Extinction of the human insulin gene expression in insulinoma x fibroblast somatic cell hybrids involves cis-acting DNA elements.

abstract：:Using methods designed for isolation of mutants defective in receptor-mediated endocytosis, a novel L-cell mutant was obtained that exhibits resistance to three different protein toxins as well as alterations in secretion. This mutant, LEFIC, is resistant to modeccin, Pseudomonas exotoxin, and ricin. These toxins, whi...

journal_title：Journal of cellular physiology

authors： Laurie SM,Robbins AR

更新日期：1991-05-01 00:00:00

abstract：:We have studied the tissue distribution of interleukin (IL) and hemopoietic colony-stimulating factor (CSF) transcripts in mice by S1-nuclease protection analysis. Accumulation of several of these mRNAs in response to intravenous injection of lipopolysaccharide (LPS) appears to occur in a tissue-specific fashion. IL-1...

journal_title：Journal of cellular physiology

authors： Troutt AB,Lee F

更新日期：1989-01-01 00:00:00

abstract：BACKGROUND:Surgical stress has been suggested to facilitate colon cancer growth and metastasis. However, the precise mechanisms by which surgical trauma promotes colon cancer progression remain poorly understood. METHODS:To unravel the mechanisms underlying surgery-induced colon cancer progression, a syngenic transpla...

journal_title：Journal of cellular physiology

authors： Sun Z,Du C,Xu P,Miao C

更新日期：2019-04-01 00:00:00

abstract：:Voltage-gated Na+ channels, classically associated with impulse conduction in excitable tissues, are also found in a variety of epithelial cell types where their possible functions are not known so well. We have previously reported expression of a voltage-gated Na+ channel specifically in the highly metastatic Mat-LyL...

journal_title：Journal of cellular physiology

authors： Grimes JA,Djamgoz MB

更新日期：1998-04-01 00:00:00

abstract：:Excess reactive oxygen species (ROS) generated in embryos during in vitro culture damage cellular macromolecules and embryo development. Glutathione (GSH) scavenges ROS and optimizes the culture system. However, how exogenous GSH influences intracellular GSH and improves the embryo developmental rate is poorly underst...

journal_title：Journal of cellular physiology

authors： Li F,Cui L,Yu D,Hao H,Liu Y,Zhao X,Pang Y,Zhu H,Du W

更新日期：2019-05-01 00:00:00

abstract：:DNA methylation can regulate gene expression and is pivotal in the occurrence and development of bladder cancer. In this study, we analyzed whole-genome DNA methylation on the basis of data from The Cancer Genome Atlas to select epigenetic biomarkers predictive of survival and further understand the molecular mechanis...

journal_title：Journal of cellular physiology

authors： Yang Z,Liu A,Xiong Q,Xue Y,Liu F,Zeng S,Zhang Z,Li Y,Sun Y,Xu C

更新日期：2019-08-01 00:00:00

abstract：:Silibinin is the primary active compound in silymarin. It has been demonstrated to exert anti-carcinogenic effects and hepato-protective effects. However, the effects of silibinin on the maturation and immunostimulatory activities exhibited by dendritic cells (DCs) remain, for the most part, unknown. In this study, we...

journal_title：Journal of cellular physiology

authors： Lee JS,Kim SG,Kim HK,Lee TH,Jeong YI,Lee CM,Yoon MS,Na YJ,Suh DS,Park NC,Choi IH,Kim GY,Choi YH,Chung HY,Park YM

更新日期：2007-02-01 00:00:00

abstract：:Calcium ions (Ca2+ ) is the main element of dental pulp capping materials. Ca 2+ signaling plays a crucial role in a myriad of cell activities. An overwhelming array of studies have already reported the experimental and clinical benefits of Ca2+ -enriched materials in the treatment of teeth with accidental vital pulp ...

journal_title：Journal of cellular physiology

authors： An S

更新日期：2019-03-01 00:00:00

abstract：:It has been shown that the insulin-like growth factor (IGF-I) gene is spliced in response to mechanical signals producing forms of IGF-I which have different actions. In order to study how mechanical signals influence this gene splicing in developing muscle, C2C12 cells were grown in three-dimensional (3D) culture and...

journal_title：Journal of cellular physiology

authors： Cheema U,Brown R,Mudera V,Yang SY,McGrouther G,Goldspink G

更新日期：2005-01-01 00:00:00

abstract：:Pulmonary fibrosis is a potentially fatal consequence of treatments for malignancy and is an increasing problem in bone marrow transplant patients and in cases of allogenic lung transplant. The fibrotic response is characterized by increases in lung fibroblast number and collagen synthesis. This laboratory previously ...

