Renal Denervation: Is It Ready for Prime Time?

Abstract:

PURPOSE OF REVIEW:Interventional cardiology and in particular the field of renal denervation is subject to constant change. This review provides an up to date overview of renal denervation trials and an outlook on what to expect in the future. RECENT FINDINGS:After the sham-controlled SYMPLICITY HTN-3 trial dampened the euphoria following early renal denervation trials, the recently published results of the sham-controlled SPYRAL HTN and RADIANCE HTN trials provided proof-of-principle for the blood pressure-lowering efficacy of renal denervation. However, these studies underline the major issue of patients' non-adherence to antihypertensive medication as well as the need for reliable patient- and procedure-related predictors of response. The second generation of sham-controlled renal denervation trials provided proof of principle for the blood pressure-lowering efficacy of RDN. However, larger trials have to assess long-term safety and efficacy.

journal_name

Curr Cardiol Rep

authors

Lauder L,Wolf MA,Scholz SS,Hohl M,Mahfoud F,Böhm M

doi

10.1007/s11886-019-1164-2

subject

Has Abstract

pub_date

2019-07-05 00:00:00

pages

80

issue

8

eissn

1523-3782

issn

1534-3170

pii

10.1007/s11886-019-1164-2

journal_volume

21

pub_type

杂志文章,评审
  • Ischemia and Viability Testing in New-Onset Heart Failure.

    abstract:PURPOSE OF REVIEW:To examine the utility and methods of coronary artery disease (CAD) assessment in patients with new-onset heart failure with reduced ejection fraction (HFrEF) of unclear etiology. Moreover, we sought to review the role and techniques of assessing myocardial viability to guide coronary revascularizatio...

    journal_title:Current cardiology reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11886-020-01304-2

    authors: Kassab K,Kattoor AJ,Doukky R

    更新日期:2020-07-06 00:00:00

  • Resistance to antiplatelet therapy.

    abstract::Cardiovascular mortality continues to be high and events continue to occur in patients taking antiplatelet medications. Aspirin and clopidogrel have become integral parts of management in patients with coronary artery disease and after percutaneous angioplasty. However, the platelet responses to aspirin and clopidogre...

    journal_title:Current cardiology reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11886-005-0044-0

    authors: Guthikonda S,Lev EI,Kleiman NS

    更新日期:2005-07-01 00:00:00

  • Autonomic Modulation in Heart Failure: Ready for Prime Time?

    abstract::It has been known for many decades that multiple abnormalities of the autonomic nervous system (ANS) are present in heart failure (HF). Moreover, many of the effective therapies currently used to treat HF have either direct or indirect effects on the ANS. While therapies that block over-activity of the sympathetic ner...

    journal_title:Current cardiology reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11886-015-0652-2

    authors: Dunlap ME,Bhardwaj A,Hauptman PJ

    更新日期:2015-11-01 00:00:00

  • Colchicine in Pericardial Disease: from the Underlying Biology and Clinical Benefits to the Drug-Drug Interactions in Cardiovascular Medicine.

    abstract:PURPOSE OF REVIEW:This is an in-depth review on the mechanism of action, clinical utility, and drug-drug interactions of colchicine in the management of pericardial disease. RECENT FINDINGS:Recent evidence about therapeutic targets on pericarditis has demonstrated that NALP3 inflammasome blockade is the cornerstone in...

    journal_title:Current cardiology reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11886-018-1008-5

    authors: Schenone AL,Menon V

    更新日期:2018-06-14 00:00:00

  • Sex-Related Differences in Dilated Cardiomyopathy with a Focus on Cardiac Dysfunction in Oncology.

    abstract:PURPOSE OF REVIEW:The aim of this report is to describe the main aspects of sex-related differences in non-ischemic dilated cardiomyopathies (DCM), focusing on chemotherapy-induced heart failure (HF) and investigating the possible therapeutic implications and clinical management applications in the era of personalized ...

    journal_title:Current cardiology reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11886-020-01377-z

    authors: D'Amario D,Camilli M,Migliaro S,Canonico F,Galli M,Arcudi A,Montone RA,Borovac JA,Crea F,Savarese G

    更新日期:2020-08-08 00:00:00

  • Radial Artery Versus Saphenous Vein Grafts in Coronary Artery Bypass Surgery: a Literature Review.

