Mechanisms of Cardiomyocyte Proliferation and Differentiation in Development and Regeneration.

abstract：PURPOSE OF REVIEW:Cardiovascular disease is a leading cause of morbidity and mortality worldwide and is the focus of extensive biomedical research. Large genetic consortia combining data from many traditional prospective cohort and ascertained case-control study designs have facilitated the discovery of genetic associa...

journal_title：Current cardiology reports

authors： Small AM,O'Donnell CJ,Damrauer SM

更新日期：2018-03-08 00:00:00

abstract：:Basic and animal research implicate inflammatory mechanisms in the pathogenesis and progression of atherosclerosis, plaque rupture, thrombosis, and stroke. Inflammatory biomarkers, particularly high-sensitivity C-reactive protein and lipoprotein-associated phospholipase A2, have been identified as potential predictors...

journal_title：Current cardiology reports

authors： Elkind MS

更新日期：2009-01-01 00:00:00

abstract：PURPOSE OF THE REVIEW:The aim of this review was to discuss the role of cardiac magnetic resonance (CMR) for the prognostic stratification of cardiomyopathies, highlighting strengths and limitations. RECENT FINDINGS:CMR is considered as a diagnostic pillar in the management of non-ischemic cardiomyopathies. Over the l...

journal_title：Current cardiology reports

authors： Grigoratos C,Todiere G,Barison A,Aquaro GD

更新日期：2020-06-19 00:00:00

abstract：PURPOSE OF REVIEW:Heart failure with preserved ejection fraction (HFpEF) is a relatively new disease entity used in medical terminology; however, both the number of patients and its clinical significance are growing. HFpEF used to be seen as a mild condition; however, the symptoms and quality of life of the patients ar...

journal_title：Current cardiology reports

authors： Adamczak DM,Oduah MT,Kiebalo T,Nartowicz S,Bęben M,Pochylski M,Ciepłucha A,Gwizdała A,Lesiak M,Straburzyńska-Migaj E

更新日期：2020-07-09 00:00:00

abstract：PURPOSE OF REVIEW:To discuss the mechanisms of iron regulation in the brain and the pathophysiological role of deregulation of iron homeostasis following a stroke, and to review existing evidence supporting the potential role of iron chelators in the treatment of ischemic and hemorrhagic stroke. RECENT FINDINGS:In rec...

journal_title：Current cardiology reports

authors： Hanafy KA,Gomes JA,Selim M

更新日期：2019-03-04 00:00:00

abstract：PURPOSE OF REVIEW:Acute pulmonary embolism (PE) is a common condition associated with high morbidity and mortality. Prior studies have evaluated the role of systemic fibrinolysis and catheter-directed therapy (CDT) in the management of PE. In this review, we examine current data on risk stratification and the appropria...

journal_title：Current cardiology reports

authors： Kosova EC,Desai KR,Schimmel DR

更新日期：2017-06-01 00:00:00

abstract：:A number of neurohormones and cytokines are activated in heart failure and their activity is related to the progression of heart failure. Inhibiting the deleterious effects of the activated sympathetic and the renin-angiotensin-aldosterone systems with b-blockers, angiotensin-converting enzyme inhibitors, and aldoster...

journal_title：Current cardiology reports

authors： Anand IS

更新日期：2004-05-01 00:00:00

abstract：PURPOSE OF REVIEW:The aim of low-density lipoprotein-cholesterol (LDL-C) lowering therapies is to safely achieve a consistent and long-term reduction in exposure of the vasculature to atherogenic lipoproteins in order to reduce the risk of atherosclerotic cardiovascular (CV) disease and the associated CV events, such a...

journal_title：Current cardiology reports

authors： Sinning D,Landmesser U

更新日期：2020-10-21 00:00:00

abstract：:Peripheral artery disease (PAD) has become increasingly common in the US patient population and can be a highly symptomatic and significant source of morbidity. When PAD is suspected, the first-line screening study that is obtained is typically a noninvasive evaluation that includes the ankle brachial index (ABI). Fol...

journal_title：Current cardiology reports

authors： Meyersohn NM,Walker TG,Oliveira GR

更新日期：2015-10-01 00:00:00

abstract：:Cardiovascular magnetic resonance (CMR) is widely regarded as capable of providing a cornucopia of detailed diagnostic information. However, of that information, very little is truly unique, and can be obtained by a combination of alternate diagnostic modalities. Given this, it is anticipated that in the short term (1...