journal_title：Journal of cellular physiology

authors： Sempowski GD,Derdak S,Phipps RP

更新日期：1996-05-01 00:00:00

abstract：:Mycoplasmas are bacteria lacking the cell wall, which is the major characteristic of this taxonomic class (Mollicutes). Among bacteria, mycoplasmas possess the smallest genome known for free-living organisms. This feature limits the autonomy of bacteria and makes them increasingly susceptible to changes in the host or...

journal_title：Journal of cellular physiology

authors： Borchsenius SN,Daks A,Fedorova O,Chernova O,Barlev NA

更新日期：2018-01-01 00:00:00

abstract：:Temperature-sensitive mutants have revealed a region of the herpes simplex virus 1 genome that affects both the uptake of hexose and the synthesis of heat shock proteins. Other inducers of heat-shock proteins, namely heat shock itself and arsenite, likewise induce an increased uptake of hexose. The increased uptake, l...

journal_title：Journal of cellular physiology

authors： Warren AP,James MH,Menzies DE,Widnell CC,Whitaker-Dowling PA,Pasternak CA

更新日期：1986-09-01 00:00:00

abstract：:Platelet-derived growth factor (PDGF) is mitogenic and chemotactic for vascular smooth muscle cells cultured in vitro, and, thus, may play a role in the smooth muscle cell proliferation and migration that occurs during atherosclerotic lesion development. Two related PDGF polypeptides, designated as the A and B chains,...

journal_title：Journal of cellular physiology

authors： Gay CG,Winkles JA

更新日期：1991-04-01 00:00:00

abstract：:Small intestinal crypt cells play a critical role in modulating Cl- secretion during digestion. The types of Cl- channels mediating Cl- secretion in the small intestine was investigated using the intestinal epithelial cell line, IEC-18, which was derived from rat small intestine crypt cells. In initial radioisotope ef...

journal_title：Journal of cellular physiology

authors： Basavappa S,Vulapalli SR,Zhang H,Yule D,Coon S,Sundaram U

更新日期：2005-01-01 00:00:00

abstract：:An artificial wound in a confluent monolayer of human keratinocyte HaCaT cells or mouse embryo fibroblast Swiss NIH 3T3 cells was used to analyze the effects of the nitric oxide (NO) chemical donor, S-nitroso-N-acetylpenicillamine (SNAP). SNAP exposure promoted an enhanced rate of wound closure and accelerated motilit...

journal_title：Journal of cellular physiology

authors： La Torre C,Cinque B,Lombardi F,Miconi G,Palumbo P,Evtoski Z,Placidi G,Fanini D,Cimini AM,Benedetti E,Giuliani M,Cifone MG

更新日期：2016-10-01 00:00:00

abstract：:The interaction between dietary lectins, especially wheat germ agglutinin (WGA), and intestinal cells has been implicated in the pathogenesis of celiac disease. The present study was undertaken to investigate the immediate effects following such an interaction. Direct WGA-stimulation of Intestine 407 cells leads to an...

journal_title：Journal of cellular physiology

authors： Sjölander A

更新日期：1988-03-01 00:00:00

abstract：:The biological effects of the Corticotropin-releasing factor (CRF) family of neuropeptides are mediated by mobilization of [Ca(2+)]. Aim of the current work was to examine if the calcineurin/NFAT (nuclear factor of activated T-cells) signaling pathway is involved in the effect of CRF peptides in catecholamine synthesi...

journal_title：Journal of cellular physiology

authors： Dermitzaki E,Tsatsanis C,Gravanis A,Margioris AN

更新日期：2012-05-01 00:00:00

abstract：:Osteoporosis (OP) is a metabolic disease caused by multiple factors, which is characterized by a reduction of bone mass per unit volume and destruction of bone microstructure. Aberrant osteoclast function is the main cause of OP, therefore, regulating the differentiation and function of osteoclast is one of the treatm...

journal_title：Journal of cellular physiology

authors： Xiao Y,Li K,Wang Z,Fu F,Shao S,Song F,Zhao J,Chen W,Liu Q,Xu J

更新日期：2019-08-01 00:00:00

abstract：:Endoplasmic reticulum (ER) stress, a common cellular stress response, is closely related to the activation of autophagy that is an important and evolutionarily conserved mechanism for maintaining cellular homeostasis. Autophagy induced by ER stress mainly includes the ER stress-mediated autophagy and ER-phagy. The ER ...

journal_title：Journal of cellular physiology

authors： Song S,Tan J,Miao Y,Zhang Q

更新日期：2018-05-01 00:00:00

abstract：:Septins play important roles in regulating development and differentiation. Septin 7 (SEPT7) is a crucial component in orchestrating the septin core complex into highly ordered filamentous structures. Here, we showed that genetic depletion of SEPT7 or treatment with forchlorfenuron (FCF; a compound known to affect sep...

