Abstract：
:The Fontan operation has been nothing short of revolutionary in its influence on the modern management of patients born with functionally univentricular hearts. The vast majority of these individuals are now surviving well into adulthood. In the 45 years since its introduction, however, there has been increasing recognition of Fontan survivors as a vulnerable population with an altered physiology that has remarkably broad, adverse impact on their long-term health. In this review, the authors discuss the varied manifestations, both cardiac and extracardiac, of the failing Fontan circulation and potential therapeutic options. In addition, a general clinical approach to the patient presenting with Fontan failure is proposed. Ultimately, the key to improving our care and understanding of the Fontan population lies in multi-institutional collaboration and partnership between subspecialty cardiologists and specialists in other organ systems.
journal_name
Curr Cardiol Repjournal_title
Current cardiology reportsauthors
Elder RW,Wu FMdoi
10.1007/s11886-016-0716-ysubject
Has Abstractpub_date
2016-05-01 00:00:00pages
44issue
5eissn
1523-3782issn
1534-3170pii
10.1007/s11886-016-0716-yjournal_volume
18pub_type
杂志文章,评审abstract：PURPOSE OF REVIEW:To review the clinical evidence on the use of percutaneous coronary intervention (PCI) revascularization options in left main (LM) disease in comparison with coronary artery bypass graft (CABG). Coronary artery disease (CAD) involving the LM is associated with high morbidity and mortality. Though CABG...
journal_title：Current cardiology reports
pub_type： 杂志文章,评审
doi：10.1007/s11886-020-1268-8
更新日期：2020-02-08 00:00:00
abstract：:Cardiac resynchronization therapy has become part of the treatment strategy for advanced, symptomatic heart failure, but newly published trials show that more patients than previously realized may benefit from this therapy, including those with mild heart failure symptoms. The REVERSE and MADIT-CRT trials showed that ...
journal_title：Current cardiology reports
pub_type： 杂志文章,评审
doi：10.1007/s11886-010-0125-6
更新日期：2010-09-01 00:00:00
abstract：:Cardiovascular mortality continues to be high and events continue to occur in patients taking antiplatelet medications. Aspirin and clopidogrel have become integral parts of management in patients with coronary artery disease and after percutaneous angioplasty. However, the platelet responses to aspirin and clopidogre...
journal_title：Current cardiology reports
pub_type： 杂志文章,评审
doi：10.1007/s11886-005-0044-0
更新日期：2005-07-01 00:00:00
abstract：PURPOSE OF REVIEW:Interventional cardiology and in particular the field of renal denervation is subject to constant change. This review provides an up to date overview of renal denervation trials and an outlook on what to expect in the future. RECENT FINDINGS:After the sham-controlled SYMPLICITY HTN-3 trial dampened t...
journal_title：Current cardiology reports
pub_type： 杂志文章,评审
doi：10.1007/s11886-019-1164-2
更新日期：2019-07-05 00:00:00
abstract：PURPOSE OF REVIEW:This review summarises and discusses the epidemiological evidence suggesting a causal relationship between sleep duration and cardio-metabolic risk and outcomes in population. RECENT FINDINGS:Sleep duration is affected by a variety of cultural, social, psychological, behavioural, pathophysiological a...
journal_title：Current cardiology reports
pub_type： 杂志文章,评审
doi：10.1007/s11886-017-0916-0
更新日期：2017-09-19 00:00:00
abstract：:Low serum levels of high-density lipoprotein cholesterol (HDL-C) are highly prevalent and are recognized as an independent risk factor for cardiovascular morbidity (myocardial infarction, stroke, peripheral arterial disease, and restenosis after coronary stenting) and mortality. HDL plays an important role in modulati...
journal_title：Current cardiology reports
pub_type： 杂志文章,评审
doi：10.1007/s11886-008-0077-2
更新日期：2008-11-01 00:00:00
abstract：PURPOSE OF REVIEW:Coronary artery bypass grafting is a preferred strategy for complete coronary revascularization in patients who have multi-vessel coronary artery disease, left ventricular dysfunction, and/or diabetes. Both arterial (internal thoracic artery/radial artery) and venous grafts are utilized to bypass the ...
journal_title：Current cardiology reports
pub_type： 杂志文章,评审
doi：10.1007/s11886-019-1112-1
更新日期：2019-03-22 00:00:00
abstract：:Aldosterone is the principal circulating mineralocorticoid in humans, and aldosterone synthesis normally occurs in the face of volume depletion and renin stimulation. In primary and secondary aldosteronism, aldosterone synthesis continues despite volume expansion and causes hypertension. Other steroid hormones that ar...
journal_title：Current cardiology reports
pub_type： 杂志文章,评审
doi：10.1007/s11886-005-0059-6
更新日期：2005-11-01 00:00:00
abstract：PURPOSE OF REVIEW:The goal of this paper is to review present knowledge regarding biological pacemakers created by somatic reprogramming as a platform for mechanistic and metabolic understanding of the rare subpopulation of pacemaker cells, with the ultimate goal of creating biological alternatives to electronic pacing...
