Abstract：
BACKGROUND:The integrity of the immune system is necessary to control tumor progression and a compromised state contributes to tumor escape. AIMS:The study intends to evaluate the presence and distribution pattern of Langerhans cells (LC) in Oral epithelial dysplasia (OED) and oral squamous cell carcinoma (OSCC) oral epithelial dysplasia and oral squamous cell carcinoma and elucidate their role. The study analyses LC in histological zones of the epithelium and connective tissue, which has seldom been attempted previously. MATERIALS AND METHODS:Forty-five microscopic sections (i.e. 5 normal, 15 OED and 25 OSCC) were examined for expression of LC marker CD1a using immunohistochemistry. LCs were counted in zones of epithelium and connective tissue. STATISTICAL ANALYSIS USED:Results were analyzed using SPSS Version 16.0 and subjected to one-way ANOVA comparison and Student's t-test and Wilcoxon Z test. RESULTS:Significant decline in LC count was observed with progressing grade of OED and OSCC. The basal and suprabasal zones in OED and superficial zone in OSCC exhibited the highest density of LCs. The low LC count in severe dysplasia was attributed to paucity in the basal zone. There was a significant paucity of LCs in the sub-epithelial zone of all the grades of OSCC, with high influx of LCs within the tumor stroma. Also, poorly differentiated OSCC exhibited a significant decrease in the LC count within the overlying epithelium as well as the tumor stroma. CONCLUSION:The present study suggests that there is a recruitment of LCs in the neoplastic process. Changes observed in LC distribution within the zones of dysplastic epithelium and tumor stroma can be interpreted as their pathophysiologic function.
journal_name
J Cancer Res Therjournal_title
Journal of cancer research and therapeuticsauthors
Upadhyay J,Rao NN,Upadhyay RBdoi
10.4103/0973-1482.106565subject
Has Abstractpub_date
2012-10-01 00:00:00pages
591-7issue
4eissn
0973-1482issn
1998-4138pii
JCanResTher_2012_8_4_591_106565journal_volume
8pub_type
杂志文章abstract：Background:Colorectal cancer (CRC) is the second most diagnosed cancer often identified during the later stages of carcinogenesis. Orientin, a C-glycoside of luteolin, is well known for its versatile therapeutic action toward oxidative stress-induced cellular response may exert chemoprevention against CRC. Materials a...
journal_title：Journal of cancer research and therapeutics
pub_type： 杂志文章
doi：10.4103/jcrt.JCRT_1363_16
更新日期：2018-10-01 00:00:00
abstract：Context:The metastasis of liver cancer is a major cause of clinical treatment failure, restrain, and control the cancer metastasis is the major strategy of the treatment and prevention of the disease. Special AT-rich sequence-binding protein 1 (SATB1) gene was overexpressed in many malignant tumors and considered as a ...
journal_title：Journal of cancer research and therapeutics
pub_type： 杂志文章
doi：10.4103/0973-1482.203597
更新日期：2018-12-01 00:00:00
abstract：OBJECTIVE:The aim of the present study was to evaluate the feasibility and safety of laparoscopic surgery for endometrial cancer in aged patients and show the experiences of laparoscopic surgery for elderly endometrial cancer patients in Eastern China. MATERIALS AND METHODS:A total of 211 patients (≥60 years) with end...
journal_title：Journal of cancer research and therapeutics
pub_type： 杂志文章
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更新日期：2017-01-01 00:00:00
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journal_title：Journal of cancer research and therapeutics
pub_type： 杂志文章
doi：10.4103/0973-1482.177504
更新日期：2016-04-01 00:00:00
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journal_title：Journal of cancer research and therapeutics
pub_type： 杂志文章
doi：10.4103/0973-1482.95201
更新日期：2012-01-01 00:00:00
abstract：BACKGROUND:Hepatocellular carcinoma is the most common primary tumor of the liver. Disease dissemination occurs through hematogenous routes and frequently involves the lungs, bone, adrenal glands, and pancreas. The patterns of the extrahepatic manifestations are diverse. Soft tissue metastasis is extremely rare and man...
journal_title：Journal of cancer research and therapeutics
pub_type： 杂志文章
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pub_type： 信件,评审
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更新日期：2014-04-01 00:00:00
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journal_title：Journal of cancer research and therapeutics
pub_type： 杂志文章,评审
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更新日期：2016-01-01 00:00:00
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journal_title：Journal of cancer research and therapeutics
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pub_type： 杂志文章
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更新日期：2014-10-01 00:00:00
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journal_title：Journal of cancer research and therapeutics
pub_type： 杂志文章
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更新日期：2016-04-01 00:00:00
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journal_title：Journal of cancer research and therapeutics
pub_type： 杂志文章
doi：10.4103/0973-1482.220416
更新日期：2017-10-01 00:00:00
abstract：OBJECTIVE:The purpose of this retrospective study was to evaluate the diagnosis efficacy of plasma interleukin 17 (IL-17) for hepatocellular carcinoma (HCC). MATERIALS AND METHODS:Thirty-nine patients with confirmed HCC and 41 healthy controls were retrospectively analyzed in this study. The serum level of IL-17 was t...
journal_title：Journal of cancer research and therapeutics
pub_type： 杂志文章
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更新日期：2014-12-01 00:00:00
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pub_type： 杂志文章
doi：10.4103/0973-1482.163761
更新日期：2018-01-01 00:00:00
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journal_title：Journal of cancer research and therapeutics
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doi：10.4103/0973-1482.143334
更新日期：2015-01-01 00:00:00
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journal_title：Journal of cancer research and therapeutics
pub_type： 杂志文章,收录出版
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更新日期：2014-07-01 00:00:00
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journal_title：Journal of cancer research and therapeutics
pub_type： 杂志文章
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更新日期：2014-12-01 00:00:00
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journal_title：Journal of cancer research and therapeutics
pub_type： 临床试验,杂志文章
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更新日期：2009-10-01 00:00:00
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journal_title：Journal of cancer research and therapeutics
pub_type： 杂志文章
doi：10.4103/jcrt.JCRT_256_18
更新日期：2018-01-01 00:00:00
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pub_type： 杂志文章,随机对照试验
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更新日期：2018-09-01 00:00:00
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pub_type： 杂志文章,meta分析,评审
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更新日期：2016-04-01 00:00:00
abstract：:[This corrects the article DOI: 10.4103/0973-1482.180685]. ...
journal_title：Journal of cancer research and therapeutics
pub_type： 已发布勘误
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更新日期：2019-10-01 00:00:00
abstract：:Camrelizumab is a programmed death receptor-1 inhibitor originally developed in China for the treatment of refractory lymphoma. It has also been effective in non-small-cell lung cancer patients. However, the rechallenge of camrelizumab was not reported previously. We report the rechallenge of camrelizumab therapy in t...
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pub_type：
doi：10.4103/jcrt.JCRT_798_20
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