Bivalirudin for percutaneous coronary intervention and in acute coronary syndromes.

Abstract:

:This review focuses on the use of bivalirudin as a replacement anticoagulant for heparin in patients undergoing percutaneous coronary intervention, or who are being treated for unstable angina pectoris, ST-elevation, or non-ST-elevation myocardial infarction. Potential advantages of bivalirudin include a lack of dependence on antithrombin III for anticoagulant activity, the ability to inactivate both fibrin-bound and soluble thrombin, a lack of aggregatory effects on platelets, a predictable anticoagulant response without monitoring, and a wider therapeutic window. Clinical trial results to date suggest that bivlirudin is at least as effective as heparin with superior safety due to lower bleeding rates.

journal_name

Curr Cardiol Rep

authors

Bates ER

doi

10.1007/s11886-001-0050-9

keywords:

subject

Has Abstract

pub_date

2001-09-01 00:00:00

pages

348-54

issue

5

eissn

1523-3782

issn

1534-3170

journal_volume

3

pub_type

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