Abstract:
:The management of chronic stable angina has undergone considerable evolution over the past two decades. This article highlights the need for a comprehensive approach to management that includes carefully identifying cardiac risk factors, using therapeutic lifestyle interventions, aggressive, multifaceted medical therapy, and judiciously using myocardial revascularization. For patients whose ischemia cannot be optimally controlled with traditional anti-ischemic agents, a novel antianginal and anti-ischemic agent (ie, ranolazine) has promise in reducing refractory ischemia as add-on therapy. This article discusses the role of coronary artery bypass graft surgery and percutaneous coronary intervention (PCI) in managing chronic stable angina patients and the clinical implications of the COURAGE (Clinical Outcomes Utilizing Revascularization and Aggressive drug Evaluation) trial. The combined use of a "focal" approach (PCI to treat the culprit stenosis) and a "systemic" approach (lifestyle intervention and aggressive pharmacotherapy) may afford the best event-free survival and clinical outcomes in patients with stable angina.
journal_name
Curr Cardiol Repjournal_title
Current cardiology reportsauthors
Eid F,Boden WEdoi
10.1007/s11886-008-0044-ysubject
Has Abstractpub_date
2008-07-01 00:00:00pages
263-71issue
4eissn
1523-3782issn
1534-3170journal_volume
10pub_type
杂志文章abstract::Exercise intolerance in patients with chronic heart failure (CHF) shows no correlation to the degree of left ventricular dysfunction. This surprising finding has directed attention to peripheral changes in CHF: reduced endothelium-dependent vasodilation and altered skeletal muscle metabolism. Physical exercise trainin...
journal_title:Current cardiology reports
pub_type: 杂志文章,评审
doi:10.1007/s11886-999-0041-9
更新日期:1999-05-01 00:00:00
abstract::Understanding the genetic risk factors for stroke is an essential step to decipher the underlying mechanisms, facilitate the identification of novel therapeutic targets, and optimize the design of prevention strategies. A very small proportion of strokes are attributable to monogenic conditions, the vast majority bein...
journal_title:Current cardiology reports
pub_type: 杂志文章,评审
doi:10.1007/s11886-016-0804-z
更新日期:2016-12-01 00:00:00
abstract:PURPOSE OF REVIEW:Magnetic resonance imaging (MRI) has enabled non-invasive myocardial tissue characterization in a wide range of cardiovascular diseases by quantifying several tissue specific parameters such as T1, T2, and T2* relaxation times. Simultaneous assessment of these parameters has recently gained interest t...
journal_title:Current cardiology reports
pub_type: 杂志文章,评审
doi:10.1007/s11886-019-1181-1
更新日期:2019-07-27 00:00:00
abstract:PURPOSE OF REVIEW:Ocular perfusion pressure (OPP) is defined as the difference between BP and intraocular pressure (IOP). With low BP comes low OPP and resultant ischemic damage to the optic nerve, leading to glaucoma progression. The purpose of this article is to review the literature on BP as it relates to glaucoma a...
journal_title:Current cardiology reports
pub_type: 杂志文章,评审
doi:10.1007/s11886-017-0927-x
更新日期:2017-09-19 00:00:00
abstract::Over the past two decades, we have witnessed a large decrease in the death and complication rate of patients experiencing acute myocardial infarction (MI), due to our ability to restore blood flow to infarct-related arteries. Therapies include strategies to inhibit platelet function and induce fibrinolysis, and mechan...
journal_title:Current cardiology reports
pub_type: 杂志文章,评审
doi:10.1007/s11886-002-0067-8
更新日期:2002-07-01 00:00:00
abstract:PURPOSE OF REVIEW:Innovation for transcatheter aortic valve replacement (TAVR) has transformed a medically complex treatment into a standardized procedure. While Edwards SAPIEN and Medtronic CoreValve occupy the market for TAVR in the United States (US), additional valve systems are being developed. The Boston Scientif...
journal_title:Current cardiology reports
pub_type: 杂志文章,评审
doi:10.1007/s11886-019-1234-5
更新日期:2019-11-25 00:00:00
abstract:PURPOSE OF REVIEW:Cell therapy for cardiovascular diseases is regarded as a rapidly growing field within regenerative medicine. Different cellular populations enriched for cardiac progenitor cells (CPCs), or derivate a-cellular products, are currently under preclinical and clinical evaluation. Here, we have reviewed th...
journal_title:Current cardiology reports
pub_type: 杂志文章,评审
doi:10.1007/s11886-018-1031-6
更新日期:2018-08-13 00:00:00
abstract:PURPOSE OF REVIEW:Interventional cardiology and in particular the field of renal denervation is subject to constant change. This review provides an up to date overview of renal denervation trials and an outlook on what to expect in the future. RECENT FINDINGS:After the sham-controlled SYMPLICITY HTN-3 trial dampened t...
