Antithrombotic strategies in gene therapy.

abstract：PURPOSE OF REVIEW:To review methodological and logistical aspects of CT myocardial perfusion, current clinical evidence and possible future directions, with specific focus on use in patients with coronary artery disease (CAD). RECENT FINDINGS:CT myocardial perfusion imaging may be performed as an add-on to standard co...

journal_title：Current cardiology reports

authors： Kofoed KF,Sørgaard MH,Linde JJ

更新日期：2017-10-25 00:00:00

abstract：:Controlled clinical trials, performed in more than 13,000 patients, have consistently shown the beneficial effects of long-term beta-blocker therapy in patients with chronic heart failure. However, it is not clear whether this is a class effect or if it is specific only for some agents. Beneficial effects on the progn...

journal_title：Current cardiology reports

authors： Metra M,Nodari S,Boldi E,Dei Cas L

更新日期：2000-05-01 00:00:00

abstract：PURPOSE OF REVIEW:While the safety and efficacy of percutaneous ASD closure has been established, new data have recently emerged regarding the negative impact of residual iatrogenic ASD (iASD) following left heart structural interventions. Additionally, new devices with potential advantages have recently been studied. ...

journal_title：Current cardiology reports

authors： Wiktor DM,Carroll JD

更新日期：2018-04-17 00:00:00

abstract：:Diabetic patients who present with an acute coronary syndrome (ACS) have a particularly adverse prognosis, largely contributed by increased platelet reactivity and higher burden of disease severity. Diabetic patients with ACS derive a greater benefit from established therapies, particularly platelet-inhibiting therapi...

journal_title：Current cardiology reports

authors： Amin AP,Marso SP

更新日期：2010-07-01 00:00:00

abstract：PURPOSE OF REVIEW:This review presents the current available evidence of the effects of several dietary patterns on atherosclerotic cardiovascular disease (ASCVD) risk in patients with type 2 diabetes (T2D). RECENT FINDINGS:Evidence demonstrates improvements in cardiovascular risk factors with some dietary patterns in...

journal_title：Current cardiology reports

authors： Liday C,Kirkpatrick C

更新日期：2019-10-17 00:00:00

abstract：:Aortic stenosis affects many people worldwide with a significant impact on morbidity and mortality with uncorrected, symptomatic aortic valve stenosis carrying mortality of 50% at one year. Degenerative calcific pathology, the most common cause of aortic stenosis, increases in prevalence with age; estimated prevalence...

journal_title：Current cardiology reports

authors： Halim SA,Kiefer TL,Hughes GC,Hurwitz LM,Harrison JK

更新日期：2013-06-01 00:00:00

abstract：:The scientific selection of antithrombotic therapy has been dominated by group-based interpretation of data in the form of probability-based statistics in evidence-based medicine. Because the data in large randomized trials are grouped and averaged, the relationship to initial conditions of the patient is lost. There ...

journal_title：Current cardiology reports

authors： Helgason CM

更新日期：2003-03-01 00:00:00

abstract：:Traditional transvenous approach for permanent cardiac pacing can be associated with significant acute and chronic complications related partly to either the insertion of transvenous lead or subcutaneous placement of pacemaker device. We summarize the current status of a novel self-contained leadless cardiac pacemaker...

journal_title：Current cardiology reports

authors： Neuzil P,Reddy VY

更新日期：2015-08-01 00:00:00

abstract：PURPOSE OF REVIEW:Real-time 3-dimensional (3-D) imaging of cardiovascular injury and regeneration remains challenging. We introduced a multi-scale imaging strategy that uses light-sheet illumination to enable applications of cardiovascular injury and repair in models ranging from zebrafish to rodent hearts. RECENT FIN...

journal_title：Current cardiology reports

authors： Ding Y,Lee J,Hsu JJ,Chang CC,Baek KI,Ranjbarvaziri S,Ardehali R,Packard RRS,Hsiai TK

更新日期：2018-03-24 00:00:00

abstract：PURPOSE OF REVIEW:The goal of this paper is to review present knowledge regarding biological pacemakers created by somatic reprogramming as a platform for mechanistic and metabolic understanding of the rare subpopulation of pacemaker cells, with the ultimate goal of creating biological alternatives to electronic pacing...

