Length-dependence of isometric twitch tension potentiation and myosin phosphorylation in mouse skeletal muscle.

Abstract:

:The effect of changes in muscle length on post-tetanic isometric twitch tension potentiation and myosin P-light chain phosphorylation was studied at 23 degrees C in the mouse extensor digitorum longus muscle. The length-tension relationship was determined for the same muscles after a 30 min period of quiescence and between 30 s and 3 min after a 1.5 s tetanus at L0. Isometric twitch tension is increased at all muscle lengths after the tetanus; however, the fractional increase in twitch tension rises from 0.2 at L0 to a maximum of 0.3 at 1.2 L0. The fractional increase in twitch tension measured at any fixed muscle length is constant between 30 s and 3 min post-tetanus. P-light chain phosphorylation remains constant between 30 s and 3 min post-tetanus followed by a slow decline to basal values. Under fixed length conditions, there is linear relationship between the relative magnitude of the twitch tension and the extent of P-light chain phosphorylation. Net myosin phosphorylation measured after a 1.5 s tetanus at 1.23 L0 is 35% less than that obtained under the same conditions at L0. Thus, contraction-induced phosphorylation of P-light chain decreases with increased muscle length and post-tetanic potentiation at a constant level of P-light chain phosphorylation increases with increasing muscle length. These observations may be consistent with alterations in the sarcoplasmic Ca2+ ion transient as the muscle is lengthened.

journal_name

J Cell Physiol

authors

Moore RL,Persechini A

doi

10.1002/jcp.1041430209

subject

Has Abstract

pub_date

1990-05-01 00:00:00

pages

257-62

issue

2

eissn

0021-9541

issn

1097-4652

journal_volume

143

pub_type

杂志文章
  • Ursolic acid ameliorates CCl4-induced liver fibrosis through the NOXs/ROS pathway.

    abstract::Liver fibrosis is a reversible wound-healing response that occurs after liver injury. NADPH oxidases (NOXs) and reactive oxygen species (ROS) which are expressed in hepatocytes (HCs), hepatic stellate cells (HSCs), and Kupffer cells (KCs) play an important role in the development of hepatic fibrosis. In in vitro studi...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章

    doi:10.1002/jcp.26541

    authors: Gan D,Zhang W,Huang C,Chen J,He W,Wang A,Li B,Zhu X

    更新日期:2018-10-01 00:00:00

  • Establishment and characterization of a telomerase-immortalized porcine bronchial epithelial cell line.

    abstract::Primary porcine bronchial epithelial cells (PBECs) are an ideal model to study the molecular and pathogenic mechanisms of various porcine respiratory pathogens. However, the short lifespan of primary PBECs greatly limit their application. Here, we isolated and cultured primary PBECs and established immortalized PBECs ...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章

    doi:10.1002/jcp.26942

    authors: Xie X,Gan Y,Pang M,Shao G,Zhang L,Liu B,Xu Q,Wang H,Feng Y,Yu Y,Chen R,Wu M,Zhang Z,Hua L,Xiong Q,Liu M,Feng Z

    更新日期:2018-12-01 00:00:00

  • Contributions of 3D Cell Cultures for Cancer Research.

    abstract::Cancer cell lines have contributed immensely in understanding the complex physiology of cancers. They are excellent material for studies as they offer homogenous samples without individual variations and can be utilised with ease and flexibility. Also, the number of assays and end-points one can study is almost limitl...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章,评审

    doi:10.1002/jcp.25664

    authors: Ravi M,Ramesh A,Pattabhi A

    更新日期:2017-10-01 00:00:00

  • Transcriptional regulation of Rex1 (zfp42) in normal prostate epithelial cells and prostate cancer cells.

    abstract::Rex1 (zfp42) was identified by our laboratory because of its reduced expression in F9 teratocarcinoma stem cells after retinoic acid (RA) treatment. The Rex1 (Zfp42) gene is currently widely used as a marker of embryonic stem cells. We compared the transcriptional regulation of the human Rex1 gene in NTera-2 (NT-2) hu...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章

    doi:10.1002/jcp.22071

    authors: Lee MY,Lu A,Gudas LJ

    更新日期:2010-07-01 00:00:00

  • Sulfated malto-oligosaccharides bind to basic FGF, inhibit endothelial cell proliferation, and disrupt endothelial cell tube formation.

