"APRIL hath put a spring of youth in everything": Relevance of APRIL for survival.

abstract：:New compounds with promising antidiabetic activity were synthesized. For the first time, a portion of the glibenclamide molecule was bound to a part of the core structure of thiazolidinedione to evaluate insulin secretagogue activity. Following studies in our laboratory, 4-{2-[2-(3,4-dichlorophenyl)-4-oxo-1,3-thiazoli...

journal_title：Journal of cellular physiology

authors： Mendes CP,Postal BG,Oliveira GTC,Castro AJG,Frederico MJS,Moraes ALL,Neuenfeldt PD,Nunes RJ,Menegaz D,Silva FRMB

更新日期：2018-01-01 00:00:00

abstract：:Detailed information regarding the synthesis rates of individual protein components is important in understanding the assembly and dynamics of the cytoskeletal matrix of eukaryotic cells. As an approach to this topic, the dual isotope technique of Clark and Zak (J. Biol. Chem., 256:4863-4870, 1981), was employed to me...

journal_title：Journal of cellular physiology

authors： Mitchell JJ,Low RB,Woodcock-Mitchell JL

更新日期：1990-06-01 00:00:00

abstract：:Pancreatic ductal adenocarcinoma (PDAC) is one of the most frequently diagnosed cancers and the fourth leading cause of cancer-related death in the United States, suggesting that there is an urgent need to design novel strategies for achieving better treatment outcome of patients diagnosed with PDAC. Our previous stud...

journal_title：Journal of cellular physiology

authors： Wang Z,Ali S,Banerjee S,Bao B,Li Y,Azmi AS,Korc M,Sarkar FH

更新日期：2013-03-01 00:00:00

abstract：:The initial step in a synthesis of thyroid hormones is the uptake of iodide from the circulation. Iodide (I(-)) is transported into thyroid cells via a Na(+)/I(-) symporter (NIS), which is electrogenic and thus sensitive to alterations in membrane potential (V(m)). I(-) is then released to the lumen of thyroid follicl...

journal_title：Journal of cellular physiology

authors： Viitanen TM,Sukumaran P,Löf C,Törnquist K

更新日期：2013-04-01 00:00:00

abstract：:In this study, we used a bioinformatics approach to analyze the nucleotide composition and pattern of synonymous codon usage in mitochondrial ND genes in three amphibian groups, that is, orders Anura, Caudata, and Gymnophiona to identify the commonality and the differences of codon usage as no research work was report...

journal_title：Journal of cellular physiology

authors： Barbhuiya PA,Uddin A,Chakraborty S

更新日期：2020-09-22 00:00:00

abstract：:The percentage of T and B lymphocytes expressing a distinct cytoplasmic aggregate enriched in spectrin, ankyrin, and in several other proteins including protein kinase C greatly increases following various activation protocols. Members of the 70 kDa family of heat shock proteins (hsp70) temporarily bind to and stabili...

journal_title：Journal of cellular physiology

authors： Di YP,Repasky E,Laszlo A,Calderwood S,Subjeck J

更新日期：1995-11-01 00:00:00

abstract：:The objective of this study was to establish whether human recombinant tumor necrosis factor (TNF) can significantly stimulate the proliferation of some tumor cells. Treatment with TNF had little or no effect on the growth of human tumor cells and murine NIH/3T3 cells cultured in medium with high serum concentration. ...

journal_title：Journal of cellular physiology

authors： Kirstein M,Baglioni C

更新日期：1988-03-01 00:00:00

abstract：:alpha-Crystallins share structural and functional properties with the stress protein hsp27. These polypeptides are expressed at low constitutive levels in many tissues including brain, and alpha B-crystallin and hsp27 can accumulate in central nervous system glia in a variety of neurological conditions. We report here...

journal_title：Journal of cellular physiology

authors： Head MW,Corbin E,Goldman JE

更新日期：1994-04-01 00:00:00

abstract：:Osteoporosis is a class of metabolic bone disease caused by complexed ramifications. Overactivation of osteoclasts due to a sudden decreased estrogen level plays a pivotal role for postmenopausal women suffering from osteoporosis. Therefore, inhibiting osteoclast formation and function has become a major direction for...

journal_title：Journal of cellular physiology

authors： Li K,Xiao Y,Wang Z,Fu F,Shao S,Song F,Zhao J,Lin X,Liu Q,Xu J

更新日期：2019-02-27 00:00:00

abstract：:Epidermal growth factor-like domain-containing protein 7 (EGFL7), a member of the epidermal growth factor (EGF)-like protein family, is a potent angiogenic factor expressed in many different cell types. EGFL7 plays a vital role in controlling vascular angiogenesis during embryogenesis, organogenesis, and maintaining s...

