Treatment of Functional Mitral Regurgitation in Heart Failure.

Abstract:

PURPOSE OF REVIEW:To analyze the current state of the art of functional mitral regurgitation (FMR) treatment. RECENT FINDINGS:The first-line treatment of severe FMR consists of guideline medical therapy (GMT) and resynchronization therapy when indicated; the impact of new medical therapies like sacubitril/valsartan needs further assessment. Valvular intervention may be considered in FMR symptomatic patients despite GMT, and can be performed surgically or percutaneously. MitraClip is a safe percutaneous procedure associated with symptoms improvement. Recently, the COAPT trial showed superior outcomes for MitraClip versus GMT contrasting the MITRA-FR trial which showed no benefit of MitraClip compared with GMT. These results should be interpreted as complementary rather than opposite. The COAPT trial provided a "proof of concept" that percutaneous treatment of severe FMR in patients without too advanced left ventricular disease translates into a prognostic benefit. Careful patient selection will play a critical role in defining the clinical niche for successful interventions.

journal_name

Curr Cardiol Rep

authors

Fabris E,De Luca A,Vitrella G,Stolfo D,Masè M,Korcova R,Merlo M,Rakar S,Van't Hof AWJ,Kedhi E,Perkan A,Sinagra G

doi

10.1007/s11886-019-1221-x

subject

Has Abstract

pub_date

2019-11-16 00:00:00

pages

139

issue

11

eissn

1523-3782

issn

1534-3170

pii

10.1007/s11886-019-1221-x

journal_volume

21

pub_type

杂志文章,评审
  • Appropriateness of percutaneous coronary intervention: a review.

    abstract::The appropriateness of coronary revascularization for various clinical scenarios has been reviewed formally by several specialty and subspecialty societies resulting in the formulation of scored appropriateness criteria. The goal of the appropriateness criteria is to guide physician decision-making and future research...

    journal_title:Current cardiology reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11886-013-0379-x

    authors: Summers MR,Patel MR

    更新日期:2013-07-01 00:00:00

  • Translating heart failure guidelines into clinical practice: clinical science and the art of medicine.

    abstract::The rapid growth of medical knowledge during the past few decades has created many potential advances in the therapeutics of chronic disease, and cardiovascular disease has been at the center of this phenomenon. Translation of these advances into everyday care of patients with chronic disease continues to be problemat...

    journal_title:Current cardiology reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11886-001-0039-4

    authors: Adams KF

    更新日期:2001-03-01 00:00:00

  • Leadless Cardiac Pacemakers: Pacing Paradigm Change.

    abstract::Traditional transvenous approach for permanent cardiac pacing can be associated with significant acute and chronic complications related partly to either the insertion of transvenous lead or subcutaneous placement of pacemaker device. We summarize the current status of a novel self-contained leadless cardiac pacemaker...

    journal_title:Current cardiology reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11886-015-0619-3

    authors: Neuzil P,Reddy VY

    更新日期:2015-08-01 00:00:00

  • Treatment of ventricular tachycardia in patients with heart failure.

    abstract::Heart failure is a major public health concern that is frequently complicated by ventricular arrhythmias. Sustained ventricular tachycardia is associated with an increased risk for progressive heart failure and sudden death. We summarize the current management strategies for ventricular tachycardia in heart failure pa...

    journal_title:Current cardiology reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11886-011-0182-5

    authors: Fong MW,Grazette L,Cesario D,Cao M,Saxon L

    更新日期:2011-06-01 00:00:00

  • Role of antithrombotic agents in heart failure.

    abstract::Despite a vast body of research on antithrombotic therapy for patients with cardiac disease, there are few clinical settings where robust evidence of their benefit exists. Patients with heart failure often have vascular disease and atrial fibrillation contributing to their poor prognosis. For patients with heart failu...

    journal_title:Current cardiology reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11886-012-0266-x

    authors: Cleland JG,Mumtaz S,Cecchini L

    更新日期:2012-06-01 00:00:00

  • Physiology of biventricular pacing.

    abstract::Biventricular pacing (cardiac resynchronization therapy ) has been shown to be a very effective therapy for patients with heart failure and dyssynchrony, with improved survival now shown in a recent trial. Electrical dyssynchrony, usually quantified by the duration of the QRS complex, is distinct from mechanical dyssy...

    journal_title:Current cardiology reports

    pub_type: 杂志文章,评审

    doi:10.1007/BF02938362

    authors: Bilchick KC,Helm RH,Kass DA

    更新日期:2007-09-01 00:00:00

  • Percutaneous versus surgical interventions for coronary artery disease in those with diabetes mellitus.

