C6 ceramide motivates the anticancer sensibility induced by PKC412 in preclinical head and neck squamous cell carcinoma models.

abstract：:Activation of CD4+ T cells requires processing of exogenous protein antigens by antigen-presenting cells (APC). A macrophage hybridoma and B cell lymphoma were comparable in their ability to process hen egg lysozyme (HEL), which involves reduction of its disulfide bonds. The intracellular levels of cysteine and glutat...

journal_title：Journal of cellular physiology

authors： Gainey D,Short S,McCoy KL

更新日期：1996-08-01 00:00:00

abstract：:Extracellular glutathione (GSH) is degraded by an external cell-surface enzyme, gamma-glutamyltranspeptidase (gamma-GT). The products are transported into cells to participate in important cellular processes. In the present study, we tested the hypothesis that extracellular GSH is a source of glutamic acid for cells t...

journal_title：Journal of cellular physiology

authors： Kang YJ,Feng Y,Hatcher EL

更新日期：1994-12-01 00:00:00

abstract：:The nuclear lamina is a fibrous structure at the nucleoplasmic surface of the inner nuclear membrane. Its assembly state is regulated by phosphorylation of its protein components, the lamins A, B, and C. The isoprenylation of the lamins is essential for their proper membrane anchoring and functionality. The content an...

journal_title：Journal of cellular physiology

authors： Bruscalupi G,Di Croce L,Lamartina S,Zaccaria ML,Luzzatto AC,Trentalance A

更新日期：1997-05-01 00:00:00

abstract：:Gastric cancer has the fifth highest incidence of disease and is the third leading cause of cancer-associated mortality in the world. The etiology of gastric cancer is complex and needs to be fully elucidated. Thus, it is necessary to explore potential pathogenic genes and pathways that contribute to gastric cancer. G...

journal_title：Journal of cellular physiology

authors： Ren F,Zhao Q,Liu B,Sun X,Tang Y,Huang H,Mei L,Yu Y,Mo H,Dong H,Zheng P,Mi Y

更新日期：2020-03-01 00:00:00

abstract：:Studies have shown that microRNAs (miRNAs) play a vital role in tumor progression and patients' prognosis. Therefore, we aimed to construct a miRNA model for forecasting the survival of hepatocellular carcinoma (HCC) patients. The gene expression data of 433 patients with HCC from The Cancer Genome Atlas (TCGA) and Ge...

journal_title：Journal of cellular physiology

authors： Fang SS,Guo JC,Zhang JH,Liu JN,Hong S,Yu B,Gao Y,Hu SP,Liu HZ,Sun L,Zhao Y

更新日期：2020-04-01 00:00:00

abstract：:At the end of December 2019, a novel acute respiratory syndrome coronavirus 2 (SARS-CoV2) appeared as the third unheard of outbreak of human coronavirus infection in the 21st century. First, in Wuhan, China, the novel SARS-CoV2 was named by the World Health Organization (WHO), as 2019-nCOV (COVID-19), and spread extre...

journal_title：Journal of cellular physiology

authors： Tahmasebi S,Khosh E,Esmaeilzadeh A

更新日期：2020-12-01 00:00:00

abstract：:Breast cancer (BC) is the most prevalent malignant cancer in the world, is the leading cause of cancer-related death female. Recently, there is accumulating evidence that long noncoding RNAs (lncRNAs) might as an important role in the progression of BC. (epithelial-mesenchymal transition (EMT) is considered to play a ...

journal_title：Journal of cellular physiology

authors： Wang YY,Yan L,Yang S,Xu HN,Chen TT,Dong ZY,Chen SL,Wang WR,Yang QL,Chen CJ

更新日期：2019-12-01 00:00:00

abstract：:Glioblastoma (GBM) is the most common, malignant, and deadly primary glioma. Six-transmembrane epithelial antigen of prostate (STEAP) family is involved in tumorigenesis; here, we have explored the biological function and the prognostic value of the STEAP family in GBM. Differentially expressed STEAP genes in tumor an...

journal_title：Journal of cellular physiology

authors： Chen H,Xu C,Yu Q,Zhong C,Peng Y,Chen J,Chen G

更新日期：2020-09-23 00:00:00

abstract：:Earlier studies in multiple epithelia have shown that cell-cell actin-based adherens junction (AJ) dynamics are regulated, at least in part, by the interplay of kinases and phosphatases that determines the intracellular phosphoprotein content. Yet it is virtually unknown regarding the role of protein kinases in Sertol...

journal_title：Journal of cellular physiology

authors： Lee NP,Cheng CY

更新日期：2005-02-01 00:00:00

abstract：:Aberrant activation of the HGF/c-Met signalling pathway is reported to be associated with cell proliferation, progression, and metastasis features of several tumor types, including cervical cancer, suggesting that it may be of potential value as a novel therapeutic target. Furthermore, HPV-positive patients had a high...

