Growth inhibitory activity in extracts from human fibroblasts.

abstract：:The desert hedgehog (Dhh) is crucial for spermatogenesis and Leydig cell differentiation, but little is known regarding its physiological function in cartilage. In this study, Dhh mRNA was abundant in antler chondrocytes, where it advanced cell proliferation concomitant with accelerated transition from the G1 to the S...

journal_title：Journal of cellular physiology

authors： Ma L,Duan CC,Yang ZQ,Ding JL,Liu S,Yue ZP,Guo B

更新日期：2020-09-01 00:00:00

abstract：:Bafilomycin A1, a specific inhibitor of H(+)-ATPases of the vacuolar type, was in the present study shown, at similar concentrations, to induce secretion of lysosomal enzyme and to elevate lysosomal pH in mouse macrophages. These results lend support to the previous suggestion of a triggering role for an increase in l...

journal_title：Journal of cellular physiology

authors： Tapper H,Sundler R

更新日期：1995-04-01 00:00:00

abstract：:Silibinin is the primary active compound in silymarin. It has been demonstrated to exert anti-carcinogenic effects and hepato-protective effects. However, the effects of silibinin on the maturation and immunostimulatory activities exhibited by dendritic cells (DCs) remain, for the most part, unknown. In this study, we...

journal_title：Journal of cellular physiology

authors： Lee JS,Kim SG,Kim HK,Lee TH,Jeong YI,Lee CM,Yoon MS,Na YJ,Suh DS,Park NC,Choi IH,Kim GY,Choi YH,Chung HY,Park YM

更新日期：2007-02-01 00:00:00

abstract：:Development and improvement of in vitro culture system supporting self-renewal and unlimited proliferation of porcine pluripotent stem cells (pPSCs) is an indispensable process for the naïve pPSCs establishment. In this study, we modified the previous culture system and attempted to develop a novel chemically defined ...

journal_title：Journal of cellular physiology

authors： Zhang X,Xue B,Li Y,Wei R,Yu Z,Jin J,Zhang Y,Liu Z

更新日期：2019-01-30 00:00:00

abstract：:Hepatic expression of the protooncogenes c-fos and c-myc occurs within 2 h after partial hepatectomy, and these immediate early genes are thought to prime the hepatocytes for subsequent proliferation. To examine whether such gene activation occurred in the setting of hepatocyte proliferation after toxic liver injury, ...

journal_title：Journal of cellular physiology

authors： Schmiedeberg P,Biempica L,Czaja MJ

更新日期：1993-02-01 00:00:00

abstract：:The role of cyclic adenosine monophosphate (cAMP) is poorly understood in the regulation of normal and abnormal hepatic cell growth. In this study, we examined the regulation of intracellular cAMP levels and its effect on nuclear cAMP responsive elements (CREs) in a rat model of hepatocellular carcinoma (HCC). Tumorig...

journal_title：Journal of cellular physiology

authors： Kovach SJ,Price JA,Shaw CM,Theodorakis NG,McKillop IH

更新日期：2006-02-01 00:00:00

abstract：:Priapism, a prolonged penile erection in the absence of sexual arousal, is common among patients with sickle cell disease (SCD). Hypogonadism is also common in patients with SCD. While the administration of exogenous testosterone reverses hypogonadism, it is contraceptive. We hypothesized that the stimulation of endog...

journal_title：Journal of cellular physiology

authors： Musicki B,Karakus S,La Favor JD,Chen H,Silva FH,Sturny M,Zirkin BR,Burnett AL

更新日期：2020-09-24 00:00:00

abstract：:Extracellular ATP and other nucleotides induce autocrine and/or paracrine purinergic signalling via activation of the P2 receptors on the cell surface, which represents one of the most common signalling mechanisms. Mesenchymal stem cells (MSC) are a type of multipotent adult stem cells that have many promising applica...

journal_title：Journal of cellular physiology

authors： Jiang LH,Hao Y,Mousawi F,Peng H,Yang X

更新日期：2017-02-01 00:00:00

abstract：:Necrotizing Enterocolitis (NEC) is a severe inflammatory disorder leading to high morbidity and mortality rates. A growing body of evidence demonstrate the key role of the Toll like receptor 4 (TLR4) in NEC. This membranal receptor recognizes lipopolysaccharides (LPS) from the bacterial wall and triggers an inflammato...

journal_title：Journal of cellular physiology

authors： Bein A,Zilbershtein A,Golosovsky M,Davidov D,Schwartz B

更新日期：2017-02-01 00:00:00

abstract：:Despite the improvements in fracture healing, about 10% of patients undergo abnormal healing. As a tumor suppressor, upregulation of microRNA (miR)-203 has been observed in osteogenic differentiation. Herein, we aimed to explore the functional role of miR-203 in osteoblasts as well as the underlying mechanisms. The ex...