journal_title：Current cardiology reports
pub_type： 杂志文章,评审
doi：10.1007/s11886-020-01281-6
更新日期：2020-03-30 00:00:00
abstract：PURPOSE OF REVIEW:Angiotensin-converting enzyme inhibitors and angiotensin receptor blockers are commonly used anti-hypertensive medications in a number of clinical settings. They are often used interchangeably, but we pose the provocative question as to whether they should be. We review the literature to evaluate for ...
journal_title：Current cardiology reports
pub_type： 杂志文章,评审
doi：10.1007/s11886-020-01352-8
更新日期：2020-07-09 00:00:00
abstract：PURPOSE OF REVIEW:Cell therapy for cardiovascular diseases is regarded as a rapidly growing field within regenerative medicine. Different cellular populations enriched for cardiac progenitor cells (CPCs), or derivate a-cellular products, are currently under preclinical and clinical evaluation. Here, we have reviewed th...
journal_title：Current cardiology reports
pub_type： 杂志文章,评审
doi：10.1007/s11886-018-1031-6
更新日期：2018-08-13 00:00:00
abstract：:The prevalence of atrial fibrillation increases significantly with age, affecting nearly 10 % of adults greater than 80 years of age. Complications from atrial fibrillation, including stroke, also increase with age. Medical therapy includes anticoagulation, ventricular rate control, and if symptoms persist, maintenanc...
journal_title：Current cardiology reports
pub_type： 杂志文章,评审
doi：10.1007/s11886-013-0406-y
更新日期：2013-10-01 00:00:00
abstract：PURPOSE OF THE REVIEW:Atrial fibrillation (AF) is the most frequent arrhythmia in the general population. This review aims to provide a comprehensive overview of the psychological aspects of AF, compiling evidence from epidemiological, clinical, and basic research sources. RECENT FINDINGS:Findings from large-scale pop...
journal_title：Current cardiology reports
pub_type： 杂志文章,评审
doi：10.1007/s11886-020-01396-w
更新日期：2020-09-10 00:00:00
abstract：PURPOSE OF REVIEW:Congenital heart disease is the most common birth defect and acquired heart disease is the leading cause of death in adults. Understanding the mechanisms that drive cardiomyocyte proliferation and differentiation has the potential to advance the understanding and potentially the treatment of different...
journal_title：Current cardiology reports
pub_type： 杂志文章,评审
doi：10.1007/s11886-017-0826-1
更新日期：2017-02-01 00:00:00
abstract：:Device therapy for the treatment of uncontrolled and resistant hypertension has evolved significantly over the past several decades. Both renal artery disease and sympathetic hyperactivity have been linked to resistant hypertension. This manuscript will review the current evidence base supporting device therapy (e.g.,...
journal_title：Current cardiology reports
pub_type： 杂志文章,评审
doi：10.1007/s11886-014-0546-8
更新日期：2014-11-01 00:00:00
abstract：:Aortic valve replacement can produce dramatic benefit in the setting of aortic stenosis. The potential for morbidity and mortality associated with thoracotomy, cardiopulmonary bypass, and aortotomy has fostered a search for alternatives. Early experience with transcatheter endovascular aortic valve implantation demons...
journal_title：Current cardiology reports
pub_type： 杂志文章,评审
doi：10.1007/s11886-008-0019-z
更新日期：2008-03-01 00:00:00
abstract：:Periprocedural thromboembolic and hemorrhagic events are complications of percutaneous radiofrequency catheter ablation (RFA) of atrial fibrillation (AF). The management of anticoagulation before and after RFA could play an important role in the prevention of these complications. The incidence of thromboembolic events...
journal_title：Current cardiology reports
pub_type： 杂志文章,评审
doi：10.1007/s11886-010-0153-2
更新日期：2011-02-01 00:00:00
abstract：:Spontaneous coronary artery dissection is an important etiology of nonatherosclerotic acute coronary syndrome, myocardial infarction, and sudden death. Innovations in the catheterization laboratory including optical coherence tomography and intravascular ultrasound have enhanced the ability to visualize intimal disrup...
journal_title：Current cardiology reports
pub_type： 杂志文章,评审
doi：10.1007/s11886-016-0737-6
更新日期：2016-07-01 00:00:00
abstract：:Randomized clinical trials have established that lipid- lowering pharmacologic therapy can substantially reduce morbidity and mortality in patients with known coronary artery disease (CAD). Researchers are now working to define the role of lipid-lowering agents in the primary prevention of CAD to extend their benefit ...
