Direct evidence for nuclear and cytoplasmic colocalization of proteasomes (multiprotease complexes) in liver.

abstract：:Sulfogalactosylglycerolipid (SGG) is the major mammalian male germ cell glycolipid and has been implicated in sperm/egg binding. Mycoplasma pulmonis, a species of Mollicutes, is associated with male infertility in rodents. Purified SGG incubated in the presence of M. pulmonis was enzymatically degraded by both desulfa...

journal_title：Journal of cellular physiology

authors： Lingwood C,Schramayr S,Quinn P

更新日期：1990-01-01 00:00:00

abstract：:CHFR acts as a tumor suppressor gene, which is frequently inactivated caused by its promoter hypermethylation in various solid tumors. Although a recent study showed that CHFR hypermethylation was a frequent event in acute myeloid leukemia (AML) and correlated with adverse clinical outcome, herein, we found that CHFR ...

journal_title：Journal of cellular physiology

authors： Zhou JD,Zhang TJ,Li XX,Ma JC,Guo H,Wen XM,Yao DM,Zhang W,Lin J,Qian J

更新日期：2018-06-01 00:00:00

abstract：:Growing evidence indicates long noncoding RNAs (lncRNAs) are significant regulators in the progression of various malignant tumors including colon cancer. Dysregulation of lncRNA LINC00261 has been identified in many cancers. Investigations on LINC00261 function have revealed that LINC00261 could act as a crucial tumo...

journal_title：Journal of cellular physiology

authors： Yan D,Liu W,Liu Y,Luo M

更新日期：2019-12-01 00:00:00

abstract：:Osteoclasts are multinucleated cells formed by fusion of preosteoclasts (POCs) derived from cells of the monocyte/macrophage lineage. We have reported a culture system that supports the formation of POCs from stroma-depleted rat bone marrow cells. Global gene expression analysis of this culture system identified genes...

journal_title：Journal of cellular physiology

authors： Funakubo N,Xu X,Kukita T,Nakamura S,Miyamoto H,Kukita A

更新日期：2018-04-01 00:00:00

abstract：:Current osteoinductive protein therapy utilizes bolus administration of large doses of bone morphogenetic proteins (BMPs), which is costly, and may not replicate normal bone healing. The limited in vivo biologic activity of BMPs requires the investigation of growth factors that may enhance this activity. In this study...

journal_title：Journal of cellular physiology

authors： Arosarena OA,Del Carpio-Cano FE,Dela Cadena RA,Rico MC,Nwodim E,Safadi FF

更新日期：2011-11-01 00:00:00

abstract：:These are the reflections of a retired physician who was introduced to cellular physiology in 1947 at the University of Pennsylvania. I majored in Zoology. I took the required major courses, which were interesting but not exciting. I was a premedical student at the time. Fortunately I was introduced to cellular physio...

journal_title：Journal of cellular physiology

authors： Perelman A

更新日期：2015-11-01 00:00:00

abstract：:Serine racemase (SR) is responsible for the biosynthesis of D-serine (D-Ser), an endogenous co-agonist for the glycine (Gly)-binding site on N-methyl-D-aspartate (NMDA) receptors, from L-Ser in the brain. We have previously demonstrated high expression of SR by chondrocytes in cartilage. In this study, we attempted to...

journal_title：Journal of cellular physiology

authors： Takarada T,Takahata Y,Iemata M,Hinoi E,Uno K,Hirai T,Yamamoto T,Yoneda Y

更新日期：2009-09-01 00:00:00

abstract：:Proteolytic cleavage of extracellular matrix (ECM) is a critical feature of tumor cell invasion, and affects cancer cell growth, differentiation, apoptosis, and migration. Malignant cells secrete most proteases as inactive proenzymes that undergo proteolytic cleavage for activation, and proteolytic activity is elevate...

journal_title：Journal of cellular physiology

authors： Kusick S,Bertram H,Oberleithner H,Ludwig T

更新日期：2005-09-01 00:00:00

abstract：:Hepatocellular carcinoma (HCC) is one of the lethal and difficult-to-cure cancers worldwide. Owing to the late diagnosis and drug resistance of malignant hepatocytes, treatment of this cancer by conventional chemotherapy agents is challenging, and researchers are seeking new alternative treatment options to overcome t...

journal_title：Journal of cellular physiology

authors： Hajiasgharzadeh K,Somi MH,Shanehbandi D,Mokhtarzadeh A,Baradaran B

更新日期：2019-04-01 00:00:00

abstract：:Galectins play key roles in the inflammatory cascade. In this study, we aimed to analyze the effect of galectin-1 (Gal-1) in the function of intestinal epithelial cells (IECs) isolated from healthy and inflamed mucosa. IECs isolated from mice or patients with inflammatory bowel diseases (IBD) were incubated with diffe...

journal_title：Journal of cellular physiology

authors： Muglia CI,Gobbi RP,Smaldini P,Delgado ML,Candia M,Zanuzzi C,Sambuelli A,Rocca A,Toscano MA,Rabinovich GA,Docena GH

