Abstract:
PURPOSE OF REVIEW:To review methodological and logistical aspects of CT myocardial perfusion, current clinical evidence and possible future directions, with specific focus on use in patients with coronary artery disease (CAD). RECENT FINDINGS:CT myocardial perfusion imaging may be performed as an add-on to standard coronary CT angiography (CCTA), to identify regions of myocardial hypoperfusion, at rest and during adenosine stress. The principle of measurement is well-validated in animal experimental models, and CT myocardial perfusion imaging has a high degree of concordance with already clinically available perfusion imaging methods. Combining CCTA and CT myocardial perfusion imaging increases the diagnostic accuracy to identify patients with CAD associated with ischemia. In patients suspected of CAD, CCTA frequently detects coronary atherosclerotic lesions, in which revascularization could be clinically beneficial. CT myocardial perfusion imaging may be helpful to identify coronary lesions associated with myocardial ischemia, and thus potentially suitable for coronary intervention.
journal_name
Curr Cardiol Repjournal_title
Current cardiology reportsauthors
Kofoed KF,Sørgaard MH,Linde JJdoi
10.1007/s11886-017-0937-8subject
Has Abstractpub_date
2017-10-25 00:00:00pages
126issue
12eissn
1523-3782issn
1534-3170pii
10.1007/s11886-017-0937-8journal_volume
19pub_type
杂志文章,评审abstract:PURPOSE OF REVIEW:The pathogenesis and progression of coronary artery disease (CAD) is now known to be largely driven by inflammation on top of the well-accepted role for the disequilibrium between cholesterol deposition and removal from the arterial wall. Recent clinical trials have supported the inflammatory hypothes...
journal_title:Current cardiology reports
pub_type: 杂志文章,评审
doi:10.1007/s11886-020-01439-2
更新日期:2021-01-06 00:00:00
abstract:PURPOSE OF REVIEW:To summarize lifestyle interventions including pharmacological and non-pharmacological methods targeting modifiable risk factors and their impact on the future cardiovascular events in patients who have suffered transient ischemic attack (TIA) and/or ischemic stroke (IS). RECENT FINDINGS:The latest r...
journal_title:Current cardiology reports
pub_type: 杂志文章,评审
doi:10.1007/s11886-019-1132-x
更新日期:2019-04-22 00:00:00
abstract:PURPOSE OF REVIEW:There is a broad spectrum of coronary artery anomalies that cardiologists may encounter either incidentally or during evaluation for cardiac symptoms. These anomalies include anomalous coronary arteries arising from the opposite sinus of Valsalva (ACAOS), coronary fistulae, and coronary artery aneurys...
journal_title:Current cardiology reports
pub_type: 杂志文章,评审
doi:10.1007/s11886-017-0854-x
更新日期:2017-05-01 00:00:00
abstract:PURPOSE OF REVIEW:This article reviews the latest data on unprotected left main (ULM) percutaneous coronary intervention (PCI) versus coronary artery bypass graft (CABG) surgery, with a focus on the NOBLE and EXCEL trials. RECENT FINDINGS:In EXCEL trial, the primary endpoint at 3 years was 15.4% in the PCI group and 1...
journal_title:Current cardiology reports
pub_type: 杂志文章,评审
doi:10.1007/s11886-019-1113-0
更新日期:2019-03-18 00:00:00
abstract:PURPOSE OF REVIEW:Interventional cardiology and in particular the field of renal denervation is subject to constant change. This review provides an up to date overview of renal denervation trials and an outlook on what to expect in the future. RECENT FINDINGS:After the sham-controlled SYMPLICITY HTN-3 trial dampened t...
journal_title:Current cardiology reports
pub_type: 杂志文章,评审
doi:10.1007/s11886-019-1164-2
更新日期:2019-07-05 00:00:00
abstract::Advances in the field of molecular medicine are making gene therapy a viable treatment strategy for the next millennium. Indeed, over the past 10 years, a number of improvements have occurred that have resulted in an increased interest in gene therapy for the treatment of diseases in cardiovascular medicine. Because a...
journal_title:Current cardiology reports
pub_type: 杂志文章,评审
doi:10.1007/s11886-000-0023-4
更新日期:2000-01-01 00:00:00
abstract::The excess risk of hypertension in black Americans continues to be a major health concern. Although there is considerable information regarding these disease trends, much of the major underpinnings of the etiology of hypertension remain unclear. The excess mortality in blacks due to heart disease, renal failure, and s...
journal_title:Current cardiology reports
pub_type: 杂志文章,评审
doi:10.1007/s11886-004-0048-1
更新日期:2004-11-01 00:00:00
abstract::The gold standard for diagnosis of cardiac amyloidosis (CA) is endomyocardial biopsy showing Congo red staining followed by mass spectroscopy, but the diagnosis can also be made with high certainty by demonstration of typical cardiac imaging features along with amyloid on biopsy of another involved organ. The use of c...