journal_title：Current cardiology reports
pub_type： 杂志文章
doi：10.1007/s11886-000-0056-8
更新日期：2000-09-01 00:00:00
abstract：:On page 2 of the original publication, in the section on TTR Silencers dosing of patisiran in the APOLLO study was stated as being given every 3 months; this is inaccurate as patisiran was dosed every 3 weeks in the APOLLO study. ...
journal_title：Current cardiology reports
pub_type： 已发布勘误
doi：10.1007/s11886-020-01426-7
更新日期：2020-09-28 00:00:00
abstract：:Patients from racial and ethnic minorities experience higher mortality after cardiac surgery compared to white patients, both during the early postoperative phase as well as long term. A number of factors likely explain poor outcomes in black and minority patients, which include differences in biology, comorbid health...
journal_title：Current cardiology reports
pub_type： 杂志文章,评审
doi：10.1007/s11886-015-0587-7
更新日期：2015-05-01 00:00:00
abstract：:Although differences diminish with age, outcomes are overall worse for women compared to men who present with suspected acute coronary syndrome. The reasons for this discrepancy are multifactorial, including sex-related differences in atherosclerosis biology and fluid dynamics, as well as a premature conclusion by pro...
journal_title：Current cardiology reports
pub_type： 杂志文章,评审
doi：10.1007/s11886-016-0767-0
更新日期：2016-09-01 00:00:00
abstract：:Angiotensin-converting enzyme (ACE) inhibitors have become the cornerstone of therapy for congestive heart failure (CHF). Because ischemic heart disease is the most common cause of CHF, aspirin is frequently given concomitantly with ACE inhibitors in patients with CHF. Increased bradykinin levels, with the consequent ...
journal_title：Current cardiology reports
pub_type： 杂志文章,评审
doi：10.1007/s11886-001-0030-0
更新日期：2001-05-01 00:00:00
abstract：:The heart and kidney interact in terms of hemodynamics and neurohumoral regulatory mechanisms, and this helps to maintain circulatory homeostasis under normal conditions. However, the normal regulatory mechanisms become inappropriate in the setting of congestive heart failure (CHF), and significant renal dysfunction o...
journal_title：Current cardiology reports
pub_type： 杂志文章,评审
doi：10.1007/s11886-012-0258-x
更新日期：2012-06-01 00:00:00
abstract：:Sodium is an essential nutrient, mostly ingested as salt (sodium chloride). Average sodium intake ranges from 3 to 6 g per day (7.5-15 g/day of salt) in most countries, with regional variations. Increasing levels of sodium intake have a positive association with higher blood pressure. Randomized controlled trials repo...
journal_title：Current cardiology reports
pub_type： 杂志文章,评审
doi：10.1007/s11886-014-0529-9
更新日期：2014-01-01 00:00:00
abstract：:Advances in the field of molecular medicine are making gene therapy a viable treatment strategy for the next millennium. Indeed, over the past 10 years, a number of improvements have occurred that have resulted in an increased interest in gene therapy for the treatment of diseases in cardiovascular medicine. Because a...
journal_title：Current cardiology reports
pub_type： 杂志文章,评审
doi：10.1007/s11886-000-0023-4
更新日期：2000-01-01 00:00:00
abstract：:This review focuses on the use of bivalirudin as a replacement anticoagulant for heparin in patients undergoing percutaneous coronary intervention, or who are being treated for unstable angina pectoris, ST-elevation, or non-ST-elevation myocardial infarction. Potential advantages of bivalirudin include a lack of depen...
journal_title：Current cardiology reports
pub_type： 杂志文章,评审
doi：10.1007/s11886-001-0050-9
更新日期：2001-09-01 00:00:00
abstract：:Plasminogen activation potential in the blood is controlled by an equilibrium between plasminogen activators, mainly tissue-type plasminogen activator (t-PA), and inhibitors, mainly plasminogen activator inhibitor (PAI)-1. In cardiovascular practice, imbalance of this fibrinolytic potential is encountered primarily in...
journal_title：Current cardiology reports
pub_type： 杂志文章,评审
doi：10.1007/s11886-999-0069-x
更新日期：1999-07-01 00:00:00
abstract：:Systemic embolic complications in patients with cardiomyopathy are associated with significant morbidity and mortality. Despite the lack of prospective, randomized control data, the literature supports the use of left ventricular ejection fraction as an important determinant of the need for systemic anticoagulation th...
journal_title：Current cardiology reports
pub_type： 杂志文章,评审
doi：10.1007/s11886-000-0006-5
更新日期：2000-03-01 00:00:00
abstract：:Statins are first line therapy for the prevention of cardiovascular disease (CVD). Only 30 %-70 % of high risk patients will attain standard low-density lipoprotein cholesterol targets. Patients with familial hypercholesterolemia and genetic mixed hyperlipidemias do not meet goals with standard therapy. Patients with ...
journal_title：Current cardiology reports
pub_type： 杂志文章,评审
doi：10.1007/s11886-013-0391-1
更新日期：2013-08-01 00:00:00
