Homogentisic acid affects human osteoblastic functionality by oxidative stress and alteration of the Wnt/β-catenin signaling pathway.

abstract：:In spite of the apparent depletion of mast cells in tissues of mutant mice of W/Wv genotype, cells with many features of mast cells do develop when bone marrow cells of W/Wv mice are cultured in the presence of pokeweed mitogen-stimulated spleen cell-conditioned medium (PWM-SCM). In order to resolve this discrepancy a...

journal_title：Journal of cellular physiology

authors： Fujita J,Nakayama H,Onoue H,Kanakura Y,Nakano T,Asai H,Takeda S,Honjo T,Kitamura Y

更新日期：1988-01-01 00:00:00

abstract：:Preincubation of human neutrophils with phorbol esters or soluble diglycerides enhances subsequent f-Met-Leu-Phe (fMLP)-stimulated arachidonate mobilization and leukotriene B4 (LTB4) synthesis. We have recently reported that 1,3-dioctanoylglycerol (1,3-diC8) is equipotent with 1,2-sn-dioctanoylglycerol (1,2-diC8) as p...

journal_title：Journal of cellular physiology

authors： Rosenthal MD,Franson RC

更新日期：1994-09-01 00:00:00

abstract：:We have characterized the physiological and biochemical properties of the Na(+)/K(+) pump and its molecular expression in L8 rat muscle cells. Pump properties were measured by [(3)H]ouabain binding and (86)Rb uptake. Scatchard plot analysis of specific ouabain binding indicated the presence of a single family of bindi...

journal_title：Journal of cellular physiology

authors： Sharabani-Yosef O,Bak A,Nir U,Sampson SR

更新日期：2001-06-01 00:00:00

abstract：:The caspase recruitment domain (CARD)-containing proteins CARMA1-3 share high degree of sequence, structure and functional homology. Whereas CARMA1 and CARMA3 have been identified as crucial components of signal transduction pathways that lead to activation of NF-κB transcription factor, little is known about the func...

journal_title：Journal of cellular physiology

authors： Scudiero I,Zotti T,Ferravante A,Vessichelli M,Vito P,Stilo R

更新日期：2011-12-01 00:00:00

abstract：:Pharmacogenomics, toxicogenomics, and small RNA expression analysis are three of the most active research topics in the biological, biomedical, pharmaceutical, and toxicological fields. All of these studies are based on gene expression analysis, which requires reference genes to reduce the variations derived from diff...

journal_title：Journal of cellular physiology

authors： Chen D,Pan X,Xiao P,Farwell MA,Zhang B

更新日期：2011-10-01 00:00:00

abstract：:Glutamine is the most abundant free amino acid in the body and is known to play a regulatory role in several cell specific processes including metabolism (e.g., oxidative fuel, gluconeogenic precursor, and lipogenic precursor), cell integrity (apoptosis, cell proliferation), protein synthesis, and degradation, contrac...

journal_title：Journal of cellular physiology

authors： Curi R,Lagranha CJ,Doi SQ,Sellitti DF,Procopio J,Pithon-Curi TC,Corless M,Newsholme P

更新日期：2005-08-01 00:00:00

abstract：:Heparan sulfate from the surface of a variety of mouse cells at different cell densities was examined by ion-exchange chromatography. The results of this analysis show that: (1) The heparan sulfate from new isolates of Swiss 3T3 cells transformed by SV40 virus (a DNA tumor virus) elutes from DEAE-cellulose at a lower ...

journal_title：Journal of cellular physiology

authors： Underhill CB,Keller JM

更新日期：1977-01-01 00:00:00

abstract：:Expression of plasminogen activator inhibitor type-1 (PAI-1), a member of the SERPIN gene family that functions to regulate the plasmin-based pericellular proteolytic cascade, is growth state-regulated in normal rat kidney (NRK) cells (Ryan and Higgins, 1990, J. Cell. Physiol., 155:376-384; Ryan et al., 1996, Biochem....

journal_title：Journal of cellular physiology

authors： Kutz SM,Nickey SA,White LA,Higgins PJ

更新日期：1997-01-01 00:00:00

abstract：:Retinoic acid (RA) reduced growth, fibronectin, and retinoic acid receptor (RAR alpha) in NIH 3T3 cells but not in cells transformed by the Ha-ras oncogene. RA lowered RAR alpha transcript and protein, increased RAR beta transcripts, and had no effect on RAR gamma. H-ras transformation downregulated RAR expression and...

journal_title：Journal of cellular physiology

authors： De Luca LM,Scita G,Takatsuka J

更新日期：1997-11-01 00:00:00

abstract：:Interleukin (IL)-18 is a pro-inflammatory cytokine belonging to the IL-1 family, first identified for its interferon-γ-inducing properties. IL-18 regulates both T helper (Th) 1 and Th2 responses. It acts synergistically with IL-12 in the Th1 paradigm, whereas with IL-2 and without IL-12 it can induce Th2 cytokine prod...

