Intracellular chloride regulates cell proliferation through the activation of stress-activated protein kinases in MKN28 human gastric cancer cells.

abstract：:Mesenchymal stem cells (MSC) are considered as potential agents for reconstructive and gene-targeting therapies since they differentiate into various cell-lineages, exhibit an extended survival once injected into a host, and can easily be transfected with engineered DNA. MSC are essentially isolated from hematopoietic...

journal_title：Journal of cellular physiology

authors： Suva D,Garavaglia G,Menetrey J,Chapuis B,Hoffmeyer P,Bernheim L,Kindler V

更新日期：2004-01-01 00:00:00

abstract：:Endothelial cells are known to bind to laminin, and two peptides derived from the laminin A (CTFALRGDNP) and B1 (CDPGYIGSR) chains block the capillary-like tube formation on a laminin-rich basement membrane matrix, Matrigel. In the present study, we have used various in vitro and in vivo assays to investigate the angi...

journal_title：Journal of cellular physiology

authors： Grant DS,Kinsella JL,Fridman R,Auerbach R,Piasecki BA,Yamada Y,Zain M,Kleinman HK

更新日期：1992-12-01 00:00:00

abstract：:Mitochondrial (mt) dysfunction and oxidative stress are involved in the pathogenesis of ischemia/reperfusion (I/R)-injury. Lycopene, a lipophilic antioxidant found mainly in tomatoes and in other vegetables and fruits, can protect mtDNA against oxidative damage. However, the role of mtDNA in myocardial I/R-injury is u...

journal_title：Journal of cellular physiology

authors： Yue R,Xia X,Jiang J,Yang D,Han Y,Chen X,Cai Y,Li L,Wang WE,Zeng C

更新日期：2015-09-01 00:00:00

abstract：:Suramin is an anti-cancer drug which induces the differentiation of the human colon cancer clone HT29-D4. Yet chronic suramin treatment of these cells eventually leads to a marked disturbance of the lysosomal system, which consists in an accumulation of hypertrophied autophagic vacuoles and the occurrence of lamellate...

journal_title：Journal of cellular physiology

authors： Baghdiguian S,Verrier B,Marvaldi J,Fantini J

更新日期：1992-01-01 00:00:00

abstract：:Tumor cells secrete extracellular vesicles (EVs) for intercellular communication. EVs by transporting different proteins, nucleic acids, and lipids contribute to affect target cell function and fate. ‎EVs which originate directly from multivesicular bodies so-called exosomes have dramatically fascinated the attention ...

journal_title：Journal of cellular physiology

authors： Jabbari N,Akbariazar E,Feqhhi M,Rahbarghazi R,Rezaie J

更新日期：2020-10-01 00:00:00

abstract：:alpha-Thrombin, bradykinin, and histamine are endogenous mediators that increase endothelial permeability. We examined the mechanism by which these three vasoactive mediators could alter permeability to albumin of human umbilical vein endothelial cells (HUVEC). HUVEC were grown to confluence on Transwell membranes and...

journal_title：Journal of cellular physiology

authors： Ehringer WD,Edwards MJ,Miller FN

更新日期：1996-06-01 00:00:00

abstract：:The development of spike potential mechanisms during cell differentiation was studied in chick myotubes formed in vitro from trypsin-dissociated myoblasts. The spike potential and its rate of rise were measured in myotubes from 4-14 day old cultures. A depolarizing current pulse was delivered to evoke the spike potent...

journal_title：Journal of cellular physiology

authors： Kano M,Yamamoto M

更新日期：1977-03-01 00:00:00

abstract：:We have investigated the role of the plasminogen activation cascade in skeletal muscle differentiation. Migrating, undifferentiated myoblasts express urokinase plasminogen activator (uPA) and its cell surface receptor (uPAR). Consequently, uPA is localized predominantly to the cell surface. Preventing uPA from associa...

journal_title：Journal of cellular physiology

authors： Wells JM,Strickland S

更新日期：1997-05-01 00:00:00

abstract：:Protease nexin-I (PN-I, Mr approximately 43,000) is representative of a newly described class of cell-secreted protease inhibitors. PN-I has been purified to apparent homogeneity, partially sequenced, and monospecific antibodies have been raised against it. PN-I is a potent inhibitor of urokinase, thrombin, plasmin, a...

journal_title：Journal of cellular physiology

authors： Knauer DJ,Orlando RA,Rosenblatt D

更新日期：1987-08-01 00:00:00

abstract：:Cells of confluent cultures of the established pig renal epithelial line, LLC-PK1, accumulate alpha-methyl-D-glucoside against a concentration gradient. This transport system is strongly inhibited by phlorizin and 6-deoxy-D-glucose, moderately inhibited by phloretin, and only weakly inhibited by 3-0-methyl-D-glucose, ...

journal_title：Journal of cellular physiology

authors： Mullin JM,Weibel J,Diamond L,Kleinzeller A

更新日期：1980-09-01 00:00:00

abstract：:RB loss has long been recognized as the causative genetic alteration underlying retinoblastoma but it is increasingly evident that other alterations are required for the tumor to develop. Therefore, we set out to identify additional inheritable susceptibility markers and new potential preventive and therapeutic target...