journal_title：Journal of cellular physiology

authors： Liu H,Chen B,Li Y

更新日期：2019-08-01 00:00:00

abstract：:Biosensors are composed of (bio)receptors, transducers, and detection systems and are able to convert the biological stimulus into a measurable signal. This systematic review evaluates the current state of the art of innovation and research in this field, identifying the biosensors that in vitro monitor the musculoske...

journal_title：Journal of cellular physiology

authors： Veronesi F,Tschon M,Visani A,Fini M

更新日期：2019-12-01 00:00:00

abstract：:Binding of concanavalin A to isolated thymocyte membrane vesicles occurs through (a) numerous (approximately 6 x 106/cell equivalent) low-affinity sites (Ka = 1.3 x 105M-1) anf (b) fewer (approximately 0.4 x 106/cell equipment) specific receptors (Ka = 6.8 x 106 M-1) defined as 55,000 D glycoprotein and its multimers....

journal_title：Journal of cellular physiology

authors： Wallach DF,Schmidt-Ullrich R

更新日期：1976-12-01 00:00:00

abstract：:Diabetic nephropathy (DN) is an important factor leading to end-stage kidney disease that affects diabetes mellitus patients globally. Our previous transcriptome sequencing has identified a large group of differentially expressed long noncoding RNA (lncRNA) in early development of DN. On basis of this, we aimed to inv...

journal_title：Journal of cellular physiology

authors： Peng W,Huang S,Shen L,Tang Y,Li H,Shi Y

更新日期：2019-08-01 00:00:00

abstract：:In this study, we compared qualitative and quantitative changes in the lateral mobility of phospholipid molecules in the plasma membrane of intact cells under various conditions of specific interaction of integrins in the cell membrane with two extracellular matrix (ECM) components viz. fibronectin (FN) and laminin (L...

journal_title：Journal of cellular physiology

authors： Ramprasad OG,Rangaraj N,Srinivas G,Thiery JP,Dufour S,Pande G

更新日期：2008-05-01 00:00:00

abstract：:Hair follicle stem cells (HFSCs) are able to differentiate into neurons and glial cells. Distinct microRNAs (miRNAs) regulate the proliferation and differentiation of HFSCs. However, the exact role of miR-124 in the neural differentiation of HFSCs has not been elucidated. HFSCs were isolated from mouse whisker follicl...

journal_title：Journal of cellular physiology

authors： Mokabber H,Najafzadeh N,Mohammadzadeh Vardin M

更新日期：2019-06-01 00:00:00

abstract：:Optimal stimulation of signal transduction and biological functions by IGF-I in porcine smooth muscle cells (pSMC) requires ligand occupancy of the alphaVbeta3 integrin. Binding of heparin-binding domain (HBD) of vitronectin (VN) to the cysteine loop (C-loop) region of beta3 is required for pSMC to respond optimally t...

journal_title：Journal of cellular physiology

authors： Xi G,Maile LA,Yoo SE,Clemmons DR

更新日期：2008-02-01 00:00:00

abstract：:Experiments were conducted to determine the extent and variability of collagen degradation in human fetal lung fibroblasts. Cells were incubated with [14C]proline, and degradation was measured by determining the hydroxy[14C]proline in a low molecular weight fraction relative to total hydroxy[14C]proline. Average (basa...

journal_title：Journal of cellular physiology

authors： Bienkowski RS

更新日期：1984-10-01 00:00:00

abstract：:Although the role of several protooncogenes, including sis, myc, and myb in the regulation of growth and differentiation of vascular cells has been examined in some detail, limited information is available on the contribution of ras genes to these processes. In the present studies the influence of oncogenic ras transf...

journal_title：Journal of cellular physiology

authors： Sadhu DN,Lundberg MS,Burghardt RC,Ramos KS

更新日期：1994-12-01 00:00:00

abstract：:To test whether the use of a striatum weighted image may improve registration accuracy and diagnostic outcome in patients with parkinsonian syndromes (PS), weighted images were generated by increasing signal intensity of striatal voxels and used as intermediate dataset for co-registering the brain image onto template....

journal_title：Journal of cellular physiology

authors： Ciarmiello A,Giovacchini G,Guidotti C,Meniconi M,Lazzeri P,Carabelli E,Mansi L,Mariani G,Volterrani D,Del Sette M

更新日期：2013-10-01 00:00:00

abstract：:Interleukin-10 (IL-10) has been shown to exert anti-inflammatory effects by suppressing macrophage proliferation and inhibiting cytokine production. In this study we show that in the presence of erythropoietin (EPO), the addition of IL-10 results in a significant dose-dependent increase in both Burst Forming Unit-Eryt...

