Abstract：
INTRODUCTION:The oncogenic form of anaplastic lymphoma kinase (ALK) gene is an attractive candidate marker for diagnostic and therapeutic purposes in several malignancies, including nonsmall cell lung cancer (NSCLC). This study aimed to examine the expression levels and clinical significance of ALK in a series of NSCLC tumors. MATERIAL AND METHODS:We retrospectively reviewed 140 samples of NSCLC, including 64 (46%) squamous cell carcinoma (SCC), 62 (44%) adenocarcinoma (ADC), and 14 (10%) large cell carcinoma (LCC) for expression of ALK using immunohistochemistry; and immunostaining patterns were correlated with clinicopathological parameters. RESULTS:Expression of ALK was significantly different between SCC with ADC (P < 0.001) and LCC samples (P < 0.001). The highest level of ALK expression was found in ADC cases with poor differentiation and high nuclear grade (P = 0.005 and P = 0.005, respectively). Furthermore, high level of ALK expression was more often observed in ADC cases with poor prognosis features (P = 0.013). CONCLUSIONS:These findings suggested that ALK can be considered as a promising target in the targeted therapy in patients with lung ADC.
journal_name
J Cancer Res Therjournal_title
Journal of cancer research and therapeuticsauthors
Roudi R,Haji G,Madjd Z,Shariftabrizi A,Mehrazma Mdoi
10.4103/0973-1482.170940subject
Has Abstractpub_date
2016-04-01 00:00:00pages
1065-9issue
2eissn
0973-1482issn
1998-4138pii
JCanResTher_2016_12_2_1065_170940journal_volume
12pub_type
杂志文章abstract：AIM:To study the role of neoadjuvant imatinib mesylate in downsizing tumors in patients with locally advanced nonmetastatic gastrointestinal stromal tumors (GISTs), thus improving the possibility of complete resection. MATERIALS AND METHODS:We used neoadjuvant imatinib in six patients with locally advanced GISTs, at a...
journal_title：Journal of cancer research and therapeutics
pub_type： 临床试验,杂志文章
doi：10.4103/0973-1482.59905
更新日期：2009-10-01 00:00:00
abstract：Background:Ghrelin plays a role in mechanisms related to cancer progression - including cell proliferation, invasion and migration, and resistance to apoptosis in the cell lines from several cancers. We investigated the role of ghrelin levels in cancer cachexia-anorexia in patients with locally advanced nonsmall-cell l...
journal_title：Journal of cancer research and therapeutics
pub_type： 杂志文章
doi：110.4103/jcrt.JCRT_10_19
更新日期：2020-07-01 00:00:00
abstract：Purpose:We aimed to report the experience of intraoperative electron radiation therapy (IOERT) with Mobetron (Intraop Medical Incorporated, Santa Clara, CA, USA) as a partial breast irradiation (PBI) for patients with early-stage breast cancer and explanation of IOERT application and present early clinical and cosmetic...
journal_title：Journal of cancer research and therapeutics
pub_type： 杂志文章
doi：10.4103/jcrt.JCRT_191_17
更新日期：2019-07-01 00:00:00
abstract：:Squamous cell carcinoma of urinary tract is a rarely encountered tumor. It is more frequently reported in urinary bladder and male urethra than renal pelvis. Squamous cell carcinoma of renal pelvis is usually associated with nephrolithiasis. However, coexistence of keratinizing squamous cell carcinoma with xanthogranu...
journal_title：Journal of cancer research and therapeutics
pub_type： 杂志文章
doi：10.4103/0973-1482.73351
更新日期：2010-07-01 00:00:00
abstract：CONTEXT:Simple screening test for resource-challenged areas. AIMS:To compare specimen adequacy and diagnostic agreement between oral rinse-based smears and conventional smears in oral cancer, oral leukoplakia, and normal controls. SETTINGS AND DESIGN:Twenty-five histologically confirmed cases of oral cancer, 29 clini...
journal_title：Journal of cancer research and therapeutics
pub_type： 杂志文章
doi：10.4103/0973-1482.137910
更新日期：2015-01-01 00:00:00
abstract：:Foot is an uncommon site for chondrosarcoma and involvement of phalanges is extremely rare. Here, a case of low-grade chondrosarcoma of the distal phalanx of the right great toe in a 37-year-old male patient is being reported. The patient complained of gradual swelling of the right great toe and pain for last 2 years....
journal_title：Journal of cancer research and therapeutics
pub_type： 杂志文章,评审
doi：10.4103/0973-1482.95191
更新日期：2012-01-01 00:00:00
abstract：Aim of the Study:Both matrix metalloproteinase-2 (MMP-2) and matrix metalloproteinase-9 (MMP-9) is involved in degradation of extracellular matrix and found to stimulate invasion and metastasis in cancer patients. However, studies on the stage-specific expression of MMPs at different stages of larynx carcinoma are stil...
