normal human fibroblasts has been obtained previously; the inhibitory activity has been found associated with crude cell extracts, but the molecule responsible for the growth inhibition has never been isolated. We have isolated a glycopeptide fraction from hu...

journal_title：Journal of cellular physiology

authors： Macieira-Coelho A,Söderberg A

更新日期：1993-01-01 00:00:00

abstract：:We report that cultured vascular endothelial cells release into the culture medium a vasoconstrictor peptide, a substance we call an endothelium-derived constricting factor (EDCF). Conditioned medium from cultured bovine aortic and pulmonary artery endothelial cells caused sustained, dose-dependent isometric constrict...

journal_title：Journal of cellular physiology

authors： O'Brien RF,Robbins RJ,McMurtry IF

更新日期：1987-08-01 00:00:00

abstract：:Runx2 and Runx3 are known to be expressed in the growth plate during endochondral bone formation. Here we addressed the functional role of Runx3 as distinct from Runx2 by using two models of postnatal bone repair: fracture healing that proceeds by an endochondral process and marrow ablation that proceeds by only an in...

journal_title：Journal of cellular physiology

authors： Wigner NA,Soung do Y,Einhorn TA,Drissi H,Gerstenfeld LC

更新日期：2013-11-01 00:00:00

abstract：:We compared the effects of endothelial-synthesized matrix and purified matrix molecules on pericyte (PC) and aortic smooth muscle cell (SMC) growth, heparin sensitivity, and contractile phenotype in vitro. When PC are plated on endothelial-synthesized (EC) matrix, cell number is, on average, 3.1-fold higher than ident...

journal_title：Journal of cellular physiology

authors： Newcomb PM,Herman IM

更新日期：1993-05-01 00:00:00

abstract：:A neuroblastoma cell line was assessed for its capacity to bind tetanus toxin (TT) by using immunofluorescence and flow cytometry to analyze cells on a single cell basis. A clone of Neuro 2a, N2AB-1, was shown to bind variable amounts of TT per cell and this binding could be saturated by increasing doses of the toxin....

journal_title：Journal of cellular physiology

authors： Notter MF,Leary JF

更新日期：1985-12-01 00:00:00

abstract：:We examined the expression of the estrogen and epidermal growth factor (EGF) receptors in a drug-resistant subline of MCF-7 cells in order to study potential alterations in hormone dependence or in the growth factor pathway that could be related to the development of drug resistance in human breast cancer. The drug-re...

journal_title：Journal of cellular physiology

authors： Dickstein B,Valverius EM,Wosikowski K,Saceda M,Pearson JW,Martin MB,Bates SE

更新日期：1993-10-01 00:00:00

abstract：:Suramin is an anti-cancer drug which induces the differentiation of the human colon cancer clone HT29-D4. Yet chronic suramin treatment of these cells eventually leads to a marked disturbance of the lysosomal system, which consists in an accumulation of hypertrophied autophagic vacuoles and the occurrence of lamellate...

journal_title：Journal of cellular physiology

authors： Baghdiguian S,Verrier B,Marvaldi J,Fantini J

更新日期：1992-01-01 00:00:00

abstract：:We investigated the radiosensitizing effects of Co-NMS, a derivative of nimesulide based on a cobalt carbonyl complex, on malignant glioma cells. In the zebrafish exposed to Co-NMS ranging from 5 to 20 μM, cell death and heat shock protein 70 expression in the brain and neurobehavioral performance were evaluated. Our ...

journal_title：Journal of cellular physiology

authors： Liu Y,Zhang T,Li G,Li S,Li J,Zhao Q,Wu Q,Xu D,Hu X,Zhang L,Li Q,Zhang H,Liu B

更新日期：2020-12-01 00:00:00

abstract：:Even though the involvement of intracellular Ca(2+) Ca(i)(2+) in hematopoiesis has been previously demonstrated, the relationship between Ca(i)(2+) signaling and cytokine-induced intracellular pathways remains poorly understood. Herein, the molecular mechanisms integrating Ca(2+) signaling with the extracellular signa...

journal_title：Journal of cellular physiology

authors： Leon CM,Barbosa CM,Justo GZ,Borelli P,Resende JD Jr,de Oliveira JS,Ferreira AT,Paredes-Gamero EJ

更新日期：2011-07-01 00:00:00

abstract：:Skeletal muscle dysfunction contributes to exercise limitation in COPD. In this study cigarette smoke exposure was hypothesized to increase expression of the inflammatory cytokine, TNF-alpha, thereby suppressing PGC-1alpha, and hence affecting down stream molecules that regulate oxygen transport and muscle function. F...

