Synthesis of glycolytic and peroxisomal enzymes in Tetrahymena following a change in culture conditions.

Abstract:

:The specific activity of a peroxisomal enzyme, lactate oxidase, and of pyruvate kinase and lactate dehydrogenase, which are not peroxisomal, increased rapidly when shaken cultures of Tetrahymena were transferred to conditions of oxygen restriction and supplemented with glucose. Two other peroxisomal enzymes, catalase and TPN-linked isocitrate dehydrogenase, did not increase substantially, nor did succinate dehydrogenase. The increases were reduced if glucose was not added at the time of transfer, and were prevented by actinomycin D or cycloheximide, but not by chloramphenicol. The results suggest an involvement of peroxisomes in the metabolism of glycolytic endproducts when the availability of oxygen to the cell is limiting.

journal_name

J Cell Physiol

authors

Levy MR

doi

10.1002/jcp.1040850106

subject

Has Abstract

pub_date

1975-02-01 00:00:00

pages

41-5

issue

1

eissn

0021-9541

issn

1097-4652

journal_volume

85

pub_type

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