TSPO ligand FGIN-1-27 controls priapism in sickle cell mice via endogenous testosterone production.

abstract：:Parkinson's disease (PD) is one of the most common movement disorders with loss of dopaminergic neurons and the presence of Lewy bodies in certain brain areas. However, it is not clear how Lewy body (inclusion with protein aggregation) formation occurs. Mutations in leucine-rich repeat kinase 2 (LRRK2) can cause a gen...

journal_title：Journal of cellular physiology

authors： Thomas JM,Wang X,Guo G,Li T,Dai B,Nucifora LG,Nucifora FC Jr,Liu Z,Xue F,Liu C,Ross CA,Smith WW

更新日期：2020-10-01 00:00:00

abstract：:In RBL-2H3 rat leukemic mast cells, cross-linking anti-DNP IgE-receptor complexes with multivalent antigen (DNP-BSA) activates a signal transduction pathway leading to Ca2+ influx and secretion. Cross-linking IgE-receptor complexes also stimulates a pathway that inactivates (desensitizes) receptors; this pathway becom...

journal_title：Journal of cellular physiology

authors： Wilson BS,Seagrave J,Oliver JM

更新日期：1991-12-01 00:00:00

abstract：:NIH-3T3 cells transformed by the EJ-ras oncogene display reduced platelet-derived growth factor (PDGF)-stimulated phospholipase C activity as measured by inositol 1,4,5-triphosphate (IP3) synthesis and Ca2+ mobilization. The lack of PDGF-stimulated Ca2+ mobilization in EJ-ras transformed cells is not due to a loss of ...

journal_title：Journal of cellular physiology

authors： Olinger PL,Benjamin CW,Gorman RR,Connor JA

更新日期：1989-05-01 00:00:00

abstract：:Mesenchymal stem cells (MSC) represent emerging cell-based therapies for diabetes and associated complications. Ongoing clinical trials are using exogenous MSC to treat type 1 and 2 diabetes, cardiovascular disease and non-healing wounds due to diabetes. The majority of these trials are aimed at exploiting the ability...

journal_title：Journal of cellular physiology

authors： Smith AN,Muffley LA,Bell AN,Numhom S,Hocking AM

更新日期：2012-09-01 00:00:00

abstract：:Factors inhibiting cell growth have been isolated from different cell types. However, little information is available concerning their mode of action. A novel growth inhibitory factor of 45 kDa (IDF45) was recently purified to homogeneity from medium conditioned by 3T3 cells. This molecule was able to inhibit DNA synt...

journal_title：Journal of cellular physiology

authors： Delbe J,Villaudy J,Blat C,Desauty G,Golde A,Harel L

更新日期：1990-02-01 00:00:00

abstract：:Rat embryo fibroblasts were grown in medium containing 14C-leucine and 3H-thymidine. After a 24-hour chase in nonlabeled medium, cultures were placed in either fresh growth medium or medium containing 10-20 microgram/ml cycloheximide. Cell monolayers were processed at daily intervals for three days. Four hours prior t...

journal_title：Journal of cellular physiology

authors： Amenta JS,Sargus MJ,Baccino FM

更新日期：1978-12-01 00:00:00

abstract：:We recently reported that peptidoglycan (PGN), a cell wall component of the Gram-positive bacterium, induces NF-κB activation and microglia activation. However, PGN-regulated AP-1 activation and cytokine expression in microglia remains unclear. This study investigated how PGN influences the signaling pathway involved ...

journal_title：Journal of cellular physiology

authors： Lin HY,Tang CH,Chen JH,Chuang JY,Huang SM,Tan TW,Lai CH,Lu DY

更新日期：2011-06-01 00:00:00

abstract：:The biological activities of crocin, one of the main bioactive compounds of saffron, include anti-inflammatory, antioxidant, antidepressant, and anticancer effects. Crocin has been shown to trigger the apoptosis of gastric cancer cells, but its effect on the metastasis of gastric cancer cells remains unclear. Krüppel-...

journal_title：Journal of cellular physiology

authors： Zhou Y,Xu Q,Shang J,Lu L,Chen G

更新日期：2019-08-01 00:00:00

abstract：:Type IV collagenases are secreted as latent 92 and 72 kDa proenzymes which are then activated extracellularly. The mechanisms by which they are activated in vivo are not clear. We have studied the activation of porcine endothelial cell type IV collagenases by tissue and plasma kallikrein, and found that tissue kallikr...

journal_title：Journal of cellular physiology

authors： Desrivières S,Lu H,Peyri N,Soria C,Legrand Y,Ménashi S

更新日期：1993-12-01 00:00:00

abstract：:Pleiotropic human KB cell mutants, selected for resistance to a conjugate of epidermal growth factor with Pseudomonas exotoxin (PE-EGF), were characterized genetically. These mutants have a pleiotropic phenotype, which includes reduced number of EGF receptors and reduced growth rate. Hybrid cells between HeLa D98 and ...

