Abstract：
:Imaging with radionuclides has historically played an important role in detection of cardiovascular disease as well as in risk stratification and prognostication. With the growth of molecular biology have come new therapeutic interventions and the requirement for new diagnostic imaging approaches. Noninvasive targeted radiotracer-based strategies require the development of new instrumentation to meet these needs. This progress has been made possible with the availability of many technologic advances, which include dedicated micro single-photon emission computed tomography (SPECT) and micro positron emission tomography (PET) hybrid systems for small animal imaging. This review is a brief overview on the subject of molecular imaging. Basic concepts of molecular imaging are reviewed, followed by description of current technologic advances, and current applications to evaluate ischemic heart disease and potential therapeutic intervention. The emphasis is on the use of both SPECT and PET radiotracers, although other imaging modalities are also briefly discussed.
journal_name
Curr Cardiol Repjournal_title
Current cardiology reportsauthors
Dobrucki LW,Sinusas AJdoi
10.1007/s11886-005-0025-3keywords:
subject
Has Abstractpub_date
2005-03-01 00:00:00pages
130-5issue
2eissn
1523-3782issn
1534-3170journal_volume
7pub_type
杂志文章,评审abstract：:Increasing barriers to medical device innovation in the United States including constrained financial resources and rising research costs require that physicians take on greater involvement in medical device development, evaluation, and regulatory processes. Such involvement requires that physicians understand basic a...
journal_title：Current cardiology reports
pub_type： 杂志文章,评审
doi：10.1007/s11886-014-0494-3
更新日期：2014-01-01 00:00:00
abstract：:The assessment of myocardial viability may be an important component of the evaluation of patients with coronary artery disease and left ventricular dysfunction. The primary goal of viability assessment in such patients is to guide therapeutic decisions by determining which patients would most likely benefit from reva...
journal_title：Current cardiology reports
pub_type： 杂志文章,评审
doi：10.1007/s11886-011-0242-x
更新日期：2012-04-01 00:00:00
abstract：:Device therapy for the treatment of uncontrolled and resistant hypertension has evolved significantly over the past several decades. Both renal artery disease and sympathetic hyperactivity have been linked to resistant hypertension. This manuscript will review the current evidence base supporting device therapy (e.g.,...
journal_title：Current cardiology reports
pub_type： 杂志文章,评审
doi：10.1007/s11886-014-0546-8
更新日期：2014-11-01 00:00:00
abstract：:Peripheral artery disease (PAD) has become increasingly common in the US patient population and can be a highly symptomatic and significant source of morbidity. When PAD is suspected, the first-line screening study that is obtained is typically a noninvasive evaluation that includes the ankle brachial index (ABI). Fol...
journal_title：Current cardiology reports
pub_type： 杂志文章,评审
doi：10.1007/s11886-015-0644-2
更新日期：2015-10-01 00:00:00
abstract：:The management of chronic stable angina has undergone considerable evolution over the past two decades. This article highlights the need for a comprehensive approach to management that includes carefully identifying cardiac risk factors, using therapeutic lifestyle interventions, aggressive, multifaceted medical thera...
journal_title：Current cardiology reports
pub_type： 杂志文章
doi：10.1007/s11886-008-0044-y
更新日期：2008-07-01 00:00:00
abstract：:Implantable cardioverter-defibrillators (ICDs) significantly reduce mortality in patients with depressed left ventricular ejection fraction (LVEF) and heart failure (HF). However, shortcomings of LVEF to accurately identify those at greatest risk of ventricular tachyarrhythmias have led to the pursuit of alternative m...
journal_title：Current cardiology reports
pub_type： 杂志文章,评审
doi：10.1007/s11886-013-0359-1
更新日期：2013-05-01 00:00:00
abstract：PURPOSE OF REVIEW:The aim of this report is to describe the main aspects of sex-related differences in non-ischemic dilated cardiomyopathies (DCM), focusing on chemotherapy-induced heart failure (HF) and investigating the possible therapeutic implications and clinical management applications in the era of personalized ...
journal_title：Current cardiology reports
pub_type： 杂志文章,评审
doi：10.1007/s11886-020-01377-z
更新日期：2020-08-08 00:00:00
abstract：:Aortic stenosis affects many people worldwide with a significant impact on morbidity and mortality with uncorrected, symptomatic aortic valve stenosis carrying mortality of 50% at one year. Degenerative calcific pathology, the most common cause of aortic stenosis, increases in prevalence with age; estimated prevalence...
journal_title：Current cardiology reports
pub_type： 杂志文章,评审
doi：10.1007/s11886-013-0367-1
更新日期：2013-06-01 00:00:00
abstract：:Observational studies have established a strong association between the presence of patent foramen ovale (PFO) and increased risk of ischemic stroke. The mechanism involved is presumed to be a paradoxical embolism from a venous thrombus that travels via the PFO to the systemic circulation. The best treatment modality ...