    abstract::The interaction of basic FGF (bFGF) with heparin, heparan sulfate and related sugars can potentiate or antagonize bFGF activity, depending on the size of the saccharide used. Oligosaccharides based on heparin structures, as small as six sugar residues, have been demonstrated to bind to bFGF and block its activity, whi...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章

    doi:10.1002/(SICI)1097-4652(199609)168:3<657::AID-JCP1

    authors: Foxall C,Wei Z,Schaefer ME,Casabonne M,Fugedi P,Peto C,Castellot JJ Jr,Brandley BK

    更新日期:1996-09-01 00:00:00

  • Emerging insights into molecular mechanisms underlying pyroptosis and functions of inflammasomes in diseases.

    abstract::Pyroptosis is a form of necrotic and inflammatory programmed cell death, which could be characterized by cell swelling, pore formation on plasma membranes, and release of proinflammatory cytokines (IL-1β and IL-18). The process of pyroptosis presents as dual effects: protecting multicellular organisms from microbial i...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章,评审

    doi:10.1002/jcp.29268

    authors: Lu F,Lan Z,Xin Z,He C,Guo Z,Xia X,Hu T

    更新日期:2020-04-01 00:00:00

  • All-trans retinoic acid blocks the antiproliferative prodifferentiating actions of 1,25-dihydroxyvitamin D3 in normal human keratinocytes.

    abstract::1,25-Dihydroxyvitamin D3 [1,25(OH)2D3] and all-trans retinoic acid (RA), the active metabolites of vitamins D and A respectively, regulate the proliferation and differentiation of keratinocytes. Both the vitamin D receptor (VDR) and the retinoic acid receptor family (RAR) bind to DNA response elements as heterodimers ...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章

    doi:10.1002/(SICI)1097-4652(199801)174:1<1::AID-JCP1>3

    authors: Gibson DF,Bikle DD,Harris J

    更新日期:1998-01-01 00:00:00

  • Activated ERK/FOXM1 pathway by low-power laser irradiation inhibits UVB-induced senescence through down-regulating p21 expression.

    abstract::Cellular senescence is a growth-arrest program that limits cell proliferation. Low-power laser irradiation (LPLI) has been demonstrated to promote cell proliferation. However, whether LPLI can inhibit cellular senescence remains unknown. In the present study, to investigate the functional role of LPLI against skin agi...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章

    doi:10.1002/jcp.24425

    authors: Ling Q,Meng C,Chen Q,Xing D

    更新日期:2014-01-01 00:00:00

  • Cell cycle dependent gene expression in quiescent stimulated and asynchronously cycling arterial smooth muscle cells in culture.

    abstract::The expression of a set of cell cycle dependent (CCD) genes (c-fos, c-myc, ornithine decarboxylase (ODC), and thymidine kinase (TK)) was comparatively studied in cultured arterial smooth muscle cells (SMC) during exit from quiescence and exponential proliferation. These genes, which were not expressed in quiescent SMC...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章

    doi:10.1002/jcp.1041500309

    authors: Campan M,Desgranges C,Gadeau AP,Millet D,Belloc F

    更新日期:1992-03-01 00:00:00

  • The half-lives of platelet-derived growth factor A- and B-chain mRNAs are similar in endothelial cells and unaffected by heparin-binding growth factor-1 or cycloheximide.

    abstract::Platelet-derived growth factor (PDGF) is mitogenic and chemotactic for vascular smooth muscle cells cultured in vitro, and, thus, may play a role in the smooth muscle cell proliferation and migration that occurs during atherosclerotic lesion development. Two related PDGF polypeptides, designated as the A and B chains,...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章

    doi:10.1002/jcp.1041470116

    authors: Gay CG,Winkles JA

    更新日期:1991-04-01 00:00:00

  • Regulation of albumin expression in fetal rat hepatocytes cultured under proliferative conditions: role of epidermal growth factor and hormones.