journal_title：Journal of cellular physiology

authors： Amano F,Pastan I,Gottesman MM

更新日期：1988-06-01 00:00:00

abstract：:Wnt/β-catenin signaling pathway plays a crucial role in diabetic cardiomyopathy (DCM), thus we aimed at investigating the effect of one therapeutic approach with resveratrol (RSV) given systemically and combined treatment of RSV with mesenchymal stem cells (MSCs) that was either RSV-preconditioned or not on Wnt/β-cate...

journal_title：Journal of cellular physiology

authors： ShamsEldeen AM,Ashour H,Shoukry HS,Fadel M,Kamar SS,Aabdelbaset M,Rashed LA,Ammar HI

更新日期：2019-07-01 00:00:00

abstract：:At the initial stage of cell-cell contact of epithelial cells, primordial spot-like junctions are formed at the tips of thin cellular protrusions radiating from adjacent cells, where E-cadherin and ZO-1 are precisely coconcentrated (Yonemura et al., 1995, J. Cell Sci. 108:127-142). In fully polarized epithelial cells,...

journal_title：Journal of cellular physiology

authors： Ando-Akatsuka Y,Yonemura S,Itoh M,Furuse M,Tsukita S

更新日期：1999-05-01 00:00:00

abstract：:Chick embryo fibroblasts were maintained at confluency for up to 35 days in medium containing 0.5% or 0.75% fetal bovine serum or 2.5% or 5.0% horse serum. At weekly intervals cells were subcultured and serially propagated in medium containing 10% FBS until their replicative lifespans were completed. The results showe...

journal_title：Journal of cellular physiology

authors： Nielsen PJ,Ryan JM

更新日期：1981-06-01 00:00:00

abstract：:Ménière's disease (MD) is a disorder of the inner ear characterized by an insidious onset and aspecific symptoms, such as dizziness, vertigo, tinnitus, and hearing loss, that may become very debilitating. The presence of endolymphatic hydrops is a common feature in MD patients, but the pathophysiology is still largely...

journal_title：Journal of cellular physiology

authors： Chiarella G,Saccomanno M,Scumaci D,Gaspari M,Faniello MC,Quaresima B,Di Domenico M,Ricciardi C,Petrolo C,Cassandro C,Costanzo FS,Cuda G,Cassandro E

更新日期：2012-01-01 00:00:00

abstract：:Acetylcholine (ACh) protected against cardiac injury via promoting autophagy and mitochondrial biogenesis, however, the involvement of mitophagy in ACh-elicited cardioprotection remains unknown. In the present study, H9c2 cardiomyocytes were subjected to hypoxia/reoxygenation (H/R) and ACh treatment during reoxygenati...

journal_title：Journal of cellular physiology

authors： Sun L,Zhao M,Yang Y,Xue RQ,Yu XJ,Liu JK,Zang WJ

更新日期：2016-05-01 00:00:00

abstract：:The concentration of ATP in cysts of the brine shrimp, Artemia salina, has been studied as a function of cyst hydration. Cysts dried over CaSO4 contain 0.02 gH2O/g cysts and 0.54 +/- 0.05 (S.D.) mumoles of ATP/g dried cysts. Addition of water up to 0.05 g/g cysts produced no net change in the level of ATP during incub...

journal_title：Journal of cellular physiology

authors： Clegg JS,Cavagnaro J

更新日期：1976-06-01 00:00:00

abstract：:Phospholipase A2 (PLA2) is pivotal in the rapid membrane-mediated actions of 1,25-dihydroxyvitamin D3 [1alpha,25(OH)2D3]. Microarray analysis indicated that PLA2 activating protein (PLAA) mRNA is upregulated 6-fold before rat growth plate cells exhibit 1alpha,25(OH)2D3-dependent protein kinase C (PKC) increases, sugge...

journal_title：Journal of cellular physiology

authors： Schwartz Z,Graham EJ,Wang L,Lossdörfer S,Gay I,Johnson-Pais TL,Carnes DL,Sylvia VL,Boyan BD

更新日期：2005-04-01 00:00:00

abstract：:The purpose of this study was to investigate the potential mechanism of interleukin-6 (IL-6) on the stimulation of excessive androgen secretion in human NCI-H295R adrenocortical cells. We performed transcriptome sequencing of cancer and paracancerous tissues obtained from functional adrenal cortical adenomas. The secr...

journal_title：Journal of cellular physiology

authors： Wei X,Zhang J,Peng W,Xu H,Wei Z,Pang L,Liu J,Wang T

更新日期：2020-12-01 00:00:00

abstract：:Former studies have linked hepatocyte growth with liver fatty acid binding protein (L-FABP) of rat liver cytosol. In search for the roles of L-FABP in hepatocytes, we previously stably transfected rat L-FABP sense and antisense cDNAs into rat hepatoma HTC cells that do not contain L-FABP RNA or protein, thereby provid...

journal_title：Journal of cellular physiology

authors： Keler T,Sorof S

更新日期：1993-10-01 00:00:00

abstract：:Melanoma as the most major skin malignancy has attracted much attention, so far. Although a successful therapeutic strategy requires an accurate understanding of the precise mechanisms for the initiation and progression of the melanoma. Several types of cell death mechanisms have recently been identified along with co...