journal_title：Current cardiology reports
pub_type： 杂志文章,评审
doi：10.1007/s11886-004-0013-z
更新日期：2004-03-01 00:00:00
abstract：PURPOSE OF REVIEW:In this review, we summarise the evidence on the association between cardiovascular disease (CVD) and cognitive impairment and explore the role of the nitric oxide (NO) pathway as a causal mechanism. RECENT FINDINGS:Evidence from epidemiological studies suggests that the presence of CVD and its risk ...
journal_title：Current cardiology reports
pub_type： 杂志文章,评审
doi：10.1007/s11886-017-0898-y
更新日期：2017-08-11 00:00:00
abstract：:Aldosterone is the principal circulating mineralocorticoid in humans, and aldosterone synthesis normally occurs in the face of volume depletion and renin stimulation. In primary and secondary aldosteronism, aldosterone synthesis continues despite volume expansion and causes hypertension. Other steroid hormones that ar...
journal_title：Current cardiology reports
pub_type： 杂志文章,评审
doi：10.1007/s11886-005-0059-6
更新日期：2005-11-01 00:00:00
abstract：:Transcatheter aortic valve replacement (TAVR) has become an alternative to surgical intervention for symptomatic or severe aortic valve stenosis in patients with high surgical risk. Successful TAVR requires a multimodality imaging approach for appropriate patient selection and prosthesis sizing. Here, we describe indi...
journal_title：Current cardiology reports
pub_type： 杂志文章,评审
doi：10.1007/s11886-015-0694-5
更新日期：2016-02-01 00:00:00
abstract：:Although advanced heart failure has been considered the main indication for heart transplantation, the increasing number of candidates and shortage of organs for transplantation, with accumulating waiting lists, has originated another look into more conventional surgery, previously considered of prohibitive risk. In f...
journal_title：Current cardiology reports
pub_type： 杂志文章,评审
doi：10.1007/s11886-004-0028-5
更新日期：2004-05-01 00:00:00
abstract：:Viable treatment options for advanced heart failure have not emerged as the number of people afflicted with this condition has grown. Although heart transplantation is the only curative strategy for patients with end-stage heart failure, the relative shortage of donors has led to a worldwide plateau of this option ove...
journal_title：Current cardiology reports
pub_type： 杂志文章,评审
doi：10.1007/s11886-014-0468-5
更新日期：2014-04-01 00:00:00
abstract：PURPOSE OF REVIEW:Cardiovascular disease is a leading cause of morbidity and mortality worldwide and is the focus of extensive biomedical research. Large genetic consortia combining data from many traditional prospective cohort and ascertained case-control study designs have facilitated the discovery of genetic associa...
journal_title：Current cardiology reports
pub_type： 杂志文章,评审
doi：10.1007/s11886-018-0969-8
更新日期：2018-03-08 00:00:00
abstract：:The most common cause of acute coronary syndrome (ACS) is rupture of an atherosclerotic lesion containing a large necrotic core and a thin fibrous cap followed by acute luminal thrombosis because the rupture of the thin fibrous cap allows contact of the platelets with the highly thrombogenic necrotic core. Pathologic ...
journal_title：Current cardiology reports
pub_type： 杂志文章,评审
doi：10.1007/s11886-010-0113-x
更新日期：2010-07-01 00:00:00
abstract：PURPOSE OF REVIEW:Results from cardiovascular (CV) outcome trials have revealed important insights into the CV safety and efficacy of glucose-lowering agents, including dipeptidyl peptidase-4 inhibitors (DPP-4i) and glucagon-like peptide-1 receptor agonists (GLP-1RA). RECENT FINDINGS:Among patients with T2DM, DPP-4i h...
journal_title：Current cardiology reports
pub_type： 杂志文章,评审
doi：10.1007/s11886-020-01355-5
更新日期：2020-08-08 00:00:00
abstract：:The Fontan operation has been nothing short of revolutionary in its influence on the modern management of patients born with functionally univentricular hearts. The vast majority of these individuals are now surviving well into adulthood. In the 45 years since its introduction, however, there has been increasing recog...
journal_title：Current cardiology reports
pub_type： 杂志文章,评审
doi：10.1007/s11886-016-0716-y
更新日期：2016-05-01 00:00:00
abstract：:Aortic valve replacement can produce dramatic benefit in the setting of aortic stenosis. The potential for morbidity and mortality associated with thoracotomy, cardiopulmonary bypass, and aortotomy has fostered a search for alternatives. Early experience with transcatheter endovascular aortic valve implantation demons...
journal_title：Current cardiology reports
pub_type： 杂志文章,评审
doi：10.1007/s11886-008-0019-z
更新日期：2008-03-01 00:00:00
abstract：PURPOSE OF REVIEW:Transcatheter aortic valve replacement (TAVR) has developed into an important alternative to surgical aortic valve replacement (SAVR) for patients with severe aortic stenosis (AS). Adjuvant antithrombotic therapies are commonly used during and after TAVR to decrease the risk of valve thrombosis and th...