    abstract::Diabetes mellitus (DM) is a metabolic disorder of multiple etiologies that causes long-term damage of various organs including the cardiovascular system. A consistent observation shows that DM amplifies the risk of cardiovascular events by 4- to 6-fold. Since coronary artery disease (CAD) in diabetic patients exhibits...

    journal_title:Current cardiology reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11886-012-0323-5

    authors: Soran O

    更新日期:2013-01-01 00:00:00

  • Is cardiac resynchronization therapy an antiarrhythmic therapy for atrial fibrillation? A systematic review and meta-analysis.

    abstract::The impact of cardiac resynchronization therapy (CRT) on atrial fibrillation (AF) burden is poorly characterized. To assess the influence of CRT on AF, we performed a systematic literature search in MEDLINE using the MeSH headings "cardiac resynchronization therapy" or "cardiac pacing, artificial" and "atrial fibrilla...

    journal_title:Current cardiology reports

    pub_type: 杂志文章,meta分析,评审

    doi:10.1007/s11886-012-0330-6

    authors: Hess PL,Jackson KP,Hasselblad V,Al-Khatib SM

    更新日期:2013-02-01 00:00:00

  • Multimodality imaging for assessment of myocardial viability: nuclear, echocardiography, MR, and CT.

    abstract::The assessment of myocardial viability may be an important component of the evaluation of patients with coronary artery disease and left ventricular dysfunction. The primary goal of viability assessment in such patients is to guide therapeutic decisions by determining which patients would most likely benefit from reva...

    journal_title:Current cardiology reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11886-011-0242-x

    authors: Arrighi JA,Dilsizian V

    更新日期:2012-04-01 00:00:00

  • Treatment of Bifurcation Lesions: Has DK Crush"ed" the Competition?

    abstract:PURPOSE:This paper reviews the double-kiss crush (DK crush) technique in coronary artery bifurcation lesions. The technical aspects of the procedure and the clinical data supporting its use are summarized. RECENT FINDINGS:Randomized studies support the adoption of DK technique in complex bifurcation lesions for both l...

    journal_title:Current cardiology reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11886-018-1024-5

    authors: Lynn BS,Hermiller JB

    更新日期:2018-09-01 00:00:00

  • The Role of Manual Aspiration Thrombectomy in Patients Undergoing Primary Percutaneous Coronary Intervention for STEMI.

    abstract::In STEMI, primary PCI restores macrovascular coronary blood flow effectively but microvascular perfusion remains a challenge. Thrombus has the potential to embolize to the microvasculature limiting effective coronary blood flow. Thrombus burden is associated with a higher mortality and manual aspiration thrombectomy h...

    journal_title:Current cardiology reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11886-016-0707-z

    authors: Alak A,Jolly SS

    更新日期:2016-03-01 00:00:00

  • Large-Scale Genomic Biobanks and Cardiovascular Disease.

    abstract:PURPOSE OF REVIEW:Cardiovascular disease is a leading cause of morbidity and mortality worldwide and is the focus of extensive biomedical research. Large genetic consortia combining data from many traditional prospective cohort and ascertained case-control study designs have facilitated the discovery of genetic associa...

    journal_title:Current cardiology reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11886-018-0969-8

    authors: Small AM,O'Donnell CJ,Damrauer SM

    更新日期:2018-03-08 00:00:00

  • Artificial Intelligence and Myocardial Contrast Enhancement Pattern.

    abstract:PURPOSE OF REVIEW:Machine learning (ML) and deep learning (DL) are two important categories of AI algorithms. Nowadays, AI technology has been gradually applied to cardiac magnetic resonance imaging (CMRI), covering the fields of myocardial contrast enhancement (MCE) pattern and automatic ventricular segmentation. This...

    journal_title:Current cardiology reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11886-020-01306-0

    authors: Tang F,Bai C,Zhao XX,Yuan WF

    更新日期:2020-07-07 00:00:00

  • Genetic determinants of drug response in heart failure.

    abstract::Heart failure management is complex and costly. Genetic variations that alter drug absorption, metabolism, and receptor-ligand interactions have the potential to modify drug response and safety. Evidence shows that genetic factors interact with numerous heart failure medications, including vasodilators, beta blockers,...

    journal_title:Current cardiology reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11886-008-0031-3

    authors: Lowes BD,Buttrick PM

    更新日期:2008-05-01 00:00:00

  • The adult with a Fontan operation.

