Search of an ideal location of isocenter in intensity-modulated radiotherapy treatment plans: A dosimetrical approach.

Abstract:

Aim:The aim of this study is to identify an ideal location of isocenter in intensity-modulated radiotherapy (IMRT) treatment plans. Materials and Methods:A total of 28 clinical target volumes and 4 English capital letters (C, L, T, and H) target volumes were considered in this study. Two IMRT treatment plans were generated for each target volume in the ECLIPSETM treatment planning system (TPS), first one with isocenter automatically placed (ISOAUTO) by TPS and the second one with geometric center-based isocenter (ISOGEOM). The geometric center of a cuboid volume, which was formed encompassing around the target volume in sagittal, transverse, and frontal planes, is considered as the geometric center of the target volume as well as the isocenter (ISOGEOM) of the IMRT plans. While performing the IMRT treatment plans using the beam angle optimization and dose volume optimization, the normal tissue objectives and target volume objectives were kept similar in both the plans. The dosimetrical parameters between the two groups of plans were compared. Results:The distance between ISOGEOM and ISOAUTO ranged from 0.16 cm to 3.04 cm with a mean and median of 0.85 cm and 0.69 cm, respectively. The ISOGEOM-based IMRT plans exhibited statistically significant advantages in total monitor units reduction (100% of cases, P ≤ 0.001), total number of field reduction (66% of cases, P ≤ 0.001), and reduction of patient mean dose (69% of cases, P ≤ 0.001) over ISOAUTO-based IMRT plans. The conformity index, homogeneity index and target mean dose were comparable between both group of plans. Conclusion:Significant dosimetrical advantages may be observed, when the geometric centroid of target volume is considered as isocenter of IMRT treatment plan.

journal_name

J Cancer Res Ther

authors

Mandal A,Asthana AK,Pradhan S,Shahi UP,Choudhary S

doi

10.4103/jcrt.JCRT_985_16

subject

Has Abstract

pub_date

2019-01-01 00:00:00

pages

211-215

issue

1

eissn

0973-1482

issn

1998-4138

pii

JCanResTher_2019_15_1_211_243508

journal_volume

15

pub_type

杂志文章
  • Hemoglobin, albumin, lymphocyte, and platelet score and neutrophil-to-lymphocyte ratio are novel significant prognostic factors for patients with small-cell lung cancer undergoing chemotherapy.

    abstract:Objective:The hemoglobin, albumin, lymphocyte, and platelet (HALP) score, neutrophil-to-lymphocyte ratio (NLR), and platelet-to-lymphocyte ratio (PLR) are the important prognostic markers in some tumor types. This study aimed to evaluate the prognostic impact of pretreatment using HALP, NLR, and PLR for patients with s...

    journal_title:Journal of cancer research and therapeutics

    pub_type: 杂志文章

    doi:10.4103/jcrt.JCRT_1066_19

    authors: Yang N,Han X,Yu J,Shu W,Qiu F,Han J

    更新日期:2020-09-01 00:00:00

  • Definitive chemoradiotherapy in Stage III nonsmall cell lung cancer: Turkey experience.

    abstract:AIM:Concurrent chemoradiotherapy (CRT) is the standard therapy for patients with unresectable Stage III nonsmall cell lung cancer (NSCLC). The aim of this study was to assess the efficacy and safety of concurrent CRT in unresectable Stage III NSCLC in Turkey. PATIENTS AND METHODS:The study included 82 patients with hi...

    journal_title:Journal of cancer research and therapeutics

    pub_type: 杂志文章

    doi:10.4103/0973-1482.163682

    authors: Yilmaz U,Yılmaz U,Yasar Z,Kıraklı EK,Ulger S,Ozdogan Y,Demirci NY,Erol S,Ozdogan I,Sahin B,Koksal D,Akcay C

    更新日期:2016-01-01 00:00:00

  • Concomitant high expression of survivin and vascular endothelial growth factor-C is strongly associated with metastatic status of lymph nodes in papillary thyroid carcinoma.

    abstract:Purpose:Papillary thyroid carcinoma (PTC) has a strong propensity to metastasize to regional lymph nodes which increases the risk of local-regional relapse and affects the course of the disease. Molecular pathogenesis of lymph node metastasis (LNM) is not yet fully understood. Survivin, a multifunctionale molecule invo...

    journal_title:Journal of cancer research and therapeutics

    pub_type: 杂志文章

    doi:10.4103/0973-1482.163675

    authors: Selemetjev S,Savin S,Paunovic I,Tatic S,Cvejic D

    更新日期:2018-01-01 00:00:00

  • A dose verification method for high-dose-rate brachytherapy treatment plans.

