Large-Scale Genomic Biobanks and Cardiovascular Disease.

abstract：PURPOSE OF REVIEW:Cell therapy for cardiovascular diseases is regarded as a rapidly growing field within regenerative medicine. Different cellular populations enriched for cardiac progenitor cells (CPCs), or derivate a-cellular products, are currently under preclinical and clinical evaluation. Here, we have reviewed th...

journal_title：Current cardiology reports

authors： Pagano F,Picchio V,Angelini F,Iaccarino A,Peruzzi M,Cavarretta E,Biondi-Zoccai G,Sciarretta S,De Falco E,Chimenti I,Frati G

更新日期：2018-08-13 00:00:00

abstract：:Patients with pre-diabetes have a tenfold higher risk of developing Type 2 DM and a twofold higher risk of developing coronary heart disease compared to non-diabetics. Interventions targeted at those in an early stage of impaired glucose metabolism can delay or prevent diabetes. Effects of these interventions on cardi...

journal_title：Current cardiology reports

authors： Popp Switzer M,Elhanafi S,San Juan ZT

更新日期：2015-03-01 00:00:00

abstract：:Conventional algorithms and noninvasive imaging tests for the identification of stable, hemodynamically significant coronary artery disease offer little insight into the detection of potentially vulnerable and inflamed coronary plaques, those most likely to rupture and cause acute coronary syndromes. Positron emission...

journal_title：Current cardiology reports

authors： Rogers IS,Tawakol A

更新日期：2011-04-01 00:00:00

abstract：:Heart failure is becoming increasingly prevalent, and currently coronary artery disease (CAD) is the primary cause of left ventricular (LV) systolic dysfunction. A potential therapeutic option for patients with severe CAD and LV dysfunction is a strategy of revascularization. In this review, we summarize the available...

journal_title：Current cardiology reports

authors： Ghose T,Thompson RC

更新日期：2006-07-01 00:00:00

abstract：PURPOSE OF REVIEW:The number of pregnancies complicated by valvular heart disease is increasing. This review describes the hemodynamic effects of clinically important valvular abnormalities during pregnancy and reviews current guideline-driven management strategies. RECENT FINDINGS:Valvular heart disease in women of c...

journal_title：Current cardiology reports

authors： Goldstein SA,Ward CC

更新日期：2017-08-24 00:00:00

abstract：:Coronary artery bypass grafting without the aid of cardiopulmonary bypass (CPB) continues to gain popularity as an alternative to standard techniques of revascularization. CPB with cardioplegic arrest is associated with complications that may negate an otherwise technically flawless procedure. Experience has identifie...

journal_title：Current cardiology reports

authors： Dewey TM,Mack MJ

更新日期：1999-11-01 00:00:00

abstract：:Traditional transvenous approach for permanent cardiac pacing can be associated with significant acute and chronic complications related partly to either the insertion of transvenous lead or subcutaneous placement of pacemaker device. We summarize the current status of a novel self-contained leadless cardiac pacemaker...

journal_title：Current cardiology reports

authors： Neuzil P,Reddy VY

更新日期：2015-08-01 00:00:00

abstract：PURPOSE OF REVIEW:Heart failure with preserved ejection fraction (HFpEF) is a relatively new disease entity used in medical terminology; however, both the number of patients and its clinical significance are growing. HFpEF used to be seen as a mild condition; however, the symptoms and quality of life of the patients ar...

journal_title：Current cardiology reports

authors： Adamczak DM,Oduah MT,Kiebalo T,Nartowicz S,Bęben M,Pochylski M,Ciepłucha A,Gwizdała A,Lesiak M,Straburzyńska-Migaj E

更新日期：2020-07-09 00:00:00

abstract：:The accurate differentiation of viable and nonviable myocardium is crucial for therapy planning in patients with coronary artery disease and left ventricular dysfunction. Traditional techniques such as echocardiography, positron emission tomography, single photon emission computed tomography, and dobutamine echocardio...

journal_title：Current cardiology reports

authors： Wagner A,Mahrholdt H,Kim RJ,Judd RM

更新日期：2005-01-01 00:00:00

abstract：PURPOSE OF THE REVIEW:Moderate or severe aortic regurgitation (AR) occurs in 0.5% of the population and typically peaks in the fourth to sixth decade of life. A significant proportion of patients have prohibitive surgical risk and are therefore treated medically with pharmacological management of heart failure and no d...