journal_title：Journal of cellular physiology

authors： Boromand N,Hasanzadeh M,ShahidSales S,Farazestanian M,Gharib M,Fiuji H,Behboodi N,Ghobadi N,Hassanian SM,Ferns GA,Avan A

更新日期：2018-06-01 00:00:00

abstract：:The effect of transforming growth factor-beta 1 (TGF-beta 1) on collagen biosynthesis was investigated in confluent primary monolayer cultures of rabbit articular chondrocytes (RAC). Exposure to TGF-beta (0.1, 1, and 10 ng/ml) in serum-free medium caused a dose- and time-dependent stimulation of collagen biosynthesis ...

journal_title：Journal of cellular physiology

authors： Galéra P,Vivien D,Pronost S,Bonaventure J,Rédini F,Loyau G,Pujol JP

更新日期：1992-12-01 00:00:00

abstract：:miR-142a-5p plays critical roles in multiple biological processes and diseases, such as inflammation and tumorigenesis. However, it remains to be explored if and how miR-142a-5p contributes to osteoblast differentiation. In this study, our results showed that miR-142a-5p was highly expressed in bone tissue of mice and...

journal_title：Journal of cellular physiology

authors： Yuan H,Li M,Feng X,Zhu E,Wang B

更新日期：2021-03-01 00:00:00

abstract：:Norepinephrine (NE) produced a dose-dependent inhibition of 125I-epidermal growth factor (EGF) binding to adult rat hepatocytes in primary culture. This effect was maximal after 1 hr of incubation with NE and could be blocked by the presence of an alpha 1-specific adrenergic receptor antagonist. The inhibition of bind...

journal_title：Journal of cellular physiology

authors： Cruise JL,Cotecchia S,Michalopoulos G

更新日期：1986-04-01 00:00:00

abstract：:Alpha-D-galactose is metabolized in species ranging from E. coli to mammals predominantly via a series of sequential reactions collectively known as the Leloir pathway. Deficiency of any one of these enzymes in humans results in a form of the inherited metabolic disorder, galactosemia, although the symptoms and severi...

journal_title：Journal of cellular physiology

authors： Fridovich-Keil JL

更新日期：2006-12-01 00:00:00

abstract：:Oral administration of ajulemic acid (AjA), a cannabinoid acid devoid of psychoactivity, prevents joint tissue injury in rats with adjuvant induced arthritis. Because activation of osteoclasts is central to the pathogenesis of bone erosion in patients with rheumatoid arthritis (RA), we investigated the influence of Aj...

journal_title：Journal of cellular physiology

authors： George KL,Saltman LH,Stein GS,Lian JB,Zurier RB

更新日期：2008-03-01 00:00:00

abstract：:Our understanding of the mechanism of cell fate transition during the direct reprogramming of fibroblasts into various central nervous system (CNS) neural cell types has been limited by the lack of a comprehensive analysis on generated cells, independently and in comparison with other CNS neural cell types. Here, we a...

journal_title：Journal of cellular physiology

authors： Khazaei N,Rastegar-Pouyani S,O'Toole N,Wee P,Mohammadnia A,Yaqubi M

更新日期：2018-04-01 00:00:00

abstract：:The plasma membrane of erythrocytes, as of other cells, is thought to act as the barrier responsible for maintaining intracellular gradients of most ions and small molecular species between the cell and its environment. Controlled application of the nonionic detergent Brij 58 effectively opened the erythrocyte plasma ...

journal_title：Journal of cellular physiology

authors： Kellermayer M,Ludány A,Miseta A,Kŏszegi T,Berta G,Bogner P,Hazlewood CF,Cameron IL,Wheatley DN

更新日期：1994-05-01 00:00:00

abstract：:We have studied the transcriptional activity, steady-state mRNA levels, and steady-state protein levels of the c-myc and transferrin receptor (TfR) genes in murine M1 myeloid leukemia cells arrested in G1 phase of the cell cycle by different methods. When cells are growth-arrested by density inhibition, a technique th...

journal_title：Journal of cellular physiology

authors： Neckers LM,Tsuda H,Weiss E,Pluznik DH

更新日期：1988-05-01 00:00:00

abstract：:Cell-based cartilage resurfacing requires ex vivo expansion of autologous articular chondrocytes. Defined culture conditions minimize expansion-dependent phenotypic alterations but maintenance of the cells' differentiation potential must be carefully assessed. Transforming growth factor β-1 (TGF β-1) positively regula...

journal_title：Journal of cellular physiology

authors： Narcisi R,Quarto R,Ulivi V,Muraglia A,Molfetta L,Giannoni P

更新日期：2012-09-01 00:00:00

abstract：:Type IV collagenases are secreted as latent 92 and 72 kDa proenzymes which are then activated extracellularly. The mechanisms by which they are activated in vivo are not clear. We have studied the activation of porcine endothelial cell type IV collagenases by tissue and plasma kallikrein, and found that tissue kallikr...