journal_title:Current cardiology reports
pub_type: 杂志文章,评审
doi:10.1007/s11886-020-01284-3
更新日期:2020-05-19 00:00:00
abstract::Recurrent pericarditis is one of the most troublesome complications of pericarditis occurring in about one third of patients with a previous attack of pericarditis. The pathogenesis is presumed to be autoimmune and/or autoinflammatory in most cases. The mainstay of therapy for recurrences is physical restriction and a...
journal_title:Current cardiology reports
pub_type: 杂志文章,评审
doi:10.1007/s11886-016-0727-8
更新日期:2016-06-01 00:00:00
abstract:PURPOSE OF THE REVIEW:Coronary artery disease is a major cause of mortality and morbidity in the world, and PCI and CABG account for over a million procedures performed annually in the USA. The goal of percutaneous coronary intervention (PCI) or coronary artery bypass grafting (CABG) is to achieve complete revasculariz...
journal_title:Current cardiology reports
pub_type: 杂志文章,评审
doi:10.1007/s11886-018-0957-z
更新日期:2018-03-06 00:00:00
abstract::Systemic embolic complications in patients with cardiomyopathy are associated with significant morbidity and mortality. Despite the lack of prospective, randomized control data, the literature supports the use of left ventricular ejection fraction as an important determinant of the need for systemic anticoagulation th...
journal_title:Current cardiology reports
pub_type: 杂志文章,评审
doi:10.1007/s11886-000-0006-5
更新日期:2000-03-01 00:00:00
abstract::Sudden cardiac death (SCD) is the leading cause of death in the United States. Although SCD occurs most commonly in patients with established heart disease, SCD can also be the initial manifestation of cardiovascular disease. Efforts to reduce the incidence of SCD include aggressive treatment of heart disease and its ...
journal_title:Current cardiology reports
pub_type: 杂志文章,评审
doi:10.1007/s11886-004-0036-5
更新日期:2004-09-01 00:00:00
abstract:PURPOSE OF REVIEW:Acute pulmonary embolism (PE) is a common condition associated with high morbidity and mortality. Prior studies have evaluated the role of systemic fibrinolysis and catheter-directed therapy (CDT) in the management of PE. In this review, we examine current data on risk stratification and the appropria...
journal_title:Current cardiology reports
pub_type: 杂志文章,评审
doi:10.1007/s11886-017-0864-8
更新日期:2017-06-01 00:00:00
abstract:PURPOSE OF REVIEW:The goal of this paper is to review present knowledge regarding biological pacemakers created by somatic reprogramming as a platform for mechanistic and metabolic understanding of the rare subpopulation of pacemaker cells, with the ultimate goal of creating biological alternatives to electronic pacing...
journal_title:Current cardiology reports
pub_type: 杂志文章,评审
doi:10.1007/s11886-020-01281-6
更新日期:2020-03-30 00:00:00
abstract::Frailty is increasingly recognized in older adults with cardiovascular disease, particularly in those with heart failure (HF). A growing body of evidence has shown that frailty has a negative effect on survival, hospitalizations, disability, and quality of life. Beyond frailty, additional domains captured by a compreh...
journal_title:Current cardiology reports
pub_type: 杂志文章,评审
doi:10.1007/s11886-015-0651-3
更新日期:2015-11-01 00:00:00
abstract::One of the most highly unexpected reports in recent medical literature was the lack of benefit of estrogen-progestin replacement therapy in cardiovascular disease prevention in postmenopausal women. The ensuing negative view of hormone replacement therapy has now extended to all forms of postmenopausal hormone treatme...
journal_title:Current cardiology reports
pub_type: 杂志文章,评审
doi:10.1007/s11886-003-0110-4
更新日期:2003-11-01 00:00:00
abstract:PURPOSE OF REVIEW:To create awareness for the devastating influence of high cholesterol in familial hypercholesterolaemia (FH) on vessel walls. Persons with high LDL-C and a known mutation associated with FH have a 22-fold increase in CVD compared with those with a normal LDL-C and no genetic mutation. If the awareness...
journal_title:Current cardiology reports
pub_type: 杂志文章,评审
doi:10.1007/s11886-018-1014-7
更新日期:2018-08-09 00:00:00
abstract::Primary aldosteronism with a prevalence of 8 % of hypertension and 20 % of pharmacologically resistant hypertension is the most common secondary cause of hypertension. Yet, the diagnosis is missed in the vast majority of patients. Current clinical practice guidelines recommend screening for primary aldosteronism in pa...
journal_title:Current cardiology reports
pub_type: 杂志文章,评审
doi:10.1007/s11886-016-0774-1
更新日期:2016-10-01 00:00:00
abstract:PURPOSE OF REVIEW:This review describes the dynamic relationship between diabetes mellitus (DM) and coronary artery disease (CAD) with respect to different revascularization strategies and how angiographic tools such as the Synergy between PCI with Taxus and Cardiac Surgery (SYNTAX) score can supplement clinical decisi...