journal_title：Journal of cellular physiology

authors： Indovina P,Acquaviva A,De Falco G,Rizzo V,Onnis A,Luzzi A,Giorgi F,Hadjistilianou T,Toti P,Tomei V,Pentimalli F,Carugi A,Giordano A

更新日期：2010-04-01 00:00:00

abstract：:Acidic pH of the Golgi lumen is known to be crucial for correct glycosylation, transport and sorting of proteins and lipids during their transit through the organelle. To better understand why Golgi acidity is important for these processes, we have examined here the most pH sensitive events in N-glycosylation by seque...

journal_title：Journal of cellular physiology

authors： Rivinoja A,Hassinen A,Kokkonen N,Kauppila A,Kellokumpu S

更新日期：2009-07-01 00:00:00

abstract：:The desert hedgehog (Dhh) is crucial for spermatogenesis and Leydig cell differentiation, but little is known regarding its physiological function in cartilage. In this study, Dhh mRNA was abundant in antler chondrocytes, where it advanced cell proliferation concomitant with accelerated transition from the G1 to the S...

journal_title：Journal of cellular physiology

authors： Ma L,Duan CC,Yang ZQ,Ding JL,Liu S,Yue ZP,Guo B

更新日期：2020-09-01 00:00:00

abstract：:Destructive bone diseases caused by osteolysis are increasing in incidence. They are characterized by an excessive imbalance of osteoclast formation and activation. During osteolysis, the activation of nuclear factor-κB (NF-κB) and mitogen-activated protein kinase (MAPK) signaling pathways are triggered by receptor ac...

journal_title：Journal of cellular physiology

authors： Liu H,Dong Y,Gao Y,Zhao L,Cai C,Qi D,Zhu M,Zhao L,Liu C,Guo F,Xiao J,Huang H

更新日期：2019-07-01 00:00:00

abstract：:microRNAs (miRNAs) and circular RNAs (circRNAs) are important for endometrial receptivity establishment and embryo implantation in mammals. miR-34a and miR-34c are highly expressed in caprine receptive endometrium (RE). Herein, the functions and mechanisms of miR-34a/c in caprine endometrial epithelial cell (CEEC) apo...

journal_title：Journal of cellular physiology

authors： Liu X,Zhang L,Yang L,Cui J,Che S,Liu Y,Han J,An X,Cao B,Song Y

更新日期：2020-12-01 00:00:00

abstract：:An analysis of which component of lipopolysaccharides (LPS), the lipid or the polysaccharide (PS), is active in stimulating the murine granulopoietic system has been performed. LPS with different structures, isolated from different mutant strains of Salmonella and chemical degradation products of lipopolysaccharides h...

journal_title：Journal of cellular physiology

authors： Apte RN,Galanos C,Pluznik DH

更新日期：1976-01-01 00:00:00

abstract：:Increasing evidence supports the idea that the finite proliferative life span of normal fibroblasts is a differentiation-like phenomenon. If this were correct, an ordered sequence of differential gene expression should be associated with the in vitro progression of cells from low passage to high passage (senescence). ...

journal_title：Journal of cellular physiology

authors： Choi AM,Olsen DR,Cook KG,Deamond SF,Uitto J,Bruce SA

更新日期：1992-04-01 00:00:00

abstract：:In a recent publication, Heubusch et al. (J Cell. Physiol, 122:266-272, 1985) reported changes of erythrocyte volume measured by the Coulter counter technique over a wide range of osmolalities (160 to 3000 m0sm). Their results showed a partially hindered, nonlinear response, in contrast to classical observations made ...

journal_title：Journal of cellular physiology

authors： Massaldi HA,Richieri GV,Mel HC

更新日期：1986-06-01 00:00:00

abstract：:Lactoferrin, a single chain cationic glycoprotein, present in the secondary granules of neutrophils, acts as a negative feedback regulator of myelopoiesis. Specific receptors for lactoferrin were detected on the surface of different hematopoietic cell types. The influence of lactoferrin on cell growth in culture has b...

journal_title：Journal of cellular physiology

authors： Garré C,Bianchi-Scarrá G,Sirito M,Musso M,Ravazzolo R

更新日期：1992-12-01 00:00:00

abstract：:Elevated oxidative stress plays a key role in diabetes-associated vascular disease. In this study, we tested the hypothesis that high glucose-induced oxidative stress was associated with changes in the expression of NADPH oxidase, superoxide dismutase (SOD) and endothelial nitric oxide synthase (eNOS). Oxidative stres...

journal_title：Journal of cellular physiology

authors： Ding H,Aljofan M,Triggle CR

更新日期：2007-09-01 00:00:00

abstract：:Hepatocyte spheroids have been proposed for drug metabolism studies and in bioartificial liver devices. However, the optimal conditions required to meet the aerobic demands of mitochondria-rich hepatocyte spheroids is not well studied. We hypothesized that an optimal concentration of oxygen could be identified and tha...

