EGF-induced ERK-activation downstream of FAK requires rac1-NADPH oxidase.

abstract：:Mycoplasmas are bacteria lacking the cell wall, which is the major characteristic of this taxonomic class (Mollicutes). Among bacteria, mycoplasmas possess the smallest genome known for free-living organisms. This feature limits the autonomy of bacteria and makes them increasingly susceptible to changes in the host or...

journal_title：Journal of cellular physiology

authors： Borchsenius SN,Daks A,Fedorova O,Chernova O,Barlev NA

更新日期：2018-01-01 00:00:00

abstract：:Tobacco smoking is associated with many diseases. Addiction is of the most notorious tobacco-related syndrome and is mainly attributed to nicotine. In this study, we employed Caenorhabditis elegans as a biological model to systemically investigate the effect of chronic nicotine exposure on microRNA (miRNA) expression ...

journal_title：Journal of cellular physiology

authors： Taki FA,Pan X,Zhang B

更新日期：2014-01-01 00:00:00

abstract：:Nucleotides released during heart injury affect myocardium electrophysiology and remodeling through P2 purinoceptors activation in cardiac myofibroblasts. ATP and UTP endorse [Ca2+ ]i accumulation and growth of DDR-2/α-SMA-expressing myofibroblasts from adult rat ventricles via P2Y4 and P2Y2 receptors activation, resp...

journal_title：Journal of cellular physiology

authors： Certal M,Vinhas A,Barros-Barbosa A,Ferreirinha F,Costa MA,Correia-de-Sá P

更新日期：2017-06-01 00:00:00

abstract：:TRPV4 (transient receptor potential vanilloid 4) is a cation channel activated by hypotonicity, moderate heat, or shear stress. We describe the expression of TRPV4 during the differentiation of a corneal epithelial cell model, RCE1(5T5) cells. TRPV4 is a late differentiation feature that is concentrated in the apical ...

journal_title：Journal of cellular physiology

authors： Martínez-Rendón J,Sánchez-Guzmán E,Rueda A,González J,Gulias-Cañizo R,Aquino-Jarquín G,Castro-Muñozledo F,García-Villegas R

更新日期：2017-07-01 00:00:00

abstract：:The purpose of this study was to delineate the traffic patterns of EGF and EGF receptors (EGFR) in primary cultured acinar epithelial cells from rabbit lacrimal glands. Uptake of [(125)I]-EGF exhibited saturable and non-saturable, temperature-dependent components, suggesting both receptor-mediated and fluid phase endo...

journal_title：Journal of cellular physiology

authors： Xie J,Qian L,Wang Y,Rose CM,Yang T,Nakamura T,Hamm-Alvarez SF,Mircheff AK

更新日期：2004-04-01 00:00:00

abstract：:The release of vasodilating substances from the vascular endothelium has been postulated to depend on a rise in the level of intracellular free calcium (Cai++). We measured Cai++ in intact monolayers of calf endothelial cells, grown in culture, that were loaded with the fluorescent calcium indicator quin 2. Fluorescen...

journal_title：Journal of cellular physiology

authors： Lückhoff A,Busse R

更新日期：1986-03-01 00:00:00

abstract：:Thioredoxin reductase (TrxR) is a flavoprotein that contains a C-terminal penultimate selenocysteine (Sec) and has an ability to reduce thioredoxin (Trx), which regulates the activity of NF-kappa B. To date, three TrxR isozymes, TrxR1, TrxR2, and TrxR3, have been identified. In the present study, we found that among t...

journal_title：Journal of cellular physiology

authors： Sakurai A,Yuasa K,Shoji Y,Himeno S,Tsujimoto M,Kunimoto M,Imura N,Hara S

更新日期：2004-01-01 00:00:00

abstract：:In quiescent human fibroblasts stimulated to proliferate by fresh medium plus 15% serum, no changes were seen in the incorporation of 3H tryptophan into the protein of nuclear ribonucleoprotein during the first three hours following re-feeding. This was in contrast to non-histone chromosomal proteins where the incorpo...

journal_title：Journal of cellular physiology

authors： Augenlicht LH,Lipkin M

更新日期：1977-07-01 00:00:00

abstract：:Transforming growth factor-beta (TGF-beta) signaling in endothelial cells is able to modulate angiogenesis and vascular remodeling, although the underlying molecular mechanisms remain poorly understood. Endoglin and ALK-1 are components of the TGF-beta receptor complex, predominantly expressed in endothelial cells, an...

journal_title：Journal of cellular physiology

authors： Blanco FJ,Santibanez JF,Guerrero-Esteo M,Langa C,Vary CP,Bernabeu C

更新日期：2005-08-01 00:00:00

abstract：:The cellular basis of the membrane-limited state of glucose utilization and the mechanism of the endogenous regulation of hexose uptake in dense monolayers of C6 glioma cells were investigated. In an earlier study, it was shown that at high rates of glucose transport and phosphorylation combined with the inhibition of...