journal_title:Current cardiology reports
pub_type: 杂志文章,评审
doi:10.1007/s11886-019-1164-2
更新日期:2019-07-05 00:00:00
abstract::Hypertension is highly prevalent affecting nearly one third of the US adult population. Though generally approached as an outpatient disorder, elevated blood pressure is observed in a majority of hospitalized patients. The spectrum of hypertensive disease ranges from patients with hypertensive emergency including mark...
journal_title:Current cardiology reports
pub_type: 杂志文章,评审
doi:10.1007/s11886-015-0648-y
更新日期:2015-11-01 00:00:00
abstract:PURPOSE OF REVIEW:Several interrelated mechanisms promote the development of hypertension in obesity, often contributing to end organ damage including cardiovascular disease and chronic kidney disease. RECENT FINDINGS:The treatment of hypertension in obesity is complicated by a high prevalence of resistant hypertensio...
journal_title:Current cardiology reports
pub_type: 杂志文章,评审
doi:10.1007/s11886-017-0912-4
更新日期:2017-08-24 00:00:00
abstract:PURPOSE OF THE REVIEW:Coronary artery disease is a major cause of mortality and morbidity in the world, and PCI and CABG account for over a million procedures performed annually in the USA. The goal of percutaneous coronary intervention (PCI) or coronary artery bypass grafting (CABG) is to achieve complete revasculariz...
journal_title:Current cardiology reports
pub_type: 杂志文章,评审
doi:10.1007/s11886-018-0957-z
更新日期:2018-03-06 00:00:00
abstract:PURPOSE OF REVIEW:Cardiac troponin (cTn) plays an essential role for assessment of outcome in acute coronary syndrome (ACS). However, the prognostic value of cTn is not absolute. In this mini-review, we summarize the evidence on the utility of established biomarkers of left-ventricular dysfunction, hemodynamic stress, ...
journal_title:Current cardiology reports
pub_type: 杂志文章,评审
doi:10.1007/s11886-017-0840-3
更新日期:2017-04-01 00:00:00
abstract:PURPOSE OF REVIEW:Cardiovascular magnetic resonance (CMR) provides the most comprehensive imaging assessment of pericardial disease, providing a three-dimensional assessment of the pericardium, functional assessment of its impact on cardiac contractility, and pericardial tissue/fluid characterization. This review prese...
journal_title:Current cardiology reports
pub_type: 杂志文章,评审
doi:10.1007/s11886-020-01392-0
更新日期:2020-09-15 00:00:00
abstract:PURPOSE OF REVIEW:Cardiovascular disease is a leading cause of morbidity and mortality worldwide and is the focus of extensive biomedical research. Large genetic consortia combining data from many traditional prospective cohort and ascertained case-control study designs have facilitated the discovery of genetic associa...
journal_title:Current cardiology reports
pub_type: 杂志文章,评审
doi:10.1007/s11886-018-0969-8
更新日期:2018-03-08 00:00:00
abstract::Biventricular pacing (cardiac resynchronization therapy ) has been shown to be a very effective therapy for patients with heart failure and dyssynchrony, with improved survival now shown in a recent trial. Electrical dyssynchrony, usually quantified by the duration of the QRS complex, is distinct from mechanical dyssy...
journal_title:Current cardiology reports
pub_type: 杂志文章,评审
doi:10.1007/BF02938362
更新日期:2007-09-01 00:00:00
abstract::Chronic total occlusion (CTO) represents one of the most challenging lesion subsets faced by the interventional cardiologist. CTO is a common problem, being present in more than 30% of patients undergoing coronary angiography. Over the past 10 years, the success rate of recanalization has increased from approximately ...
journal_title:Current cardiology reports
pub_type: 杂志文章,评审
doi:10.1007/s11886-010-0131-8
更新日期:2010-09-01 00:00:00
abstract::The burgeoning ranks of patients with heart failure, the limited number of organs available for heart transplant, and technological improvements have made ventricular assist devices (VADs) important therapeutic options for patients with acute and chronic cardiac decompensation. The increased use of VADs is paralleled ...
journal_title:Current cardiology reports
pub_type: 杂志文章,评审
doi:10.1007/s11886-010-0102-0
更新日期:2010-05-01 00:00:00
abstract:PURPOSE OF THE REVIEW:Moderate or severe aortic regurgitation (AR) occurs in 0.5% of the population and typically peaks in the fourth to sixth decade of life. A significant proportion of patients have prohibitive surgical risk and are therefore treated medically with pharmacological management of heart failure and no d...
journal_title:Current cardiology reports
pub_type: 杂志文章,评审
doi:10.1007/s11886-020-01338-6
更新日期:2020-07-28 00:00:00
abstract:PURPOSE OF REVIEW:The development of biventricular repair and conversion pathways for patients with borderline hypoplastic heart disease represents an area of recent inquiry and innovation. This review summarizes emerging techniques and novel treatment algorithms for borderline hypoplastic heart disease with a focus on...
