Potent chemopreventive effect of mangiferin on lung carcinogenesis in experimental Swiss albino mice.

Abstract:

AIM OF THE STUDY:In the present study the effects of mangiferin were tested against lung cancer-bearing mice in both the pre-initiation and post-initiation periods. MATERIALS AND METHODS:Healthy male Swiss albino mice (6-8 weeks old) were used throughout the study. The animals were treated with mangiferin (100 mg/kg body weight dissolved in corn oil) two weeks before (pre-initiation) and the twelfth week after (post-initiation) the establishment of B (a) P (50 mg/kg body weight)-induced lung carcinoma. RESULTS:The body weight decreased and the lung weight and levels of xenobiotic and liver marker enzymes markedly increased in the carcinogen-administered animals; and mangiferin treatment brought the values of these parameters back to the near-normal ones. The activities of lysosomal enzymes in the animals with B (a) P-induced experimental lung carcinogenesis were also assessed. In these animals there was an increase in the activities of lysosomal enzymes such as acidphosphatase, β-glucuronidase, N-acetyl glucosaminidase, and β-galactosidase. CONCLUSION:Supplementation with mangiferin attenuated all these alterations, thus indicating its anticancer effect. Overall, the above data showed that the anticancer effect of mangiferin as a chemopreventive agent was pronounced.

journal_name

J Cancer Res Ther

authors

Rajendran P,Rengarajan T,Nishigaki I,Ekambaram G,Sakthisekaran D

doi

10.4103/0973-1482.137966

subject

Has Abstract

pub_date

2014-10-01 00:00:00

pages

1033-9

issue

4

eissn

0973-1482

issn

1998-4138

pii

JCanResTher_2014_10_4_1033_137966

journal_volume

10

pub_type

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