Good prognostic factor in patients with nonmetastatic nasopharyngeal carcinoma: Programmed death ligand-1 expression in tumor cells.

Abstract:

Purpose:Programmed death ligand-1 (PD-L1) is the main ligand for programmed death-1 (PD-1), and is one of the major targets for cancer immunotherapy. Only a few studies are available for the clinical significance of PD-1/PD-L1 in nasopharyngeal carcinoma (NPC). There is a controversial association between PD-L1 expression and survival in NPC. This study aimed at defining any potential association between PD-L1 expression in tumor cells (TCs) and prognosis in NPC. Patients and Methods:A total of seventy NPC patients treated between January 2008 and December 2016 were included in the study. PD-L1 expression was assessed by immunohistochemistry (IHC) in tumor specimens. The IHC assay was considered positive if ≥5% of TCs are stained. Clinicopathological variables were documented. Variables included in the analysis were PD-L1 expression, clinicopathological characteristics, and prognosis. Results:The estimated 5-year overall survival (OS) rate was 62%. Nearly 55.7% (n = 39) of the TCs tested positive for PD-L1 expression. No associations were found between the level of PD-L1 in TCs and clinicopathological characteristics. Comparisons between patients with PD-L1-positive tumors and PD-L1-negative tumors revealed that OS was statistically significantly longer in patients with PD-L1-positive tumors as assessed by the univariate Cox regression analysis (hazard ratio [HR], 0.378; 95% confidence interval, 0.158-0.905; P = 0.029) and Kaplan-Meier curves (P = 0.023). Conclusion:PD-L1 expression is an important prognostic factor in NPC. PD-L1 expression positively correlates with survival.

journal_name

J Cancer Res Ther

authors

Sahinli H,Akyürek N,Yılmaz M,Kandemir O,Duran AO,Kulaçoǧlu S,Uçar G,Acar E,Özet A,Öksüzoǧlu OBÇ,Özdemir NY

doi

10.4103/jcrt.JCRT_759_19

subject

Has Abstract

pub_date

2020-12-01 00:00:00

pages

S43-S47

issue

Supplement

eissn

0973-1482

issn

1998-4138

pii

JCanResTher_2020_16_8_43_290471

journal_volume

16

pub_type

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