journal_title：Journal of cellular physiology

authors： Hong G,Kuek V,Shi J,Zhou L,Han X,He W,Tickner J,Qiu H,Wei Q,Xu J

更新日期：2018-11-01 00:00:00

abstract：:Bafilomycin A1, a specific inhibitor of H(+)-ATPases of the vacuolar type, was in the present study shown, at similar concentrations, to induce secretion of lysosomal enzyme and to elevate lysosomal pH in mouse macrophages. These results lend support to the previous suggestion of a triggering role for an increase in l...

journal_title：Journal of cellular physiology

authors： Tapper H,Sundler R

更新日期：1995-04-01 00:00:00

abstract：:This study is carried out to elucidate the role of long noncoding RNAs (lncRNAs) MT1JP in proliferation, invasion, migration, and apoptosis of glioma cells through the regulation of PTEN/Akt signaling pathway. The expression of MT1JP in 80 normal brain tissues and 138 glioma tissues, as well as glioma cell lines, was ...

journal_title：Journal of cellular physiology

authors： Zhang Y,Sui R,Chen Y,Liang H,Shi J,Piao H

更新日期：2019-11-01 00:00:00

abstract：:Thymosin β4 (Tβ4), a G-actin-sequestering secreted peptide, improves neurovascular remodeling and central nervous system plasticity, which leads to neurological recovery in many neurological diseases. Inflammatory response adjustment and tissue inflammation consequences from neurological injury are vital for neurologi...

journal_title：Journal of cellular physiology

authors： Shomali N,Baradaran B,Deljavanghodrati M,Akbari M,Hemmatzadeh M,Mohammadi H,Jang Y,Xu H,Sandoghchian Shotorbani S

更新日期：2020-04-01 00:00:00

abstract：:Apoptosis of matrix producing cells is common among many inflammatory diseases. The goal of the present study was to examine the apoptotic effects of tumor necrosis factor-alpha (TNF-alpha) on fibroblastic cells in vivo and to investigate the role of different caspases in this process. This was accomplished in vivo by...

journal_title：Journal of cellular physiology

authors： Alikhani M,Alikhani Z,Raptis M,Graves DT

更新日期：2004-12-01 00:00:00

abstract：:Myeloid cells, including granulocytes and monocyte/macrophages, are important in disease-associated inflammatory reactions. These cells come from a common progenitor, the promyelocyte. The human promyelocytic cell line, HL-60, can be induced to terminally differentiate into granulocytes or monocyte/ macrophages in a c...

journal_title：Journal of cellular physiology

authors： Brent LH,Rubenstein B,Gong QH,Wieland SJ

更新日期：1996-07-01 00:00:00

abstract：:Melatonin, the major pineal secretory product, has a significant impact on the female reproductive system. Recently, the beneficial effects of melatonin on mammalian oocyte maturation and embryonic development have drawn increased attention. However, the exact underlying mechanisms remain to be fully elucidated. This ...

journal_title：Journal of cellular physiology

authors： He B,Yin C,Gong Y,Liu J,Guo H,Zhao R

更新日期：2018-01-01 00:00:00

abstract：:Alkaptonuria (AKU) is a rare disease correlated with deficiency of the enzyme homogentisate 1,2 dioxygenase, which causes homogentisic acid (HGA) accumulation. HGA is subjected to oxidation/polymerization reactions, leading to the production of a peculiar melanin-like pigmentation (ochronosis) after chronic inflammati...

journal_title：Journal of cellular physiology

authors： Schiavone ML,Millucci L,Bernardini G,Giustarini D,Rossi R,Marzocchi B,Santucci A

更新日期：2020-10-01 00:00:00

abstract：:Cover: The cover image, by Michaela R. Reagan et al., is based on the Perspective A Perspective on Malignancy in the Marrow, DOI 10.1002/jcp.25860. ...

journal_title：Journal of cellular physiology

authors： Reagan MR,Lian JB,Rosen CJ,Stein GS

更新日期：2017-12-01 00:00:00

abstract：:Indian hedgehog (Ihh) is produced by growth plate pre-hypertrophic chondrocytes, and is an important regulator of endochondral ossification. However, little is known about the regulation of Ihh in chondrocytes. We have examined the role of integrins and mitogen-activated protein (MAP) kinases in Ihh mRNA regulation in...

journal_title：Journal of cellular physiology

authors： Lai LP,DaSilva KA,Mitchell J

更新日期：2005-04-01 00:00:00

abstract：:Neuroblastoma (NB) is the leading pediatric cancer known for its heterogeneity and clinical aggressiveness leading to chemoresistance. Recent evidence in small RNA research has led to the discovery of PIWI-interacting RNAs (piRNAs) which work in an orchestrated fashion to modulate gene expression both in homeostatic c...

