Stress kinase p38 mediates EGFR transactivation by hyperosmolar concentrations of sorbitol.

abstract：:The myelin basic protein (MBP) gene contains sequences located upstream of its transcription start site which play a key role in glial-specific transcription of the MBP promoter. Earlier analysis of the 320 bp upstream regulatory sequence of MBP has revealed multiple cis-acting regulatory motifs which differentially r...

journal_title：Journal of cellular physiology

authors： Haque NS,Haas S,Knobler RL,Khalili K

更新日期：1995-05-01 00:00:00

abstract：:Silibinin is the primary active compound in silymarin. It has been demonstrated to exert anti-carcinogenic effects and hepato-protective effects. However, the effects of silibinin on the maturation and immunostimulatory activities exhibited by dendritic cells (DCs) remain, for the most part, unknown. In this study, we...

journal_title：Journal of cellular physiology

authors： Lee JS,Kim SG,Kim HK,Lee TH,Jeong YI,Lee CM,Yoon MS,Na YJ,Suh DS,Park NC,Choi IH,Kim GY,Choi YH,Chung HY,Park YM

更新日期：2007-02-01 00:00:00

abstract：:The carboxyl-terminal domain (CTD) of the largest subunit of mammalian RNA polymerase II (RNAP II) consists of 52 repeats of a consensus heptapeptide and is subject to phosphorylation and dephosphorylation events during each round of transcription. RNAP II activity is regulated during the cell cycle and cell cycle-dep...

journal_title：Journal of cellular physiology

authors： Oelgeschläger T

更新日期：2002-02-01 00:00:00

abstract：:Retinoic acid inhibits proliferation of hormone-dependent, but not hormone-independent breast cancer cells. Retinoic acid-induced changes in cellular proliferation and differentiation are associated with disturbances in growth factor signaling and frequently with changes in protein kinase C expression. PKC delta, epsi...

journal_title：Journal of cellular physiology

authors： Cho Y,Tighe AP,Talmage DA

更新日期：1997-09-01 00:00:00

abstract：:Recently, after the identification of ferritin light chain (L-ferritin) gene and protein over-expression in human metastatic melanoma cells, we engineered, starting from the LM metastatic melanoma cell line, clones in which L-ferritin gene expression was down-regulated by the stable expression of a specific antisense ...

journal_title：Journal of cellular physiology

authors： Maresca V,Flori E,Cardinali G,Briganti S,Lombardi D,Mileo AM,Paggi MG,Picardo M

更新日期：2006-03-01 00:00:00

abstract：:When human diploid fibroblasts IMR-90 are cultured in routinely used medium (Eagle's basal medium supplemented with 10% fetal calf serum), sulfhydryl compounds appear in the medium. The major component of these sulfhydryl compounds is cysteine, and it is shown that a part of medium cystine is converted into cysteine b...

journal_title：Journal of cellular physiology

authors： Bannai S,Ishii T

更新日期：1980-08-01 00:00:00

abstract：:We have studied the transcriptional activity, steady-state mRNA levels, and steady-state protein levels of the c-myc and transferrin receptor (TfR) genes in murine M1 myeloid leukemia cells arrested in G1 phase of the cell cycle by different methods. When cells are growth-arrested by density inhibition, a technique th...

journal_title：Journal of cellular physiology

authors： Neckers LM,Tsuda H,Weiss E,Pluznik DH

更新日期：1988-05-01 00:00:00

abstract：:Regulation of cellular Mg(2+) levels by insulin has been shown in various tissues. However, the mechanisms for hormonal regulation of cellular Mg(2+) have not been well described. We studied the effect of insulin on Na(+)/Mg(2+) exchange in normal human cells, measuring Na(+)/Mg(2+) exchange activity as net total Mg(2...

journal_title：Journal of cellular physiology

authors： Ferreira A,Rivera A,Romero JR

更新日期：2004-06-01 00:00:00

abstract：:We recently reported that peptidoglycan (PGN), a cell wall component of the Gram-positive bacterium, induces NF-κB activation and microglia activation. However, PGN-regulated AP-1 activation and cytokine expression in microglia remains unclear. This study investigated how PGN influences the signaling pathway involved ...

journal_title：Journal of cellular physiology

authors： Lin HY,Tang CH,Chen JH,Chuang JY,Huang SM,Tan TW,Lai CH,Lu DY

更新日期：2011-06-01 00:00:00

abstract：:Ethanol induces neuronal cell injury and death by dysregulating several signaling events that are controlled, in part, by activation of MAPK/ERK1/2 and/or inactivation of its corresponding phosphatase, PP1. Recently, we have purified a novel protein of 38 kDa in size, p38SJ, from a callus culture of Hypericum perforat...