journal_title：Journal of cellular physiology

authors： Lange K,Brandt U,Keller K,Zimmermann B

更新日期：1989-07-01 00:00:00

abstract：:We have previously reported that the proliferation of cloned MCF-7 and T47D human mammary tumor cells can be inhibited by increasing concentrations of charcoal-dextran stripped female human serum (CDFHS). The maximal proliferation rate was restored by the addition of 3 X 10(-11) M estradiol-17 beta to the culture medi...

journal_title：Journal of cellular physiology

authors： Schatz RW,Soto AM,Sonnenschein C

更新日期：1985-09-01 00:00:00

abstract：:An imbalance between matrix synthesis and degradation is the hallmark of intervertebral disc degeneration while inflammatory cytokines contribute to the imbalance. Bromodomain and extra-terminal domain (BET) family is associated with the pathogenesis of inflammation, and inhibition of BRD4, a vital member of BET famil...

journal_title：Journal of cellular physiology

authors： Hong J,Li S,Markova DZ,Liang A,Kepler CK,Huang Y,Zhou J,Yan J,Chen W,Huang D,Xu K,Ye W

更新日期：2020-07-01 00:00:00

abstract：:Galectins play key roles in the inflammatory cascade. In this study, we aimed to analyze the effect of galectin-1 (Gal-1) in the function of intestinal epithelial cells (IECs) isolated from healthy and inflamed mucosa. IECs isolated from mice or patients with inflammatory bowel diseases (IBD) were incubated with diffe...

journal_title：Journal of cellular physiology

authors： Muglia CI,Gobbi RP,Smaldini P,Delgado ML,Candia M,Zanuzzi C,Sambuelli A,Rocca A,Toscano MA,Rabinovich GA,Docena GH

更新日期：2016-07-01 00:00:00

abstract：:Pulmonary fibrosis is a potentially fatal consequence of treatments for malignancy and is an increasing problem in bone marrow transplant patients and in cases of allogenic lung transplant. The fibrotic response is characterized by increases in lung fibroblast number and collagen synthesis. This laboratory previously ...

journal_title：Journal of cellular physiology

authors： Sempowski GD,Derdak S,Phipps RP

更新日期：1996-05-01 00:00:00

abstract：:Lung cancer (LC) is the leading cause of cancer-related deaths all over the world, among both men and women, with an incidence of over 200,000 new cases per year coupled with a very high mortality rate. LC comprises of two major clinicopathological categories: small-cell (SCLC) and nonsmall-cell lung carcinoma (NSCLC)...

journal_title：Journal of cellular physiology

authors： Uddin A,Chakraborty S

更新日期：2018-04-20 00:00:00

abstract：:We investigated the role of mammalian target of rapamycin/nuclear factor-kappa B (mTOR/NF-κB) signaling pathway in high thoracic epidural anesthesia (HTEA) against myocardial ischemia-reperfusion (I/R) injury in rats. The rat model of myocardial I/R injury was established. Ninety rats were divided into the normal, sha...

journal_title：Journal of cellular physiology

authors： Huang WQ,Wen JL,Lin RQ,Wei P,Huang F

更新日期：2018-09-01 00:00:00

abstract：:Retinopathy has become one of the major factors that lead to blindness worldwide. Although many clinical therapies are concerned about such disease, most of them focus on symptoms alleviation. In this study, we aim to investigate whether coculture retinal stem cells (RSCs) with bone marrow mesenchymal stem cells trans...

journal_title：Journal of cellular physiology

authors： Ma QQ,Liu FY,Shi M,Sun CH,Tan Z,Chang XD,Li QP,Feng ZC

更新日期：2019-11-01 00:00:00

abstract：:Aberrations of DNA methylation are early events in the development of tumors. In this study, we investigated the DNA methylation status of growth hormone secretagogue receptor (GHSR), a promising pan-cancer biomarker, in gastric cancer (GC). Initially, data sets from DNA methylation and gene expression studies availab...

journal_title：Journal of cellular physiology

authors： Amini M,Foroughi K,Talebi F,Aghagolzade Haji H,Kamali F,Jandaghi P,Hoheisel JD,Manoochehri M

更新日期：2019-01-24 00:00:00

abstract：:The specific activity of a peroxisomal enzyme, lactate oxidase, and of pyruvate kinase and lactate dehydrogenase, which are not peroxisomal, increased rapidly when shaken cultures of Tetrahymena were transferred to conditions of oxygen restriction and supplemented with glucose. Two other peroxisomal enzymes, catalase ...

journal_title：Journal of cellular physiology

authors： Levy MR

更新日期：1975-02-01 00:00:00

abstract：:The differentiation of mesenchymal stem cells (MSCs) into type II alveolar epithelial (AT II) cells in vivo and in vitro, is critical for reepithelization and recovery in acute lung injury (ALI), but the mechanisms responsible for differentiation are unclear. In the present study, we investigated the role of the canon...

