Abstract:
:Mycoplasmas are bacteria lacking the cell wall, which is the major characteristic of this taxonomic class (Mollicutes). Among bacteria, mycoplasmas possess the smallest genome known for free-living organisms. This feature limits the autonomy of bacteria and makes them increasingly susceptible to changes in the host organism. Many mycoplasmas themselves cause pathological changes in the host organism, often complicated by immune disorders. Infection with certain strains of mycoplasma results in the activation of the nuclear factor kappa-light-chain-enhancer of activated B cells, which is the major mediator of the inflammatory response. Furthermore, mycoplasmas can inhibit p53-mediated checkpoint control of cell cycle and apoptosis. Collectively, these properties indicate that mycoplasmas might act as cancer-promoting factors. In this review, we summarize the information known to date on the role of mycoplasmas in the regulation of the host immune response and their functional interactions with p53.
journal_name
J Cell Physioljournal_title
Journal of cellular physiologyauthors
Borchsenius SN,Daks A,Fedorova O,Chernova O,Barlev NAdoi
10.1002/jcp.26781subject
Has Abstractpub_date
2018-01-01 00:00:00pages
171-180issue
1eissn
0021-9541issn
1097-4652journal_volume
234pub_type
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