journal_title：Journal of cellular physiology

authors： Amini S,Merabova N,Khalili K,Darbinian N

更新日期：2009-12-01 00:00:00

abstract：:Parathyroid hormone (PTH) greatly increased the level of adenosine 3', 5' cyclic monophosphate (cAMP) in rabbit costal chondrocytes in culture 2 minutes after its addition. PTH, as well as N6 O2' dibutyryl adenosine 3', 5' cyclic monophosphate (DBcAMP) and 8 Bromo adenosine 3', 5' cyclic monophosphate (8 Br-cAMP) indu...

journal_title：Journal of cellular physiology

authors： Takigawa M,Takano T,Suzuki F

更新日期：1981-02-01 00:00:00

abstract：:Thymosin β4 (Tβ4), a G-actin-sequestering secreted peptide, improves neurovascular remodeling and central nervous system plasticity, which leads to neurological recovery in many neurological diseases. Inflammatory response adjustment and tissue inflammation consequences from neurological injury are vital for neurologi...

journal_title：Journal of cellular physiology

authors： Shomali N,Baradaran B,Deljavanghodrati M,Akbari M,Hemmatzadeh M,Mohammadi H,Jang Y,Xu H,Sandoghchian Shotorbani S

更新日期：2020-04-01 00:00:00

abstract：:Established RAW264.7 cell lines for osteoclastic differentiation has been widely engaged in bone homeostasis research, however, the efficacy of RANKL independently stimulating has rarely been defined, because protocols were usually developed and modified by various laboratories. Otherwise, problematic issues are also ...

journal_title：Journal of cellular physiology

authors： Song C,Yang X,Lei Y,Zhang Z,Smith W,Yan J,Kong L

更新日期：2019-07-01 00:00:00

abstract：:The effect of the glucocorticoids, insulin, and glucose concentration on glycogen deposition in adult rat liver parenchymal cells maintained in a chemically defined, serum-free medium has been studied. Increasing the medium concentration of glucose from 5.6 mM to 30.6 mM in the absence of hormones increased cellular g...

journal_title：Journal of cellular physiology

authors： Weber CA,Kletzien RF

更新日期：1982-03-01 00:00:00

abstract：:Homeostasis of proteins involved in contractility of individual cardiomyocytes and those coupling adjacent cells is of critical importance as any abnormalities in cardiac electrical conduction may result in cardiac irregular activity and heart failure. Bcl2-associated athanogene 3 (BAG3) is a stress-induced protein wh...

journal_title：Journal of cellular physiology

authors： Tahrir FG,Gordon J,Feldman AM,Cheung J,Khalili K,Mohseni Ahooyi T

更新日期：2019-08-01 00:00:00

abstract：:Cells are quite sensitive to a change of the extracellular pH and respond to it through detection of the H+/HCO3- level in extracellular fluid. However, little is known about molecular details induced by acidosis, such as intracellular pathways and gene expression. Here we describe properties of gene expression, prote...

journal_title：Journal of cellular physiology

authors： Shimokawa N,Kumaki I,Qiu CH,Ohmiya Y,Takayama K,Koibuchi N

更新日期：2005-10-01 00:00:00

abstract：:Addition of bombesin in the presence of either forskolin or cholera toxin caused a marked (4-6 fold) enhancement of cAMP accumulation in Swiss 3T3 cells. This effect was time and concentration dependent, induced by various bombesin-like peptides and blocked by a bombesin antagonist. Enhancement of cAMP accumulation by...

journal_title：Journal of cellular physiology

authors： Millar JB,Rozengurt E

更新日期：1988-11-01 00:00:00

abstract：:Numerous studies have reported that long noncoding RNA (lncRNA) dysregulation is involved in the progression of many malignant tumors, including glioma. The lncRNA ZNFX1 antisense RNA 1 (ZFAS1) plays an oncogenic role in various malignant tumors, such as gastric cancer and hepatocellular carcinoma. However, the underl...

journal_title：Journal of cellular physiology

authors： Li X,Luo Y,Liu L,Cui S,Chen W,Zeng A,Shi Y,Luo L

更新日期：2020-03-01 00:00:00

abstract：:The effect of hypoxia on 3T3-L1 cell differentiation was examined in confluent cultures incubated with differentiation medium (DM) followed by incubation in growth medium (GM). Control cultures remained in GM throughout the incubation period. Eight days after the incubation, cells were assessed either for changes in m...

journal_title：Journal of cellular physiology

authors： Sahai A,Patel MS,Zavosh AS,Tannen RL

更新日期：1994-07-01 00:00:00

abstract：:Cdk9, a member of the cyclin-dependent kinase family, is the catalytic subunit of P-TEFb, a protein kinase complex that stimulates transcriptional elongation. Cdk9, complexed with its regulatory partner cyclin T1, serves as the cellular mediator of the transactivation function of the HIV Tat protein. There are two kno...

