Advances in PET-Based Cardiac Amyloid Radiotracers.

Abstract:

:The gold standard for diagnosis of cardiac amyloidosis (CA) is endomyocardial biopsy showing Congo red staining followed by mass spectroscopy, but the diagnosis can also be made with high certainty by demonstration of typical cardiac imaging features along with amyloid on biopsy of another involved organ. The use of cardiac imaging techniques to detect amyloid deposits may frequently obviate the need for invasive methods in order to ascertain the presence, and potentially the type, of amyloid deposition. PURPOSE OF REVIEW: We aim to review the evidence behind the development of novel positron emission tomography (PET) radiotracers for demonstrating cardiac amyloid deposition and potentially distinguishing between light-chain (AL) or transthyretin (ATTR) cardiac amyloidosis. RECENT FINDINGS: Multiple recent studies have shown that thioflavin-analogue tracers such as18F-florbetapir, 18F-florbetaben, 18F-flutemetamol, and 11C-labeled Pittsburg Compound-B (PiB) may be able to fulfill the unmet need of elucidating the presence of amyloid deposition in the heart. Because they bind to the beta-pleated motif of the amyloid fibril due to their similarity to the thioflavin structure, they could potentially be used to image CA (Table 1). The use of PET amyloid radiotracers shows promise; however, further data is needed to define their overall accuracy and additive value to the care of patients with suspected systemic and/or cardiac amyloidosis.

journal_name

Curr Cardiol Rep

authors

Gallegos C,Miller EJ

doi

10.1007/s11886-020-01284-3

subject

Has Abstract

pub_date

2020-05-19 00:00:00

pages

40

issue

6

eissn

1523-3782

issn

1534-3170

pii

10.1007/s11886-020-01284-3

journal_volume

22

pub_type

杂志文章,评审
  • Advances in axial imaging of peripheral vascular disease.

    abstract::Peripheral artery disease (PAD) has become increasingly common in the US patient population and can be a highly symptomatic and significant source of morbidity. When PAD is suspected, the first-line screening study that is obtained is typically a noninvasive evaluation that includes the ankle brachial index (ABI). Fol...

    journal_title:Current cardiology reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11886-015-0644-2

    authors: Meyersohn NM,Walker TG,Oliveira GR

    更新日期:2015-10-01 00:00:00

  • The Biological Mechanisms of Action of Cardiac Progenitor Cell Therapy.

    abstract:PURPOSE OF REVIEW:Cell therapy for cardiovascular diseases is regarded as a rapidly growing field within regenerative medicine. Different cellular populations enriched for cardiac progenitor cells (CPCs), or derivate a-cellular products, are currently under preclinical and clinical evaluation. Here, we have reviewed th...

    journal_title:Current cardiology reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11886-018-1031-6

    authors: Pagano F,Picchio V,Angelini F,Iaccarino A,Peruzzi M,Cavarretta E,Biondi-Zoccai G,Sciarretta S,De Falco E,Chimenti I,Frati G

    更新日期:2018-08-13 00:00:00

  • GP IIb/IIIa inhibitors during primary percutaneous coronary intervention for STEMI: new trial and registry data.

    abstract::Primary percutaneous coronary intervention (PCI) with adjunctive glycoprotein (GP) IIb/IIIa receptor inhibitor therapy administered in the cardiac catheterization laboratory is the optimal reperfusion strategy for patients with ST-elevation myocardial infarction. Most available data regarding these agents are from tri...

    journal_title:Current cardiology reports

    pub_type: 杂志文章

    doi:10.1007/s11886-008-0066-5

    authors: Tamhane UU,Gurm HS

    更新日期:2008-09-01 00:00:00

  • Stroke prevention in atrial fibrillation: atrial appendage closure.

    abstract::The left atrial appendage (LAA) is the primary nonvalvular cause of cardioembolic stroke in patients with atrial fibrillation (AF). Warfarin and direct thrombin inhibitors such as dabigatran are presumed to prevent formation of LAA thrombus, and are first-line treatments to prevent ischemic stroke in AF. However, thes...

    journal_title:Current cardiology reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11886-010-0162-1

    authors: Fuller CJ,Reisman M

    更新日期:2011-04-01 00:00:00

  • Genetics of lipid traits and relationship to coronary artery disease.

    abstract::Despite the critical importance of plasma lipoproteins in the development of atherosclerosis, varying degrees of evidence surround the causal associations of lipoproteins with coronary artery disease (CAD). These causal contributions can be assessed by employing genetic variants as unbiased proxies for lipid levels. A...

