Abstract:
:Cell adhesion receptors, referred to as integrins, are recognized as key regulators of cellular processes including growth and differentiation. Integrins communicate with growth factor receptors (GFRs) to control specific cellular responses to stimuli originating in the extracellular environment. In this article, we review the role of integrins as molecular switches that modulate GFR activation and specificity. We also examine the reciprocal modulation of integrin functions by GFRs and the mechanisms through which those actions are fine-tuned.
journal_name
J Cell Physioljournal_title
Journal of cellular physiologyauthors
Alam N,Goel HL,Zarif MJ,Butterfield JE,Perkins HM,Sansoucy BG,Sawyer TK,Languino LRdoi
10.1002/jcp.21278subject
Has Abstractpub_date
2007-12-01 00:00:00pages
649-53issue
3eissn
0021-9541issn
1097-4652journal_volume
213pub_type
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