journal_title：Journal of cellular physiology

authors： Vecchié A,Bonaventura A,Toldo S,Dagna L,Dinarello CA,Abbate A

更新日期：2021-03-01 00:00:00

abstract：:A proliferation inducing ligand (APRIL or TALL-2 and TRDL-1) was first discovered as a cytokine over-expressed in many transformed cells and with the capacity to stimulate proliferation. APRIL was shown to bind two different receptors of the TNF receptor superfamily: B cell maturation antigen (BCMA) and transmembrane ...

journal_title：Journal of cellular physiology

authors： Kimberley FC,Hahne M,Medema JP

更新日期：2009-01-01 00:00:00

abstract：:Resistance to tamoxifen remains a prominent conundrum in the therapy of hormone-sensitive breast cancer. Also, the molecular underpinnings leading to tamoxifen resistance remain unclear. In the present study, we utilized the Gene Expression Omnibus database to identify that SOX11 might exert a pivotal function in conf...

journal_title：Journal of cellular physiology

authors： Xiao Y,Xie Q,Qin Q,Liang Y,Lin H,Zeng

更新日期：2020-10-01 00:00:00

abstract：:Although glucocorticoids strongly affect numerous biological processes including cell growth, development, and homeostasis, their effects on migration of human mesenchymal stem cells (hMSCs) are unclear. Therefore, we investigated the role of dexamethasone (DEX) and its related signaling pathways on migration of hMSCs...

journal_title：Journal of cellular physiology

authors： Yun SP,Ryu JM,Han HJ

更新日期：2011-03-01 00:00:00

abstract：:Pleiotropic human KB cell mutants, selected for resistance to a conjugate of epidermal growth factor with Pseudomonas exotoxin (PE-EGF), were characterized genetically. These mutants have a pleiotropic phenotype, which includes reduced number of EGF receptors and reduced growth rate. Hybrid cells between HeLa D98 and ...

journal_title：Journal of cellular physiology

authors： Amano F,Pastan I,Gottesman MM

更新日期：1988-06-01 00:00:00

abstract：:Cultures of HeLa cells, strains S3G (HeLa65) and S3K (HeLa71) were grown in plastic dishes until firmly attached and were then treated with sonic dispersions of Rosenthal's phospholipase inhibitor. A rapid increase in alkaline phosphatase activity occurred following this treatment in the S3G strain (low inducible alka...

journal_title：Journal of cellular physiology

authors： Melnykovych G,Lopez IC

更新日期：1977-07-01 00:00:00

abstract：:Myocardium infarction is one of the most deathly cardiovascular diseases. It is characterized by myocardium ischemia as a result of nutrients depletion and hypoxia. The cell can respond to this injury by autophagy or apoptosis, which determines the evolution and possible recovery of the myocardium infarction. Lipids p...

journal_title：Journal of cellular physiology

authors： Sousa B,Melo T,Campos A,Moreira AS,Maciel E,Domingues P,Carvalho RP,Rodrigues TR,Girão H,Domingues MR

更新日期：2016-10-01 00:00:00

abstract：:Parkinson's disease (PD) is one of the most common movement disorders with loss of dopaminergic neurons and the presence of Lewy bodies in certain brain areas. However, it is not clear how Lewy body (inclusion with protein aggregation) formation occurs. Mutations in leucine-rich repeat kinase 2 (LRRK2) can cause a gen...

journal_title：Journal of cellular physiology

authors： Thomas JM,Wang X,Guo G,Li T,Dai B,Nucifora LG,Nucifora FC Jr,Liu Z,Xue F,Liu C,Ross CA,Smith WW

更新日期：2020-10-01 00:00:00

abstract：:Liver fibrosis (LF) is the result of a vicious cycle between inflammation-induced chronic hepatocyte injury and persistent activation of hepatic stellate cells (HSCs). Mesenchymal stem cell (MSC)-based therapy may represent a potential remedy for treatment of LF. However, the fate of transplanted MSCs in LF remains la...

journal_title：Journal of cellular physiology

authors： Wang HY,Li C,Liu WH,Deng FM,Ma Y,Guo LN,Kong H,Hu KA,Liu Q,Wu J,Sun J,Liu YL

更新日期：2020-03-01 00:00:00

abstract：:Dauricine, a bioactive component of Asiatic Moonseed Rhizome, has been widely used to treat a large number of inflammatory diseases in traditional Chinese medicine. In our study, we demonstrated that dauricine inhibited colon cancer cell proliferation and invasion, and induced apoptosis by suppressing nuclear factor-k...

journal_title：Journal of cellular physiology

authors： Yang Z,Li C,Wang X,Zhai C,Yi Z,Wang L,Liu B,Du B,Wu H,Guo X,Liu M,Li D,Luo J

更新日期：2010-10-01 00:00:00

abstract：:The biological roles of sphingosine 1-phosphate (S1P) and S1P receptors (S1PRs) have been broadly investigated. However, at present pathophysiological roles of S1P/S1PRs axis in liver fibrosis are not well defined. Here, we investigated the functions of S1P/S1PRs axis in human hepatic stellate cells (HSC) line, LX-2 c...