    journal_title:Current cardiology reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11886-013-0396-9

    authors: Keenan TE,Rader DJ

    更新日期:2013-09-01 00:00:00

  • Methods of minimizing inappropriate implantable cardioverter-defibrillator shocks.

    abstract::As more and more patients receive complex implantable cardioverter-defibrillators (ICDs), profound knowledge about the incidence of inappropriate device therapy, the reasons it happens, and the possibilities for prevention is crucial. In this article, the most important prevention algorithms incorporated in current IC...

    journal_title:Current cardiology reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11886-000-0092-4

    authors: Schaer B,Osswald S

    更新日期:2000-07-01 00:00:00

  • Utilizing risk scores in determining the optimal revascularization strategy for complex coronary artery disease.

    abstract::Percutaneous coronary intervention (PCI) of multivessel and/or left main stem disease have been shown to be potentially legitimate revascularization alternatives in appropriately selected patients. Risk stratification is an important component in guiding patients to identify the most appropriate revascularization moda...

    journal_title:Current cardiology reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11886-011-0202-5

    authors: Farooq V,Brugaletta S,Serruys PW

    更新日期:2011-10-01 00:00:00

  • Catheter ablation of ventricular tachycardia in patients with ischemic heart disease.

    abstract::Radiofrequency ablation is a valuable adjunctive therapy to implantable defibrillators in patients with recurrent monomorphic ventricular tachycardia (VT) after myocardial infarction. Episodes of VT are markedly reduced in most patients, and the major complications are less than 5%. Newer approaches allow successful a...

    journal_title:Current cardiology reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11886-003-0092-2

    authors: Soejima K,Stevenson WG

    更新日期:2003-09-01 00:00:00

  • Estrogen therapies, lipids, and the heart disease prevention controversy.

    abstract::One of the most highly unexpected reports in recent medical literature was the lack of benefit of estrogen-progestin replacement therapy in cardiovascular disease prevention in postmenopausal women. The ensuing negative view of hormone replacement therapy has now extended to all forms of postmenopausal hormone treatme...

    journal_title:Current cardiology reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11886-003-0110-4

    authors: Knopp RH,Aikawa K,Knopp EA

    更新日期:2003-11-01 00:00:00

  • Imaging Approaches for Coronary Artery Anomalies: Purpose and Techniques.

    abstract:PURPOSE OF REVIEW:Comprehensive discussion of alternative techniques in imaging coronary artery anomalies (CAAs) in different diagnostic scenarios. RECENT FINDINGS:At primary screening, intramural course essentially correlates with stenosis and clinical repercussion in some types of CAAs. Potential clinical aims in im...

    journal_title:Current cardiology reports

    pub_type: 杂志文章

    doi:10.1007/s11886-019-1188-7

    authors: Angelini P

    更新日期:2019-07-29 00:00:00

  • What is the role of aldosterone excess in resistant hypertension and how should it be investigated and treated?

    abstract::Resistant hypertension has evolved as an important global health care problem. Primary aldosteronism is one of several potentially reversible causes of resistant hypertension. Primary aldosteronism can be effectively treated, when recognized, with a mineralocorticoid receptor antagonist, such as spironolactone and epl...

    journal_title:Current cardiology reports

    pub_type: 杂志文章

    doi:10.1007/s11886-011-0224-z

    authors: Sica DA

    更新日期:2011-12-01 00:00:00

  • White Coat Hypertension and Cardiovascular Diseases: Innocent or Guilty.

    abstract:PURPOSE OF REVIEW:This review aims to clarify the cardiovascular risk of white coat hypertension (WCH). RECENT FINDINGS:Cardiovascular risk of WCH has been evaluated in multiple meta-analyses and population-based studies. International Database on Ambulatory Blood Pressure Monitoring in Relation to Cardiovascular Outc...

    journal_title:Current cardiology reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11886-018-0964-0

    authors: Abolbashari M

    更新日期:2018-03-08 00:00:00

  • Dosing considerations and monitoring of low molecular weight heparins and glycoprotein IIb/IIIa antagonists in patients with renal insufficiency.

    abstract::Glycoprotein IIb/IIIa inhibitors and low molecular heparins are important new components of the medical treatment for acute coronary syndromes (ACS). Renal insufficiency is a common comorbid condition and high-risk marker for ACS. The safety and efficacy of these treatments in ACS are dependent on the pharmacokinetics...