journal_title：Current cardiology reports

authors： Xiao A,Cho HC

更新日期：2020-03-30 00:00:00

abstract：:Fifty thousand Americans suffer an intracerebral hemorrhage (ICH) annually, one third of whom die as a result. Poorly controlled hypertension is the most important risk factor for ICH. Over time it results in pathologic changes to small intracranial vessels, leading to their rupture. All stroke patients, including tho...

journal_title：Current cardiology reports

authors： Tuhrim S

更新日期：2002-03-01 00:00:00

abstract：:Shared decision-making, central to evidence-based medicine and good patient care, begins and ends with the patient. It is the process by which a clinician and a patient jointly make a health decision after discussing options, potential benefits and harms, and considering the patient's values and preferences. Patient e...

journal_title：Current cardiology reports

authors： Kambhampati S,Ashvetiya T,Stone NJ,Blumenthal RS,Martin SS

更新日期：2016-05-01 00:00:00

abstract：PURPOSE OF REVIEW:Comprehensive discussion of alternative techniques in imaging coronary artery anomalies (CAAs) in different diagnostic scenarios. RECENT FINDINGS:At primary screening, intramural course essentially correlates with stenosis and clinical repercussion in some types of CAAs. Potential clinical aims in im...

journal_title：Current cardiology reports

authors： Angelini P

更新日期：2019-07-29 00:00:00

abstract：:Device therapy for the treatment of uncontrolled and resistant hypertension has evolved significantly over the past several decades. Both renal artery disease and sympathetic hyperactivity have been linked to resistant hypertension. This manuscript will review the current evidence base supporting device therapy (e.g.,...

journal_title：Current cardiology reports

authors： Aronow HD,Li J,Parikh SA

更新日期：2014-11-01 00:00:00

abstract：:Primary aldosteronism with a prevalence of 8 % of hypertension and 20 % of pharmacologically resistant hypertension is the most common secondary cause of hypertension. Yet, the diagnosis is missed in the vast majority of patients. Current clinical practice guidelines recommend screening for primary aldosteronism in pa...

journal_title：Current cardiology reports

authors： Carey RM

更新日期：2016-10-01 00:00:00

abstract：:Spontaneous coronary artery dissection is an important etiology of nonatherosclerotic acute coronary syndrome, myocardial infarction, and sudden death. Innovations in the catheterization laboratory including optical coherence tomography and intravascular ultrasound have enhanced the ability to visualize intimal disrup...

journal_title：Current cardiology reports

authors： Tweet MS,Gulati R,Hayes SN

更新日期：2016-07-01 00:00:00

abstract：PURPOSE OF REVIEW:To assess current management strategies for advanced heart failure in adults with congenital heart disease, including heart transplantation and mechanical circulatory support. RECENT FINDINGS:Current data demonstrate that adults with CHD generally experience higher short-term mortality after heart tr...

journal_title：Current cardiology reports

authors： Serfas JD,Patel PA,Krasuski RA

更新日期：2018-08-09 00:00:00

abstract：:There are a number of limitations associated with conventional mapping for ablation of ventricular tachycardia (VT) in ischemic heart disease, such as the high recurrence rates after initially successful ablation. The development of a noncontact mapping system capable of producing high-resolution isopotential maps of ...

journal_title：Current cardiology reports

authors： Chow AW,Schilling RJ,Peters NS,Davies DW

更新日期：2000-11-01 00:00:00

abstract：:Patients with pre-diabetes have a tenfold higher risk of developing Type 2 DM and a twofold higher risk of developing coronary heart disease compared to non-diabetics. Interventions targeted at those in an early stage of impaired glucose metabolism can delay or prevent diabetes. Effects of these interventions on cardi...

journal_title：Current cardiology reports

authors： Popp Switzer M,Elhanafi S,San Juan ZT

更新日期：2015-03-01 00:00:00

abstract：:Angiotensin-converting enzyme (ACE) inhibitors have become the cornerstone of therapy for congestive heart failure (CHF). Because ischemic heart disease is the most common cause of CHF, aspirin is frequently given concomitantly with ACE inhibitors in patients with CHF. Increased bradykinin levels, with the consequent ...