journal_title：Journal of cellular physiology

authors： Liu X,Yue S,Li C,Yang L,You H,Li L

更新日期：2011-09-01 00:00:00

abstract：:The matricellular protein periostin is strongly expressed in collagen-rich connective tissues such as periodontal ligaments (PDLs), skeletal muscle, adipose tissue, tendons, skin, and bone. It is prominent in tumorigenesis, angiogenesis, and cardiac repair. It is localized in the periosteum and PDL, where it is seen i...

journal_title：Journal of cellular physiology

authors： Romanos GE,Asnani KP,Hingorani D,Deshmukh VL

更新日期：2014-01-01 00:00:00

abstract：:Hyperammonaemia and hyperethanolaemia are thought to be driving factors behind skeletal muscle myopathy in liver disease, that is, cirrhosis. Despite this, the singular and combined impacts of ethanol- and ammonia-induced protein catabolism are poorly defined. As such, we aimed to dissect out the effects of ammonia an...

journal_title：Journal of cellular physiology

authors： Crossland H,Smith K,Atherton PJ,Wilkinson DJ

更新日期：2018-12-01 00:00:00

abstract：:Low-grade chronic inflammation is a salient feature of obesity and many associated disorders. This condition frequently occurs in central obesity and is connected to alterations of the visceral adipose tissue (AT) microenvironment. Understanding how obesity is related to inflammation may allow the development of thera...

journal_title：Journal of cellular physiology

authors： Petrangeli E,Coroniti G,Brini AT,de Girolamo L,Stanco D,Niada S,Silecchia G,Morgante E,Lubrano C,Russo MA,Salvatori L

更新日期：2016-03-01 00:00:00

abstract：:Diabetic nephropathy (DN) is an important factor leading to end-stage kidney disease that affects diabetes mellitus patients globally. Our previous transcriptome sequencing has identified a large group of differentially expressed long noncoding RNA (lncRNA) in early development of DN. On basis of this, we aimed to inv...

journal_title：Journal of cellular physiology

authors： Peng W,Huang S,Shen L,Tang Y,Li H,Shi Y

更新日期：2019-08-01 00:00:00

abstract：:We have used HeLa cells without mitochondrial DNA (rho0-cells) and transient rho0-phenocopies, obtained from wild-type cells by short-term treatment with ethidium bromide, to analyze how the absence of a functional mitochondrial respiratory chain slows down proliferation. We ruled out an energetic problem (ATP/ADP con...

journal_title：Journal of cellular physiology

authors： Schauen M,Spitkovsky D,Schubert J,Fischer JH,Hayashi J,Wiesner RJ

更新日期：2006-10-01 00:00:00

abstract：:Septins play important roles in regulating development and differentiation. Septin 7 (SEPT7) is a crucial component in orchestrating the septin core complex into highly ordered filamentous structures. Here, we showed that genetic depletion of SEPT7 or treatment with forchlorfenuron (FCF; a compound known to affect sep...

journal_title：Journal of cellular physiology

authors： Chen TY,Lin TC,Kuo PL,Chen ZR,Cheng HL,Chao YY,Syu JS,Lu FI,Wang CY

更新日期：2020-09-01 00:00:00

abstract：:Breast cancer (BC) is the most prevalent malignant cancer in the world, is the leading cause of cancer-related death female. Recently, there is accumulating evidence that long noncoding RNAs (lncRNAs) might as an important role in the progression of BC. (epithelial-mesenchymal transition (EMT) is considered to play a ...

journal_title：Journal of cellular physiology

authors： Wang YY,Yan L,Yang S,Xu HN,Chen TT,Dong ZY,Chen SL,Wang WR,Yang QL,Chen CJ

更新日期：2019-12-01 00:00:00

abstract：:Therapeutic application of stem cells and oncolytic viruses in cancer treatment has rapidly increased in the last decade. Oncolytic viruses are considered as a new class of anticancer agents because of their ability to selectively infect and destroy cancer cells. Furthermore, regarding the specific migratory capacity ...

journal_title：Journal of cellular physiology

authors： Zendedel E,Atkin SL,Sahebkar A

更新日期：2019-02-15 00:00:00

abstract：:Sprouting angiogenesis is a major form of neovascularization of tissues suffering from hypoxia and other related stress. Endothelial cells (ECs) undergo proliferation, differentiation, programmed death, and migration during angiogenic sprouting, but the underlying molecular mechanisms regulating ECs in angiogenesis ha...

journal_title：Journal of cellular physiology

authors： Liu Y,Zheng Q,He G,Zhang M,Yan X,Yang Z,Zhang P,Wang L,Liu J,Liang L,Han H

更新日期：2019-06-01 00:00:00

abstract：:Nonalcoholic fatty liver disease (NAFLD) is one of the main liver diseases today, and may progress to steatohepatitis, cirrhosis, and hepatocellular carcinoma. Some studies have shown the beneficial effects of aerobic exercise on reversing NAFLD. To verify whether chronic aerobic exercise improves the insulin resistan...

journal_title：Journal of cellular physiology

authors： Batatinha HA,Lima EA,Teixeira AA,Souza CO,Biondo LA,Silveira LS,Lira FS,Rosa Neto JC

更新日期：2017-05-01 00:00:00