Abstract:
AIM OF STUDY:To explore sanazole (AK) directed targeting of the antineoplastic drug doxorubicin (DOX) complexed with silver nanoparticles (SNs) to tumor growth in a murine model. MATERIALS AND METHODS:Sanazole (AK) and DOX were complexed with SNs, individually and in combination to obtain SN-AK, SN-DOX, and SN-AK-DOX. Solid tumors were developed on hind limbs of Swiss albino mice by transplanting Dalton's lymphoma ascitess (DLAs) tumor cells. Induction of cytotoxicity and apoptosis in the DLA cells by AK and DOX complexed with SN, individually and in combination, were examined under in vitro conditions by incubating the cells with them. SN, AK, DOX, SN-AK, SN-DOX, AK-DOX, and SN-AK-DOX were administered orally to the tumor bearing mice and the therapeutic efficacy of AK-directed targeting of SN-DOX complexes to achieve tumor control was monitored. RESULTS:Under in vitro conditions, SN, AK, DOX, SN-AK, SN-DOX, AK-DOX, and SN-AK-DOX induced cytotoxicity and apoptosis in DLA cells to varying extents. The SN-AK-DOX complex showed higher level of cytotoxicity and apoptosis-induction in DLA cells. Similarly, administration of SN, AK, DOX, SN-AK, SN-DOX, AK-DOX, and SN-AK-DOX resulted in significant reduction in tumor volume and delay in tumor growth. The animals treated with SN-AK-DOX had the highest reduction in tumor volume and tumor growth. In fact, the tumor was almost absent in the animals of this group after the treatment. CONCLUSION:The SN complex of sanazole and doxorubicin together (SN-AK-DOX) has high anticancer activity under in vivo conditions and has great potential in tumor therapy.
journal_name
J Cancer Res Therjournal_title
Journal of cancer research and therapeuticsauthors
Nair GG,Nair CKdoi
10.4103/0973-1482.148705subject
Has Abstractpub_date
2014-10-01 00:00:00pages
979-84issue
4eissn
0973-1482issn
1998-4138pii
JCanResTher_2014_10_4_979_148705journal_volume
10pub_type
杂志文章abstract::Villous adenoma is a known entity in the gastrointestinal tract, but very rare in the urinary tract. It is a benign tumor with excellent prognosis, but its progression to adenocarcinoma is not established. Here, we report an additional case of villous adenoma of the urinary bladder. ...
journal_title:Journal of cancer research and therapeutics
pub_type: 信件
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journal_title:Journal of cancer research and therapeutics
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journal_title:Journal of cancer research and therapeutics
pub_type: 杂志文章,meta分析
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journal_title:Journal of cancer research and therapeutics
pub_type: 杂志文章
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journal_title:Journal of cancer research and therapeutics
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pub_type: 杂志文章,评审
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journal_title:Journal of cancer research and therapeutics
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journal_title:Journal of cancer research and therapeutics
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journal_title:Journal of cancer research and therapeutics
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journal_title:Journal of cancer research and therapeutics
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journal_title:Journal of cancer research and therapeutics
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