Impaired muscle regeneration and myoblast differentiation in mice with a muscle-specific KO of IGF-IR.

abstract：:Human cell lines derived from a melanoma and a colon carcinoma, and cultures of human melanocytes and intestinal epithelial cells, as well as a mouse mesenchymal non-neoplastic cell line and a malignant subline of the same have been quantitatively studied in tissue culture for their sensitivity to thymidine. All three...

journal_title：Journal of cellular physiology

authors： Lee SS,Giovanella BC,Stehlin JS Jr

更新日期：1977-09-01 00:00:00

abstract：:A mutant of BHK cells (ts422E) temperature-sensitive for processing 32S rRNA to 28S rRNA (Toniolo et al., '73) also loses the ability to synthesize polyamines and 5.8S rRNA when shifted to the non-permissive temperature (39 degrees). The activity of several enzymes not involved with polyamine synthesis, methylation of...

journal_title：Journal of cellular physiology

authors： Levin EG,Clark JL

更新日期：1979-12-01 00:00:00

abstract：:Anti-angiogenic agents regulate tumor growth by inhibiting endothelial cell proliferation and invasion. Carboxyamido-triazole (CAI), an inhibitor of non-voltage-operated calcium entry and calcium influx-mediated pathways, has angiogenesis and invasion inhibitory activity. We hypothesized that CAI may express its anti-...

journal_title：Journal of cellular physiology

authors： Oliver VK,Patton AM,Desai S,Lorang D,Libutti SK,Kohn EC

更新日期：2003-10-01 00:00:00

abstract：:A high proportion of murine resident peritoneal macrophages bear complement receptors 1 and 3 (CR1, CR3) which bind C3b and iC3b components of complement, respectively. By contrast, macrophages derived from bone marrow, blood, and the elicited peritoneal exudate are predominantly CR1+3. To determine if the microenviro...

journal_title：Journal of cellular physiology

authors： Yen SE,Walker WS

更新日期：1983-04-01 00:00:00

abstract：:The synthesis and turnover of metabolically labeled proteoglycans from medium, cell layer, and substratum-associated compartments were characterized in four cell lines of fibroblastic origin, including a fibrosarcoma line, and in the murine melanoma cell type, B16.F10. Substantial differences were apparent between the...

journal_title：Journal of cellular physiology

authors： Piepkorn M,Hovingh P,Linker A

更新日期：1988-05-01 00:00:00

abstract：:BHK fibroblasts can be growth arrested by incubation in low serum (0.1%) medium. Growth is initiated by incubating cells in high serum (10%) medium. We have found that if the quiescent cells in low serum medium are incubated with insulin, the G0 to S transit time is decreased by two to six hours when serum (10%) is ad...

journal_title：Journal of cellular physiology

authors： Kletzien RF,Day P

更新日期：1980-12-01 00:00:00

abstract：:This study is performed to examine the impacts of microRNA-218 (miR-218) on cardiac microvascular endothelial cells (CMECs) injury induced by coronary artery disease (CAD). Reverse-transcription quantitative polymerase chain reaction (RT-qPCR) was applied for detecting miR-218 expression in serum of patients with CAD ...

journal_title：Journal of cellular physiology

authors： Gao W,Cui H,Li Q,Zhong H,Yu J,Li P,He X

更新日期：2020-03-01 00:00:00

abstract：:Optical indicators of the cationic, cyanine and anionic oxonol classes were used to evaluate the plasma membrane potential of animal cells in suspension and in monolayer culture. The optical signals were calibrated by using diffusion potentials either of K+ (in the presence of valinomycin) or of H+ (in the presence of...

journal_title：Journal of cellular physiology

authors： Bashford CL,Alder GM,Gray MA,Micklem KJ,Taylor CC,Turek PJ,Pasternak CA

更新日期：1985-06-01 00:00:00

abstract：:Insulin gene expression in rat insulinoma (RIN) cells is extinct in RIN x fibroblast hybrids and can reappear upon loss of DNA contributed by the fibroblast parent. (Besnard et al., Exp. Cell Res. 185:101-108, 1989). In the present study, we looked for the role of 5'-flanking sequences of the human insulin gene in the...

journal_title：Journal of cellular physiology

authors： Besnard C,Monthioux E,Loràs P,Jami J,Daegelen D

更新日期：1991-03-01 00:00:00

abstract：:The cell surface phenotype of pluripotent hemopoietic stem cells (CFU-S) and committed progenitors (CFU-C1, CFU-C2, BFU-E) of mouse bone marrow was analyzed with respect to their binding of wheat germ agglutinin (WGA) and two monoclonal antibodies, anti-GM-1.2 and anti-PGP-1. Stained cells were fractionated on the bas...