更新日期：2016-07-01 00:00:00

abstract：:Colorectal cancer (CRC) is the third most common cancer and a leading cause of cancer-related death worldwide. About 1.8 million new cases were reported in 2018. Accordingly, there is an urgent need for development of effective strategies to lower the mortality and morbidity originated from this malignancy. MicroRNAs ...

journal_title：Journal of cellular physiology

authors： Anvarnia A,Mohaddes-Gharamaleki F,Asadi M,Akbari M,Yousefi B,Shanehbandi D

更新日期：2019-12-01 00:00:00

abstract：:Adult stem cell therapy is being used extensively to rejuvenate damaged tissue. One important tissue source to obtain these cells is adipose, which contains cells called adipose-derived stem cells (ADSCs). These cells have a great therapeutic potential not only for their multipotent properties as well as for immunomod...

journal_title：Journal of cellular physiology

authors： Muñoz MF,Argüelles S,Medina R,Cano M,Ayala A

更新日期：2019-08-01 00:00:00

abstract：:The growth of human epithelial cells is stimulated by cholera toxin and analogues of cyclic AMP, while the growth of breast derived fibroblasts is inhibited. These compounds have little effect on DNA synthesis in the absence of other mitogens but show a synergistic effect with serum and/or EGF. The results suggest tha...

journal_title：Journal of cellular physiology

authors： Taylor-Papadimitriou J,Purkis P,Fentiman IS

更新日期：1980-03-01 00:00:00

abstract：:Although immortalized cultured cells are useful for various functional assays or transcriptome analysis, highly efficient and reproducible immortalization methods have not been developed in avian-derived cells. We introduced the simian virus 40 T antigen (SV40T) and human papillomavirus (HPV)-E6E7 to chick and Okinawa...

journal_title：Journal of cellular physiology

authors： Katayama M,Kiyono T,Ohmaki H,Eitsuka T,Endoh D,Inoue-Murayama M,Nakajima N,Onuma M,Fukuda T

更新日期：2019-05-01 00:00:00

abstract：:We tested the expression of genes coding receptors of a cutaneous serotoninergic/melatoninergic system in whole human skin and in normal and pathologic cultured skin cells. Evaluation of serotonin (5HT), melatonin (MT), and melatonin-related receptors (MRR) showed expression of the isoforms 5HT2B, 5HT7, and MT1 genes ...

journal_title：Journal of cellular physiology

authors： Slominski A,Pisarchik A,Zbytek B,Tobin DJ,Kauser S,Wortsman J

更新日期：2003-07-01 00:00:00

abstract：:We analyzed the effect of exposure to hypoxic/hypercapnic (HH) gas mixture (5% O2 /9% CO2 ) on the maintenance of functional cord blood CD34(+) hematopoietic stem and progenitor cells in severe hypothermia (4°C) employing the physiological and proteomic approaches. Ten-day exposure to HH maintained the Day 0 (D-0) lev...

journal_title：Journal of cellular physiology

authors： Vlaski M,Negroni L,Kovacevic-Filipovic M,Guibert C,Brunet de la Grange P,Rossignol R,Chevaleyre J,Duchez P,Lafarge X,Praloran V,Schmitter JM,Ivanovic Z

更新日期：2014-12-01 00:00:00

abstract：:Considerable evidence has accumulated for a role of a nonsteroidal mevalonate product in the regulation of DNA replication and cell division. We report here a similar requirement for mevalonate in a nonreplicative function, that of natural killer (NK) cell cytotoxicity. Treatment of NK cells with 10 microM compactin f...

journal_title：Journal of cellular physiology

authors： Cutts JL,Scallen TJ,Watson J,Bankhurst AD

更新日期：1989-06-01 00:00:00

abstract：:In vitro generation of HSCs from pluripotent stem cells (PSCs) can be regarded as novel therapeutic approaches for replacing bone marrow (BM) transplantation without immune rejection or graft versus host disease(GVHD). To date, many differentiation approaches have been evaluated in terms of directing PSCs toward diffe...

journal_title：Journal of cellular physiology

authors： Shan W,Wang B,Xu Y,Li X,Li X,Wang H,Lin Y,Tie R,Zhao Q,Wang J,Zheng W,Hu Y,Shi J,Yu X,Huang H

更新日期：2018-01-31 00:00:00

abstract：:Glioblastoma multiforme (GBM) cells are characterised by their extreme chemoresistance. The activity of multiple-drug resistance (MDR) transporters that extrude antitumor drugs from cells plays the most important role in this phenomenon. To date, the mechanism controlling the expression and activity of MDR transporter...

journal_title：Journal of cellular physiology

authors： Quezada C,Garrido W,Oyarzún C,Fernández K,Segura R,Melo R,Casanello P,Sobrevia L,San Martín R

更新日期：2013-03-01 00:00:00

abstract：:Lesional psoriatic epidermis displays a number of phenotypic changes that are distinct from the differentiation program found in normal interfollicular epidermis. In psoriatic epidermis, keratinocytes are hyperproliferative and several differentiation-associated molecules are expressed that are absent in normal skin (...