journal_title：Current cardiology reports

authors： Doyle M,Biederman RW

更新日期：2004-01-01 00:00:00

abstract：PURPOSE OF REVIEW:Ebstein's anomaly (EA) is a rare, but complex form of congenital heart disease consisting of a right ventricular myopathy and morphologic tricuspid valve disease leading to a high incidence of right ventricular dysfunction and arrhythmias. This review offers an updated overview of the current understa...

journal_title：Current cardiology reports

authors： Possner M,Gensini FJ,Mauchley DC,Krieger EV,Steinberg ZL

更新日期：2020-10-09 00:00:00

abstract：:Congestive heart failure is increasing in prevalence in the United States, and associated morbidity and mortality remain high. Aggressive treatment of decompensated heart failure is associated with improved outcomes; however, therapies must be tailored to the presenting characteristics of each patient and most carry a...

journal_title：Current cardiology reports

authors： Hiestand B,Abraham WT

更新日期：2007-05-01 00:00:00

abstract：:Synthesized as an antianginal compound 40 years ago, amiodarone has emerged as a uniquely effective antiarrhythmic compound in recent years. It has numerous properties, the most prominent being the ability to lengthen repolarization in the atria and ventricles associated with bradycardia without the significant potent...

journal_title：Current cardiology reports

authors： Singh BN

更新日期：2006-09-01 00:00:00

abstract：:Cardiac resynchronization therapy has become part of the treatment strategy for advanced, symptomatic heart failure, but newly published trials show that more patients than previously realized may benefit from this therapy, including those with mild heart failure symptoms. The REVERSE and MADIT-CRT trials showed that ...

journal_title：Current cardiology reports

authors： Reynolds CR,Gold MR

更新日期：2010-09-01 00:00:00

abstract：:The long QT syndrome (LQTS) and the Brugada syndrome (BrS) are the most common genetic causes of malignant ventricular arrhythmias and sudden cardiac death in young patients with normal cardiac morphology. To date, more than 250 different mutations in seven genes have been identified as causing LQTS, whereas the only ...

journal_title：Current cardiology reports

authors： Goldenberg I,Moss AJ,Zareba W

更新日期：2005-09-01 00:00:00

abstract：:The decline in the use of sodium channel blockers has led to an expanding use of b-blockers and complex class III agents such as sotalol and amiodarone for controlling cardiac arrhythmias. Success with these agents in the context of their side effects has spurred the development of compounds with simpler ion channel-b...

journal_title：Current cardiology reports

authors： Singh BN,Sarma JS

更新日期：2001-07-01 00:00:00

abstract：:Conventional algorithms and noninvasive imaging tests for the identification of stable, hemodynamically significant coronary artery disease offer little insight into the detection of potentially vulnerable and inflamed coronary plaques, those most likely to rupture and cause acute coronary syndromes. Positron emission...

journal_title：Current cardiology reports

authors： Rogers IS,Tawakol A

更新日期：2011-04-01 00:00:00

abstract：:Aortic stenosis is a common valvular abnormality. Surgical valve replacement is the standard of care for symptomatic patients with severe aortic stenosis and is appropriate for certain asymptomatic patients. Statin therapy may slow progression of the disease. Contrary to conventional wisdom, vasodilator therapy may in...

journal_title：Current cardiology reports

authors： Botkin NF,Aurigemma GP

更新日期：2004-03-01 00:00:00

abstract：:Clinical trials in the last decade have improved the quality of evidence to support preventive medical strategies to reduce the risk of recurrences after pericarditis. There are essentially three main strategies: (1) to use full anti-inflammatory doses for the treatment of each attack of pericarditis till symptoms res...

journal_title：Current cardiology reports

authors： Imazio M

更新日期：2015-01-01 00:00:00

abstract：PURPOSE OF REVIEW:This review discusses the complementary roles of echocardiography and cardiac magnetic resonance in the diagnosis and management of patients with hypertrophic cardiomyopathy (HCM). RECENT FINDINGS:Imaging using novel echocardiographic techniques and cardiac magnetic resonance (CMR) imaging in HCM has...