journal_title:Current cardiology reports
pub_type: 杂志文章,评审
doi:10.1007/s11886-018-0971-1
更新日期:2018-03-23 00:00:00
abstract::The assessment of myocardial viability may be an important component of the evaluation of patients with coronary artery disease and left ventricular dysfunction. The primary goal of viability assessment in such patients is to guide therapeutic decisions by determining which patients would most likely benefit from reva...
journal_title:Current cardiology reports
pub_type: 杂志文章,评审
doi:10.1007/s11886-011-0242-x
更新日期:2012-04-01 00:00:00
abstract::Spontaneous coronary artery dissection is an important etiology of nonatherosclerotic acute coronary syndrome, myocardial infarction, and sudden death. Innovations in the catheterization laboratory including optical coherence tomography and intravascular ultrasound have enhanced the ability to visualize intimal disrup...
journal_title:Current cardiology reports
pub_type: 杂志文章,评审
doi:10.1007/s11886-016-0737-6
更新日期:2016-07-01 00:00:00
abstract::Revascularization in stable ischemic heart disease (SIHD) is indicated in patients on optimal medical therapy with angina and/or demonstrable ischemia and a significant stenosis in one or more epicardial coronary arteries. Angiography alone, however, cannot accurately determine the hemodynamic significance of coronary...
journal_title:Current cardiology reports
pub_type: 杂志文章,评审
doi:10.1007/s11886-016-0711-3
更新日期:2016-04-01 00:00:00
abstract:PURPOSE OF REVIEW:Real-time 3-dimensional (3-D) imaging of cardiovascular injury and regeneration remains challenging. We introduced a multi-scale imaging strategy that uses light-sheet illumination to enable applications of cardiovascular injury and repair in models ranging from zebrafish to rodent hearts. RECENT FIN...
journal_title:Current cardiology reports
pub_type: 杂志文章,评审
doi:10.1007/s11886-018-0979-6
更新日期:2018-03-24 00:00:00
abstract::The scientific selection of antithrombotic therapy has been dominated by group-based interpretation of data in the form of probability-based statistics in evidence-based medicine. Because the data in large randomized trials are grouped and averaged, the relationship to initial conditions of the patient is lost. There ...
journal_title:Current cardiology reports
pub_type: 杂志文章,评审
doi:10.1007/s11886-003-0083-3
更新日期:2003-03-01 00:00:00
abstract::A number of neurohormones and cytokines are activated in heart failure and their activity is related to the progression of heart failure. Inhibiting the deleterious effects of the activated sympathetic and the renin-angiotensin-aldosterone systems with b-blockers, angiotensin-converting enzyme inhibitors, and aldoster...
journal_title:Current cardiology reports
pub_type: 杂志文章,评审
doi:10.1007/s11886-004-0019-6
更新日期:2004-05-01 00:00:00
abstract::Shared decision-making, central to evidence-based medicine and good patient care, begins and ends with the patient. It is the process by which a clinician and a patient jointly make a health decision after discussing options, potential benefits and harms, and considering the patient's values and preferences. Patient e...
journal_title:Current cardiology reports
pub_type: 杂志文章,评审
doi:10.1007/s11886-016-0729-6
更新日期:2016-05-01 00:00:00
abstract::Although assessment of traditional coronary heart disease risk factors can often stratify individuals into low- or high-risk categories, additional means are needed to more precisely classify people clinically defined as intermediate-risk, to guide the intensity of risk-reducing therapies. The recognition that inflamm...
journal_title:Current cardiology reports
pub_type: 杂志文章,评审
doi:10.1007/s11886-009-0065-1
更新日期:2009-11-01 00:00:00
abstract:PURPOSE OF REVIEW:We provide a concise update on the contemporary management of cardiogenic shock in the setting of acute coronary syndrome (ACS). Early shock recognition, optimal selection and initiation of mechanical circulatory support (MCS), early coronary revascularization, and a team-based, protocol-driven approa...
journal_title:Current cardiology reports
pub_type: 杂志文章,评审
doi:10.1007/s11886-019-1102-3
更新日期:2019-03-04 00:00:00
abstract::Chronic total occlusion (CTO) represents one of the most challenging lesion subsets faced by the interventional cardiologist. CTO is a common problem, being present in more than 30% of patients undergoing coronary angiography. Over the past 10 years, the success rate of recanalization has increased from approximately ...
journal_title:Current cardiology reports
pub_type: 杂志文章,评审
doi:10.1007/s11886-010-0131-8
更新日期:2010-09-01 00:00:00
abstract:PURPOSE OF REVIEW:To review the clinical evidence on the use of percutaneous coronary intervention (PCI) revascularization options in left main (LM) disease in comparison with coronary artery bypass graft (CABG). Coronary artery disease (CAD) involving the LM is associated with high morbidity and mortality. Though CABG...
journal_title:Current cardiology reports
pub_type: 杂志文章,评审
doi:10.1007/s11886-020-1268-8
更新日期:2020-02-08 00:00:00