journal_title：Journal of cellular physiology

authors： Ashrafizadeh M,Mohammadinejad R,Tavakol S,Ahmadi Z,Roomiani S,Katebi M

更新日期：2019-11-01 00:00:00

abstract：:The SV40 transformed murine macrophage cell line, BAC1, proliferates in response to the colony stimulating factor, CSF-1 (Schwarzbaum et al., J. Immunol., 132:1158, 1984). In order to obtain a cell line suitable for biochemical and genetic studies of CSF-1 signal transduction, clones of BAC1 were established. Clones r...

journal_title：Journal of cellular physiology

authors： Morgan C,Pollard JW,Stanley ER

更新日期：1987-03-01 00:00:00

abstract：:A method for killing dividing cells (Puck and Kao, '67) was adapted for the elimination of dividing heart muscle cells (myoblasts) in cultures. We have used this method to demonstrate their presence and to estimate their number as well as the number of nondividing heart muscle cells (myocytes) in the neo-natal rat hea...

journal_title：Journal of cellular physiology

authors： Masse MJ,Harary I

更新日期：1980-11-01 00:00:00

abstract：:The potential usage of curcumin in diverse human diseases has been widely studied, including arteriosclerosis (AS). This study focused on investigating the relationship between curcumin and AS-associated microRNA, which may provide a better understanding of curcumin in a different mechanism. Human microvascular endoth...

journal_title：Journal of cellular physiology

authors： Li Y,Tian L,Sun D,Yin D

更新日期：2019-11-01 00:00:00

abstract：:Previously, serum miR-188-5p is differentially expressed in breast cancer, but the diagnostic potential of circulating miR-188-5p as well as its regulatory mechanism in breast cancer remain uncertain. Herein, serum miR-188-5p was detected by real-time polymerase chain reaction in patients with breast cancer, breast fi...

journal_title：Journal of cellular physiology

authors： Wang M,Zhang H,Yang F,Qiu R,Zhao X,Gong Z,Yu W,Zhou B,Shen B,Zhu W

更新日期：2020-05-01 00:00:00

abstract：:Liver fibrosis (LF) is the result of a vicious cycle between inflammation-induced chronic hepatocyte injury and persistent activation of hepatic stellate cells (HSCs). Mesenchymal stem cell (MSC)-based therapy may represent a potential remedy for treatment of LF. However, the fate of transplanted MSCs in LF remains la...

journal_title：Journal of cellular physiology

authors： Wang HY,Li C,Liu WH,Deng FM,Ma Y,Guo LN,Kong H,Hu KA,Liu Q,Wu J,Sun J,Liu YL

更新日期：2020-03-01 00:00:00

abstract：:Endothelial-mesenchymal transition (EndMT) plays a pivotal role in organ fibrosis. This study examined the effect of SIRT1 on transforming growth factor beta (TGF-β)-induced EndMT in human endothelial cells (ECs) and its probable molecular mechanism. We assessed EndMT by immunofluorescence staining, quantitative real-...

journal_title：Journal of cellular physiology

authors： Li Z,Wang F,Zha S,Cao Q,Sheng J,Chen S

更新日期：2018-11-01 00:00:00

abstract：:The significance of low pH-induced stimulation of osteoclastic bone resorption has recently been questioned following the finding that embryonic chick osteoclasts were only weakly stimulated by extremely low pH (6.5) and that the effect was transient, apparently due to cytotoxicity. Although low pH in the range 6.8-7....

journal_title：Journal of cellular physiology

authors： Murrills RJ,Stein LS,Dempster DW

更新日期：1993-03-01 00:00:00

abstract：:Current osteoinductive protein therapy utilizes bolus administration of large doses of bone morphogenetic proteins (BMPs), which is costly, and may not replicate normal bone healing. The limited in vivo biologic activity of BMPs requires the investigation of growth factors that may enhance this activity. In this study...

journal_title：Journal of cellular physiology

authors： Arosarena OA,Del Carpio-Cano FE,Dela Cadena RA,Rico MC,Nwodim E,Safadi FF

更新日期：2011-11-01 00:00:00

abstract：:Visualizing protein dynamics is the key to a quantitative understanding of molecular mechanisms in biological systems. Recent developments in fluorescent microscopy techniques allow for novel experimental approaches to study stochastic localization, distribution, and movement of fluorescently labeled molecules in high...

journal_title：Journal of cellular physiology

authors： Rieckher M

更新日期：2017-01-01 00:00:00

abstract：:Nowadays, fat tissue transplantation is widely used in regenerative and reconstructive surgery. However, a shared method of lipoaspirate handling for ensuring a good quality fat transplant has not yet been established. The study was to identify a method to recover from the lipoaspirate samples the highest number of hu...

journal_title：Journal of cellular physiology

authors： Palumbo P,Miconi G,Cinque B,La Torre C,Lombardi F,Zoccali G,Orsini G,Leocata P,Giuliani M,Cifone MG

更新日期：2015-08-01 00:00:00