journal_title：Current cardiology reports

authors： Hindieh W,Chan R,Rakowski H

更新日期：2017-09-01 00:00:00

abstract：:Despite the critical importance of plasma lipoproteins in the development of atherosclerosis, varying degrees of evidence surround the causal associations of lipoproteins with coronary artery disease (CAD). These causal contributions can be assessed by employing genetic variants as unbiased proxies for lipid levels. A...

journal_title：Current cardiology reports

authors： Keenan TE,Rader DJ

更新日期：2013-09-01 00:00:00

abstract：:The impact of cardiac resynchronization therapy (CRT) on atrial fibrillation (AF) burden is poorly characterized. To assess the influence of CRT on AF, we performed a systematic literature search in MEDLINE using the MeSH headings "cardiac resynchronization therapy" or "cardiac pacing, artificial" and "atrial fibrilla...

journal_title：Current cardiology reports

authors： Hess PL,Jackson KP,Hasselblad V,Al-Khatib SM

更新日期：2013-02-01 00:00:00

abstract：PURPOSE OF REVIEW:The cardiovascular (CV) risk related to lipid disorders is well established and is based on a robust body of evidence from well-designed randomized clinical trials, as well as prospective observational studies. In the last two decades, significant advances have been made in understanding the genetic b...

journal_title：Current cardiology reports

authors： Stein R,Ferrari F,Scolari F

更新日期：2019-06-21 00:00:00

abstract：:Sudden cardiac death (SCD) is the leading cause of death in the United States. Although SCD occurs most commonly in patients with established heart disease, SCD can also be the initial manifestation of cardiovascular disease. Efforts to reduce the incidence of SCD include aggressive treatment of heart disease and its ...

journal_title：Current cardiology reports

authors： Ganz LI

更新日期：2004-09-01 00:00:00

abstract：:The scientific selection of antithrombotic therapy has been dominated by group-based interpretation of data in the form of probability-based statistics in evidence-based medicine. Because the data in large randomized trials are grouped and averaged, the relationship to initial conditions of the patient is lost. There ...

journal_title：Current cardiology reports

authors： Helgason CM

更新日期：2003-03-01 00:00:00

abstract：PURPOSE OF REVIEW:Comprehensive discussion of alternative techniques in imaging coronary artery anomalies (CAAs) in different diagnostic scenarios. RECENT FINDINGS:At primary screening, intramural course essentially correlates with stenosis and clinical repercussion in some types of CAAs. Potential clinical aims in im...

journal_title：Current cardiology reports

authors： Angelini P

更新日期：2019-07-29 00:00:00

abstract：:Traditional transvenous approach for permanent cardiac pacing can be associated with significant acute and chronic complications related partly to either the insertion of transvenous lead or subcutaneous placement of pacemaker device. We summarize the current status of a novel self-contained leadless cardiac pacemaker...

journal_title：Current cardiology reports

authors： Neuzil P,Reddy VY

更新日期：2015-08-01 00:00:00

abstract：:Several next generation sequencing platforms allow for a DNA-to-diagnosis protocol to identify the molecular basis of monogenic dyslipidemias. However, recent reports of the application of whole genome or whole exome sequencing in families with severe dyslipidemias have largely identified genetic variants in known lip...

journal_title：Current cardiology reports

authors： Farhan SM,Hegele RA

更新日期：2014-07-01 00:00:00

abstract：:Recent advances in clinical cardiac SPECT instrumentation are reviewed from a systems perspective. New hardware technologies include pixelated scintillator and semiconductor detector elements; photodetectors such as position-sensitive photomultiplier tubes (PSPMT), avalanche photodiodes (APD) and silicon photomultipli...

journal_title：Current cardiology reports

authors： Smith MF

更新日期：2013-08-01 00:00:00

abstract：:Lifestyle modification is primary in cardiovascular (CV) disease prevention. A major contribution is the Mediterranean diet (MedDiet), defined by two of seven components. Italian investigators determined a significant decrease in peripheral arterial disease of 56 % for a high score. Multiple specific CV risk factors a...

journal_title：Current cardiology reports

authors： Whayne TF Jr

更新日期：2014-01-01 00:00:00