当前位置： SCI文献检索 > Journal of Cancer Research and Therapeutics期刊下所有文献 > Evaluation of the organs at risk doses for lung tumors in gated and conventional radiotherapy.

Evaluation of the organs at risk doses for lung tumors in gated and conventional radiotherapy.

Abstract：

Purpose:The purpose of this study was to evaluate the organs at risk (OARs) doses for lung tumors in gated radiotherapy (RT) compared to conventional RT using the four-dimensional extended cardiac-torso (4D-XCAT) digital phantom in a simulation study. Materials and Methods:4D-XCAT digital phantom was used to create 32 digital phantom datasets of different tumor diameters of 3 and 4 cm, and motion ranges (MRs) of 2, 2.5, 3, and 3.5 cm and each tumor was placed in four different lung locations (right lower lobe, right upper lobe, left lower lobe, and left upper lobe). XCAT raw binary images were converted to the digital imaging and communication in medicine format using an in-house MATLAB-based program and were imported to treatment planning system (TPS). For each dataset, gated and conventional treatment plans were prepared using Planning Computerized RadioTherapy-three dimensional (PCRT-3D) TPS with superposition computational algorithm. Dose differences between gated and conventional plans were evaluated and compared (as a function of 3D motion and tumor volume and its location) with respect to the dose-volume histograms of different organs-at-risk. Results:There are statistically significant differences in dosimetric parameters among gated and conventional RT, especially for the tumors near the diaphragm (P < 0.05). The maximum reduction in the mean dose of the lung, heart, and liver were 6.11 Gy, 1.51 Gy, and 10.49 Gy, respectively, using gated RT. Conclusions:Dosimetric comparison between gated and conventional RT showed that gated RT provides relevant dosimetric improvements to lung normal tissue and the other OARs, especially for the tumors near the diaphragm. In addition, dosimetric differences between gated and conventional RT did generally increase with increasing tumor motion and decreasing tumor volume.

journal_name

J Cancer Res Ther

journal_title

Journal of cancer research and therapeutics

authors

Shahzadeh S,Gholami S,Aghamiri SMR,Mahani H,Nabavi M

doi

10.4103/jcrt.JCRT_735_18

subject

Has Abstract

pub_date

2020-07-01 00:00:00

pages

726-730

issue

eissn

0973-1482

issn

1998-4138

pii

JCanResTher_2020_16_4_726_268951

journal_volume

pub_type

杂志文章

在线工具

Evaluation of the organs at risk doses for lung tumors in gated and conventional radiotherapy.