Cellular Reprogramming Approaches to Engineer Cardiac Pacemakers.

Abstract:

PURPOSE OF REVIEW:The goal of this paper is to review present knowledge regarding biological pacemakers created by somatic reprogramming as a platform for mechanistic and metabolic understanding of the rare subpopulation of pacemaker cells, with the ultimate goal of creating biological alternatives to electronic pacing devices. RECENT FINDINGS:Somatic reprogramming of cardiomyocytes by reexpression of embryonic transcription factor T-box 18 (TBX18) converts them into pacemaker-like. Recent studies take advantage of this model to gain insight into the electromechanical, metabolic, and architectural intricacies of the cardiac pacemaker cell across various models, including a surgical model of complete atrioventricular block (CAVB) in adult rats. The studies reviewed here reinforce the potential utility of TBX18-induced pacemaker myocytes (iPMS) as a minimally invasive treatment for heart block. Several challenges which must be overcome to develop a viable therapeutic intervention based on these observations are discussed.

journal_name

Curr Cardiol Rep

authors

Xiao A,Cho HC

doi

10.1007/s11886-020-01281-6

subject

Has Abstract

pub_date

2020-03-30 00:00:00

pages

29

issue

5

eissn

1523-3782

issn

1534-3170

pii

10.1007/s11886-020-01281-6

journal_volume

22

pub_type

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