HMB-45 negative multifocal malignant perivascular epithelioid cell tumor of the soft tissue responding to sirolimus: First case report from India.

Abstract:

:Perivascular epithelioid cell tumor (PEComa) is a group of sarcomas that exhibit a myomelanocytic phenotype and possess a unique cell type in the perivascular epithelioid cell. Traditionally HMB-45 immunoreactivity is the first criteria required to consider a tumor to be PEComa. We report a case of multifocal PEComa with negative HMB-45 marker. The patient presented with three big ulceroproliferative lesions; two over right thigh and one over the scalp in the right frontal region. The patient was prescribed with oral sirolimus to which good response was seen. To the best of our knowledge, this is the first case of HMB-45 negative multifocal malignant PEComa from India.

journal_name

J Cancer Res Ther

authors

Kapoor A,Beniwal S,Singhal MK,Kumar N,Kumar V,Kumar HS

doi

10.4103/0973-1482.146098

subject

Has Abstract

pub_date

2015-10-01 00:00:00

pages

1036

issue

4

eissn

0973-1482

issn

1998-4138

pii

JCanResTher_2015_11_4_1036_146098

journal_volume

11

pub_type

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