journal_title：Journal of cellular physiology

authors： Bauman JG,Wagemaker G,Visser JW

更新日期：1986-07-01 00:00:00

abstract：:The effect of cell culture age and concomitant changes in cell density on the biosynthesis of sulfated-proteoglycan by rabbit articular chondrocytes in secondary monolayer culture was studied. Low density (LD, 2 d), middle density (MD, 5-7 d), and high density (HD, 12-15 d) cultures demonstrated changes in cellular mo...

journal_title：Journal of cellular physiology

authors： Malemud CJ,Papay RS

更新日期：1984-12-01 00:00:00

abstract：:The transforming growth factor-beta (TGF-beta) superfamily includes more than 30 members which have a broad array of biological activities. TGF-beta superfamily ligands bind to type II and type I serine/threonine kinase receptors and transduce signals via Smad proteins. Receptor-regulated Smads (R-Smads) can be classi...

journal_title：Journal of cellular physiology

authors： Miyazono K,Kusanagi K,Inoue H

更新日期：2001-06-01 00:00:00

abstract：:Osteogenic differentiation is a complicated process that depends on various regulatory factors and signal pathways. In our research, the osteogenic differentiation capacity was analyzed by alizarin red staining, alkaline phosphatase activity, and protein levels of osteogenic differentiation markers including runt-rela...

journal_title：Journal of cellular physiology

authors： Li Z,Sun Y,Cao S,Zhang J,Wei J

更新日期：2019-05-01 00:00:00

abstract：:HIV transcription is induced by the HIV-1 Tat protein, in concert with cellular co-factors including CDK9, CDK2, NF-kappaB, and others. The cells of most of the body's organs are exposed to approximately 3-6% oxygen, but most in vitro studies of HIV replication are conducted at 21% oxygen. We hypothesized that activit...

journal_title：Journal of cellular physiology

authors： Charles S,Ammosova T,Cardenas J,Foster A,Rotimi J,Jerebtsova M,Ayodeji AA,Niu X,Ray PE,Gordeuk VR,Kashanchi F,Nekhai S

更新日期：2009-11-01 00:00:00

abstract：:We examined the importance of tyrosine kinase(s) on the ATP-evoked Ca2+ entry and DNA synthesis of thyroid FRTL-5 cells. ATP rapidly and transiently tyrosine phosphorylated a 72-kDa protein(s). This phosphorylation was abolished by pertussis toxin and by the tyrosine kinase inhibitor genistein, and was dependent on Ca...

journal_title：Journal of cellular physiology

authors： Törnquist K,Dugué B,Ekokoski E

更新日期：1998-05-01 00:00:00

abstract：:Kaposi's sarcoma (KS) is the most frequent malignant lesion in patients with AIDS and is characterized by spindle cell proliferation, inflammatory cell infiltration, angiogenesis, edema, and invasiveness. KS origin is still debated. The complex aspect of this disease is probably supported by multiple concomitant patho...

journal_title：Journal of cellular physiology

authors： Montaldo F,Maffé A,Morini M,Noonan D,Giordano S,Albini A,Prat M

更新日期：2000-08-01 00:00:00

abstract：:New perspectives have been opened by advances in stem cell research for reproductive and regenerative medicine. Several different cell types can be differentiated from stem cells (SCs) under suitable in vitro and in vivo conditions. The differentiation of SCs into male germ cells has been reported by many groups. Due ...

journal_title：Journal of cellular physiology

authors： Mahabadi JA,Sabzalipoor H,Nikzad H,Seyedhosseini E,Enderami SE,Gheibi Hayat SM,Sahebkar A

更新日期：2019-08-01 00:00:00

abstract：:Intramedullary stabilization is frequently used to treat long bone fractures. Since implant removal can become technically very challenging with the potential to cause further tissue damage, biodegradable materials are emerging as alternative options. Magnesium (Mg)-based biodegradable implants have a controllable deg...

journal_title：Journal of cellular physiology

authors： Li D,Yu K,Xiao T,Dai Y,Liu L,Li H,Jiang D,Xiong L

更新日期：2019-11-01 00:00:00

abstract：:Progenitor cells for the endothelial lineage have been widely investigated for more than a decade, but continue to be controversial since no unique identifying marker has yet been identified. This review will begin with a discussion of the basic tenets originally proposed for proof that a cell displays properties of a...

journal_title：Journal of cellular physiology

authors： Basile DP,Yoder MC

更新日期：2014-01-01 00:00:00

abstract：:Activation of the epidermal growth factor receptor (EGFR) has been shown to occur by ligand-dependent and ligand-independent mechanisms. Different molecular mechanisms have been found to be responsible for ligand-independent receptor transactivation. Here, we show that hyperosmolar concentrations of sorbitol activate ...