journal_title：Journal of cancer research and therapeutics
pub_type： 杂志文章
doi：10.4103/jcrt.JCRT_360_18
更新日期：2020-04-01 00:00:00
abstract：AIM:This study was aimed to assess the in vivo anti-tumoral potency of the novel 6-nitro-2-(3-chloropropyl)-1H-benz[de]isoquinoline-1,3-dione [Compound 1] that has earlier demonstrated excellent cytotoxicity in 15 out of 17 human tumor cell lines tested. MATERIALS AND METHODS:Two murine tumors namely Sarcoma-180 (S-18...
journal_title：Journal of cancer research and therapeutics
pub_type： 杂志文章
doi：10.4103/0973-1482.119332
更新日期：2013-07-01 00:00:00
abstract：:We report a case of a 63-year-old lady presenting with pain in the right hypochondrium, jaundice, anorexia, and firm tender hepatomegaly with remarkably high serum alkaline phosphatase. Abdominal ultrasonography revealed a hypoechoic solid space-occupying lesion in right lobe of liver which was cytologically diagnosed...
journal_title：Journal of cancer research and therapeutics
pub_type： 信件
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更新日期：2014-01-01 00:00:00
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journal_title：Journal of cancer research and therapeutics
pub_type： 杂志文章
doi：10.4103/0973-1482.194346
更新日期：2018-06-01 00:00:00
abstract：:Gardasil is the first quadrivalent human papillomavirus (HPV)-types 6, 11, 16, 18 recombinant vaccine approved by the FDA on June 8, 2006. It induces genotype-specific virus-neutralizing antibodies and prevents infection with HPV. Various clinical trials demonstrated a reduction in the incidence of vaccine-type-specif...
journal_title：Journal of cancer research and therapeutics
pub_type： 杂志文章,评审
doi：10.4103/0973-1482.34686
更新日期：2007-04-01 00:00:00
abstract：Introduction:Oral squamous cell carcinoma (OSCC) accounts 94% of all malignant lesions in the oral cavity. In the assessment of OSCC, nowadays the WHO grading system has been followed widely but due to its subjectivity, investigators applied the sophisticated technique of computer-assisted image analysis in the grading...
journal_title：Journal of cancer research and therapeutics
pub_type： 杂志文章
doi：10.4103/0973-1482.189423
更新日期：2018-01-01 00:00:00
abstract：:Primary vascular leiomyosarcoma (LMS) is a rare tumor accounting for 2% of all LMSs, with the most common site being inferior vena cava (IVC). Overall prognosis is poor, with median survival of 2 years only. We present four cases diagnosed with LMS of IVC, treated with surgery, radiation and chemotherapy. The diagnosi...
journal_title：Journal of cancer research and therapeutics
pub_type： 信件
doi：10.4103/0973-1482.138029
更新日期：2015-07-01 00:00:00
abstract：BACKGROUND:Measuring the microvascular and mast cell density in squamous cell carcinoma of lung and correlating them with the patient survival may be helpful to guide the use of cancer chemotherapeutic agents which target molecular mechanisms of tumour angiogenesis and mast cells. MATERIALS AND METHODS:It was an obser...
journal_title：Journal of cancer research and therapeutics
pub_type： 杂志文章
doi：10.4103/0973-1482.126487
更新日期：2013-10-01 00:00:00
abstract：AIM OF STUDY:The present work aimed to examine the efficacy of two ayurvedic formulations, Brahma Rasayana (BRM) and Chyavanaprash (CHM) to alleviate doxorubicin (DOX) induced acute cardiotoxicity. MATERIALS AND METHODS:Swiss albino mice were administered with DOX (25 mg/kg, i.p.) and two doses of BRM or CHM (1 and 2 ...
journal_title：Journal of cancer research and therapeutics
pub_type： 杂志文章
doi：10.4103/0973-1482.151931
更新日期：2016-04-01 00:00:00
abstract：Objective:To discuss and assess the clinical value of treating lung cancer cachexia with thalidomide combined with cinobufagin.s. Methods:A cohort of 54 patients, who were diagnosed with lung carcinoma, was randomly divided into two groups, a trial group and a control group, respectively. The trial group was given 150...
journal_title：Journal of cancer research and therapeutics
pub_type： 杂志文章
doi：10.4103/0973-1482.188436
更新日期：2018-01-01 00:00:00
abstract：:Lymphoproliferative malignancies can involve both nodal- and extra-nodal tissues. The most common extranodal site involved is the gastrointestinal (GI) tract, and it is secondary to the widespread primary nodal disease. However, about 33% of non-Hodgkin's lymphoma primarily arise from tissues other than lymph nodes, s...
journal_title：Journal of cancer research and therapeutics
pub_type：
doi：10.4103/jcrt.JCRT_239_17
更新日期：2020-01-01 00:00:00
abstract：BACKGROUND:Activating mutations in the epidermal growth factor (EGFR) gene confer sensitivity to the tyrosine kinase inhibitors (TKIs) in patients with advanced non-small cell lung cancer (NSCLC). TKI treatment efficacy and EGFR mutation implications were evaluated in clinically selected advanced NSCLC patients treated...
journal_title：Journal of cancer research and therapeutics
pub_type： 杂志文章
doi：10.4103/0973-1482.113379
更新日期：2013-04-01 00:00:00
abstract：:Acinic cell carcinoma (ACC) is a low-grade malignant salivary gland neoplasm that comprises approximately 17% of primary salivary gland malignancies or about 6% of all salivary gland neoplasms. The most common intraoral sites are the buccal mucosa, lips, and palate. The diagnosis of ACC frequently presents difficultie...
