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Therapeutic results of Denver percutaneous peritoneovenous shunt in cancer patients with malignant ascites.

Abstract：

Background:Intractable ascites secondary to malignant disease deteriorates patients' quality of life. The purpose of this study was to evaluate the safety and efficacy of percutaneous peritoneovenous (Denver) shunt in treating intractable malignant ascites in cancer patients. Materials and Methods:Thirty-five patients who had undergone Denver peritoneovenous shunt for the treatment of ascites associated with malignant tumor from October 2014 to 2017 were retrospectively analyzed. The demographic characteristics, laboratory values, and complications were recorded. Univariate and multivariate logistic regression analyses were performed. Results:The sites of primary tumor were pancreatic cancer in 19 patients, bile duct cancer in 8, gallbladder cancer in 5, breast cancer in 2, and peritoneal malignant mesothelioma in 1. Palliation of abdominal distention was achieved in 29 patients (82.9%). Postoperative complications of Grade 2 or higher were seen in 11 patients (31.4%), and Grade 5 complications were observed in three patients (8.6%). Patients with a high American Society of Anesthesiologists (ASA) grade and high ascites drainage volume had a significantly higher incidence of postoperative complications than a low ASA grade and low ascites drainage volume, and a multivariate logistic analysis showed that the intraoperative ascites drainage volume was an independent risk factor for all complications. Conclusions:The Denver shunt for malignant ascites is useful for improving patients' quality of life if the indications are selected properly. Drainage of intraoperative ascites was a risk factor for postoperative complications after the Denver shunt technique in cancer patients with malignant ascites. Further experience and discussion are necessary to establish the patient selection criteria.

journal_name

J Cancer Res Ther

journal_title

Journal of cancer research and therapeutics

authors

Tamagawa H,Aoyama T,Inoue H,Fujikawa H,Sawazaki S,Numata M,Sato T,Oshima T,Yukawa N,Morimoto M,Ueno M,Rino Y,Masuda M

doi

10.4103/jcrt.JCRT_606_18

subject

Has Abstract

pub_date

2020-12-01 00:00:00

pages

S95-S98

issue

Supplement

eissn

0973-1482

issn

1998-4138

pii

JCanResTher_2020_16_8_95_264703

journal_volume

pub_type

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Therapeutic results of Denver percutaneous peritoneovenous shunt in cancer patients with malignant ascites.