journal_title：Journal of cellular physiology

authors： Cheng H,Kartenbeck J,Kabsch K,Mao X,Marqués M,Alonso A

更新日期：2002-08-01 00:00:00

abstract：:Although prostate carcinoma is an aggressive cancer preferentially metastasizing to the bones, many prostate tumors remain localized and confined to the prostate indefinitely. Prediction of the behavior of anatomically localized and moderately differentiated prostate tumors remains difficult because of lack of prognos...

journal_title：Journal of cellular physiology

authors： de Amicis F,Lanzino M,Kisslinger A,Calì G,Chieffi P,Andò S,Mancini FP,Tramontano D

更新日期：2006-10-01 00:00:00

abstract：:The C3H/10T 1/2 embryo cell line, which is nontumorigenic when inoculated subcutaneously in saline suspension, produces tumors when implanted subcutaneously attached to 1 X 5 X 10 mm plastic plates. Under these in vivo conditions there is direct selection for "spontaneous" transformants that have undergone the specifi...

journal_title：Journal of cellular physiology

authors： Paranjpe M,del Ande Eaton S,Boone CW

更新日期：1978-07-01 00:00:00

abstract：:Exosomes extracted from mesenchymal stem cells (MSCs) was reported to reduce myocardial ischemia/reperfusion damage. Besides, stromal-derived factor 1 (SDF1a) functions as cardiac repair after myocardial infarction (MI). Therefore, the present study aims to identify whether exosomes (Exo) released from SDF1-overexpres...

journal_title：Journal of cellular physiology

authors： Gong XH,Liu H,Wang SJ,Liang SW,Wang GG

更新日期：2019-08-01 00:00:00

abstract：:A mouse mammary epithelial cell line, NMuMG, exhibits a low capacity to grow in semisolid medium as colonies and it is not tumorigenic in nude mice. In contrast, NMuMG cells which have been transformed by an activated c-Harvey ras proto-oncogene, NMuMG/rasH, or by the polyoma middle T-transforming gene, NMuMG/pyt, are...

journal_title：Journal of cellular physiology

authors： Salomon DS,Perroteau I,Kidwell WR,Tam J,Derynck R

更新日期：1987-03-01 00:00:00

abstract：:Monocytes are recruited to the material surface of an implanted biomedical device recognizing it as a foreign body. Differentiation into macrophages subsequently occurs followed by fusion to form foreign body giant cells (FBGCs). Consequently, implants can become degraded, cause chronic inflammation or become isolated...

journal_title：Journal of cellular physiology

authors： Matheson LA,Santerre JP,Labow RS

更新日期：2004-04-01 00:00:00

abstract：:Catecholamines produce mitotic inhibition in primary cell cultures of human keratinocytes probably via a block in the G2 part of the cell cycle. Epinephrine produced significant mitotic inhibition (49%) at a concentration as low as 4.5 X 10(-10) M, while its analog, isoproterenol, produced 47% inhibition at 1 X 10(-10...

journal_title：Journal of cellular physiology

authors： Harper RA,Flaxman BA

更新日期：1975-10-01 00:00:00

abstract：:Conditioned medium from Sertoli cells, prepared from testes of 20-day-old rats, contains component(s) that inhibit the incorporation of [3H]-thymidine into DNA of peritubular myoid cells (PMC) and inhibit the proliferation of PMC. These components are trypsin-resistant, heat-stable compounds having a molecular weight ...

journal_title：Journal of cellular physiology

authors： Tung PS,Fritz IB

更新日期：1991-06-01 00:00:00

abstract：:Growth-contingent alterations in potassium and sodium fluxes, ouabain binding, and potassium ion content were examined following serum stimulation of quiescent, density-inhibited chicken embryo fibroblasts. Serum stimulation resulted in very rapid 1.5- to 1.8-fold increases in ouabain-sensitive potassium influx and le...

journal_title：Journal of cellular physiology

authors： Johnson MA,Weber MJ

更新日期：1980-05-01 00:00:00

abstract：:Stimulation of postconfluent Swiss 3T3 cells in serum-free medium with 4.3 mM Ca2+ results in marked increases in both released and cell-associated plasminogen activator (PA). Increased release of PA commenced approximately 10 to 12 hours post-stimulation and continued to increase steadily until 48 hours at which time...

journal_title：Journal of cellular physiology

authors： Chou IN,Cox R,Black PH

更新日期：1979-09-01 00:00:00

abstract：:Exposure of live cells to shear flow induces major changes in cell shape, adhesion to the extracellular matrix, and migration. In the present study, we show that exposure of cultured multiple myeloma (MM) cells to shear flow of 4-36 dynes/cm(2) triggers the extension of long tubular protrusions (denoted flow-induced p...

journal_title：Journal of cellular physiology

authors： Porat Z,Yaron I,Katz BZ,Kam Z,Geiger B

更新日期：2011-12-01 00:00:00