journal_title:Current cardiology reports
pub_type: 杂志文章,评审
doi:10.1007/s11886-020-01363-5
更新日期:2020-08-08 00:00:00
abstract:PURPOSE OF REVIEW:This review presents the current available evidence of the effects of several dietary patterns on atherosclerotic cardiovascular disease (ASCVD) risk in patients with type 2 diabetes (T2D). RECENT FINDINGS:Evidence demonstrates improvements in cardiovascular risk factors with some dietary patterns in...
journal_title:Current cardiology reports
pub_type: 杂志文章,评审
doi:10.1007/s11886-019-1232-7
更新日期:2019-10-17 00:00:00
abstract::Patients with severe carotid and coronary disease-especially if they require coronary artery bypass grafting (CABG)-are at high risk of cardiac events and stroke. Carotid revascularization should be considered for patients with symptomatic carotid disease and bilateral severe asymptomatic carotid stenosis. In patients...
journal_title:Current cardiology reports
pub_type: 杂志文章,评审
doi:10.1007/s11886-012-0246-1
更新日期:2012-04-01 00:00:00
abstract::The accurate differentiation of viable and nonviable myocardium is crucial for therapy planning in patients with coronary artery disease and left ventricular dysfunction. Traditional techniques such as echocardiography, positron emission tomography, single photon emission computed tomography, and dobutamine echocardio...
journal_title:Current cardiology reports
pub_type: 杂志文章,评审
doi:10.1007/s11886-005-0012-8
更新日期:2005-01-01 00:00:00
abstract:PURPOSE OF REVIEW:The goal was to evaluate published data on the incidence, diagnosis, and management of symptomatic combined mitral and aortic valvular disease. Furthermore, to identify the role of treatment using contemporary transcatheter techniques. RECENT FINDINGS:Up to a quarter of symptomatic adult valvular dis...
journal_title:Current cardiology reports
pub_type: 杂志文章,评审
doi:10.1007/s11886-019-1205-x
更新日期:2019-09-13 00:00:00
abstract::Cardiovascular magnetic resonance (CMR) is widely regarded as capable of providing a cornucopia of detailed diagnostic information. However, of that information, very little is truly unique, and can be obtained by a combination of alternate diagnostic modalities. Given this, it is anticipated that in the short term (1...
journal_title:Current cardiology reports
pub_type: 杂志文章,评审
doi:10.1007/s11886-004-0067-y
更新日期:2004-01-01 00:00:00
abstract:PURPOSE OF REVIEW:To analyze the current state of the art of functional mitral regurgitation (FMR) treatment. RECENT FINDINGS:The first-line treatment of severe FMR consists of guideline medical therapy (GMT) and resynchronization therapy when indicated; the impact of new medical therapies like sacubitril/valsartan ne...
journal_title:Current cardiology reports
pub_type: 杂志文章,评审
doi:10.1007/s11886-019-1221-x
更新日期:2019-11-16 00:00:00
abstract:PURPOSE OF REVIEW:To assess current management strategies for advanced heart failure in adults with congenital heart disease, including heart transplantation and mechanical circulatory support. RECENT FINDINGS:Current data demonstrate that adults with CHD generally experience higher short-term mortality after heart tr...
journal_title:Current cardiology reports
pub_type: 杂志文章,评审
doi:10.1007/s11886-018-1028-1
更新日期:2018-08-09 00:00:00
abstract::Since 1971, the Fontan operation has been performed for the repair of single-ventricle physiology. This ingenious operation commits a single ventricle to the systemic circulation and takes advantage of cardiovascular and respiratory physiology to propel deoxygenated blood to the lungs, thus minimizing right-to-left sh...
journal_title:Current cardiology reports
pub_type: 杂志文章,评审
doi:10.1007/BF02938382
更新日期:2007-07-01 00:00:00
abstract::Coronary artery bypass grafting without the aid of cardiopulmonary bypass (CPB) continues to gain popularity as an alternative to standard techniques of revascularization. CPB with cardioplegic arrest is associated with complications that may negate an otherwise technically flawless procedure. Experience has identifie...
journal_title:Current cardiology reports
pub_type: 杂志文章,评审
doi:10.1007/s11886-999-0056-2
更新日期:1999-11-01 00:00:00
abstract::Aldosterone is known to have multiple adverse cardiovascular effects that are reminiscent of but independent from angiotensin II. These effects include endothelial dysfunction, heightened thrombogenicity, inflammation, and reparative fibrosis, and have been described in experimental and human models of aldosterone exc...
journal_title:Current cardiology reports
pub_type: 杂志文章,评审
doi:10.1007/s11886-004-0073-0
更新日期:2004-07-01 00:00:00
abstract:PURPOSE OF REVIEW:Machine learning (ML) and deep learning (DL) are two important categories of AI algorithms. Nowadays, AI technology has been gradually applied to cardiac magnetic resonance imaging (CMRI), covering the fields of myocardial contrast enhancement (MCE) pattern and automatic ventricular segmentation. This...
journal_title:Current cardiology reports
pub_type: 杂志文章,评审
doi:10.1007/s11886-020-01306-0
更新日期:2020-07-07 00:00:00