    abstract:AIM:To evolve a fast dose verification method for high-dose-rate (HDR) brachytherapy treatment plans and to demonstrate its applicability in different clinical cases. MATERIALS AND METHODS:We developed a software tool in VC++ for the Varisource HDR unit for HDR dosimetry plan verification using TG-43 parameters. HDR t...

    journal_title:Journal of cancer research and therapeutics

    pub_type: 杂志文章

    doi:10.4103/0973-1482.44288

    authors: Kumar R,Sharma SD,Vijaykumar C,Deshpande S,Sharma PK,Vandana S,Philomena A,Chilkulwar RH

    更新日期:2008-10-01 00:00:00

  • Chondrosarcoma of the distal phalanx of the right great toe: report of a rare malignancy and review of literature.

    abstract::Foot is an uncommon site for chondrosarcoma and involvement of phalanges is extremely rare. Here, a case of low-grade chondrosarcoma of the distal phalanx of the right great toe in a 37-year-old male patient is being reported. The patient complained of gradual swelling of the right great toe and pain for last 2 years....

    journal_title:Journal of cancer research and therapeutics

    pub_type: 杂志文章,评审

    doi:10.4103/0973-1482.95191

    authors: Mondal SK

    更新日期:2012-01-01 00:00:00

  • Systemic lupus erythematous increased lung cancer risk: Evidence from a meta-analysis.

    abstract:AIMS:Several studies suggested that systemic lupus erythematosus (SLE) were associated with the risk of lung cancer. However, other studies did not confirm the result. Therefore, we conducted a meta-analysis to investigate this association. MATERIALS AND METHODS:A systematic literature search was conducted using the P...

    journal_title:Journal of cancer research and therapeutics

    pub_type: 杂志文章,meta分析

    doi:10.4103/0973-1482.172115

    authors: Wu Y,Hou Q

    更新日期:2016-04-01 00:00:00

  • Primary spinal glioblastoma treated with adjuvant radiation and temozolomide: Report of two cases.

    abstract::Primary spinal glioblastoma multiforme (GBM) is a rare entity, which is invariably associated with poor outcome. Standard treatment is surgery followed by post-operative radiotherapy. Due to paucity of cases role of chemotherapy is investigational. We intend to report two cases of primary spinal GBM treated with radia...

    journal_title:Journal of cancer research and therapeutics

    pub_type: 信件

    doi:10.4103/0973-1482.137998

    authors: Mallick S,Madan R,Julka PK

    更新日期:2015-07-01 00:00:00

  • Impact of Toombak dipping in the etiology of oral cancer: gender-exclusive hazard in the Sudan.

    abstract:BACKGROUND:Oral cancer (OC) mortality is very high in Sudan, particularly among men due to the habit of Toombak use (tobacco specific nitrose amine (TSN)) rich tobacco. AIMS:Our aim was to determine whether OC is gender-specific due to increased Toombak use among males as suggested a risk for subsequent development of...

    journal_title:Journal of cancer research and therapeutics

    pub_type: 杂志文章

    doi:10.4103/0973-1482.34696

    authors: Ahmed HG,Mahgoob RM

    更新日期:2007-04-01 00:00:00

  • Tooth agenesis: A susceptible indicator for colorectal cancer?

    abstract:Context/Background:Tooth agenesis (excluding third molars) is a common congenital disorder that affects 2.2-10% of the general population. A number of different genes have been shown to be associated with cases of tooth agenesis including AXIN2, IRF6, FGFR1, MSX1, PAX9, and TGFA. Wingless/integration signaling gene, AX...

    journal_title:Journal of cancer research and therapeutics

    pub_type: 杂志文章

    doi:10.4103/0973-1482.168997

    authors: Paranjyothi MV,Kumaraswamy KL,Begum LF,Manjunath K,Litha.,Basheer S

    更新日期:2018-04-01 00:00:00

  • Intractable nausea in a patient with synchronous pancreatic cancer and a fourth-ventricular ependymoma.

    abstract::Symptoms of nausea and vomiting can present a diagnostic challenge for physicians. In this article, we report a patient who was found to have synchronous presentation of an ependymoma and pancreatic cancer. This case illustrates some of the diagnostic challenges in patients with constitutional symptoms. Furthermore, i...

    journal_title:Journal of cancer research and therapeutics

    pub_type: 杂志文章

    doi:10.4103/0973-1482.126474

    authors: Chowdhry VK,Carter DA,Shapiro A

    更新日期:2013-10-01 00:00:00

  • Video-assisted thoracoscopic lobectomy for elderly nonsmall cell lung cancer: Short-term and long-term outcomes.