journal_title：Current cardiology reports
pub_type： 杂志文章,评审
doi：10.1007/s11886-017-0850-1
更新日期：2017-05-01 00:00:00
abstract：PURPOSE OF REVIEW:Although rare, sudden cardiac death (SCD) in the young is a tragic event, having a dramatic impact upon all involved. The psychosocial burden associated with SCD can leave friends, families, and entire communities bereft. With only limited evidence to describe the volatile emotional reactions associat...
journal_title：Current cardiology reports
pub_type： 杂志文章,评审
doi：10.1007/s11886-020-01419-6
更新日期：2020-10-10 00:00:00
abstract：PURPOSE OF REVIEW:Drug-coated balloons (DEB) and drug-eluting stents (DES) emerged as a tool to aid in lowering the rates of neointimal hyperplasia and target lesion restenosis following endovascular peripheral arterial disease (PAD) interventions. RECENT FINDINGS:Although the initial trials comparing these devices wi...
journal_title：Current cardiology reports
pub_type： 杂志文章,评审
doi：10.1007/s11886-019-1211-z
更新日期：2019-09-07 00:00:00
abstract：PURPOSE OF REVIEW:Ebstein's anomaly (EA) is a rare, but complex form of congenital heart disease consisting of a right ventricular myopathy and morphologic tricuspid valve disease leading to a high incidence of right ventricular dysfunction and arrhythmias. This review offers an updated overview of the current understa...
journal_title：Current cardiology reports
pub_type： 杂志文章,评审
doi：10.1007/s11886-020-01412-z
更新日期：2020-10-09 00:00:00
abstract：:Fifty thousand Americans suffer an intracerebral hemorrhage (ICH) annually, one third of whom die as a result. Poorly controlled hypertension is the most important risk factor for ICH. Over time it results in pathologic changes to small intracranial vessels, leading to their rupture. All stroke patients, including tho...
journal_title：Current cardiology reports
pub_type： 杂志文章,评审
doi：10.1007/s11886-002-0029-1
更新日期：2002-03-01 00:00:00
abstract：:The accurate differentiation of viable and nonviable myocardium is crucial for therapy planning in patients with coronary artery disease and left ventricular dysfunction. Traditional techniques such as echocardiography, positron emission tomography, single photon emission computed tomography, and dobutamine echocardio...
journal_title：Current cardiology reports
pub_type： 杂志文章,评审
doi：10.1007/s11886-005-0012-8
更新日期：2005-01-01 00:00:00
abstract：:Echocardiography is the most common noninvasive tool used in assessing cardiac masses. Real-time three-dimensional echocardiography expands the diagnostic capabilities of cardiac ultrasound in assessing the location, composition, size, and relationship to other structures of cardiac masses. The improved characterizati...
journal_title：Current cardiology reports
pub_type： 杂志文章,评审
doi：10.1007/s11886-009-0029-5
更新日期：2009-05-01 00:00:00
abstract：PURPOSE OF REVIEW:The present review aims to discuss the recent advances in surgical management of spontaneous intracerebral hemorrhage (ICH), safety and efficacy of minimally invasive surgical techniques, and the existing evidence supporting their use. RECENT FINDINGS:Newer surgical techniques, collectively referred ...
journal_title：Current cardiology reports
pub_type： 杂志文章,评审
doi：10.1007/s11886-018-1078-4
更新日期：2018-10-11 00:00:00
abstract：:Sodium is an essential nutrient, mostly ingested as salt (sodium chloride). Average sodium intake ranges from 3 to 6 g per day (7.5-15 g/day of salt) in most countries, with regional variations. Increasing levels of sodium intake have a positive association with higher blood pressure. Randomized controlled trials repo...
journal_title：Current cardiology reports
pub_type： 杂志文章,评审
doi：10.1007/s11886-014-0529-9
更新日期：2014-01-01 00:00:00
abstract：:Management of severe chronic mitral regurgitation (MR) in severe heart failure is challenging. There are controversies over the efficacy of surgical correction of MR in the presence of severely depressed left ventricular (LV) function. The etiology of MR plays an important role in clinical decision making. In organic ...
journal_title：Current cardiology reports
pub_type： 杂志文章,评审
doi：10.1007/s11886-006-0038-6
更新日期：2006-05-01 00:00:00
abstract：:Intracranial stenosis accounts for 8-10% of all ischemic strokes in North America, a frequency slightly less than that of extracranial carotid stenosis. Among patients presenting with transient ischemic attack or stroke due to intracranial stenosis, the risk of recurrent stroke in the first year after initial symptoms...
journal_title：Current cardiology reports
pub_type： 杂志文章,评审
doi：10.1007/s11886-009-0070-4
更新日期：2010-01-01 00:00:00