    abstract:PURPOSE OF REVIEW:Coronary artery bypass grafting is a preferred strategy for complete coronary revascularization in patients who have multi-vessel coronary artery disease, left ventricular dysfunction, and/or diabetes. Both arterial (internal thoracic artery/radial artery) and venous grafts are utilized to bypass the ...

    journal_title:Current cardiology reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11886-019-1112-1

    authors: Virk HUH,Lakhter V,Ahmed M,O' Murchu B,Chatterjee S

    更新日期:2019-03-22 00:00:00

  • The angiotensin-converting enzyme inhibitor and aspirin interaction in congestive heart failure: fear or reality?

    abstract::Angiotensin-converting enzyme (ACE) inhibitors have become the cornerstone of therapy for congestive heart failure (CHF). Because ischemic heart disease is the most common cause of CHF, aspirin is frequently given concomitantly with ACE inhibitors in patients with CHF. Increased bradykinin levels, with the consequent ...

    journal_title:Current cardiology reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11886-001-0030-0

    authors: Moskowitz R

    更新日期:2001-05-01 00:00:00

  • Stroke prevention in atrial fibrillation: atrial appendage closure.

    abstract::The left atrial appendage (LAA) is the primary nonvalvular cause of cardioembolic stroke in patients with atrial fibrillation (AF). Warfarin and direct thrombin inhibitors such as dabigatran are presumed to prevent formation of LAA thrombus, and are first-line treatments to prevent ischemic stroke in AF. However, thes...

    journal_title:Current cardiology reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11886-010-0162-1

    authors: Fuller CJ,Reisman M

    更新日期:2011-04-01 00:00:00

  • Cardiomyopathy and embolization: risks and benefits of anticoagulation in sinus rhythm.

    abstract::Systemic embolic complications in patients with cardiomyopathy are associated with significant morbidity and mortality. Despite the lack of prospective, randomized control data, the literature supports the use of left ventricular ejection fraction as an important determinant of the need for systemic anticoagulation th...

    journal_title:Current cardiology reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11886-000-0006-5

    authors: Rho R,DeNofrio D,Loh E

    更新日期:2000-03-01 00:00:00

  • The impact of atrial fibrillation and its treatment on dementia.

    abstract::Atrial fibrillation (AF) is a very common tachyarrhythmia and is becoming increasingly prevalent, while dementia is a neurological condition manifested as loss of memory and cognitive ability. Both these conditions share several common risk factors. It is becoming increasingly evident that AF increases the risk of dem...

    journal_title:Current cardiology reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11886-014-0519-y

    authors: Kanmanthareddy A,Vallakati A,Sridhar A,Reddy M,Sanjani HP,Pillarisetti J,Atkins D,Bommana S,Jaeger M,Berenbom L,Lakkireddy D

    更新日期:2014-08-01 00:00:00

  • Hypertension in Obesity and the Impact of Weight Loss.

    abstract:PURPOSE OF REVIEW:Several interrelated mechanisms promote the development of hypertension in obesity, often contributing to end organ damage including cardiovascular disease and chronic kidney disease. RECENT FINDINGS:The treatment of hypertension in obesity is complicated by a high prevalence of resistant hypertensio...

    journal_title:Current cardiology reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11886-017-0912-4

    authors: Cohen JB

    更新日期:2017-08-24 00:00:00

  • New clinical trials in acute and recurrent pericarditis.

    abstract::Clinical trials in the last decade have improved the quality of evidence to support preventive medical strategies to reduce the risk of recurrences after pericarditis. There are essentially three main strategies: (1) to use full anti-inflammatory doses for the treatment of each attack of pericarditis till symptoms res...

    journal_title:Current cardiology reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11886-015-0575-y

    authors: Imazio M

    更新日期:2015-01-01 00:00:00

  • Update on MRI Techniques for Evaluation of Pericardial Disease.

    abstract:PURPOSE OF REVIEW:Cardiovascular magnetic resonance (CMR) provides the most comprehensive imaging assessment of pericardial disease, providing a three-dimensional assessment of the pericardium, functional assessment of its impact on cardiac contractility, and pericardial tissue/fluid characterization. This review prese...

    journal_title:Current cardiology reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11886-020-01392-0

    authors: Abou Hassan OK,Kwon D

    更新日期:2020-09-15 00:00:00

  • Role of antithrombotic agents in heart failure.

    abstract::Despite a vast body of research on antithrombotic therapy for patients with cardiac disease, there are few clinical settings where robust evidence of their benefit exists. Patients with heart failure often have vascular disease and atrial fibrillation contributing to their poor prognosis. For patients with heart failu...