    abstract:BACKGROUND:Lung cancer is the leading cause of cancer-related death worldwide, and the number of elderly patients with nonsmall-cell lung cancer (NSCLC) has risen with increasing life-expectancy. AIMS:To evaluate safety and efficacy of thoracoscopic lobectomy for NSCLC patients above 75 years old. PATIENTS AND METHOD...

    journal_title:Journal of cancer research and therapeutics

    pub_type: 杂志文章

    doi:10.4103/0973-1482.140930

    authors: Qiang G,Liang C,Guo Y,Shi B,Tian Y,Song Z,Liu D

    更新日期:2015-10-01 00:00:00

  • Laparoscopic partial splenectomy of benign tumors assisted by microwave ablation.

    abstract:Objective:The aim of this study is to investigate the application and the feasibility of microwave ablation in laparoscopic partial splenectomy. Materials and Methods:From January 2018 to June 2019, four patients with benign spleen lesions in our hospital underwent laparoscopic partial splenectomy assisted by microwav...

    journal_title:Journal of cancer research and therapeutics

    pub_type: 杂志文章

    doi:10.4103/jcrt.JCRT_816_19

    authors: Li Q,Liu Z,Hu M,Ou M,Liu K,Lin W,Wu F,Cao M

    更新日期:2020-09-01 00:00:00

  • Metastatic dermatofibrosarcoma protuberans: A rare case report from North India.

    abstract::Dermatofibrosarcoma protuberans (DFSP) is a low-grade tumor with rare metastasis. A 26-year-old male presented with multiple cutaneous nodular lesions of DFSP since 3 months along with distant metastasis to the brain, pleura, and muscles that were detected on investigations. The case is being reported due to its rare ...

    journal_title:Journal of cancer research and therapeutics

    pub_type: 信件

    doi:10.4103/0973-1482.146099

    authors: Mahajan BB,Sumir K,Singla M

    更新日期:2015-07-01 00:00:00

  • Off-label use of anti-cancer drugs in India: to be or not to be!

    abstract:BACKGROUND:Administering drugs outside the terms of their official labeling is called off-label use. In the West, oncologists often use drugs off-label, which offers several advantages especially while treating patients with multiple comorbidities or advanced cancer. The practice of off-label prescribing of anticancer ...

    journal_title:Journal of cancer research and therapeutics

    pub_type: 杂志文章

    doi:10.4103/0973-1482.80455

    authors: Gota V,Patial P

    更新日期:2011-01-01 00:00:00

  • Targeting energy metabolism in brain cancer through calorie restriction and the ketogenic diet.

    abstract::Malignant brain tumors are a significant health problem in children and adults and are largely unmanageable. As a metabolic disorder involving the dysregulation of glycolysis and respiration (the Warburg effect), malignant brain cancer can be managed through changes in metabolic environment. In contrast to malignant b...

    journal_title:Journal of cancer research and therapeutics

    pub_type: 杂志文章,评审

    doi:10.4103/0973-1482.55134

    authors: Seyfried BT,Kiebish M,Marsh J,Mukherjee P

    更新日期:2009-09-01 00:00:00

  • Adenocarcinoma located at a Meckel's Diverticulum: A case report and literature review.

    abstract::Tumors arising from Meckel's diverticulum (MD) reported in the literature are mainly carcinoid and gastrointestinal stromal tumors. We herein report a rare case of adenocarcinoma arising from intestinal mucosa in an MD with multiple liver metastases at the onset of symptoms. A 57-year-old female complaining of bloody ...

    journal_title:Journal of cancer research and therapeutics

    pub_type: 信件,评审

    doi:10.4103/jcrt.JCRT_124_17

    authors: Zhao Y,Yang X,Ye Y

    更新日期:2017-01-01 00:00:00

  • Lipoblastoma and lipoblastomatosis: A clinicopathological study of six cases.

    abstract::Lipoblastoma and lipoblastomatosis are benign adipocytic tumors seen in children less than 3 years of age. Awareness amongst surgeons of this fast growing lipomatous tumor in young children is important to avoid mutilating surgery and chemotherapy. Histological diagnosis of lipoblastoma is sometimes difficult because ...

    journal_title:Journal of cancer research and therapeutics

    pub_type: 信件

    doi:10.4103/0973-1482.176135

    authors: Ghosh P,Das RN,Ghosh R,Chatterjee U,Datta C,Mishra PK

    更新日期:2015-10-01 00:00:00

  • ATP7B rs9535826 is associated with gastrointestinal toxicity of platinum-based chemotherapy in nonsmall cell lung cancer patients.

