Overview of the US FDA medical device approval process.

abstract：:Congestive heart failure increasingly contributes to the overall morbidity and mortality associated with cardiovascular disease. Although significant advances in therapies allow patients to feel better and have improved functional status and survival, not all patients respond equally to these therapies. Moreover, for ...

journal_title：Current cardiology reports

authors： Chen GP,Caldwell JH

更新日期：2009-03-01 00:00:00

abstract：PURPOSE OF REVIEW:While the safety and efficacy of percutaneous ASD closure has been established, new data have recently emerged regarding the negative impact of residual iatrogenic ASD (iASD) following left heart structural interventions. Additionally, new devices with potential advantages have recently been studied. ...

journal_title：Current cardiology reports

authors： Wiktor DM,Carroll JD

更新日期：2018-04-17 00:00:00

abstract：PURPOSE OF REVIEW:Transcatheter aortic valve replacement (TAVR) has developed into an important alternative to surgical aortic valve replacement (SAVR) for patients with severe aortic stenosis (AS). Adjuvant antithrombotic therapies are commonly used during and after TAVR to decrease the risk of valve thrombosis and th...

journal_title：Current cardiology reports

authors： O'Malley RG,Mahaffey KW,Fearon WF

更新日期：2017-05-01 00:00:00

abstract：:A number of reports demonstrate the importance of serum triglyceride values in predicting the clinical onset of vascular disease. However, adjustment for measurements highly correlated with triglyceride (TG) levels, such as history of diabetes, body mass index, and high-density lipoprotein cholesterol (HDL-C), lessen ...

journal_title：Current cardiology reports

authors： Sprecher DL

更新日期：2001-09-01 00:00:00

abstract：:The scientific selection of antithrombotic therapy has been dominated by group-based interpretation of data in the form of probability-based statistics in evidence-based medicine. Because the data in large randomized trials are grouped and averaged, the relationship to initial conditions of the patient is lost. There ...

journal_title：Current cardiology reports

authors： Helgason CM

更新日期：2003-03-01 00:00:00

abstract：:The feasibility and safety of transradial coronary intervention was demonstrated soon after the description of the transfemoral approach, despite which the use of the femoral artery still dominates in acute coronary syndrome intervention. The advantages of using the radial artery are virtual elimination of access site...

journal_title：Current cardiology reports

authors： Routledge H,Sastry S

更新日期：2015-12-01 00:00:00

abstract：:Over the past two decades, we have witnessed a large decrease in the death and complication rate of patients experiencing acute myocardial infarction (MI), due to our ability to restore blood flow to infarct-related arteries. Therapies include strategies to inhibit platelet function and induce fibrinolysis, and mechan...

journal_title：Current cardiology reports

authors： Maranian AM,Steinhubl SR

更新日期：2002-07-01 00:00:00

abstract：:Aortic stenosis is a common valvular abnormality. Surgical valve replacement is the standard of care for symptomatic patients with severe aortic stenosis and is appropriate for certain asymptomatic patients. Statin therapy may slow progression of the disease. Contrary to conventional wisdom, vasodilator therapy may in...

journal_title：Current cardiology reports

authors： Botkin NF,Aurigemma GP

更新日期：2004-03-01 00:00:00

abstract：:Intracranial stenosis accounts for 8-10% of all ischemic strokes in North America, a frequency slightly less than that of extracranial carotid stenosis. Among patients presenting with transient ischemic attack or stroke due to intracranial stenosis, the risk of recurrent stroke in the first year after initial symptoms...

journal_title：Current cardiology reports

authors： Fields JD,Liu KC,Barnwell SL,Clark WM,Lutsep HL

更新日期：2010-01-01 00:00:00

abstract：:Cardiac resynchronization therapy has become part of the treatment strategy for advanced, symptomatic heart failure, but newly published trials show that more patients than previously realized may benefit from this therapy, including those with mild heart failure symptoms. The REVERSE and MADIT-CRT trials showed that ...

journal_title：Current cardiology reports

authors： Reynolds CR,Gold MR

更新日期：2010-09-01 00:00:00

abstract：:The burgeoning ranks of patients with heart failure, the limited number of organs available for heart transplant, and technological improvements have made ventricular assist devices (VADs) important therapeutic options for patients with acute and chronic cardiac decompensation. The increased use of VADs is paralleled ...