    abstract::Sustained production of plasma proteins, notably albumin, is a reliable indicator of the differentiated state of hepatocytes. In this work, we have developed a fetal hepatocyte culture system where studying the regulation of albumin expression in proliferating liver cells. Our results show that under proliferative con...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章

    doi:10.1002/jcp.1041520113

    authors: de Juan C,Benito M,Fabregat I

    更新日期:1992-07-01 00:00:00

  • Protein tyrosine phosphorylation and calcium signaling in thyroid FRTL-5 cells.

    abstract::We examined the importance of tyrosine kinase(s) on the ATP-evoked Ca2+ entry and DNA synthesis of thyroid FRTL-5 cells. ATP rapidly and transiently tyrosine phosphorylated a 72-kDa protein(s). This phosphorylation was abolished by pertussis toxin and by the tyrosine kinase inhibitor genistein, and was dependent on Ca...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章

    doi:10.1002/(SICI)1097-4652(199805)175:2<211::AID-JCP1

    authors: Törnquist K,Dugué B,Ekokoski E

    更新日期:1998-05-01 00:00:00

  • ERalpha and AP-1 interact in vivo with a specific sequence of the F promoter of the human ERalpha gene in osteoblasts.

    abstract::Estrogen-responsive genes often have an estrogen response element (ERE) positioned next to activator protein-1 (AP-1) binding sites. Considering that the interaction between ERE and AP-1 elements has been described for the modulation of bone-specific genes, we investigated the 17-beta-estradiol responsiveness and the ...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章

    doi:10.1002/jcp.21379

    authors: Lambertini E,Tavanti E,Torreggiani E,Penolazzi L,Gambari R,Piva R

    更新日期:2008-07-01 00:00:00

  • Evidence for variation in the number of functional gene copies at the AmaR locus in Chinese hamster cell lines.

    abstract::The hypothesis of functional hemizygosity has been examined for the alpha-amanitin resistant (AmaR, a codominant marker) locus in a series of Chinese hamster cell lines. AmaR mutants were obtained from different cell lines, e.g., CHO, DHW, M3- 1 and CHO-Kl, at similar frequencies. After fractionation of different RNA ...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章

    doi:10.1002/jcp.1040970321

    authors: Gupta RS,Chan DY,Siminovitch L

    更新日期:1978-12-01 00:00:00

  • Overexpression of the type-1 insulin-like growth factor receptor increases ligand-dependent proliferation and differentiation in bovine skeletal myogenic cultures.

    abstract::Previous studies demonstrated that overexpression of the type-1 insulin-like growth factor (IGF) receptor (IGF-1R) in skeletal myogenic cell lines increased proliferation and differentiation responses to IGF. However, it was unclear if such manipulations in primary, untransformed skeletal myogenic cells would result i...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章

    doi:10.1002/(SICI)1097-4652(199607)168:1<34::AID-JCP5>

    authors: Quinn LS,Haugk KL

    更新日期:1996-07-01 00:00:00

  • SIRT1 interacts with p73 and suppresses p73-dependent transcriptional activity.

    abstract::The tumor suppressor p53-related p73 shares significant amino-acid sequence identity with p53. Like p53, p73 recognizes canonical p53 DNA-binding sites and activates p53-responsive target genes and induces apoptosis. Moreover, SIRT1 binds to p53 while repressing the expression of their target genes. Here, we report th...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章

    doi:10.1002/jcp.20831

    authors: Dai JM,Wang ZY,Sun DC,Lin RX,Wang SQ

    更新日期:2007-01-01 00:00:00

  • Fetuin and alpha-2HS glycoprotein induce alkaline phosphatase in epiphyseal growth plate chondrocytes.

    abstract::A previously described chondrocyte alkaline phosphatase induction factor (CAP-IF) for chicken epiphyseal growth plate chondrocytes has been purified to SDS-PAGE homogeneity from fetal bovine serum by ammonium sulfate precipitation and by dye-ligand affinity (Affi-Gel Blue and Reactive Green-19 agarose) and hydroxyapat...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章

    doi:10.1002/jcp.1041490208

    authors: Ishikawa Y,Wu LN,Valhmu WB,Wuthier RE

    更新日期:1991-11-01 00:00:00

  • Epoxyeicosatrienoic acids activate Na+/H+ exchange and are mitogenic in cultured rat glomerular mesangial cells.