    abstract:Aims:Platinum-based chemotherapy is considered as the first-line treatment for nonsmall cell lung cancer (NSCLC) patients. However, platinum resistance and toxicity are major obstacles to its clinical applications. The two P-type ATPases ATP7A and ATP7B have been identified to play an essential role in the transport of...

    journal_title:Journal of cancer research and therapeutics

    pub_type: 杂志文章

    doi:10.4103/jcrt.JCRT_890_17

    authors: Li YQ,Zhang XY,Chen J,Yin JY,Li XP

    更新日期:2018-01-01 00:00:00

  • Antitumoral potential of microvesicles extracted from human adipose-derived mesenchymal stem cells on human breast cancer cells.

    abstract:Aim of Study:One of the new methods that have promising results is the use of cell-derived microvesicles (MVs) to kill tumor cells. Given that MVs contain apoptotic materials, genes, and proteins, they can interfere with the fate of adjacent cells. Materials and Methods:In the present study, after adipose tissue-deriv...

    journal_title:Journal of cancer research and therapeutics

    pub_type: 杂志文章

    doi:10.4103/jcrt.JCRT_147_18

    authors: Rezaie Z,Ardeshirylajimi A,Ashkezari MD,Seifati SM

    更新日期:2019-07-01 00:00:00

  • Evaluating factors affecting survival in colon and rectum cancer: A prospective cohort study with 161 patients.

    abstract:Context:Colorectal cancers are frequent among cancers of gastrointestinal system. Whether there are any differences between survival in rectum and colon cancer patients is controversial. Aims:In this study, we aimed to compare survival in surgically treated rectum and colon cancers and determine the factors affecting ...

    journal_title:Journal of cancer research and therapeutics

    pub_type: 杂志文章

    doi:10.4103/0973-1482.199390

    authors: Kalcan S,Sisik A,Basak F,Hasbahceci M,Kilic A,Kosmaz K,Kivanc AE,Kudas I,Bas G,Alimoglu O

    更新日期:2018-01-01 00:00:00

  • Evaluation of antitumor efficacy and toxicity of novel 6-nitro-2-(3-chloropropyl)-1H-benz[de]isoquinoline-1,3-dione in vivo in mouse.

    abstract:AIM:This study was aimed to assess the in vivo anti-tumoral potency of the novel 6-nitro-2-(3-chloropropyl)-1H-benz[de]isoquinoline-1,3-dione [Compound 1] that has earlier demonstrated excellent cytotoxicity in 15 out of 17 human tumor cell lines tested. MATERIALS AND METHODS:Two murine tumors namely Sarcoma-180 (S-18...

    journal_title:Journal of cancer research and therapeutics

    pub_type: 杂志文章

    doi:10.4103/0973-1482.119332

    authors: Mukherjee A,Dutta S,Sanyal U

    更新日期:2013-07-01 00:00:00

  • Emphasizing on heat shock protein 90's utility in head and neck squamous cell carcinoma treatment.

    abstract::Heat shock protein 90 (Hsp90) a member of the heat shock proteins (HSPs) family, is an adenosine triphosphate dependent molecular chaperone protein, which integrates multiple oncogenic pathways. Clinically, encouraging results have been demonstrated in melanoma, acute myeloid leukemia, castrate refractory prostate can...

    journal_title:Journal of cancer research and therapeutics

    pub_type: 杂志文章,评审

    doi:10.4103/0973-1482.126451

    authors: Routray S,Sunkavalli A,Swain N,Shankar AA

    更新日期:2013-10-01 00:00:00

  • Radiation recall phenomenon presenting as myositis triggered by carboplatin plus paclitaxel and related literature review.

    abstract::While most case reports to date are radiation recall dermatitis, radiation recall myositis, which is a distinct form of radiation recall phenomenon caused by carboplatin plus paclitaxel, has not been reported. We treated a 57-year-old female patient who suffered from recurrent cervical cancer. When the patient develop...

    journal_title:Journal of cancer research and therapeutics

    pub_type: 信件,评审

    doi:10.4103/0973-1482.146090

    authors: Maeng CH,Park JS,Lee SA,Kim DH,Yun DH,Yoo SD,Kim HS,Chon J

    更新日期:2014-10-01 00:00:00

  • Adjuvant treatment for Stage I seminoma: Why radiotherapy is better than carboplatin.

    abstract::Adjuvant treatment options for Stage I seminoma include active surveillance, chemotherapy, and radiotherapy. Active surveillance may not be ideal for the average Indian patient. Of the two accepted adjuvant therapy options, namely single-dose carboplatin chemotherapy and radiotherapy to the retroperitoneal nodes, thou...