    abstract::Since 1971, the Fontan operation has been performed for the repair of single-ventricle physiology. This ingenious operation commits a single ventricle to the systemic circulation and takes advantage of cardiovascular and respiratory physiology to propel deoxygenated blood to the lungs, thus minimizing right-to-left sh...

    journal_title:Current cardiology reports

    pub_type: 杂志文章,评审

    doi:10.1007/BF02938382

    authors: Aboulhosn J,Child JS

    更新日期:2007-07-01 00:00:00

  • Routine Angiographic Follow-Up After Coronary Artery Disease Revascularization: Is Seeing Believing?

    abstract:PURPOSE OF THE REVIEW:Coronary artery disease is a major cause of mortality and morbidity in the world, and PCI and CABG account for over a million procedures performed annually in the USA. The goal of percutaneous coronary intervention (PCI) or coronary artery bypass grafting (CABG) is to achieve complete revasculariz...

    journal_title:Current cardiology reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11886-018-0957-z

    authors: Agrawal H,Teleb M,Lahsaei S,Carbajal L,Montanez R,Carrozza JP Jr

    更新日期:2018-03-06 00:00:00

  • Weighing the evidence for infection as a risk factor for coronary heart disease.

    abstract::There has been considerable attention in recent years to the intriguing hypothesis that coronary heart disease and other atherosclerotic diseases may be caused by infection with pathogens such as Chlamydia pneumoniae, Helicobacter pylori, and cytomegalovirus. Supporting this hypothesis are studies that localize bacter...

    journal_title:Current cardiology reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11886-000-0082-6

    authors: O'Donnell CJ,Levy D

    更新日期:2000-07-01 00:00:00

  • Advances in axial imaging of peripheral vascular disease.

    abstract::Peripheral artery disease (PAD) has become increasingly common in the US patient population and can be a highly symptomatic and significant source of morbidity. When PAD is suspected, the first-line screening study that is obtained is typically a noninvasive evaluation that includes the ankle brachial index (ABI). Fol...

    journal_title:Current cardiology reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11886-015-0644-2

    authors: Meyersohn NM,Walker TG,Oliveira GR

    更新日期:2015-10-01 00:00:00

  • Interventional echocardiography in structural heart disease.

    abstract::Over the past decade, catheter based treatments of an increasing variety of cardiac diseases have expanded dramatically. These advancements became available through new developments and improvements in available devices, as well as increasing expertise of operators. However, arguably it is the innovation and progress ...

    journal_title:Current cardiology reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11886-012-0338-y

    authors: Perk G,Kronzon I

    更新日期:2013-03-01 00:00:00

  • Evaluating presynaptic and postsynaptic innervation in heart failure.

    abstract::Congestive heart failure increasingly contributes to the overall morbidity and mortality associated with cardiovascular disease. Although significant advances in therapies allow patients to feel better and have improved functional status and survival, not all patients respond equally to these therapies. Moreover, for ...

    journal_title:Current cardiology reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11886-009-0021-0

    authors: Chen GP,Caldwell JH

    更新日期:2009-03-01 00:00:00

  • Multivessel coronary bypass grafting without cardiopulmonary support.

    abstract::Coronary artery bypass grafting without the aid of cardiopulmonary bypass (CPB) continues to gain popularity as an alternative to standard techniques of revascularization. CPB with cardioplegic arrest is associated with complications that may negate an otherwise technically flawless procedure. Experience has identifie...

    journal_title:Current cardiology reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11886-999-0056-2

    authors: Dewey TM,Mack MJ

    更新日期:1999-11-01 00:00:00

  • White Coat Hypertension and Cardiovascular Diseases: Innocent or Guilty.

    abstract:PURPOSE OF REVIEW:This review aims to clarify the cardiovascular risk of white coat hypertension (WCH). RECENT FINDINGS:Cardiovascular risk of WCH has been evaluated in multiple meta-analyses and population-based studies. International Database on Ambulatory Blood Pressure Monitoring in Relation to Cardiovascular Outc...

    journal_title:Current cardiology reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11886-018-0964-0

    authors: Abolbashari M

    更新日期:2018-03-08 00:00:00

  • Colchicine in Pericardial Disease: from the Underlying Biology and Clinical Benefits to the Drug-Drug Interactions in Cardiovascular Medicine.

    abstract:PURPOSE OF REVIEW:This is an in-depth review on the mechanism of action, clinical utility, and drug-drug interactions of colchicine in the management of pericardial disease. RECENT FINDINGS:Recent evidence about therapeutic targets on pericarditis has demonstrated that NALP3 inflammasome blockade is the cornerstone in...

