Abstract：
:Hematological disorders, especially single lineage abnormalities, have been described in hyperthyroidism. Pancytopenia has been reported, without myelodysplastic syndrome or megaloblastic anemia. We studied the peripheral blood smear and the bone marrow aspiration and biopsy of a 65-year-old lady, who presented with pancytopenia and thyrotoxicosis due to multinodular goiter. She denied ingesting any toxic medication. At diagnosis: WBC: 2500/ul, platelets count: 58,000/ul, hemoglobin level: 6.5 g/dl. The bone marrow was moderately hyper cellular with moderate myelofibrosis and arrested hematopoiesis. The TSH level was: 0.02 mIU/l (N: 0.25-4), the fT3: 18 pmol/l (N: 4-10), the routine serum immunologic tests were negative. After treatment with single agent neomercazole (carbimazole), complete recovery of the blood cell counts was obtained within one month. The bone marrow aspiration, performed three months after starting therapy, showed normal hematopoiesis. The thyroid function tests returned to normal and no autoimmune reaction was detected on routine serum testing. Persistent response was observed six months later under medical treatment. The patient has refused surgical treatment. Reversible myelodysplastic syndrome may also be part of the changes in blood picture of patients with hyperthyroidism, probably due to direct toxic mechanism.
journal_name
J Cancer Res Therjournal_title
Journal of cancer research and therapeuticsauthors
Akoum R,Michel S,Wafic T,Emile B,Marwan M,Khaled H,Gerard Adoi
10.4103/0973-1482.31972subject
Has Abstractpub_date
2007-01-01 00:00:00pages
43-6issue
1eissn
0973-1482issn
1998-4138journal_volume
3pub_type
杂志文章abstract：:Krukenberg tumor is bilateral ovarian carcinoma's metastasizing most commonly from a gastric primary followed by a colon. We report a case of 36-year-old female with bilateral ovarian mass diagnosed as Krukenberg with a work up for locating the primary site. In this case, we discuss widely the clinical aspects with hi...
journal_title：Journal of cancer research and therapeutics
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journal_title：Journal of cancer research and therapeutics
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journal_title：Journal of cancer research and therapeutics
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journal_title：Journal of cancer research and therapeutics
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更新日期：2020-07-01 00:00:00
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journal_title：Journal of cancer research and therapeutics
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更新日期：2015-01-01 00:00:00
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journal_title：Journal of cancer research and therapeutics
pub_type： 杂志文章
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journal_title：Journal of cancer research and therapeutics
pub_type： 杂志文章
doi：10.4103/jcrt.JCRT_296_17
更新日期：2020-12-01 00:00:00
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journal_title：Journal of cancer research and therapeutics
pub_type： 杂志文章
doi：10.4103/jcrt.JCRT_295_17
更新日期：2018-10-01 00:00:00
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journal_title：Journal of cancer research and therapeutics
pub_type： 信件
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journal_title：Journal of cancer research and therapeutics
pub_type： 信件
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更新日期：2015-07-01 00:00:00
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journal_title：Journal of cancer research and therapeutics
pub_type： 杂志文章
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更新日期：2005-07-01 00:00:00
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journal_title：Journal of cancer research and therapeutics
pub_type： 杂志文章,meta分析
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更新日期：2016-12-01 00:00:00
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pub_type： 杂志文章
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journal_title：Journal of cancer research and therapeutics
pub_type： 杂志文章
doi：10.4103/0973-1482.187387
更新日期：2018-10-01 00:00:00
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pub_type： 杂志文章,评审
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pub_type： 杂志文章
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journal_title：Journal of cancer research and therapeutics
pub_type： 杂志文章
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更新日期：2018-12-01 00:00:00
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journal_title：Journal of cancer research and therapeutics
pub_type： 杂志文章
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journal_title：Journal of cancer research and therapeutics
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journal_title：Journal of cancer research and therapeutics
pub_type： 临床试验,杂志文章
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更新日期：2010-01-01 00:00:00
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pub_type： 杂志文章,评审
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journal_title：Journal of cancer research and therapeutics
pub_type： 杂志文章
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更新日期：2019-01-01 00:00:00
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journal_title：Journal of cancer research and therapeutics
pub_type： 杂志文章
doi：10.4103/0973-1482.34696
更新日期：2007-04-01 00:00:00