    journal_title:Journal of cancer research and therapeutics

    pub_type: 杂志文章,评审

    doi:10.4103/0973-1482.176171

    authors: Yathiraj PH,Sharan K,Fernandes DJ,Vidyasagar MS

    更新日期:2016-10-01 00:00:00

  • Hodgkin's lymphoma of the breast.

    abstract::Hodgkin's lymphoma of the breast is very rare. We report a case of Hodgkin's lymphoma of the breast in a 61 year old post-menopausal female who presented with a 3 month history of left breast painless lump. Excision biopsy was done and histology showed nodular sclerotic Hodgkin's lymphoma confirmed by immunohistochemi...

    journal_title:Journal of cancer research and therapeutics

    pub_type: 杂志文章

    doi:10.4103/0973-1482.119369

    authors: Osuji CU,Ahaneku GI,Onwubuya EI,Okocha EC,Ukah C,Emegoakor CD,Omejua EG

    更新日期:2013-07-01 00:00:00

  • Rare coexistence of keratinizing squamous cell carcinoma with xanthogranulomatous pyelonephritis in the same kidney: report of two cases.

    abstract::Squamous cell carcinoma of urinary tract is a rarely encountered tumor. It is more frequently reported in urinary bladder and male urethra than renal pelvis. Squamous cell carcinoma of renal pelvis is usually associated with nephrolithiasis. However, coexistence of keratinizing squamous cell carcinoma with xanthogranu...

    journal_title:Journal of cancer research and therapeutics

    pub_type: 杂志文章

    doi:10.4103/0973-1482.73351

    authors: Mardi K,Kaushal V,Sharma V

    更新日期:2010-07-01 00:00:00

  • Hypopharyngeal cancer risk in Japanese: Genetic polymorphisms related to the metabolism of alcohol- and tobacco-associated carcinogens.

    abstract:Background:Several studies have investigated hypopharyngeal cancer (HC) risk in combination with xenobiotic metabolism-related genetic polymorphisms and the burden of alcohol consumption and smoking in European countries but not in East Asian countries. Patients and Methods:This hospital-based case-control study invol...

    journal_title:Journal of cancer research and therapeutics

    pub_type: 杂志文章

    doi:10.4103/jcrt.JCRT_980_17

    authors: Yamashita Y,Ikegami T,Suzuki M,Hirakawa H,Maeda H,Yamada S,Deng Z,Kondo S,Kinjyo H,Kiyuna A,Agena S,Uehara T,Ganaha A

    更新日期:2019-07-01 00:00:00

  • Intranodal palisaded myofibroblastoma: a case report and an update on etiopathogenesis and differential diagnosis.

    abstract::Intra-nodal palisaded myofibroblastoma (IPM) is a rare benign lymph node mesenchymal tumor. It presents as a slow growing, painless nodular mass confined mostly to the inguinal area. Histologically, it shows palisading spindle cells, hemorrhages, hemosiderin laden macrophages, and amianthoid fibers, almost totally rep...

    journal_title:Journal of cancer research and therapeutics

    pub_type: 杂志文章

    doi:10.4103/0973-1482.113395

    authors: Sarma NH,Arora KS,Varalaxmi KP

    更新日期:2013-04-01 00:00:00

  • The impact of perioperative blood transfusion on survival and recurrence after radical prostatectomy for prostate cancer: A systematic review and meta-analysis.

    abstract:Objective:Conflicting data have been reported regarding the association between perioperative blood transfusion (PBT) and clinical outcomes for prostate cancer patients. We conducted a systematic review and meta-analysis to evaluate the impact of PBT on cancer survival and recurrence for patients who underwent radical ...

    journal_title:Journal of cancer research and therapeutics

    pub_type: 杂志文章,meta分析,评审

    doi:10.4103/0973-1482.193115

    authors: Pushan Z,Manbiao C,Sulai L,Jun L,Ruidong Z,Hanshen Y

    更新日期:2018-09-01 00:00:00

  • Investigating the risk factors of hepatocellular carcinoma and survival analysis for cirrhosis after transjugular intrahepatic portosystemic shunt in treating portal hypertension.

    abstract:Objective:This study aimed to explore the risk factors of hepatocellular carcinoma (HCC) and survival analysis for cirrhosis after transjugular intrahepatic portosystemic shunt (TIPS) in treating portal hypertension. Materials and Methods:A retrospective database review was performed, including 106 patients (33 female...

    journal_title:Journal of cancer research and therapeutics

    pub_type: 杂志文章

    doi:10.4103/jcrt.JCRT_930_17

    authors: Wei J,Li H,Li C

    更新日期:2018-01-01 00:00:00