journal_title：Journal of cellular physiology

authors： Chen TY,Lin TC,Kuo PL,Chen ZR,Cheng HL,Chao YY,Syu JS,Lu FI,Wang CY

更新日期：2020-09-01 00:00:00

abstract：:The S100 protein family comprises more than 20 members of small calcium binding proteins operating as Ca2 +-activated switches that interact and modulate the activity of a large number of targets. S100A1 and S100B, two members of this family, have been recently associated with the differentiation status of human artic...

journal_title：Journal of cellular physiology

authors： Diaz-Romero J,Nesic D

更新日期：2017-08-01 00:00:00

abstract：:The calcium-sensitive fluorescent indicator fura-2 and a microscope equipped for rapidly changing excitation wavelengths were used to look at the effects of growth factors on cytosolic free calcium ([Ca2+]i) in NRK-49F cells. In these cells bradykinin induced a rapid increase in [Ca2+]i, which generally decayed to nea...

journal_title：Journal of cellular physiology

authors： Marks PW,Kruskal BA,Maxfield FR

更新日期：1988-09-01 00:00:00

abstract：:Mitochondrial transcription factor A (TFAM) is responsible for stability, maintenance, and transcriptional control of mitochondrial DNA (mtDNA). We have studied the expression and distribution of TFAM in the gametes and preimplantation embryos of the domestic pig (Sus scrofa). We hypothesized that TFAM is not present ...

journal_title：Journal of cellular physiology

authors： Antelman J,Manandhar G,Yi YJ,Li R,Whitworth KM,Sutovsky M,Agca C,Prather RS,Sutovsky P

更新日期：2008-11-01 00:00:00

abstract：:Cover: Diagram illustrating the chromatic median analysis. See article by Pliss et al. on pages 427-439. ...

journal_title：Journal of cellular physiology

authors：

更新日期：2015-02-01 00:00:00

abstract：:Nowadays, epigenetics covers a crucial role in different fields of science. The enhancer of zeste homolog 2 (EZH2), the catalytic subunit of the Polycomb Repressive Complex 2 (PRC2), is a big proponent of how epigenetic changes can affect the initiation and progression of several diseases. Through its catalytic activi...

journal_title：Journal of cellular physiology

authors： Sanna L,Marchesi I,Melone MAB,Bagella L

更新日期：2018-09-01 00:00:00

abstract：:Circular RNAs (circRNAs) are reported to regulate the development and progression of multiple cancers. However, the functions of circRNAs in nasopharyngeal carcinoma (NPC) are unclear. In this study, we identified that circular homeodomain interacting protein kinase 3 (circHIPK3) was highly expressed in NPC tissues an...

journal_title：Journal of cellular physiology

authors： Ke Z,Xie F,Zheng C,Chen D

更新日期：2019-02-01 00:00:00

abstract：:The prevalence of chronic hyperglycemia and its complications, imposing a critical burden on the worldwide economy and the global healthcare system, is a pressing issue. Mounting evidence indicates that oxidative stress and hypoxia, two noticeable features of hyperglycemia, play a joint crucial role in mediating cellu...

journal_title：Journal of cellular physiology

authors： Huang YT,Liu CH,Yang YC,Aneja R,Wen SY,Huang CY,Kuo WW

更新日期：2019-08-01 00:00:00

abstract：:Cell-extracellular matrix interaction plays a major role in maintaining the structural integrity of connective tissues and sensing changes in the biomechanical environment of cells. Collagen VI is a widely expressed non-fibrillar collagen, which regulates tissues homeostasis. The objective of the present investigation...

journal_title：Journal of cellular physiology

authors： Sardone F,Traina F,Tagliavini F,Pellegrini C,Merlini L,Squarzoni S,Santi S,Neri S,Faldini C,Maraldi N,Sabatelli P

更新日期：2014-07-01 00:00:00

abstract：:Adipose-derived stem cells (ADSCs) are a type of mesenchymal stem cells isolated from adipose tissue and have the ability to differentiate into adipogenic, osteogenic, and chondrogenic lineages. Despite their great therapeutic potentials, previous studies showed that ADSCs could enhance the proliferation and metastati...

journal_title：Journal of cellular physiology

authors： Chan YW,So C,Yau KL,Chiu KC,Wang X,Chan FL,Tsang SY

更新日期：2020-10-01 00:00:00

abstract：:The tuftelin protein isoforms undergo post-translation modifications, and are ubiquitously expressed in various tissues in embryos, adults, and tumors. Developmental and pathological studies suggested an apparent correlation between oxygen deprivation and tuftelin expression. The aim of the study was therefore to inve...

journal_title：Journal of cellular physiology

authors： Leiser Y,Silverstein N,Blumenfeld A,Shilo D,Haze A,Rosenfeld E,Shay B,Tabakman R,Lecht S,Lazarovici P,Deutsch D

更新日期：2011-01-01 00:00:00