Abstract：
BACKGROUND:Changes in salivary flow rate were studied in head and neck (H and N) cancer patients who, after receiving moderately accelerated radiotherapy (RT) and concurrent chemotherapy (CT), were free of disease at 1 year. MATERIALS AND METHODS:Between July 2003 and July 2005, saliva estimation was performed for 36 patients of locally advanced (AJCC stages III and IV) squamous cell carcinoma of the H and N. RT, moderately accelerated (70 Gy/35 fx/6 weeks) along with concurrent weekly cisplatin at 35 mg/m 2 (capped at 50 mg) with standard hydration and anti-emetic cover, was planned using conventional planning on telecobalt or 6 MV photons. The saliva flow rate was estimated for 5 min at rest (unstimulated) and after using lemon drops (stimulated) for the next 5 min at baseline (pre-treatment), 3, 6 and 12 months following treatment. RESULTS:The median follow-up of this study was 29 months. Compared with baseline, by 3 months, a significant reduction in unstimulated (0.35 ml/min and 0.10 ml/min) and stimulated (0.97 ml/min and 0.28 ml/min) salivary flow rate was observed, respectively. This continued to decrease further till 6 months (0.06 ml/min and 0.17 ml/min) and, by 12 months, a minimal and non-significant recovery was observed in both unstimulated (0.08 ml/min) and stimulated salivary flow rates (0.22 ml/min), respectively. CONCLUSIONS:Salivary flow rates fall to a fourth of the baseline value with the above CT + RT protocol, with minimal recovery at 12 months following completion of treatment.
journal_name
J Cancer Res Therjournal_title
Journal of cancer research and therapeuticsauthors
Lal P,Bajpai R,Khurana R,Das KJ,Kumar P,Tiwari A,Gupta N,Kumar Sdoi
10.4103/0973-1482.77105subject
Has Abstractpub_date
2010-10-01 00:00:00pages
458-62issue
4eissn
0973-1482issn
1998-4138pii
JCanResTher_2010_6_4_458_77105journal_volume
6pub_type
杂志文章abstract：BACKGROUND:Bleomycin-induced pulmonary (BIP) toxicity is a notorious entity and cropped up in roughly 10% of cases. The aim of the study is to evaluate BIP at our tertiary care cancer center. PATIENTS AND METHODS:This is a retrospective, analytical study conducted at a tertiary care center from January 1998 to Decembe...
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