journal_title：Journal of cellular physiology

authors： Liu H,Herrmann CH

更新日期：2005-04-01 00:00:00

abstract：:Treatment of CEM-C7 cells with glucocorticoids produces a 2.5-fold increase in the activity of the enzyme glutamine synthetase (GS). This increase is specific for steroids with glucocorticoid activity adn occurs over a range of steroid concentrations consistent with a receptor-mediated mechanism. Half-maximal and maxi...

journal_title：Journal of cellular physiology

authors： Harmon JM,Thompson EB

更新日期：1982-02-01 00:00:00

abstract：:The catalytic subunit of DNA-dependent protein kinase (DNA-PKcs) is a pleiotropic enzyme involved in DNA repair, cell cycle control, and transcription regulation. A potential role for DNA-PKcs in the regulation of osteoblastogenesis remains to be established. We show that pharmacological inhibition of DNA-PKcs kinase ...

journal_title：Journal of cellular physiology

authors： Farhat T,Dudakovic A,Chung JH,van Wijnen AJ,St-Arnaud R

更新日期：2021-02-01 00:00:00

abstract：:The physiological approach suggests that an environment associating the mesenchymal stromal cells (MSC) and low O(2) concentration would be most favorable for the maintenance of hematopoietic stem cells (HSCs) in course of ex vivo expansion of hematopoietic grafts. To test this hypothesis, we performed a co-culture of...

journal_title：Journal of cellular physiology

authors： Hammoud M,Vlaski M,Duchez P,Chevaleyre J,Lafarge X,Boiron JM,Praloran V,Brunet De La Grange P,Ivanovic Z

更新日期：2012-06-01 00:00:00

abstract：:The biosynthesis and turnover of nicotinamide adenine dinucleotide (NAD) have been examined in mitotic cells of the human culture line, D98/AH2. No significant difference in the incorporation of nicotinic acid or nicotinamide could be detected between mitotic and interphase cells. The distribution of newly-incorporate...

journal_title：Journal of cellular physiology

authors： Elliott G,Rechsteiner M

更新日期：1975-12-01 00:00:00

abstract：:Several agents that act through G-protein-coupled receptors and also stimulate phosphoinositide-specific phospholipase C (PI-PLC), including angiotensin II, vasopressin, norepinephrine, and prostaglandin (PG) F2alpha, activated the ERK1 (p44mapk) and ERK2 (p42mapk) members of the mitogen-activated protein (MAP) kinase...

journal_title：Journal of cellular physiology

authors： Melien O,Thoresen GH,Sandnes D,Ostby E,Christoffersen T

更新日期：1998-06-01 00:00:00

abstract：:Pleiotropic human KB cell mutants, selected for resistance to a conjugate of epidermal growth factor with Pseudomonas exotoxin (PE-EGF), were characterized genetically. These mutants have a pleiotropic phenotype, which includes reduced number of EGF receptors and reduced growth rate. Hybrid cells between HeLa D98 and ...

journal_title：Journal of cellular physiology

authors： Amano F,Pastan I,Gottesman MM

更新日期：1988-06-01 00:00:00

abstract：:We have partially purified a mitogenic factor, termed colony stimulating factor, which is secreted from a human T lymphocytic cell line, and which stimulates in vitro formation of colonies of macrophages and granulocytes by human bone marrow cells. Colony stimulating factor (CSF) produced by cells grown in serum suppl...

journal_title：Journal of cellular physiology

authors： Frölich M

更新日期：1981-12-01 00:00:00

abstract：:The actions of prostaglandins (PG) on cAMP in dispersed chief cells from guinea pig stomach were examined and compared to the actions of these agents on pepsinogen secretion. Maximal concentrations of A, B, or E prostaglandins caused a 2-5-fold increase in pepsinogen secretion and cellular cAMP. The relative order of ...

journal_title：Journal of cellular physiology

authors： Raufman JP,Cosowsky L

更新日期：1987-07-01 00:00:00

abstract：:Changes in the concentration of intracellular Ca(2+) ([Ca(2+) ]i) trigger and/or regulate principal sperm functions during fertilization, such as motility, capacitation, and the acrosome reaction (AR). Members of the large TRP channel family participate in a variety of Ca(2+) -dependent cell signaling processes. The e...

journal_title：Journal of cellular physiology

authors： Martínez-López P,Treviño CL,de la Vega-Beltrán JL,De Blas G,Monroy E,Beltrán C,Orta G,Gibbs GM,O'Bryan MK,Darszon A

更新日期：2011-06-01 00:00:00

abstract：:Parathyroid hormone-related protein (PTHrP) (107-139), in contrast to the N-terminal fragment PTHrP (1-36), has been shown to interact with the vascular endothelial growth factor (VEGF) system to modulate human osteoblast differentiation. In this study, we evaluated whether this interaction might affect human osteobla...

journal_title：Journal of cellular physiology

authors： Alonso V,de Gortázar AR,Ardura JA,Andrade-Zapata I,Alvarez-Arroyo MV,Esbrit P

更新日期：2008-12-01 00:00:00