journal_title：Current cardiology reports

authors： Markham R,Ghodsian M,Sharma R

更新日期：2020-07-28 00:00:00

abstract：:Since 1971, the Fontan operation has been performed for the repair of single-ventricle physiology. This ingenious operation commits a single ventricle to the systemic circulation and takes advantage of cardiovascular and respiratory physiology to propel deoxygenated blood to the lungs, thus minimizing right-to-left sh...

journal_title：Current cardiology reports

authors： Aboulhosn J,Child JS

更新日期：2007-07-01 00:00:00

abstract：:Cardiac resynchronization therapy (CRT) is a proven treatment for heart failure and requires the implantation of a left ventricular (LV) lead, usually placed in a tributary of the coronary sinus. Encouraged by the fact that approximately 30 % of the patients receiving CRT do not benefit from this therapy, LV endocardi...

journal_title：Current cardiology reports

authors： Bordachar P,Ploux S,Lumens J

更新日期：2012-10-01 00:00:00

abstract：:Several next generation sequencing platforms allow for a DNA-to-diagnosis protocol to identify the molecular basis of monogenic dyslipidemias. However, recent reports of the application of whole genome or whole exome sequencing in families with severe dyslipidemias have largely identified genetic variants in known lip...

journal_title：Current cardiology reports

authors： Farhan SM,Hegele RA

更新日期：2014-07-01 00:00:00

abstract：PURPOSE OF REVIEW:Congenital heart disease is the most common birth defect and acquired heart disease is the leading cause of death in adults. Understanding the mechanisms that drive cardiomyocyte proliferation and differentiation has the potential to advance the understanding and potentially the treatment of different...

journal_title：Current cardiology reports

authors： Yester JW,Kühn B

更新日期：2017-02-01 00:00:00

abstract：:While pulmonary arterial hypertension is a disease primarily affecting the pulmonary vasculature, the right ventricle plays an integral part in the disease process. Although widely used, two-dimensional echocardiography is limited in visualizing the right ventricle and, therefore, assessment of its structure and funct...

journal_title：Current cardiology reports

authors： Freed BH,Patel AR,Lang RM

更新日期：2012-06-01 00:00:00

abstract：:A natural extension of current imaging paradigms for diagnosing coronary artery disease may well be the integration of CT with myocardial perfusion single-photon CT (SPECT). Although there is a wealth of clinical information regarding the utility of SPECT, the value of CT in the cardiology arena has only recently been...

journal_title：Current cardiology reports

authors： Mahmarian JJ

更新日期：2007-04-01 00:00:00

abstract：:Transcatheter aortic valve replacement (TAVR) has become an alternative to surgical intervention for symptomatic or severe aortic valve stenosis in patients with high surgical risk. Successful TAVR requires a multimodality imaging approach for appropriate patient selection and prosthesis sizing. Here, we describe indi...

journal_title：Current cardiology reports

authors： Caruso D,Rosenberg RD,De Cecco CN,Mangold S,Wichmann JL,Varga-Szemes A,Steinberg DH,Laghi A,Schoepf UJ

更新日期：2016-02-01 00:00:00

abstract：PURPOSE OF REVIEW:Variant angina, which is characterized by recurrent chest pain and transient ECG changes along with angiographic evidence of coronary artery spasm, generally has a favorable prognosis. However, episodes of ischemia caused by vasospasm may lead to potentially life-threatening ventricular arrhythmias an...

journal_title：Current cardiology reports

authors： Kundu A,Vaze A,Sardar P,Nagy A,Aronow WS,Botkin NF

更新日期：2018-03-08 00:00:00

abstract：:As women with congenital heart disease (CHD) approach childbearing age, issues such as pregnancy and contraception need to be addressed. Women with CHD represent a heterogeneous population. While some have simple cardiac lesions and thus have contraceptive risks that are no different from those of the general populati...

journal_title：Current cardiology reports

authors： Silversides CK,Sermer M,Siu SC

更新日期：2009-07-01 00:00:00

abstract：:In recent years, the importance of alterations of cardiac autonomic nerve function in the pathophysiology of heart diseases including heart failure, arrhythmia, ische-mic heart disease, and diabetes has been increasingly recognized. Several radiolabeled compounds have been synthesized for noninvasive imaging, includin...