    journal_title:Current cardiology reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11886-003-0067-3

    authors: Rammohan C,Fintel D

    更新日期:2003-07-01 00:00:00

  • Endocardial pacing: the wave of the future?

    abstract::Cardiac resynchronization therapy (CRT) is a proven treatment for heart failure and requires the implantation of a left ventricular (LV) lead, usually placed in a tributary of the coronary sinus. Encouraged by the fact that approximately 30 % of the patients receiving CRT do not benefit from this therapy, LV endocardi...

    journal_title:Current cardiology reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11886-012-0298-2

    authors: Bordachar P,Ploux S,Lumens J

    更新日期:2012-10-01 00:00:00

  • PET Imaging of the Human Nicotinic Cholinergic Pathway in Atherosclerosis.

    abstract::During the past years, non-neuronal vascular nicotinic acetylcholine receptors (nAChRs) increasingly have gained interest in cardiovascular research, as they are known to mediate the deleterious effects of nicotine and nitrosamines, components of tobacco smoke, on the vasculature. Because smoking is a major risk facto...

    journal_title:Current cardiology reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11886-015-0614-8

    authors: Bauwens M,Mottaghy FM,Bucerius J

    更新日期:2015-08-01 00:00:00

  • Rationale and Current Evidence for Testing Iron Chelators for Treating Stroke.

    abstract:PURPOSE OF REVIEW:To discuss the mechanisms of iron regulation in the brain and the pathophysiological role of deregulation of iron homeostasis following a stroke, and to review existing evidence supporting the potential role of iron chelators in the treatment of ischemic and hemorrhagic stroke. RECENT FINDINGS:In rec...

    journal_title:Current cardiology reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11886-019-1106-z

    authors: Hanafy KA,Gomes JA,Selim M

    更新日期:2019-03-04 00:00:00

  • The growing problem of stroke among young adults.

    abstract::Although overall stroke incidence has been declining in developed countries, there is evidence that stroke in the young is increasing. Increasing incidence may be particularly pronounced among minorities in whom historically a higher burden of stroke has been reported. Compared with older adults, time spent with disab...

    journal_title:Current cardiology reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11886-013-0421-z

    authors: Sultan S,Elkind MS

    更新日期:2013-12-01 00:00:00

  • When high is low: raising low levels of high-density lipoprotein cholesterol.

    abstract::Low serum levels of high-density lipoprotein cholesterol (HDL-C) are highly prevalent and are recognized as an independent risk factor for cardiovascular morbidity (myocardial infarction, stroke, peripheral arterial disease, and restenosis after coronary stenting) and mortality. HDL plays an important role in modulati...

    journal_title:Current cardiology reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11886-008-0077-2

    authors: Toth PP

    更新日期:2008-11-01 00:00:00

  • Future prospects in magnetic resonance imaging.

    abstract::Cardiovascular magnetic resonance (CMR) is widely regarded as capable of providing a cornucopia of detailed diagnostic information. However, of that information, very little is truly unique, and can be obtained by a combination of alternate diagnostic modalities. Given this, it is anticipated that in the short term (1...

    journal_title:Current cardiology reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11886-004-0067-y

    authors: Doyle M,Biederman RW

    更新日期:2004-01-01 00:00:00

  • ASD Closure in Structural Heart Disease.

    abstract:PURPOSE OF REVIEW:While the safety and efficacy of percutaneous ASD closure has been established, new data have recently emerged regarding the negative impact of residual iatrogenic ASD (iASD) following left heart structural interventions. Additionally, new devices with potential advantages have recently been studied. ...

    journal_title:Current cardiology reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11886-018-0983-x

    authors: Wiktor DM,Carroll JD

    更新日期:2018-04-17 00:00:00

  • Functional Information in Coronary Artery Disease: The Case of Computed Tomography Myocardial Perfusion.

    abstract:PURPOSE OF REVIEW:To review methodological and logistical aspects of CT myocardial perfusion, current clinical evidence and possible future directions, with specific focus on use in patients with coronary artery disease (CAD). RECENT FINDINGS:CT myocardial perfusion imaging may be performed as an add-on to standard co...

    journal_title:Current cardiology reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11886-017-0937-8

    authors: Kofoed KF,Sørgaard MH,Linde JJ

    更新日期:2017-10-25 00:00:00

  • Is There Currently a Place for Combined Mitral and Aortic Transcatheter Interventions?

    abstract:PURPOSE OF REVIEW:The goal was to evaluate published data on the incidence, diagnosis, and management of symptomatic combined mitral and aortic valvular disease. Furthermore, to identify the role of treatment using contemporary transcatheter techniques. RECENT FINDINGS:Up to a quarter of symptomatic adult valvular dis...