    journal_title:Current cardiology reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11886-012-0266-x

    authors: Cleland JG,Mumtaz S,Cecchini L

    更新日期:2012-06-01 00:00:00

  • Complementary Role of Echocardiography and Cardiac Magnetic Resonance in Hypertrophic Cardiomyopathy.

    abstract:PURPOSE OF REVIEW:This review discusses the complementary roles of echocardiography and cardiac magnetic resonance in the diagnosis and management of patients with hypertrophic cardiomyopathy (HCM). RECENT FINDINGS:Imaging using novel echocardiographic techniques and cardiac magnetic resonance (CMR) imaging in HCM has...

    journal_title:Current cardiology reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11886-017-0897-z

    authors: Hindieh W,Chan R,Rakowski H

    更新日期:2017-09-01 00:00:00

  • Amiodarone: a multifaceted antiarrhythmic drug.

    abstract::Synthesized as an antianginal compound 40 years ago, amiodarone has emerged as a uniquely effective antiarrhythmic compound in recent years. It has numerous properties, the most prominent being the ability to lengthen repolarization in the atria and ventricles associated with bradycardia without the significant potent...

    journal_title:Current cardiology reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11886-006-0074-2

    authors: Singh BN

    更新日期:2006-09-01 00:00:00

  • Ebstein's Anomaly of the Tricuspid Valve: an Overview of Pathology and Management.

    abstract:PURPOSE OF REVIEW:Ebstein's anomaly (EA) is a rare, but complex form of congenital heart disease consisting of a right ventricular myopathy and morphologic tricuspid valve disease leading to a high incidence of right ventricular dysfunction and arrhythmias. This review offers an updated overview of the current understa...

    journal_title:Current cardiology reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11886-020-01412-z

    authors: Possner M,Gensini FJ,Mauchley DC,Krieger EV,Steinberg ZL

    更新日期:2020-10-09 00:00:00

  • Cardiovascular Risk Assessment in Patients with Hypertriglyceridemia.

    abstract:PURPOSE OF REVIEW:Assessing the cardiovascular risk associated with hypertriglyceridemia can be challenging due to frequent confounding conditions such as hypertension, diabetes mellitus, and hyperlipidemia. We sought to quantify this risk by examining several meta-analyses as well as subgroup analyses of previously pu...

    journal_title:Current cardiology reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11886-018-1013-8

    authors: Evans MC,Stalam T,Miller M

    更新日期:2018-07-10 00:00:00

  • Imaging cardiac neuronal function and dysfunction.

    abstract::In recent years, the importance of alterations of cardiac autonomic nerve function in the pathophysiology of heart diseases including heart failure, arrhythmia, ische-mic heart disease, and diabetes has been increasingly recognized. Several radiolabeled compounds have been synthesized for noninvasive imaging, includin...

    journal_title:Current cardiology reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11886-006-0024-z

    authors: Higuchi T,Schwaiger M

    更新日期:2006-03-01 00:00:00

  • Exercise: friend or foe in adult congenital heart disease?

    abstract::Exercise training is beneficial in healthy adults as well as patients with acquired cardiovascular disease such as coronary artery disease and heart failure. While a reduced exercise capacity is common in adults with congenital heart disease, it is not clear if these patients stand to benefit from exercise training or...

    journal_title:Current cardiology reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11886-013-0416-9

    authors: Tutarel O,Gabriel H,Diller GP

    更新日期:2013-11-01 00:00:00

  • 25 by 25: Achieving Global Reduction in Cardiovascular Mortality.

    abstract::Four non-communicable diseases-cardiovascular disease, chronic respiratory disease, diabetes mellitus, and cancer-account for over 60 % of all deaths globally. In recognition of this significant epidemic, the United Nations set forth a target of reducing the four major NCDs by 25 % by 2025. Cardiovascular disease alon...

    journal_title:Current cardiology reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11886-015-0679-4

    authors: Dugani S,Gaziano TA

    更新日期:2016-01-01 00:00:00

  • Light-Sheet Imaging to Elucidate Cardiovascular Injury and Repair.

    abstract:PURPOSE OF REVIEW:Real-time 3-dimensional (3-D) imaging of cardiovascular injury and regeneration remains challenging. We introduced a multi-scale imaging strategy that uses light-sheet illumination to enable applications of cardiovascular injury and repair in models ranging from zebrafish to rodent hearts. RECENT FIN...

