Molecular biology and immunoregulation of human neurotropic JC virus in CNS.


:The human polyomavirus, JC virus (JCV), provides an excellent model system to investigate the reciprocal interaction of the immune and nervous systems. Infection with JCV occurs during childhood and the virus remains in the latent state with no apparent clinical symptoms. However, under immunosuppressed conditions, the virus enters the lytic cycle and upon cytolytic destruction of glial cells, causes the fatal demyelinating disease of the central nervous system (CNS), named progressive multifocal leukoencephalopathy (PML). In this short review, we discuss the molecular pathogenesis of PML by highlighting the role of the immune system in modulating JCV gene activation and replication, and the latency/reactivation of this virus upon immunosuppression. Further, due to the higher incidence of PML among AIDS patients, we further elaborate on the cross-talk between JCV and HIV-1 by direct and indirect pathways that lead to enhanced expression of the JCV genome.


J Cell Physiol


Sweet TM,Del Valle L,Khalili K





Has Abstract


2002-06-01 00:00:00












  • Uptake of [3H]ouabain from the cell surface into the lysosomal compartment of HeLa cells.

    abstract::[3H]Ouabain specifically bound at sublethal concentrations to Na,K-ATPase on the surface of HeLa cells is taken up (internalized) by the cells at a rate of three membrane equivalents of labeled sites per generation. Immediately following a pulse label with the glycoside, codistribution of radioactivity with the surfac...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章


    authors: Cook JS,Tate EH,Shaffer C

    更新日期:1982-01-01 00:00:00

  • p120-catenin is required for regulating epidermal proliferation, differentiation, and barrier function.

    abstract::p120-catenin (p120) is an important regulator in the function and stability of E-cadherin. However, the role of p120 in the epidermis is unclear. Previous studies have shown that globally knockout of p120 caused increased epidermal proliferation but little changes in epidermal differentiation and permeability. In the ...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章


    authors: Xie Z,Tang Y,Man MQ,Shrestha C,Bikle DD

    更新日期:2018-01-01 00:00:00

  • Induction of macrophage elastase (MMP-12) gene expression by statins.

    abstract::The statins (including mevastatin and lovastatin) are a widely prescribed class of serum-cholesterol lowering drugs that function by inhibiting 3-hydroxymethylglutaryl coenzyme A (HMG CoA) reductase activity and cellular sterol synthesis. Statins are also widely being appreciated for their inhibitory effects upon infl...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章


    authors: Arikan MC,Shapiro SD,Mariani TJ

    更新日期:2005-07-01 00:00:00

  • What role does pyroptosis play in microbial infection?

    abstract::Pyroptosis, a type of programmed cell death mediated by gasdermin, is characterized by the swelling and rupture of cells, release of cellular contents and a strong inflammatory response, which is critical for controlling microbial infection. Pattern recognition receptors recognize the intracellular and extracellular p...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章,评审


    authors: Xia X,Wang X,Zheng Y,Jiang J,Hu J

    更新日期:2019-06-01 00:00:00

  • Plasminogen activator inhibitor-1 deficiency suppresses osteoblastic differentiation of mesenchymal stem cells in mice.

    abstract::Plasminogen activator inhibitor-1 (PAI-1) is known as an inhibitor of fibrinolytic system. Previous studies suggest that PAI-1 is involved in the pathogenesis of osteoporosis induced by ovariectomy, diabetes, and glucocorticoid excess in mice. However, the roles of PAI-1 in early-stage osteogenic differentiation have ...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章


    authors: Takafuji Y,Tatsumi K,Ishida M,Kawao N,Okada K,Matsuo O,Kaji H

    更新日期:2019-06-01 00:00:00

  • Mesenchymal stem cells contribute to endogenous FVIII:c production.

    abstract::Besides the liver, it has been difficult to identify which organ(s) and/or cellular component(s) contribute significantly to the production of human FVIII:c (FVIII). Thus far, only endothelial cells have been shown to constitute a robust extrahepatic source of FVIII, possibly explaining both the diverse presence of FV...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章


    authors: Sanada C,Kuo CJ,Colletti EJ,Soland M,Mokhtari S,Knovich MA,Owen J,Zanjani ED,Porada CD,Almeida-Porada G

    更新日期:2013-05-01 00:00:00

  • Involvement of glutathione in the inhibition of sea urchin egg mitosis by phenyl glyoxal.