journal_title：Journal of cellular physiology

authors： Tang K,Wagner PD,Breen EC

更新日期：2010-02-01 00:00:00

abstract：:Aberrant proliferation of vascular smooth muscle cells (VSMC) is a critical contributor to the pathogenesis of atherosclerosis (AS). Our previous studies have demonstrated that apelin-13/APJ confers a proliferative response in VSMC, however, its underlying mechanism remains elusive. In this study, we aimed to investig...

journal_title：Journal of cellular physiology

authors： He L,Zhou Q,Huang Z,Xu J,Zhou H,Lv D,Lu L,Huang S,Tang M,Zhong J,Chen JX,Luo X,Li L,Chen L

更新日期：2019-06-01 00:00:00

abstract：:In vitro bioluminescence components of the dinoflagellates Gonyaulax polyedra, G. tamarensis, Dissodinium lunual, and Pyrocystis noctiluca were studied. The luciferases and luciferins of the four species cross-react in all combinations. All of these species possess high-molecular weight luciferases (200,000-400,000 da...

journal_title：Journal of cellular physiology

authors： Schmitter RE,Njus D,Sulzman FM,Gooch VD,Hastings JW

更新日期：1976-01-01 00:00:00

abstract：:Growing evidence from recent studies has shown that the X-inactive specific transcript (XIST), a well-known long noncoding RNA involved in early embryonic development, is aberrantly regulated in various human cancers. However, the prognostic value of XIST in cancers remains uncharacterized. In this study, we searched ...

journal_title：Journal of cellular physiology

authors： Liu JL,Zhang WQ,Zhao M,Huang MY

更新日期：2019-05-01 00:00:00

abstract：:Cultured hepatic stellate cells (HSCs), the cell type primarily involved in the progression of liver fibrosis, secrete insulin-like growth factor-I (IGF-I) and IGF binding protein (IGFBP) activity. IGF-I exerts a mitogenic effect on HSCs, thus potentially contributing to the fibrogenic process in an autocrine fashion....

journal_title：Journal of cellular physiology

authors： Gentilini A,Feliers D,Pinzani M,Woodruff K,Abboud S

更新日期：1998-02-01 00:00:00

abstract：:Retinoic acid (RA) is known to induce differentiation in many cell systems. This induction is mediated by nuclear RA receptors (RARs), which act as transactivating factors belonging to the superfamily of steroid/thyroid nuclear receptors. In this study, effects of RA were studied in a mouse myogenic C2 cell line and i...

journal_title：Journal of cellular physiology

authors： Halevy O,Lerman O

更新日期：1993-03-01 00:00:00

abstract：:Recent studies have indicated that endoplasmic reticulum stress, the unfolded protein response activation and altered GRP78 expression can play an important role in a variety of tumors development and progression. Very recently we reported for the first time that GRP78 is increased in endometrial tumors. However, whet...

journal_title：Journal of cellular physiology

authors： Calì G,Insabato L,Conza D,Bifulco G,Parrillo L,Mirra P,Fiory F,Miele C,Raciti GA,Di Jeso B,Terrazzano G,Beguinot F,Ulianich L

更新日期：2014-10-01 00:00:00

abstract：:The ubiquitous α-catulin acts as a scaffold for distinct signalosomes including RhoA/ROCK; however, its function is not well understood. While α-catulin has homology to the cytoskeletal linkers α-catenin and vinculin, it appears to be functionally divergent. Here we further investigated α-catulin function in pulmonary...

journal_title：Journal of cellular physiology

authors： Bear MD,Liu T,Abualkhair S,Ghamloush MA,Hill NS,Preston I,Fanburg BL,Kayyali US,Toksoz D

更新日期：2016-04-01 00:00:00

abstract：:The basic fibroblast growth factor (FGF) is a potent mitogen that has vascular endothelium as one of its principle target cells. Recent work has provided both the complete amino acid sequence of basic FGF and the nucleotide sequence of the genes for both human and bovine basic FGF. Although capillary endothelial cells...

journal_title：Journal of cellular physiology

authors： Hanneken A,Lutty GA,McLeod DS,Robey F,Harvey AK,Hjelmeland LM

更新日期：1989-01-01 00:00:00

abstract：:Wg/Wnts are paracrine and autocrine ligands that activate distinct signaling pathways while being internalized through surface receptors. Converging and contrasting views are shaping our understanding of whether, where, and how endocytosis may modulate Wnt signaling. We gather considerable amount of evidences to elabo...

journal_title：Journal of cellular physiology

authors： Feng Q,Gao N

更新日期：2015-06-01 00:00:00

abstract：:The development and progression of hepatocellular carcinoma (HCC) have been associated with abnormal cellular metabolism. Gene Expression Profiling Interactive Analysis RNA sequencing data revealed caveolin-1 (CAV-1) and hexokinase 2 (HK2) messenger RNA (mRNA) were significantly upregulated in human HCC compared with ...