    abstract::The present study examined responses of cultured rat glomerular mesangial cells to exogenous exposure of epoxyeicosatrienoic acids (EET's), products of cytochrome P450 epoxygenase. One day after administration of 8,9- or 14,15-EET, cultured rat mesangial cells demonstrated significant increases in [3H]thymidine incorp...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章

    doi:10.1002/jcp.1041440310

    authors: Harris RC,Homma T,Jacobson HR,Capdevila J

    更新日期:1990-09-01 00:00:00

  • Impaired secretion and increased insolubilization of IgE-receptor complexes in mycophenolic acid-treated (guanine nucleotide-depleted) RBL-2H3 mast cells.

    abstract::In RBL-2H3 rat leukemic mast cells, cross-linking anti-DNP IgE-receptor complexes with multivalent antigen (DNP-BSA) activates a signal transduction pathway leading to Ca2+ influx and secretion. Cross-linking IgE-receptor complexes also stimulates a pathway that inactivates (desensitizes) receptors; this pathway becom...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章

    doi:10.1002/jcp.1041490307

    authors: Wilson BS,Seagrave J,Oliver JM

    更新日期:1991-12-01 00:00:00

  • Enhanced transbilayer mobility of phospholipids in malaria-infected monkey erythrocytes: a spin-label study.

    abstract::Using a recently described technique of electron spin resonance spectroscopy, we determined the rate of transbilayer mobility (flip) of the four major simian-erythrocyte phospholipids in the erythrocyte membrane after infection by Plasmodium knowlesi. The development of the malarial parasite induces a very large incre...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章

    doi:10.1002/jcp.1041350113

    authors: Beaumelle BD,Vial HJ,Bienvenüe A

    更新日期:1988-04-01 00:00:00

  • Coordinated Dynamics of RNA Splicing Speckles in the Nucleus.

    abstract::Despite being densely packed with chromatin, nuclear bodies and a nucleoskeletal network, the nucleus is a remarkably dynamic organelle. Chromatin loops form and relax, RNA transcripts and transcription factors move diffusively, and nuclear bodies move. We show here that RNA splicing speckled domains (splicing speckle...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章

    doi:10.1002/jcp.25224

    authors: Zhang Q,Kota KP,Alam SG,Nickerson JA,Dickinson RB,Lele TP

    更新日期:2016-06-01 00:00:00

  • Abnormal behavior of cultured fibroblasts from nodule and nonaffected aponeurosis of Dupuytren's disease.

    abstract::Vimentin-positive, desmin-negative cells were established in culture from the nodule and from apparently normal palmar aponeurosis of a patient with Dupuytren's disease and compared with normal human embryonic and adult fibroblasts or sarcomatous cells. Cells from the nodule display in vitro biological properties that...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章

    doi:10.1002/jcp.1041170310

    authors: Azzarone B,Failly-Crepin C,Daya-Grosjean L,Chaponnier C,Gabbiani G

    更新日期:1983-12-01 00:00:00

  • Critical role for intracellular calcium in tight junction biogenesis.

    abstract::Using the Madin Darby canine kidney (MDCK) cell "calcium switch," we have previously demonstrated that, as MDCK cells establish contact and ultimately form tight junctions, there are marked global and localized changes in intracellular calcium at the sites of cell-cell contact (Nigam et al., 1992, Proc. Natl. Acad. Sc...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章

    doi:10.1002/jcp.1041590306

    authors: Stuart RO,Sun A,Panichas M,Hebert SC,Brenner BM,Nigam SK

    更新日期:1994-06-01 00:00:00

  • Gene expression fluctuations in murine hematopoietic stem cells with cell cycle progression.