journal_title：Journal of cellular physiology

authors： Wang CQ,Udupa KB,Lipschitz DA

更新日期：1996-02-01 00:00:00

abstract：:Dexamethasone (Dex), a synthetic glucocorticoid (GC) with long-lasting treatment effects, has been proved to exert a modulatory effect on osteoblast proliferation and differentiation during embryonic osteogenesis. However, it is still controversial if Dex exposure influences endochondral ossification and the underlyin...

journal_title：Journal of cellular physiology

authors： Xu S,Guo R,Li PZ,Li K,Yan Y,Chen J,Wang G,Brand-Saberi B,Yang X,Cheng X

更新日期：2019-01-22 00:00:00

abstract：:The binding of [3H]tuftsin to normal and in vivo stimulated mouse peritoneal macrophage populations was studied at 22 degrees C. The [3H]tuftsin binding to thioglycollate-stimulated macrophages was shown to be rapid and saturable, with an equilibrium dissociation constant (K(D)) (calculated from a Scatchard plot) of 5...

journal_title：Journal of cellular physiology

authors： Bar-Shavit Z,Stabinsky Y,Fridkin M,Goldman R

更新日期：1979-07-01 00:00:00

abstract：:Connective tissue growth factor (CTGF) is a secreted, extracellular matrix-associated signaling protein that regulates diverse cellular functions. In vivo, CTGF is expressed in many tissues with highest levels in the kidney and brain. The purpose of this study was twofold; first, to localize CTGF in normal bone in viv...

journal_title：Journal of cellular physiology

authors： Safadi FF,Xu J,Smock SL,Kanaan RA,Selim AH,Odgren PR,Marks SC Jr,Owen TA,Popoff SN

更新日期：2003-07-01 00:00:00

abstract：:An unusual inward current which is slowly elicited in the Xenopus oocyte membrane during sustained depolarization is reportedly carried by Na+. It is thought that Na+ selective channels are in some way induced to become voltage-sensitive by the depolarization. Earlier studies report that the induction process involves...

journal_title：Journal of cellular physiology

authors： Charpentier G,Kado RT

更新日期：1999-02-01 00:00:00

abstract：:Low-grade astrocytomas (LGAs) are the most common type of brain tumor in children. Until recently, very little was known about the underlying biology and molecular genetics of these tumors. However, within the past year a number of studies have shown that the MAPK pathway is constitutively activated in a high proporti...

journal_title：Journal of cellular physiology

authors： Tatevossian RG,Lawson AR,Forshew T,Hindley GF,Ellison DW,Sheer D

更新日期：2010-03-01 00:00:00

abstract：:The calcium-sensitive fluorescent indicator fura-2 and a microscope equipped for rapidly changing excitation wavelengths were used to look at the effects of growth factors on cytosolic free calcium ([Ca2+]i) in NRK-49F cells. In these cells bradykinin induced a rapid increase in [Ca2+]i, which generally decayed to nea...

journal_title：Journal of cellular physiology

authors： Marks PW,Kruskal BA,Maxfield FR

更新日期：1988-09-01 00:00:00

abstract：:We report the continuous growth maintenance of untransformed and chemically transformed fibroblasts (AKR-2B, AKR-MCA cells) in low concentrations of serum (0.1% FBS). The cell lines established (AKR-0.1F, MCA-0.1F) proliferated at rates comparable to cells maintained under high serum conditions (10% FBS). Complete rem...

journal_title：Journal of cellular physiology

authors： Mulder KM,Brattain MG

更新日期：1989-03-01 00:00:00

abstract：:MC3T3-E1 cells in culture exhibit a temporal sequence of development similar to in vivo bone formation. To examine whether the developmental expression of the osteoblast phenotype depends on serum derived factors, we compared the time-dependent expression of alkaline phosphatase (ALP)-a marker of osteoblastic maturati...

journal_title：Journal of cellular physiology

authors： Yohay DA,Zhang J,Thrailkill KM,Arthur JM,Quarles LD

更新日期：1994-03-01 00:00:00

abstract：:Abdominal aortic aneurysm (AAA) is a potentially lethal disease featured by focal dilatation in the aorta. The transition of vascular smooth muscle cells (SMCs) from a contractile/differentiated to a synthetic/dedifferentiated phenotype is considered to contribute to AAA formation and expansion. Our previous gene micr...

journal_title：Journal of cellular physiology

authors： Shi X,Xu C,Li Y,Wang H,Ma W,Tian Y,Yang H,Li L

更新日期：2020-12-01 00:00:00

abstract：:The oxygen dependence of hepatic cellular respiration was studied by employing simultaneous organ spectrophotometry of cytochromes and hemoglobin, the latter used as an intrasinusoidal optical oxygen probe. The Km of cytochrome aa3 for oxygen was found to be 6.8 microM in the isolated perfused liver and 0.3 microM in ...

journal_title：Journal of cellular physiology

authors： Kekonen EM,Jauhonen VP,Hassinen IE

更新日期：1987-10-01 00:00:00