journal_title：Journal of cellular physiology

authors： Chai F,Li Y,Liu K,Li Q,Sun H

更新日期：2019-02-01 00:00:00

abstract：:Hyperinsulinemia is a likely cause of the increased cancer incidence and mortality in diabetic patients, but its role is difficult to define in vivo. Previous in vitro studies testing the mitogenic potential of insulin and its analogs provided incomplete and sometimes contradictory results. To better evaluate cancer c...

journal_title：Journal of cellular physiology

authors： Sciacca L,Cassarino MF,Genua M,Vigneri P,Giovanna Pennisi M,Malandrino P,Squatrito S,Pezzino V,Vigneri R

更新日期：2014-11-01 00:00:00

abstract：:The purpose of this study was to evaluate the anti-head and neck squamous cell carcinoma (anti-HNSCC) cell activity by C6 ceramide and multikinase inhibitor PKC412. Experiments were performed on HNSCC cell lines (SQ20B and SCC-9) and primary human oral carcinoma cells. Results showed that PKC412 inhibited HNSCC cell p...

journal_title：Journal of cellular physiology

authors： Zhu Y,Wang C,Zhou Y,Ma N,Zhou J

更新日期：2018-12-01 00:00:00

abstract：:Despite being densely packed with chromatin, nuclear bodies and a nucleoskeletal network, the nucleus is a remarkably dynamic organelle. Chromatin loops form and relax, RNA transcripts and transcription factors move diffusively, and nuclear bodies move. We show here that RNA splicing speckled domains (splicing speckle...

journal_title：Journal of cellular physiology

authors： Zhang Q,Kota KP,Alam SG,Nickerson JA,Dickinson RB,Lele TP

更新日期：2016-06-01 00:00:00

abstract：:Hepatocellular carcinoma (HCC) is mainly associated with hepatitis B virus (HBV) infection and characterized by metastasizing and infiltrating adjacent and distant tissues. Notably, microRNA-1271 (miR-1271) is a tumor suppressor in various cancers. Therefore, we evaluate the ability of miR-1271 to influence cell proli...

journal_title：Journal of cellular physiology

authors： Chen Y,Zhao ZX,Huang F,Yuan XW,Deng L,Tang D

更新日期：2019-04-01 00:00:00

abstract：:MicroRNAs (miRNAs) are noncoding RNA molecules that regulate gene expression at the post-transcriptional level to cause translational repression or degradation of targets. The profiles of miRNAs across stages of lactation in small ruminant species such as dairy goats is unknown. A small RNA library was constructed usi...

journal_title：Journal of cellular physiology

authors： Wang H,Shi H,Luo J,Yi Y,Yao D,Zhang X,Ma G,Loor JJ

更新日期：2017-05-01 00:00:00

abstract：:Polycystic ovary syndrome (PCOS) is the most common endocrine abnormality in women of reproductive age. Although its clinical consequences have been known for a long time to extend beyond the reproductive system, with type-2 diabetes and obesity being the most common, the involvement of the ocular surface in PCOS has ...

journal_title：Journal of cellular physiology

authors： Mantelli F,Moretti C,Macchi I,Massaro-Giordano G,Cozzupoli GM,Lambiase A,Bonini S

更新日期：2016-05-01 00:00:00

abstract：:Subcellular localization of the large multicatalytic protease complexes called proteasomes, which have been found in soluble fractions of various cells, was examined by biochemical, immunological, and immunohistological methods. Rat liver nuclei, purified by two different procedures, showed high activities for degradi...

journal_title：Journal of cellular physiology

authors： Tanaka K,Kumatori A,Ii K,Ichihara A

更新日期：1989-04-01 00:00:00

abstract：:Cultured rat embryo cells were stimulated to rapidly release a small group of proteins that included several heat-shock proteins (hsp110, hsp71, hscp73) and nonmuscle actin. The extracellular proteins were analyzed by two-dimensional polyacrylamide gel electrophoresis. Heat-shocked cells released the same set of prote...

journal_title：Journal of cellular physiology

authors： Hightower LE,Guidon PT Jr

更新日期：1989-02-01 00:00:00

abstract：:Skeletal muscle atrophy/wasting is associated with impaired protein metabolism in diverse physiological and pathophysiological conditions. Elevated levels of reactive oxygen species (ROS), disturbed redox status, and weakened antioxidant defense system are the major contributing factors toward atrophy. Regulation of p...

journal_title：Journal of cellular physiology

authors： Kaur N,Gupta P,Saini V,Sherawat S,Gupta S,Dua A,Kumar V,Injeti E,Mittal A

更新日期：2019-05-01 00:00:00