    journal_title:Current cardiology reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11886-019-1205-x

    authors: De Palma R,O'Sullivan CJ,Settergren M

    更新日期:2019-09-13 00:00:00

  • Emerging inflammatory markers for assessing coronary heart disease risk.

    abstract::Although assessment of traditional coronary heart disease risk factors can often stratify individuals into low- or high-risk categories, additional means are needed to more precisely classify people clinically defined as intermediate-risk, to guide the intensity of risk-reducing therapies. The recognition that inflamm...

    journal_title:Current cardiology reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11886-009-0065-1

    authors: Corson MA

    更新日期:2009-11-01 00:00:00

  • Advanced Imaging and Diagnostic Methods in the Assessment of Suspected Ischemic Heart Disease in Women.

    abstract::Although differences diminish with age, outcomes are overall worse for women compared to men who present with suspected acute coronary syndrome. The reasons for this discrepancy are multifactorial, including sex-related differences in atherosclerosis biology and fluid dynamics, as well as a premature conclusion by pro...

    journal_title:Current cardiology reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11886-016-0767-0

    authors: Joly JM,Bittner V

    更新日期:2016-09-01 00:00:00

  • Which antithrombin for whom? Identifying the patient population that benefits most from novel antithrombin agents.

    abstract::Anticoagulation has proven to be a key component in the management of acute coronary syndromes (ACS). Pharmacological agents with various modes of action are utilized to reduce thrombus development by impairing thrombin formation, platelet activation, and platelet aggregation. The optimal management of these patients ...

    journal_title:Current cardiology reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11886-012-0286-6

    authors: Burke DA,Warraich HJ,Pinto DS

    更新日期:2012-08-01 00:00:00

  • Genetic determinants of drug response in heart failure.

    abstract::Heart failure management is complex and costly. Genetic variations that alter drug absorption, metabolism, and receptor-ligand interactions have the potential to modify drug response and safety. Evidence shows that genetic factors interact with numerous heart failure medications, including vasodilators, beta blockers,...

    journal_title:Current cardiology reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11886-008-0031-3

    authors: Lowes BD,Buttrick PM

    更新日期:2008-05-01 00:00:00

  • Clinical Phenotyping of Transthyretin Cardiac Amyloidosis with Bone-Seeking Radiotracers in Heart Failure with Preserved Ejection Fraction.

    abstract:PURPOSE OF REVIEW:The two most common types of cardiac amyloidosis are caused by fibril deposits of immunoglobulin light chains (AL) and transthyretin (TTR), each with distinct prognosis and clinical management. Cardiac amyloidosis is under-recognized among heart failure patients with preserved ejection fraction (HFpEF...

    journal_title:Current cardiology reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11886-018-0970-2

    authors: Chen W,Ton VK,Dilsizian V

    更新日期:2018-03-08 00:00:00

  • Antithrombotic strategies in gene therapy.

    abstract::Advances in the field of molecular medicine are making gene therapy a viable treatment strategy for the next millennium. Indeed, over the past 10 years, a number of improvements have occurred that have resulted in an increased interest in gene therapy for the treatment of diseases in cardiovascular medicine. Because a...

    journal_title:Current cardiology reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11886-000-0023-4

    authors: Channon KM,Annex BH

    更新日期:2000-01-01 00:00:00

  • Multimodality imaging for assessment of myocardial viability: nuclear, echocardiography, MR, and CT.

    abstract::The assessment of myocardial viability may be an important component of the evaluation of patients with coronary artery disease and left ventricular dysfunction. The primary goal of viability assessment in such patients is to guide therapeutic decisions by determining which patients would most likely benefit from reva...

    journal_title:Current cardiology reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11886-011-0242-x

    authors: Arrighi JA,Dilsizian V

    更新日期:2012-04-01 00:00:00

  • Indications and applications of arterial stents for stroke prevention in atherosclerotic intracranial stenosis.

    abstract::Intracranial stenosis accounts for 8-10% of all ischemic strokes in North America, a frequency slightly less than that of extracranial carotid stenosis. Among patients presenting with transient ischemic attack or stroke due to intracranial stenosis, the risk of recurrent stroke in the first year after initial symptoms...

    journal_title:Current cardiology reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11886-009-0070-4

    authors: Fields JD,Liu KC,Barnwell SL,Clark WM,Lutsep HL

    更新日期:2010-01-01 00:00:00