    abstract::Evolving data suggest that marrow hematopoietic stem cells show reversible changes in homing, engraftment, and differentiation phenotype with cell cycle progression. Furthermore, marrow stem cells are a cycling population. Traditional concepts hold that the system is hierarchical, but the information on the lability o...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章

    doi:10.1002/jcp.21273

    authors: Dooner GJ,Colvin GA,Dooner MS,Johnson KW,Quesenberry PJ

    更新日期:2008-03-01 00:00:00

  • Temporal studies on the tissue compartmentalization of bone sialoprotein (BSP), osteopontin (OPN), and SPARC protein during bone formation in vitro.

    abstract::To study the role of noncollagenous proteins in bone formation, the synthesis and tissue distribution of BSP (bone sialoprotein), OPN (osteopontin) and SPARC (secreted protein acidic and rich in cysteine) were analyzed using pulse-chase and continuous labeling protocols during bone formation by cultures of rat calvari...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章

    doi:10.1002/jcp.1041520305

    authors: Kasugai S,Nagata T,Sodek J

    更新日期:1992-09-01 00:00:00

  • Unexpected regulation pattern of the IKKβ/NF-κB/MuRF1 pathway with remarkable muscle plasticity in the Daurian ground squirrel (Spermophilus dauricus).

    abstract::As a typical hibernator, the Daurian ground squirrel (Spermophilus dauricus) spends considerable time in a state of reduced activity with prolonged fasting. Despite this, they experience little muscle atrophy and have thus become an interesting anti-disuse muscle atrophy model. The IKKβ/NF-κB signaling pathway is sign...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章

    doi:10.1002/jcp.26751

    authors: Wei Y,Gong L,Fu W,Xu S,Wang Z,Zhang J,Ning E,Chang H,Wang H,Gao Y

    更新日期:2018-11-01 00:00:00

  • Biological roles of glial fibrillary acidic protein as a biomarker in cartilage regenerative medicine.

    abstract::Glial fibrillary acidic protein (GFAP) is an intermediate filament that is expressed in specifically expressed auricular chondrocytes, which are good cell sources of cartilage regenerative medicine. Although our group uses GFAP as a biomarker of matrix production in the cultured auricular chondrocytes, the biological ...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章

    doi:10.1002/jcp.25771

    authors: Kanazawa S,Nishizawa S,Takato T,Hoshi K

    更新日期:2017-11-01 00:00:00

  • miR-497a-5p attenuates lipopolysaccharide-induced inflammatory injury by targeting IRAK2.

    abstract::Acute lung injury (ALI) is a severe acute inflammatory reaction of the lungs caused by a variety of factors, which can lead to a high mortality rate. MicroRNAs are a novel therapeutic molecule that play a vital role in many diseases. However, its mechanism of action in lipopolysaccharide (LPS)-induced mouse ALI is not...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章

    doi:10.1002/jcp.28850

    authors: Guo S,Chen Y,Liu J,Yang J,Yang C,Zhang T,Jiang K,Wu Z,Shaukat A,Deng G

    更新日期:2019-12-01 00:00:00

  • Platelet-derived growth factor: morphologic and biochemical studies of binding, internalization, and degradation.

    abstract::Kinetic studies of binding and internalization of 125I-platelet-derived growth factor (PDGF) demonstrate that up to 15% of membrane-associated radioactivity is internalized within 2 minutes after warming to 37 degrees C in a variety of cell types. The T 1/2 for internalization is approximately 20 minutes. The T 1/2 fo...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章

    doi:10.1002/jcp.1041210202

    authors: Rosenfeld ME,Bowen-Pope DF,Ross R

    更新日期:1984-11-01 00:00:00

  • MicroRNA-140-5p targeting tumor necrosis factor-α prevents pulmonary arterial hypertension.

    abstract:BACKGROUND:Pulmonary arterial hypertension (PAH) is characterized by the apoptosis resistance and hyperproliferation of pulmonary artery smooth muscle cells (PASMCs). Its pathogenesis has not been revealed. Here, we carried out experiments to investigate the functions of miR-140-5p and tumor necrosis factor-α (TNF-α). ...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章

    doi:10.1002/jcp.27642

    authors: Zhu TT,Zhang WF,Yin YL,Liu YH,Song P,Xu J,Zhang MX,Li P

    更新日期:2019-06-01 00:00:00