journal_title：Journal of cancer research and therapeutics
pub_type：
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更新日期：2020-04-01 00:00:00
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journal_title：Journal of cancer research and therapeutics
pub_type： 杂志文章
doi：10.4103/jcrt.JCRT_878_18
更新日期：2020-01-01 00:00:00
abstract：AIM OF STUDY:Colorectal cancer (CRC), now the third most common cancer across the world, is known to aggregate in families. Recently, genome-wide association studies have identified two single nucleotide polymorphisms (SNP) associated with CRC in Caucasians. MATERIALS AND METHODS:To validate whether the same variation...
journal_title：Journal of cancer research and therapeutics
pub_type： 杂志文章
doi：10.4103/0973-1482.150346
更新日期：2015-04-01 00:00:00
abstract：Objectives:Increasing evidence suggests that Wnt5a plays an important role in tumorigenesis. In particular, its expression is downregulated in hepatocellular carcinoma (HCC). The aim of this study was to explore the effect of Wnt5a overexpression on HCC cells. Materials and Methods:We transfected the human HCC cell li...
journal_title：Journal of cancer research and therapeutics
pub_type： 杂志文章
doi：10.4103/jcrt.JCRT_886_18
更新日期：2019-01-01 00:00:00
abstract：:A rare and unique variant of breast cancer--metaplastic matrix producing carcinoma, is presented. Surgery has been the mainstay of treatment. The role of adjuvant postoperative radiotherapy, as has been used in this patient, has been reviewed. ...
journal_title：Journal of cancer research and therapeutics
pub_type： 杂志文章
doi：10.4103/0973-1482.25855
更新日期：2006-04-01 00:00:00
abstract：Background:Colorectal cancer (CRC) is the second most diagnosed cancer often identified during the later stages of carcinogenesis. Orientin, a C-glycoside of luteolin, is well known for its versatile therapeutic action toward oxidative stress-induced cellular response may exert chemoprevention against CRC. Materials a...
journal_title：Journal of cancer research and therapeutics
pub_type： 杂志文章
doi：10.4103/jcrt.JCRT_1363_16
更新日期：2018-10-01 00:00:00
abstract：PURPOSE:This retrospective study aims to assess the cut-off value of thyroglobulin (Tg) levels in nux or metastatic well-differentiated thyroid cancers (DTCs) with normal anti-Tg levels using with fluorodeoxyglucose/positron emission tomography/computed tomography (FDG PET/CT). MATERIALS AND METHODS:We reviewed FDG PE...
journal_title：Journal of cancer research and therapeutics
pub_type： 杂志文章
doi：10.4103/0973-1482.176412
更新日期：2016-04-01 00:00:00
abstract：Aims:The goal of this study was to analyze the puncture routes of imaging-guided thermal ablation for tumors of the hepatic caudate lobe. Materials and Methods:The imaging-guided thermal ablation puncture routes of 12 cases of hepatic caudate lobe tumors were collected in our hospital from January 2013 to February 201...
journal_title：Journal of cancer research and therapeutics
pub_type： 杂志文章
doi：10.4103/jcrt.JCRT_341_19
更新日期：2020-01-01 00:00:00
abstract：:Primary mucinous epithelial tumors of the testis are extremely rare. Although isolated case reports and small series have been published, these interesting neoplasms are less well-known. We report a case of a primary intratesticular mucinous cystadenoma in an asymptomatic 44-year-old man. Right radical orchiectomy was...
journal_title：Journal of cancer research and therapeutics
pub_type： 信件
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更新日期：2015-07-01 00:00:00
abstract：:Primary mediastinal synovial sarcomas are exceedingly uncommon tumors. Herein, we present the case of primary mediastinal synovial sarcoma (monophasic spindle cell-shaped variant) fully occupying the right hemithorax in a 37-year-old woman who presented to clinic with a 2-month history of right-sided chest pain and sh...
journal_title：Journal of cancer research and therapeutics
pub_type： 信件
doi：10.4103/0973-1482.172137
更新日期：2018-04-01 00:00:00
abstract：Aim:This study was carried out to determine the fungal profile and antifungal susceptibility pattern in the brushing samples of candidiasis in patients with carcinoma of esophagus. Materials and Methods:The study was carried out in the Departments of Microbiology and Surgical Oncology of a regional cancer center from ...
journal_title：Journal of cancer research and therapeutics
pub_type： 杂志文章
doi：10.4103/jcrt.JCRT_581_18
更新日期：2020-12-01 00:00:00
abstract：:Rectal cancers may rarely metastasize in bone and when it occurs, is usually preceded by lung and/or liver metastasis. However, whether it may ever bypasses other organs, particularly lung and liver and metastasizes directly to bone or not, is debatable. Some authors have described the presence of isolated bone metast...
journal_title：Journal of cancer research and therapeutics
pub_type： 信件
doi：10.4103/0973-1482.136675
更新日期：2014-04-01 00:00:00