journal_title：Current cardiology reports

authors： Moskowitz R

更新日期：2001-05-01 00:00:00

abstract：PURPOSE OF REVIEW:The goal was to evaluate published data on the incidence, diagnosis, and management of symptomatic combined mitral and aortic valvular disease. Furthermore, to identify the role of treatment using contemporary transcatheter techniques. RECENT FINDINGS:Up to a quarter of symptomatic adult valvular dis...

journal_title：Current cardiology reports

authors： De Palma R,O'Sullivan CJ,Settergren M

更新日期：2019-09-13 00:00:00

abstract：:The most common cause of acute coronary syndrome (ACS) is rupture of an atherosclerotic lesion containing a large necrotic core and a thin fibrous cap followed by acute luminal thrombosis because the rupture of the thin fibrous cap allows contact of the platelets with the highly thrombogenic necrotic core. Pathologic ...

journal_title：Current cardiology reports

authors： Choi SY,Mintz GS

更新日期：2010-07-01 00:00:00

abstract：:Radiofrequency ablation is a valuable adjunctive therapy to implantable defibrillators in patients with recurrent monomorphic ventricular tachycardia (VT) after myocardial infarction. Episodes of VT are markedly reduced in most patients, and the major complications are less than 5%. Newer approaches allow successful a...

journal_title：Current cardiology reports

authors： Soejima K,Stevenson WG

更新日期：2003-09-01 00:00:00

abstract：:The heart and kidney interact in terms of hemodynamics and neurohumoral regulatory mechanisms, and this helps to maintain circulatory homeostasis under normal conditions. However, the normal regulatory mechanisms become inappropriate in the setting of congestive heart failure (CHF), and significant renal dysfunction o...

journal_title：Current cardiology reports

authors： Sobotka PA,Krum H,Böhm M,Francis DP,Schlaich MP

更新日期：2012-06-01 00:00:00

abstract：:Systemic embolic complications in patients with cardiomyopathy are associated with significant morbidity and mortality. Despite the lack of prospective, randomized control data, the literature supports the use of left ventricular ejection fraction as an important determinant of the need for systemic anticoagulation th...

journal_title：Current cardiology reports

authors： Rho R,DeNofrio D,Loh E

更新日期：2000-03-01 00:00:00

abstract：PURPOSE OF REVIEW:The aim of low-density lipoprotein-cholesterol (LDL-C) lowering therapies is to safely achieve a consistent and long-term reduction in exposure of the vasculature to atherogenic lipoproteins in order to reduce the risk of atherosclerotic cardiovascular (CV) disease and the associated CV events, such a...

journal_title：Current cardiology reports

authors： Sinning D,Landmesser U

更新日期：2020-10-21 00:00:00

abstract：PURPOSE OF REVIEW:The cardiovascular (CV) risk related to lipid disorders is well established and is based on a robust body of evidence from well-designed randomized clinical trials, as well as prospective observational studies. In the last two decades, significant advances have been made in understanding the genetic b...

journal_title：Current cardiology reports

authors： Stein R,Ferrari F,Scolari F

更新日期：2019-06-21 00:00:00

abstract：:Noninvasive cardiac imaging techniques have made a striking impact on the evaluation and management of pericardial disorders. Two-dimensional and Doppler echocardiography are the methods of choice in the evaluation of pericardial effusion and cardiac tamponade. Magnetic resonance imaging, computed tomography, and tran...

journal_title：Current cardiology reports

authors： Karia DH,Xing YQ,Kuvin JT,Nesser HJ,Pandian NG

更新日期：2002-01-01 00:00:00

abstract：PURPOSE OF REVIEW:Monoclonal antibodies that inhibit proprotein convertase subtilisin/kexin type 9 (PCSK9) have emerged as a novel approach to low-density lipoprotein cholesterol (LDL-C) lowering. The potential role of PCSK9 inhibitors in clinical practice will be reviewed. RECENT FINDINGS:Clinical trials have demonst...

journal_title：Current cardiology reports

authors： King P,Nicholls SJ

更新日期：2017-08-01 00:00:00

abstract：:Sodium is an essential nutrient, mostly ingested as salt (sodium chloride). Average sodium intake ranges from 3 to 6 g per day (7.5-15 g/day of salt) in most countries, with regional variations. Increasing levels of sodium intake have a positive association with higher blood pressure. Randomized controlled trials repo...

journal_title：Current cardiology reports

authors： O'Donnell M,Mente A,Yusuf S

更新日期：2014-01-01 00:00:00