    journal_title:Current cardiology reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11886-018-0979-6

    authors: Ding Y,Lee J,Hsu JJ,Chang CC,Baek KI,Ranjbarvaziri S,Ardehali R,Packard RRS,Hsiai TK

    更新日期:2018-03-24 00:00:00

  • Management of hemorrhagic stroke.

    abstract::Fifty thousand Americans suffer an intracerebral hemorrhage (ICH) annually, one third of whom die as a result. Poorly controlled hypertension is the most important risk factor for ICH. Over time it results in pathologic changes to small intracranial vessels, leading to their rupture. All stroke patients, including tho...

    journal_title:Current cardiology reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11886-002-0029-1

    authors: Tuhrim S

    更新日期:2002-03-01 00:00:00

  • Telestroke.

    abstract:PURPOSE OF REVIEW:This study aims to describe the current state of telestroke clinical applications and policies, in addition to key technical and operational aspects of the telemedicine practice. RECENT FINDINGS:Delivery of telestroke services for neurovascular care expanded from the intravenous alteplase decision an...

    journal_title:Current cardiology reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11886-017-0895-1

    authors: Dumitrascu OM,Demaerschalk BM

    更新日期:2017-09-01 00:00:00

  • Ischemic heart disease and the Mediterranean diet.

    abstract::Lifestyle modification is primary in cardiovascular (CV) disease prevention. A major contribution is the Mediterranean diet (MedDiet), defined by two of seven components. Italian investigators determined a significant decrease in peripheral arterial disease of 56 % for a high score. Multiple specific CV risk factors a...

    journal_title:Current cardiology reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11886-014-0491-6

    authors: Whayne TF Jr

    更新日期:2014-01-01 00:00:00

  • Renovascular hypertension in 2007: where are we now?

    abstract::Hypertension in patients with renovascular disease poses a major clinical challenge. Renal arterial disease accelerates hypertension by activation of multiple pressor systems. Although younger individuals with fibromuscular lesions often respond well to angioplasty with minor associated risks, care must be taken in ca...

    journal_title:Current cardiology reports

    pub_type: 杂志文章,评审

    doi:10.1007/BF02938389

    authors: Textor SC

    更新日期:2007-11-01 00:00:00

  • Exome sequencing: new insights into lipoprotein disorders.

    abstract::Several next generation sequencing platforms allow for a DNA-to-diagnosis protocol to identify the molecular basis of monogenic dyslipidemias. However, recent reports of the application of whole genome or whole exome sequencing in families with severe dyslipidemias have largely identified genetic variants in known lip...

    journal_title:Current cardiology reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11886-014-0507-2

    authors: Farhan SM,Hegele RA

    更新日期:2014-07-01 00:00:00

  • Carotid Artery Stenting Versus Carotid Endarterectomy: Post CREST.

    abstract::The risk of stroke associated with carotid artery stenosis can be reduced with carotid endarterectomy or carotid artery stenting in carefully selected patients. While surgery has been the traditional treatment there have been many trials comparing carotid endarterectomy with carotid artery stenting, and stenting has s...

    journal_title:Current cardiology reports

    pub_type: 杂志文章

    doi:10.1007/s11886-012-0250-5

    authors: Buschur M,Gurm HS

    更新日期:2012-02-05 00:00:00

  • Adjuvant Antithrombotic Therapy in TAVR.

    abstract:PURPOSE OF REVIEW:Transcatheter aortic valve replacement (TAVR) has developed into an important alternative to surgical aortic valve replacement (SAVR) for patients with severe aortic stenosis (AS). Adjuvant antithrombotic therapies are commonly used during and after TAVR to decrease the risk of valve thrombosis and th...

    journal_title:Current cardiology reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11886-017-0850-1

    authors: O'Malley RG,Mahaffey KW,Fearon WF

    更新日期:2017-05-01 00:00:00

  • Coronary Artery Anomalies: When You Need to Worry.

    abstract:PURPOSE OF REVIEW:There is a broad spectrum of coronary artery anomalies that cardiologists may encounter either incidentally or during evaluation for cardiac symptoms. These anomalies include anomalous coronary arteries arising from the opposite sinus of Valsalva (ACAOS), coronary fistulae, and coronary artery aneurys...

    journal_title:Current cardiology reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11886-017-0854-x

    authors: Kochar A,Kiefer T

    更新日期:2017-05-01 00:00:00