journal_title：Journal of cellular physiology

authors： Desrivières S,Lu H,Peyri N,Soria C,Legrand Y,Ménashi S

更新日期：1993-12-01 00:00:00

abstract：:Anoctamin1 (ANO1) encodes a Ca(2+)-activated chloride (Cl(-)) channel (CaCC) in variety tissues of many species. Whether ANO1 expresses and functions as a CaCC in cardiomyocytes remain unknown. The objective of this study is to characterize the molecular and functional expression of ANO1 in cardiac myocytes and the ro...

journal_title：Journal of cellular physiology

authors： Ye Z,Wu MM,Wang CY,Li YC,Yu CJ,Gong YF,Zhang J,Wang QS,Song BL,Yu K,Hartzell HC,Duan DD,Zhao D,Zhang ZR

更新日期：2015-02-01 00:00:00

abstract：:In this study, we focused on ERβ regulation in the adenohypophysis under different estrogenic milieu, by analyzing whether ER modulates the phosphatase and tensin homolog deleted on chromosome 10 (PTEN) expression and its subcellular localization on anterior pituitary glands from Wistar rats and GH3 lactosomatotroph c...

journal_title：Journal of cellular physiology

authors： Perez PA,Petiti JP,Picech F,Guido CB,dV Sosa L,Grondona E,Mukdsi JH,De Paul AL,Torres AI,Gutierrez S

更新日期：2018-02-01 00:00:00

abstract：:Cell adhesion receptors, referred to as integrins, are recognized as key regulators of cellular processes including growth and differentiation. Integrins communicate with growth factor receptors (GFRs) to control specific cellular responses to stimuli originating in the extracellular environment. In this article, we r...

journal_title：Journal of cellular physiology

authors： Alam N,Goel HL,Zarif MJ,Butterfield JE,Perkins HM,Sansoucy BG,Sawyer TK,Languino LR

更新日期：2007-12-01 00:00:00

abstract：:Syndecans are constitutively shed from growing epithelial cells as the part of normal cell surface turnover. However, increased serum levels of the soluble syndecan ectodomain have been reported to occur during bacterial infections. The aim of this study was to evaluate the potential of lipopolysaccharide (LPS) from t...

journal_title：Journal of cellular physiology

authors： Andrian E,Grenier D,Rouabhia M

更新日期：2005-07-01 00:00:00

abstract：:Methylglyoxal bis-(guanylhydrazone) (mGBG) blocked the stimulation of DNA synthesis in quiescent, density-inhibited BALB/c-3T3 cells treated with platelet-derived growth factor (PDGF) and platelet-poor plasma (PPP). Competence formation produced by a transient exposure to PDGF was not effected by mGBG. In contrast, mG...

journal_title：Journal of cellular physiology

authors： Wharton W,Van Wyk JJ,Pledger WJ

更新日期：1981-04-01 00:00:00

abstract：:The initial step in a synthesis of thyroid hormones is the uptake of iodide from the circulation. Iodide (I(-)) is transported into thyroid cells via a Na(+)/I(-) symporter (NIS), which is electrogenic and thus sensitive to alterations in membrane potential (V(m)). I(-) is then released to the lumen of thyroid follicl...

journal_title：Journal of cellular physiology

authors： Viitanen TM,Sukumaran P,Löf C,Törnquist K

更新日期：2013-04-01 00:00:00

abstract：:The biosynthesis and turnover of nicotinamide adenine dinucleotide (NAD) have been examined in mitotic cells of the human culture line, D98/AH2. No significant difference in the incorporation of nicotinic acid or nicotinamide could be detected between mitotic and interphase cells. The distribution of newly-incorporate...

journal_title：Journal of cellular physiology

authors： Elliott G,Rechsteiner M

更新日期：1975-12-01 00:00:00

abstract：:The effects of artificial cryptorchidism and its surgical reversal on spermatogenesis were examined in germ cell mutant, S1/+ and wild type, +/+, mice. In cryptorchid testes no difference was found between S1/+ and +/+ mice in the number of undifferentiated type A spermatogonia. The activity of type A spermatogonia in...

journal_title：Journal of cellular physiology

authors： Nishimune Y,Haneji T,Kitamura Y

更新日期：1980-10-01 00:00:00

abstract：:Ischemic stroke (IS), which is characterized by high morbidity, disability, and mortality, is recognized as a major cerebrovascular disease. MicroRNA-31 (miR-31) was reported to participate in the progression of brain disease. The present study was conducted in order to investigate the effect of miR-31 on oxidative st...

journal_title：Journal of cellular physiology

authors： Li J,Lv H,Che YQ

更新日期：2020-03-01 00:00:00

abstract：:p120-catenin (p120) is an important regulator in the function and stability of E-cadherin. However, the role of p120 in the epidermis is unclear. Previous studies have shown that globally knockout of p120 caused increased epidermal proliferation but little changes in epidermal differentiation and permeability. In the ...

journal_title：Journal of cellular physiology

authors： Xie Z,Tang Y,Man MQ,Shrestha C,Bikle DD

更新日期：2018-01-01 00:00:00