journal_title：Journal of cellular physiology

authors： Lillegard JB,Fisher JE,Nedredal G,Luebke-Wheeler J,Bao J,Wang W,Amoit B,Nyberg SL

更新日期：2011-11-01 00:00:00

abstract：:The protein kinase C stimulator TPA (12-O-tetradecanoyl phorbol-13-acetate) enhanced the responsiveness of adenylate cyclase to IPR (isoproterenol) and PGE1 (prostaglandin E1) in quiescent tsKSV-NRK cells at the nonpermissive 41 degrees C. Reactivating the thermolabile mitogenic/oncogenic K-ras protein in tsKSV-NRK ce...

journal_title：Journal of cellular physiology

authors： Franks DJ,Durkin JP,Whitfield JF

更新日期：1989-09-01 00:00:00

abstract：:Human peripheral blood monocytes and neutrophils secrete TGF-beta. Activation of monocytes with LPS stimulates the secretion of TGF-beta; however, the production of TGF-beta by neutrophils was not altered by treatment with LPS. The secreted TGF-beta appears to be in a fully active form since acid treatment of the cond...

journal_title：Journal of cellular physiology

authors： Grotendorst GR,Smale G,Pencev D

更新日期：1989-08-01 00:00:00

abstract：:Sepsis, a complex and dynamic syndrome resulting from microbial invasion and immune system dysregulation, is associated with an increased mortality, reaching up to 35% worldwide. Cholesterol metabolism is often disturbed during sepsis, with low plasma cholesterol levels being associated with poor prognosis. Proprotein...

journal_title：Journal of cellular physiology

authors： Paciullo F,Fallarino F,Bianconi V,Mannarino MR,Sahebkar A,Pirro M

更新日期：2017-09-01 00:00:00

abstract：:Tyrosine hydroxylase (TH), catalyzing the conversion of tyrosine into l-DOPA, is the rate-limiting enzyme in dopamine synthesis. Defects in insulin action contribute to alterations of TH expression and/or activity in the brain and insulin increases TH levels in 1-methyl-4-phenylpyridinium (MPP+)-treated neuronal cells...

journal_title：Journal of cellular physiology

authors： Fiory F,Mirra P,Nigro C,Pignalosa FC,Zatterale F,Ulianich L,Prevete N,Formisano P,Beguinot F,Miele C

更新日期：2019-07-01 00:00:00

abstract：:Although immortalized cultured cells are useful for various functional assays or transcriptome analysis, highly efficient and reproducible immortalization methods have not been developed in avian-derived cells. We introduced the simian virus 40 T antigen (SV40T) and human papillomavirus (HPV)-E6E7 to chick and Okinawa...

journal_title：Journal of cellular physiology

authors： Katayama M,Kiyono T,Ohmaki H,Eitsuka T,Endoh D,Inoue-Murayama M,Nakajima N,Onuma M,Fukuda T

更新日期：2019-05-01 00:00:00

abstract：:Increased vascular resistance in the fetoplacental circulation is a characteristic of preeclampsia. However, the potential molecular mechanisms of this condition remain obscure. The current study aimed to determine the direct effect of the peptide antigen corresponding to the second extracellular loop of the angiotens...

journal_title：Journal of cellular physiology

authors： Zhang S,Zheng R,Yang L,Zhang X,Zuo L,Yang X,Bai K,Song L,Tian J,Yang J,Liu H

更新日期：2013-01-01 00:00:00

abstract：:Members of the epidermal growth-factor-receptor tyrosine-kinase (EGFR) family play important roles both in normal growth regulation/cell differentiation and in the genesis and progression of human neoplasia. In the present study, we analysed distinct heregulin (HRG) signals mediated by the HRG receptors HER3 and HER4....

journal_title：Journal of cellular physiology

authors： Weiss FU,Wallasch C,Campiglio M,Issing W,Ullrich A

更新日期：1997-11-01 00:00:00

abstract：:The extracellular matrix (ECM) physically supports cells and influences stem cell behaviour, modulating kinase-mediated signalling cascades. Cell-derived ECMs have emerged in bone regeneration as they reproduce physiological tissue-architecture and ameliorate mesenchymal stromal cell (MSC) properties. Titanium scaffol...

journal_title：Journal of cellular physiology

authors： Baroncelli M,Fuhler GM,van de Peppel J,Zambuzzi WF,van Leeuwen JP,van der Eerden BCJ,Peppelenbosch MP

更新日期：2019-03-01 00:00:00

abstract：:We examined the expression of the estrogen and epidermal growth factor (EGF) receptors in a drug-resistant subline of MCF-7 cells in order to study potential alterations in hormone dependence or in the growth factor pathway that could be related to the development of drug resistance in human breast cancer. The drug-re...

journal_title：Journal of cellular physiology

authors： Dickstein B,Valverius EM,Wosikowski K,Saceda M,Pearson JW,Martin MB,Bates SE

更新日期：1993-10-01 00:00:00