    abstract::Cell division in fertilized sea urchin eggs was reversibly inhibited when the ketoaldehyde phenyl glyoxal (PG) at a concentration of 0.1 mM was added to eggs for ten minutes prior to the formation of the mitotic spindle. We investigated whether inhibition of mitosis was due to PG binding to the cell surface (as previo...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章


    authors: Amy CM,Rebhun LI

    更新日期:1979-07-01 00:00:00

  • c-Src kinase contributes on endothelial cells mechanotransduction in a heat shock protein 70-dependent turnover manner.

    abstract::Shear stress changes are associated with a repertory of signaling cascade modulating vascular phenotype. As shear stress-related tensional forces might be associated with pathophysiological susceptibility, a more comprehensive molecular map needs to be addressed. Thus, we subjected human umbilical vein endothelial cel...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章


    authors: Pinto TS,Fernandes CJDC,da Silva RA,Gomes AM,Vieira JCS,Padilha PM,Zambuzzi WF

    更新日期:2019-07-01 00:00:00

  • Maintenance of granulocyte-monocyte progenitor cells in liquid cultures of human foetal liver.

    abstract::These studies describe a liquid suspension culture system for normal myeloid cells derived from human foetal liver. A simple one-step fractionation procedure was employed to obtain a cell population capable of expanding into all stages of myeloid differentiation, including committed myeloid progenitor cells (GM-CFC). ...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章


    authors: Toksoz D,Brown G

    更新日期:1984-05-01 00:00:00

  • RAB39B's role in membrane traffic, autophagy, and associated neuropathology.

    abstract::Neuropathological disorders are increasingly associated with dysfunctions in neuronal membrane traffic and autophagy, with defects among members of the Rab family of small GTPases implicated. Mutations in the human Xq28 localized gene RAB39B have been associated with X-linked neurodevelopmental defects including macro...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章,评审


    authors: Tang BL

    更新日期:2021-03-01 00:00:00

  • Inorganic phosphate enhances sensitivity of human osteosarcoma U2OS cells to doxorubicin via a p53-dependent pathway.

    abstract::Osteosarcoma is the most common malignant primary bone tumor in children and adolescents. The clinical outcome for osteosarcoma remains discouraging despite aggressive surgery and intensive radiotherapy and chemotherapy regimens. Thus, novel therapeutic approaches are needed. Previously, we have shown that inorganic p...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章


    authors: Spina A,Sorvillo L,Di Maiolo F,Esposito A,D'Auria R,Di Gesto D,Chiosi E,Naviglio S

    更新日期:2013-01-01 00:00:00

  • The long noncoding RNA ZFAS1 promotes the progression of glioma by regulating the miR-150-5p/PLP2 axis.

    abstract::Numerous studies have reported that long noncoding RNA (lncRNA) dysregulation is involved in the progression of many malignant tumors, including glioma. The lncRNA ZNFX1 antisense RNA 1 (ZFAS1) plays an oncogenic role in various malignant tumors, such as gastric cancer and hepatocellular carcinoma. However, the underl...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章


    authors: Li X,Luo Y,Liu L,Cui S,Chen W,Zeng A,Shi Y,Luo L

    更新日期:2020-03-01 00:00:00

  • Inhibition of human methionine adenosyltransferase 1A transcription by coding region methylation.

    abstract::Two genes (MAT1A and MAT2A) encode for the essential enzyme methionine adenosyltransferase (MAT). MAT1A is silenced in hepatocellular carcinoma (HCC), and absence of MAT1A leads to spontaneous development of HCC in mice. Previous report correlated promoter methylation to silencing of MAT1A but definitive proof was lac...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章


    authors: Tomasi ML,Li TW,Li M,Mato JM,Lu SC

    更新日期:2012-04-01 00:00:00

  • Control of alkaline phosphatase activity in C3H10T1/2 cells: role of retinoic acid and cell density.

    abstract::The enzyme alkaline phosphatase (AP) has been shown to be lost or inappropriately expressed during carcinogenesis in some tissues. Because retinoic acid (RA) appears to play a role in the normal regulation of the enzyme (RA up-regulates AP in a variety of cell types) we have suggested that altered AP expression in som...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章


    authors: Reese DH,Larsen RA,Hornicek FJ

    更新日期:1992-05-01 00:00:00

  • Combination of Rapamycin and Resveratrol for Treatment of Bladder Cancer.

    abstract::Loss of TSC1 function, a crucial negative regulator of mTOR signaling, is a common alteration in bladder cancer. Mutations in other members of the PI3K pathway, leading to mTOR activation, are also found in bladder cancer. This provides rationale for targeting mTOR for treatment of bladder cancer characterized by TSC1...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章


    authors: Alayev A,Salamon RS,Schwartz NS,Berman AY,Wiener SL,Holz MK

    更新日期:2017-02-01 00:00:00

  • Phospholipase A2 activating protein (PLAA) is required for 1alpha,25(OH)2D3 signaling in growth plate chondrocytes.