journal_title：Journal of cellular physiology

authors： Liu AR,Liu L,Chen S,Yang Y,Zhao HJ,Liu L,Guo FM,Lu XM,Qiu HB

更新日期：2013-06-01 00:00:00

abstract：:Insufficient invasion ability of trophoblasts might be associated with the development of recurrent miscarriage (RM). Ubiquitin-specific protease 25 (USP25) can regulate the processes of invasion and migration in different types of cancer cells. However, the effect of USP25 on trophoblasts and its roles in the develop...

journal_title：Journal of cellular physiology

authors： Ding J,Cheng Y,Zhang Y,Liao S,Yin T,Yang J

更新日期：2019-11-01 00:00:00

abstract：:Arg8-vasopressin (AVP) is a potent inducer of myogenic differentiation stimulating the expression of myogenic regulatory factors. To understand the mechanism of its effect on myogenesis, we investigated the early signals induced by AVP in myogenic target cells. In the rat skeletal muscle cell line L6, AVP selectively ...

journal_title：Journal of cellular physiology

authors： Naro F,Donchenko V,Minotti S,Zolla L,Molinaro M,Adamo S

更新日期：1997-04-01 00:00:00

abstract：:The highly conserved homeodomains and HMG domains are components of a large number of proteins that play a role in the transcriptional regulation of gene expression during embryogenesis. Both the HMG domain and the homeodomain serve as interfaces for factor interactions with DNA, as well as with other proteins, and it...

journal_title：Journal of cellular physiology

authors： Dailey L,Basilico C

更新日期：2001-03-01 00:00:00

abstract：:Minute virus of mice (MVM), a non-defective parvovirus, has been shown to infect cultures of non-pluripotent differentiated teratocarcinoma-derived cells, but pluripotent (and "nullipotent") embryonal carcinoma cells derived from the same teratocarcinoma resist MVN infection. Somatic cell hybrids between an embryonal ...

journal_title：Journal of cellular physiology

authors： Miller RA,Ward DC,Ruddle FH

更新日期：1977-06-01 00:00:00

abstract：:Activated hepatic stellate cells promote hepatocellular carcinoma (HCC) progression. Hepatic stellate cells play a key role in retinoid metabolism, and activation of stellate cells increases retinoic acid (RA) in the liver. However, the role of RA in HCC proliferation remains unclear. We aimed to analyse the mechanism...

journal_title：Journal of cellular physiology

authors： Lin HH,Peng YJ,Tsai MJ,Wu YY,Tsai TN,Huang HH,Shih YL,Chang WK,Hsieh TY

更新日期：2020-02-01 00:00:00

abstract：:Sulfogalactosylglycerolipid (SGG) is the major mammalian male germ cell glycolipid and has been implicated in sperm/egg binding. Mycoplasma pulmonis, a species of Mollicutes, is associated with male infertility in rodents. Purified SGG incubated in the presence of M. pulmonis was enzymatically degraded by both desulfa...

journal_title：Journal of cellular physiology

authors： Lingwood C,Schramayr S,Quinn P

更新日期：1990-01-01 00:00:00

abstract：:Incubation of primary cultures of parenchymal hepatocytes in a conditioned medium (CM), collected over the first 3 h of serum-free rat hepatocyte culture (CM(0-3)), induces a time dependent increase of the frequency of apoptotic cells which is accompanied by prominent changes of cell morphology. Short-term treatment w...

journal_title：Journal of cellular physiology

authors： Bresgen N,Rolinek R,Hochleitner E,Lottspeich F,Eckl PM

更新日期：2004-03-01 00:00:00

abstract：:Control of the terminal event in cellular differentiation is an important normal regulatory process, and the expression of defects in the control of this process has been implicated in the pathogenesis of cancer. To determine if tumor necrosis factor (TNF), which is an important biological response modifier, can inhib...

journal_title：Journal of cellular physiology

authors： Filipak M,Sparks RL,Tzen CY,Scott RE

更新日期：1988-11-01 00:00:00

abstract：:BP3T3, a clonal benzo(a)pyrene-transformed BALB/c-3T3 cell line, is conditionally responsive to growth factor stimulation. Density arrested cell populations deprived of growth factors by pretreatment with 0.5% platelet-poor plasma synthesized DNA both in response to ng/ml concentrations of PDGF, EGF, and somatomedin C...

journal_title：Journal of cellular physiology

authors： Whipple AP,Furlanetto RW,Scher CD

更新日期：1987-02-01 00:00:00

abstract：:Neuroblastoma (NBL) exists in a complex tumor-immune microenvironment. Immune cell infiltration and tumor-immune molecules play a critical role in tumor development and significantly impact the prognosis of patients. However, the molecular characteristics describing the NBL-immune interaction and their prognostic pote...

journal_title：Journal of cellular physiology

authors： Jin W,Zhang Y,Liu Z,Che Z,Gao M,Peng H

更新日期：2021-01-01 00:00:00