journal_title：Journal of cellular physiology

authors： Roy J,Das B,Jain N,Mallick B

更新日期：2020-03-01 00:00:00

abstract：:Bone marrow mesenchymal stem cells (BMSC) can ameliorate ischemic injury of various tissues. However, the molecular mechanisms involved remain to be clarified. In this study, we intend to investigate the effects of BMSC-derived conditioned medium (BMSC-CM) on hypoxia/reoxygenation (H/R)-induced injury of H9c2 myocardi...

journal_title：Journal of cellular physiology

authors： Li X,Xie X,Yu Z,Chen Y,Qu G,Yu H,Luo B,Lei Y,Li Y

更新日期：2019-08-01 00:00:00

abstract：:Galectins play key roles in the inflammatory cascade. In this study, we aimed to analyze the effect of galectin-1 (Gal-1) in the function of intestinal epithelial cells (IECs) isolated from healthy and inflamed mucosa. IECs isolated from mice or patients with inflammatory bowel diseases (IBD) were incubated with diffe...

journal_title：Journal of cellular physiology

authors： Muglia CI,Gobbi RP,Smaldini P,Delgado ML,Candia M,Zanuzzi C,Sambuelli A,Rocca A,Toscano MA,Rabinovich GA,Docena GH

更新日期：2016-07-01 00:00:00

abstract：:Mouse epidermal cells can be grown as a proliferating monolayer in medium containing 0.02-0.1 mM calcium. Terminal differentiation of these cells with formation of cornified cells and cell death is induced by elevating calcium in the medium to greater than 0.1 mM. A variety of agents were studied as potential modifier...

journal_title：Journal of cellular physiology

authors： Hennings H,Holbrook KA,Yuspa SH

更新日期：1983-09-01 00:00:00

abstract：:Adipose-derived stem cells (ADSCs) are a type of mesenchymal stem cells isolated from adipose tissue and have the ability to differentiate into adipogenic, osteogenic, and chondrogenic lineages. Despite their great therapeutic potentials, previous studies showed that ADSCs could enhance the proliferation and metastati...

journal_title：Journal of cellular physiology

authors： Chan YW,So C,Yau KL,Chiu KC,Wang X,Chan FL,Tsang SY

更新日期：2020-10-01 00:00:00

abstract：:Retinoic acid reduces the growth rate of mouse S91 melanoma cells in culture and increases the proportion of cells in the G1 phase of the cell cycle. Because of the integral role protein synthesis has been shown to play in growth control we studied the effect of retinoic acid on the protein synthesis machinery with a ...

journal_title：Journal of cellular physiology

authors： Lotan R,Fischer I,Meromsky L,Moldave K

更新日期：1982-10-01 00:00:00

abstract：:Stromal cell-derived factor-1 (SDF-1) and CXC chemokine receptor 4 (CXCR4) have been found to be tightly correlated with the progression of prostate cancer (PC). In this study, we investigated the effects of an SDF-1α/CXCR4 inhibitor, AMD3100, on cell progression and metastasis potential of human PC cells. Human PC ce...

journal_title：Journal of cellular physiology

authors： Zhu WB,Zhao ZF,Zhou X

更新日期：2019-07-01 00:00:00

abstract：:Peptidoglycan (PGN) is a potent immune adjuvant derived from bacterial cell walls. Previous investigations suggest that intestinal epithelium may absorb PGN from the lumen. Nonetheless, how PGN is taken up and crosses intestinal epithelium remains largely unclear. Here, we first characterized PGN transport in vitro us...

journal_title：Journal of cellular physiology

authors： Bu HF,Wang X,Tang Y,Koti V,Tan XD

更新日期：2010-03-01 00:00:00

abstract：:We have recently described a novel nuclear antigen, AF-2, which is related to cell cycle dependent alterations of chromatin structure. We show by two parameter flow cytometry on a cell by cell basis that the antigen is accessible to specific monoclonal antibodies only in mitotic and postmitotic early G1-phase cells. T...

journal_title：Journal of cellular physiology

authors： Pfeffer U,Di Vinci A,Geido E,Vidali G,Giaretti W

更新日期：1991-12-01 00:00:00

abstract：:In areolar "loose" connective tissue, fibroblasts remodel their cytoskeleton within minutes in response to static stretch resulting in increased cell body cross-sectional area that relaxes the tissue to a lower state of resting tension. It remains unknown whether the loosely arranged collagen matrix, characteristic of...

journal_title：Journal of cellular physiology

authors： Abbott RD,Koptiuch C,Iatridis JC,Howe AK,Badger GJ,Langevin HM

更新日期：2013-01-01 00:00:00

abstract：:Serine/threonine protein phosphatase (PP) 2A regulates many biological processes, however it remains unclear whether PP2A participates in cadherin-mediated cell-cell adhesion. We show here that the core enzyme of PP2A (PP2A-AC) is localized in the cell-cell adhesion sites between adjacent cells and associated with the...

journal_title：Journal of cellular physiology

authors： Takahashi K,Nakajima E,Suzuki K

更新日期：2006-03-01 00:00:00