    abstract::Phospholipase A2 (PLA2) is pivotal in the rapid membrane-mediated actions of 1,25-dihydroxyvitamin D3 [1alpha,25(OH)2D3]. Microarray analysis indicated that PLA2 activating protein (PLAA) mRNA is upregulated 6-fold before rat growth plate cells exhibit 1alpha,25(OH)2D3-dependent protein kinase C (PKC) increases, sugge...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章


    authors: Schwartz Z,Graham EJ,Wang L,Lossdörfer S,Gay I,Johnson-Pais TL,Carnes DL,Sylvia VL,Boyan BD

    更新日期:2005-04-01 00:00:00

  • Parathyroid hormone-related protein (107-139) increases human osteoblastic cell survival by activation of vascular endothelial growth factor receptor-2.

    abstract::Parathyroid hormone-related protein (PTHrP) (107-139), in contrast to the N-terminal fragment PTHrP (1-36), has been shown to interact with the vascular endothelial growth factor (VEGF) system to modulate human osteoblast differentiation. In this study, we evaluated whether this interaction might affect human osteobla...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章


    authors: Alonso V,de Gortázar AR,Ardura JA,Andrade-Zapata I,Alvarez-Arroyo MV,Esbrit P

    更新日期:2008-12-01 00:00:00

  • Serum response elements mediate protein kinase C dependent transcriptional induction of early growth response gene-1 by arginine vasopressin in rat mesangial cells.

    abstract::Arginine vasopressin (AVP) regulates glomerular hemodynamics, alters extracellular matrix production, and induces proliferation of glomerular mesangial cells (MCs). Therefore, AVP may play a role in glomerular sclerosis and the progression of chronic renal failure. To investigate changes in early gene expression which...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章


    authors: Rupprecht HD,Sukhatme VP,Rupprecht AP,Sterzel RB,Coleman DL

    更新日期:1994-05-01 00:00:00

  • Endogenous thiol levels in heterogeneous murine tumor cells as a function of the physiological state and the response to X-irradiation.

    abstract::The endogenous thiols (PSH, protein sulfhydryls; NPSH, nonprotein sulfhydryls; and GSH, glutathione) were measured in the 66 and 67 murine carcinoma cells growing under different physiological conditions in vitro (e.g., proliferation, P; nutrient-deprived quiescence QI; and QI cells stimulated by refeeding the monolay...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章


    authors: Dethlefsen LA,Biaglow JE,Peck VM,Ridinger DN

    更新日期:1987-07-01 00:00:00

  • Adipose-derived stem cells for wound healing.

    abstract::Wound healing is a complex but a fine-tuned biological process in which human skin has the ability to regenerate itself following damage. However, in particular conditions such as deep burn or diabetes the process of wound healing is compromised. Despite investigations on the potency of a wide variety of stem cells fo...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章,评审


    authors: Hassanshahi A,Hassanshahi M,Khabbazi S,Hosseini-Khah Z,Peymanfar Y,Ghalamkari S,Su YW,Xian CJ

    更新日期:2019-06-01 00:00:00

  • Signatures of DNA double strand breaks produced in irradiated G1 and G2 cells persist into mitosis.

    abstract::We have observed that some of the DNA damage or damage product caused by irradiation of interphase cells persisted throughout the cell cycle, and resulted in the expression of gamma-H2AX foci on the mitotic chromosomes. These mitotic expressions of damage after gamma-irradiation of G1 or G2 phase cells were compared i...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章


    authors: Kato TA,Okayasu R,Bedford JS

    更新日期:2009-06-01 00:00:00

  • Mitochondrial activity regulates myoblast differentiation by control of c-Myc expression.

    abstract::We have previously shown that mitochondrial activity is an important regulator of myoblast differentiation, partly through processes targeting myogenin expression. Here, we investigated the possible involvement of c-myc in these processes. Inhibition of mitochondrial activity by chloramphenicol abrogated the decrease ...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章


    authors: Seyer P,Grandemange S,Busson M,Carazo A,Gamaléri F,Pessemesse L,Casas F,Cabello G,Wrutniak-Cabello C

    更新日期:2006-04-01 00:00:00

  • Spindle pole fragmentation due to proteasome inhibition.