    journal_title:Current cardiology reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11886-018-1008-5

    authors: Schenone AL,Menon V

    更新日期:2018-06-14 00:00:00

  • Renal Denervation: Is It Ready for Prime Time?

    abstract:PURPOSE OF REVIEW:Interventional cardiology and in particular the field of renal denervation is subject to constant change. This review provides an up to date overview of renal denervation trials and an outlook on what to expect in the future. RECENT FINDINGS:After the sham-controlled SYMPLICITY HTN-3 trial dampened t...

    journal_title:Current cardiology reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11886-019-1164-2

    authors: Lauder L,Wolf MA,Scholz SS,Hohl M,Mahfoud F,Böhm M

    更新日期:2019-07-05 00:00:00

  • Transradial versus transfemoral approach for percutaneous coronary procedures.

    abstract::Selective coronary angiography was originally performed through open brachial arteriotomy. Thereafter, the percutaneous Seldinger technique and the use of preformed Judkins-type catheters popularized the femoral approach. More recently, after the first report of successful coronary angiography by the transradial appro...

    journal_title:Current cardiology reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11886-009-0054-4

    authors: Franchi E,Marino P,Biondi-Zoccai GG,De Luca G,Vassanelli C,Agostoni P

    更新日期:2009-09-01 00:00:00

  • The Biological Mechanisms of Action of Cardiac Progenitor Cell Therapy.

    abstract:PURPOSE OF REVIEW:Cell therapy for cardiovascular diseases is regarded as a rapidly growing field within regenerative medicine. Different cellular populations enriched for cardiac progenitor cells (CPCs), or derivate a-cellular products, are currently under preclinical and clinical evaluation. Here, we have reviewed th...

    journal_title:Current cardiology reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11886-018-1031-6

    authors: Pagano F,Picchio V,Angelini F,Iaccarino A,Peruzzi M,Cavarretta E,Biondi-Zoccai G,Sciarretta S,De Falco E,Chimenti I,Frati G

    更新日期:2018-08-13 00:00:00

  • Racial disparities in outcomes after cardiac surgery: the role of hospital quality.

    abstract::Patients from racial and ethnic minorities experience higher mortality after cardiac surgery compared to white patients, both during the early postoperative phase as well as long term. A number of factors likely explain poor outcomes in black and minority patients, which include differences in biology, comorbid health...

    journal_title:Current cardiology reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11886-015-0587-7

    authors: Khera R,Vaughan-Sarrazin M,Rosenthal GE,Girotra S

    更新日期:2015-05-01 00:00:00

  • Is There Currently a Place for Combined Mitral and Aortic Transcatheter Interventions?

    abstract:PURPOSE OF REVIEW:The goal was to evaluate published data on the incidence, diagnosis, and management of symptomatic combined mitral and aortic valvular disease. Furthermore, to identify the role of treatment using contemporary transcatheter techniques. RECENT FINDINGS:Up to a quarter of symptomatic adult valvular dis...

    journal_title:Current cardiology reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11886-019-1205-x

    authors: De Palma R,O'Sullivan CJ,Settergren M

    更新日期:2019-09-13 00:00:00

  • Transcatheter aortic valve replacement: an update.

    abstract::Aortic stenosis affects many people worldwide with a significant impact on morbidity and mortality with uncorrected, symptomatic aortic valve stenosis carrying mortality of 50% at one year. Degenerative calcific pathology, the most common cause of aortic stenosis, increases in prevalence with age; estimated prevalence...

    journal_title:Current cardiology reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11886-013-0367-1

    authors: Halim SA,Kiefer TL,Hughes GC,Hurwitz LM,Harrison JK

    更新日期:2013-06-01 00:00:00

  • Low-density Lipoprotein-Cholesterol Lowering Strategies for Prevention of Atherosclerotic Cardiovascular Disease: Focus on siRNA Treatment Targeting PCSK9 (Inclisiran).

    abstract:PURPOSE OF REVIEW:The aim of low-density lipoprotein-cholesterol (LDL-C) lowering therapies is to safely achieve a consistent and long-term reduction in exposure of the vasculature to atherogenic lipoproteins in order to reduce the risk of atherosclerotic cardiovascular (CV) disease and the associated CV events, such a...

    journal_title:Current cardiology reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11886-020-01427-6

    authors: Sinning D,Landmesser U

    更新日期:2020-10-21 00:00:00