journal_title：Current cardiology reports

authors： Higuchi T,Schwaiger M

更新日期：2006-03-01 00:00:00

abstract：:Intracranial stenosis accounts for 8-10% of all ischemic strokes in North America, a frequency slightly less than that of extracranial carotid stenosis. Among patients presenting with transient ischemic attack or stroke due to intracranial stenosis, the risk of recurrent stroke in the first year after initial symptoms...

journal_title：Current cardiology reports

authors： Fields JD,Liu KC,Barnwell SL,Clark WM,Lutsep HL

更新日期：2010-01-01 00:00:00

abstract：PURPOSE OF REVIEW:This review summarises and discusses the epidemiological evidence suggesting a causal relationship between sleep duration and cardio-metabolic risk and outcomes in population. RECENT FINDINGS:Sleep duration is affected by a variety of cultural, social, psychological, behavioural, pathophysiological a...

journal_title：Current cardiology reports

authors： Cappuccio FP,Miller MA

更新日期：2017-09-19 00:00:00

abstract：:The management of chronic stable angina has undergone considerable evolution over the past two decades. This article highlights the need for a comprehensive approach to management that includes carefully identifying cardiac risk factors, using therapeutic lifestyle interventions, aggressive, multifaceted medical thera...

journal_title：Current cardiology reports

authors： Eid F,Boden WE

更新日期：2008-07-01 00:00:00

abstract：:Glycoprotein IIb/IIIa inhibitors and low molecular heparins are important new components of the medical treatment for acute coronary syndromes (ACS). Renal insufficiency is a common comorbid condition and high-risk marker for ACS. The safety and efficacy of these treatments in ACS are dependent on the pharmacokinetics...

journal_title：Current cardiology reports

authors： Rammohan C,Fintel D

更新日期：2003-07-01 00:00:00

abstract：:Thrombolytic therapy aims to achieve rapid and sustained infarct-related artery patency, although this results in a procoagulant state. Heparin has limitations as an antithrombin agent, which has led to clinical investigation of alternative agents. Direct thrombin inhibitors, as adjuncts to thrombolytic therapy, have ...

journal_title：Current cardiology reports

authors： French JK,White HD

更新日期：1999-09-01 00:00:00

abstract：:Aortic valve replacement can produce dramatic benefit in the setting of aortic stenosis. The potential for morbidity and mortality associated with thoracotomy, cardiopulmonary bypass, and aortotomy has fostered a search for alternatives. Early experience with transcatheter endovascular aortic valve implantation demons...

journal_title：Current cardiology reports

authors： Webb JG

更新日期：2008-03-01 00:00:00

abstract：:Due to an increase in the number of patients with heart failure and ventricular arrhythmias, ventricular tachycardia ablation has a growing clinical role. Long-term success rates remain suboptimal and require creating a detailed electroanatomic map during the procedure to identify fibrotic areas responsible for arrhyt...

journal_title：Current cardiology reports

authors： Duell J,Dilsizian V,Smith M,Chen W,Dickfeld T

更新日期：2016-02-01 00:00:00

abstract：PURPOSE OF REVIEW:This review describes the dynamic relationship between diabetes mellitus (DM) and coronary artery disease (CAD) with respect to different revascularization strategies and how angiographic tools such as the Synergy between PCI with Taxus and Cardiac Surgery (SYNTAX) score can supplement clinical decisi...

journal_title：Current cardiology reports

authors： Kundu A,Sardar P,O'Day K,Chatterjee S,Owan T,Dawn Abbott J

更新日期：2018-03-23 00:00:00

abstract：:One of the most highly unexpected reports in recent medical literature was the lack of benefit of estrogen-progestin replacement therapy in cardiovascular disease prevention in postmenopausal women. The ensuing negative view of hormone replacement therapy has now extended to all forms of postmenopausal hormone treatme...

journal_title：Current cardiology reports

authors： Knopp RH,Aikawa K,Knopp EA

更新日期：2003-11-01 00:00:00

abstract：PURPOSE OF REVIEW:To analyze the current state of the art of functional mitral regurgitation (FMR) treatment. RECENT FINDINGS:The first-line treatment of severe FMR consists of guideline medical therapy (GMT) and resynchronization therapy when indicated; the impact of new medical therapies like sacubitril/valsartan ne...

journal_title：Current cardiology reports

authors： Fabris E,De Luca A,Vitrella G,Stolfo D,Masè M,Korcova R,Merlo M,Rakar S,Van't Hof AWJ,Kedhi E,Perkan A,Sinagra G

更新日期：2019-11-16 00:00:00