journal_title：Journal of cellular physiology

authors： Van Ruissen F,de Jongh GJ,Zeeuwen PL,Van Erp PE,Madsen P,Schalkwijk J

更新日期：1996-08-01 00:00:00

abstract：:This study investigated whether brain-derived neurotrophic factor (BDNF) regulates the L-glutamate/L-aspartate transporter (GLAST) and glutamine synthetase (GS) in mouse retinal Müller cells (RMCs) under normal and hypoxic conditions. Mouse RMCs were treated with recombinant human BDNF (50, 75, 100, 125, or 150  ng/ml...

journal_title：Journal of cellular physiology

authors： Dai M,Xia XB,Xiong SQ

更新日期：2012-02-01 00:00:00

abstract：:We have utilized the in situ perfused rat liver under nonrecirculating conditions to examine the effect of temperature on the metabolism and biliary secretion of [125I]-asialoorosomucid (ASOR). In this manner we were able to follow the fate of a single round of internalized ligand. In control livers perfused at 37 deg...

journal_title：Journal of cellular physiology

authors： Kloppel TM

更新日期：1989-03-01 00:00:00

abstract：:We report here that heptanol (3.5 mM) induces in vitro a rapid formation of smooth endoplasmic reticulum aggregates (SERA) within isolated islets of Langerhans. SERA appeared after only 15 min of exposure to the alkanol and increased in number during the first 30 min of incubation. At that time, SERA represented 2% an...

journal_title：Journal of cellular physiology

authors： Knodel S,Meda P,Orci L

更新日期：1987-10-01 00:00:00

abstract：:Mitochondrial (mt) dysfunction and oxidative stress are involved in the pathogenesis of ischemia/reperfusion (I/R)-injury. Lycopene, a lipophilic antioxidant found mainly in tomatoes and in other vegetables and fruits, can protect mtDNA against oxidative damage. However, the role of mtDNA in myocardial I/R-injury is u...

journal_title：Journal of cellular physiology

authors： Yue R,Xia X,Jiang J,Yang D,Han Y,Chen X,Cai Y,Li L,Wang WE,Zeng C

更新日期：2015-09-01 00:00:00

abstract：:The single-stranded DNA and RNA binding protein, Puralpha, has recently received special attention as this protein, by associating with the specific nucleotide sequence (GGN repeats) and/or several important cellular and viral proteins regulates crucial biological events such as transcription, replication, and cell pr...

journal_title：Journal of cellular physiology

authors： Muralidharan V,Sweet T,Nadraga Y,Amini S,Khalili K

更新日期：2001-03-01 00:00:00

abstract：BACKGROUND:Cigarette smoke exposure, increasing Toll-like receptor 4 (TLR4) and reactive oxygen species (ROS), promotes inflammatory responses in airway epithelial cells. Chronic inflammation, microRNA (miRNA), and oxidative stress are associated with cancer development. AIMS:The present study was aimed to explore whe...

journal_title：Journal of cellular physiology

authors： Pace E,Di Vincenzo S,Di Salvo E,Genovese S,Dino P,Sangiorgi C,Ferraro M,Gangemi S

更新日期：2019-12-01 00:00:00

abstract：:Prkdc encodes for the catalytic subunit of the DNA-dependent protein kinase (DNA-PKcs) playing a key role in nonhomologous end joining pathway during DNA double-strand break repair and also influencing the homologous recombination (HR) repair system by phosphorylation of proteins involved in HR. In addition, Prkdc has...

journal_title：Journal of cellular physiology

authors： Soleimani F,Babaei E,H Feizi MA,Fathi F

更新日期：2020-04-01 00:00:00

abstract：:Osteopontin (OPN) is a major non-collagenous bone matrix protein implicated in the regulation of cell function. Although OPN is rich in the cementum of the tooth, the significance of OPN in this tissue is not understood. Tooth root resorption is the most frequent complication of orthodontic tooth movement (TM). The ob...

journal_title：Journal of cellular physiology

authors： Chung CJ,Soma K,Rittling SR,Denhardt DT,Hayata T,Nakashima K,Ezura Y,Noda M

更新日期：2008-03-01 00:00:00

abstract：:Glioblastoma, the most common brain tumor, is characterized by high proliferation rate, invasion, angiogenesis, and chemo- and radio-resistance. One of most remarkable feature of glioblastoma is the switch toward a glycolytic energetic metabolism that leads to high glucose uptake and consumption and a strong productio...

journal_title：Journal of cellular physiology

authors： Cimini A,d'Angelo M,Benedetti E,D'Angelo B,Laurenti G,Antonosante A,Cristiano L,Di Mambro A,Barbarino M,Castelli V,Cinque B,Cifone MG,Ippoliti R,Pentimalli F,Giordano A

更新日期：2017-02-01 00:00:00

abstract：:DH23A cells, an alpha-difluoromethylornithine (DFMO)-resistant variant of rat hepatoma tissue culture cells (HTC), contain high levels of very stable ornithine decarboxylase (ODC). In the absence of DFMO, the high ODC activity results in a large accumulation of endogenous putrescine. Concomitant with the putrescine in...

journal_title：Journal of cellular physiology

authors： Tome ME,Fiser SM,Gerner EW

更新日期：1994-02-01 00:00:00