journal_title：Current cardiology reports

authors： Kirkpatrick JN,Wiegers SE,Lang RM

更新日期：2010-05-01 00:00:00

abstract：:Patients with advanced peripheral arterial disease may develop critical limb ischemia with rest pain, non-healing ulcerations, and eventually may require major amputation despite currently available revascularization technologies. Stem cell therapies hold promise as novel therapeutics to promote vasculogenesis and imp...

journal_title：Current cardiology reports

authors： Gupta NK,Armstrong EJ,Parikh SA

更新日期：2014-02-01 00:00:00

abstract：PURPOSE OF REVIEW:Assessing the cardiovascular risk associated with hypertriglyceridemia can be challenging due to frequent confounding conditions such as hypertension, diabetes mellitus, and hyperlipidemia. We sought to quantify this risk by examining several meta-analyses as well as subgroup analyses of previously pu...

journal_title：Current cardiology reports

authors： Evans MC,Stalam T,Miller M

更新日期：2018-07-10 00:00:00

abstract：:Aldosterone is known to have multiple adverse cardiovascular effects that are reminiscent of but independent from angiotensin II. These effects include endothelial dysfunction, heightened thrombogenicity, inflammation, and reparative fibrosis, and have been described in experimental and human models of aldosterone exc...

journal_title：Current cardiology reports

authors： Meier DJ,Pitt B,Rajagopalan S

更新日期：2004-07-01 00:00:00

abstract：PURPOSE OF REVIEW:The goal was to evaluate published data on the incidence, diagnosis, and management of symptomatic combined mitral and aortic valvular disease. Furthermore, to identify the role of treatment using contemporary transcatheter techniques. RECENT FINDINGS:Up to a quarter of symptomatic adult valvular dis...

journal_title：Current cardiology reports

authors： De Palma R,O'Sullivan CJ,Settergren M

更新日期：2019-09-13 00:00:00

abstract：:Antiarrhythmic drugs are widely used, but are of modest efficacy and have important side effects. However, even with the advance of catheter ablation for atrial fibrillation and ventricular tachycardia, antiarrhythmic drugs remain an important tool for treating arrhythmias. Antiarrhythmic drug development has remained...

journal_title：Current cardiology reports

authors： Kumar K,Zimetbaum PJ

更新日期：2013-10-01 00:00:00

abstract：:During the past years, non-neuronal vascular nicotinic acetylcholine receptors (nAChRs) increasingly have gained interest in cardiovascular research, as they are known to mediate the deleterious effects of nicotine and nitrosamines, components of tobacco smoke, on the vasculature. Because smoking is a major risk facto...

journal_title：Current cardiology reports

authors： Bauwens M,Mottaghy FM,Bucerius J

更新日期：2015-08-01 00:00:00

abstract：PURPOSE OF REVIEW:The present review aims to discuss the recent advances in surgical management of spontaneous intracerebral hemorrhage (ICH), safety and efficacy of minimally invasive surgical techniques, and the existing evidence supporting their use. RECENT FINDINGS:Newer surgical techniques, collectively referred ...

journal_title：Current cardiology reports

authors： Bhatia K,Hepburn M,Ziu E,Siddiq F,Qureshi AI

更新日期：2018-10-11 00:00:00

abstract：PURPOSE OF REVIEW:This review presents the current available evidence of the effects of several dietary patterns on atherosclerotic cardiovascular disease (ASCVD) risk in patients with type 2 diabetes (T2D). RECENT FINDINGS:Evidence demonstrates improvements in cardiovascular risk factors with some dietary patterns in...

journal_title：Current cardiology reports

authors： Liday C,Kirkpatrick C

更新日期：2019-10-17 00:00:00

abstract：:Advances in the field of molecular medicine are making gene therapy a viable treatment strategy for the next millennium. Indeed, over the past 10 years, a number of improvements have occurred that have resulted in an increased interest in gene therapy for the treatment of diseases in cardiovascular medicine. Because a...