    abstract::During interphase, the centrosome concentrates cell stress response molecules, including chaperones and proteasomes, into a proteolytic center. However, whether the centrosome functions as proteolytic center during mitosis is not known. In this study, cultured mammalian cells were treated with the proteasome inhibitor...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章


    authors: Ehrhardt AG,Sluder G

    更新日期:2005-09-01 00:00:00

  • Functional alpha1- and beta2-adrenergic receptors in human osteoblasts.

    abstract::Central (hypothalamic) control of bone mass is proposed to be mediated through beta2-adrenergic receptors (beta2-ARs). While investigations in mouse bone cells suggest that epinephrine enhances both RANKL and OPG mRNA via both beta-ARs and alpha-ARs, whether alpha-ARs are expressed in human bone cells is controversial...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章


    authors: Huang HH,Brennan TC,Muir MM,Mason RS

    更新日期:2009-07-01 00:00:00

  • Apoptosis of human erythroid colony-forming cells is decreased by stem cell factor and insulin-like growth factor I as well as erythropoietin.

    abstract::To clarify the manner by which erythropoietin (EP), stem cell factor (SCF), or insulin-like growth factor I (IGF-I) regulate erythropoiesis, apoptosis of human erythroid progenitor cells was investigated. Human burst-forming units-erythroid (BFU-E) partially purified from peripheral blood were cultured for 6 days to g...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章


    authors: Muta K,Krantz SB

    更新日期:1993-08-01 00:00:00

  • Inhibition of chemotactic factor-induced neutrophil responsiveness by arachidonic acid.

    abstract::Arachidonic acid when added simultaneously with the chemotactic peptide formyl-methionyl-leucyl-phenylalanine (f-Met-Leu-Phe) inhibits the ability of the latter to initiate several but not all of its effects on rabbit peritoneal neutrophils. Stimulated neutrophil aggregation, calcium uptake, and increases in the stead...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章


    authors: Naccache PH,Molski TF,Volpi M,Mackin WM,Becker EL,Sha'afi RI

    更新日期:1983-06-01 00:00:00

  • Restoration of miR-152 expression suppresses cell proliferation, survival, and migration through inhibition of AKT-ERK pathway in colorectal cancer.

    abstract:BACKGROUND:MiR-152 has been reported as a tumor suppressor microRNA that is downregulated in a number of cancers, including colorectal cancer (CRC). A recent study suggested that miR-152 could be one of the key regulators of CRC. The aim of this study is to investigate the role of miR-152 in CRC and its mechanisms. ME...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章


    authors: Ghazanchaei A,Mansoori B,Mohammadi A,Biglari A,Baradaran B

    更新日期:2018-01-01 00:00:00

  • Transient receptor potential vanilloid 4 channel deletion regulates pathological but not developmental retinal angiogenesis.

    abstract::Transient receptor potential vanilloid 4 (TRPV4) channels are mechanosensitive ion channels that regulate systemic endothelial cell (EC) functions such as vasodilation, permeability, and angiogenesis. TRPV4 is expressed in retinal ganglion cells, Müller glia, pigment epithelium, microvascular ECs, and modulates cell v...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章


    authors: Cappelli HC,Guarino BD,Kanugula AK,Adapala RK,Perera V,Smith MA,Paruchuri S,Thodeti CK

    更新日期:2020-10-20 00:00:00

  • miR-497a-5p attenuates lipopolysaccharide-induced inflammatory injury by targeting IRAK2.

    abstract::Acute lung injury (ALI) is a severe acute inflammatory reaction of the lungs caused by a variety of factors, which can lead to a high mortality rate. MicroRNAs are a novel therapeutic molecule that play a vital role in many diseases. However, its mechanism of action in lipopolysaccharide (LPS)-induced mouse ALI is not...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章


    authors: Guo S,Chen Y,Liu J,Yang J,Yang C,Zhang T,Jiang K,Wu Z,Shaukat A,Deng G

    更新日期:2019-12-01 00:00:00

  • Acute L-glutamine deprivation compromises VEGF-a upregulation in A549/8 human carcinoma cells.

    abstract::Tumor ischemia participates in angiogenesis and cancer progression through cellular responses to hypoxia and nutrient deprivation. However, the contribution of amino acids limitation to this process remains poorly understood. Using serum-free cell culture conditions, we tested the impact of L-glutamine deprivation on ...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章


    authors: Drogat B,Bouchecareilh M,North S,Petibois C,Déléris G,Chevet E,Bikfalvi A,Moenner M

    更新日期:2007-08-01 00:00:00