journal_title：Current cardiology reports

authors： Channon KM,Annex BH

更新日期：2000-01-01 00:00:00

abstract：PURPOSE OF REVIEW:Drug-coated balloons (DEB) and drug-eluting stents (DES) emerged as a tool to aid in lowering the rates of neointimal hyperplasia and target lesion restenosis following endovascular peripheral arterial disease (PAD) interventions. RECENT FINDINGS:Although the initial trials comparing these devices wi...

journal_title：Current cardiology reports

authors： Gad MM,Karrthik AK,Mahmoud AA,Mahmoud AN

更新日期：2019-09-07 00:00:00

abstract：PURPOSE OF REVIEW:The cardiovascular (CV) risk related to lipid disorders is well established and is based on a robust body of evidence from well-designed randomized clinical trials, as well as prospective observational studies. In the last two decades, significant advances have been made in understanding the genetic b...

journal_title：Current cardiology reports

authors： Stein R,Ferrari F,Scolari F

更新日期：2019-06-21 00:00:00

abstract：:Atherosclerosis is the proximate cause of arterial thrombosis, leading to acute occlusive cardiovascular syndromes. Thrombosis in atherosclerosis usually results from rupture of the fibrous cap of atherosclerotic plaques with a smaller proportion resulting from superficial endothelial erosion. Ruptured plaques are oft...

journal_title：Current cardiology reports

authors： Shah PK

更新日期：2014-12-01 00:00:00

abstract：:Hypertension is highly prevalent affecting nearly one third of the US adult population. Though generally approached as an outpatient disorder, elevated blood pressure is observed in a majority of hospitalized patients. The spectrum of hypertensive disease ranges from patients with hypertensive emergency including mark...

journal_title：Current cardiology reports

authors： Axon RN,Turner M,Buckley R

更新日期：2015-11-01 00:00:00

abstract：PURPOSE OF REVIEW:The review is focused on "digital health", which means advanced analytics based on multi-modal data. The "Health Care Internet of Things", which uses sensors, apps, and remote monitoring could provide continuous clinical information in the cloud that enables clinicians to access the information they n...

journal_title：Current cardiology reports

authors： Mazzanti M,Shirka E,Gjergo H,Hasimi E

更新日期：2018-05-10 00:00:00

abstract：:Conventional algorithms and noninvasive imaging tests for the identification of stable, hemodynamically significant coronary artery disease offer little insight into the detection of potentially vulnerable and inflamed coronary plaques, those most likely to rupture and cause acute coronary syndromes. Positron emission...

journal_title：Current cardiology reports

authors： Rogers IS,Tawakol A

更新日期：2011-04-01 00:00:00

abstract：:Systemic embolic complications in patients with cardiomyopathy are associated with significant morbidity and mortality. Despite the lack of prospective, randomized control data, the literature supports the use of left ventricular ejection fraction as an important determinant of the need for systemic anticoagulation th...

journal_title：Current cardiology reports

authors： Rho R,DeNofrio D,Loh E

更新日期：2000-03-01 00:00:00

abstract：:The impact of cardiac resynchronization therapy (CRT) on atrial fibrillation (AF) burden is poorly characterized. To assess the influence of CRT on AF, we performed a systematic literature search in MEDLINE using the MeSH headings "cardiac resynchronization therapy" or "cardiac pacing, artificial" and "atrial fibrilla...

journal_title：Current cardiology reports

authors： Hess PL,Jackson KP,Hasselblad V,Al-Khatib SM

更新日期：2013-02-01 00:00:00

abstract：:Randomized clinical trials have established that lipid- lowering pharmacologic therapy can substantially reduce morbidity and mortality in patients with known coronary artery disease (CAD). Researchers are now working to define the role of lipid-lowering agents in the primary prevention of CAD to extend their benefit ...

journal_title：Current cardiology reports

authors： Nass CM,Wiviott SD,Allen JK,Post WS,Blumenthal aR

更新日期：2000-09-01 00:00:00

abstract：:Aortic valve replacement can produce dramatic benefit in the setting of aortic stenosis. The potential for morbidity and mortality associated with thoracotomy, cardiopulmonary bypass, and aortotomy has fostered a search for alternatives. Early experience with transcatheter endovascular aortic valve implantation demons...

journal_title：Current cardiology reports

authors： Webb JG

更新日期：2008-03-01 00:00:00